- ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A clinical study of MK-7228 in healthy men (MK-7228-001)
This study is looking at a new medicine called MK-7228 in healthy men. It's the very first time this medicine is being given to people. Researchers want to see how it works in the body and if it's safe. It's part of understanding how to treat serious heart conditions like atherosclerosis.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-1403 in healthy people (MK-1403-002)
This study is looking at a new medicine called MK-1403 in healthy volunteers. It's an early-stage study to see how the medicine works in the body and if it's safe. The goal is to help people with a condition called atherosclerosis, which affects the arteries.
Belgium - authorisedTherapeutic use (Phase IV)
Statins to Prevent Immune checkpoint inhibitor-induced pRogression of AtheroscLerosis
This study is looking at whether a common medicine called atorvastatin can help prevent or slow down the build-up of fatty deposits (atherosclerosis) in blood vessels for people who are taking certain cancer treatments. It aims to see if the medicine can reduce changes in these deposits over time.
Netherlands - recruiting
Barts Sex-CAD Database - Sex Hormones and Inflammatory Status in Coronary Artery Disease
This study looks at how hormones and inflammation affect heart artery disease in men and women, especially for women after menopause. Researchers at Barts Heart Centre hope to find better ways to treat heart conditions by understanding these differences.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A clinical study of MK-2828 in healthy people (MK-2828-001)
This study is looking for healthy men aged 18 and over to test a new medicine called MK-2828. It's the first time this medicine will be given to people. The aim is to check if it's safe and how it works in the body.
Belgium - active not recruitingNA
IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
This study compares two ways to guide heart stent procedures: standard X-rays or a more detailed ultrasound method. It aims to see if the detailed ultrasound improves results for people with complex heart blockages and is good value for money.
United States · Cyprus · Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-1403 in healthy men (MK-1403-004)
This study is looking into a new medicine called MK-1403 in healthy men. It aims to understand how the medicine works in the body and if it could help with conditions like atherosclerosis, which affects blood vessels.
Belgium - recruitingNA
PET Imaging of Inflammation and Lipid Lowering Study
This study looks at new ways to scan and treat high cholesterol and hardened arteries. It uses special scans and medications like Inclisiran or Colchicine to see how they affect swelling in the arteries. We hope to find better ways to understand and treat these conditions.
United Kingdom - recruiting
Assessment of Lipoprotein(a) and Endogenous Fibrinolysis in Atherosclerotic Cardiovascular Disease/Aortic Valve Disease
This study looks at a blood fat called Lp(a) and how well your body breaks down blood clots, especially in people with heart or aortic valve disease. We're also checking if new cholesterol medicines can help improve clot breakdown.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A clinical study of MK-2828 in healthy people (MK-2828-002)
This study is looking into a new medicine called MK-2828. It's for healthy men to check if the medicine is safe and how it works in the body. The goal is to see if it could help people with a condition called atherosclerosis, where arteries get clogged.
Belgium - recruitingPHASE3
A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk
This study investigates a new medicine, lepodisiran, to reduce fatty deposits (plaque) in heart arteries. It's for adults aged 45-80 with high Lp(a), a type of cholesterol, who have heart problems or are at high risk. Researchers will use special scans to see if the medicine helps.
United States · Australia · Czechia - ongoing, recruitingHuman Pharmacology (Phase I)- Other
MK-1403 Single Dose Formulation PK Study
This study is looking at a new medicine called MK-1403. It's for a condition called atherosclerosis, which is when arteries get blocked. We want to see how the body uses and gets rid of this new medicine after a single dose. This is an early-stage study to understand the medicine better.
Belgium - active not recruiting
Residual Inflammation and Plaque Progression Long-term Evaluation
This study looks at how inflammation in blood vessels after a heart attack might lead to future problems. We use special scans to see inflammation and track changes in blood vessels over time. The goal is to understand how to better prevent future heart issues.
United Kingdom - recruiting
Studying the Effects of Cannabis on Vasculature
This study looks at how long-term cannabis use affects your heart and blood vessels. Researchers will compare people who use cannabis regularly with those who don't, checking blood vessel health and signs of inflammation using simple tests and blood samples.
Canada - recruiting
Carotid Intraplaque Neovascularization Combined With Stress Echo
This study looks at a new way to predict heart attacks and strokes. It combines a standard heart stress test with a special neck ultrasound. This aims to find people at higher risk whose usual tests might miss them, by looking closely at fatty build-ups in blood vessels.
Canada - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Single Ascending Dose Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MK-1403 in Healthy Male Participants
This early-stage study is looking at a new medicine called MK-1403 for a condition called atherosclerosis, which is a build-up in your arteries. We want to see how safe it is and how the body handles it in healthy men. It's the first time this medicine is being given to people.
Belgium