- recruitingNA
Early Atrial Fibrillation Ablation for Stroke Prevention in Patients With High Comorbidity Burden (EASThigh-AFNET 11)
This study looks at whether a heart procedure called 'ablation' can better prevent serious problems like stroke or heart failure in people with an irregular heartbeat (atrial fibrillation) and other health issues, compared to standard care.
Australia · Canada · Germany - active not recruitingNA
Triple Cardiovascular Disease Detection With an Artificial Intelligence-enabled Stethoscope
This study is testing a new AI-powered stethoscope to see if it can help doctors in local clinics find heart problems like heart failure earlier. The aim is to improve heart health and reduce emergency hospital visits for these conditions.
United Kingdom - authorisedTherapeutic use (Phase IV)
Short-Term Anticoagulation versus Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure. The ANDES study.
This study, called ANDES, looks at different blood-thinning medicines given for a short time after a procedure called Left Atrial Appendage Closure (LAAC). It aims to find the best way to prevent blood clots forming on the device used in the heart, especially for people with an irregular heartbeat.
Spain - authorisedTherapeutic exploratory (Phase II)
Effect of H2 inhalation therapy on early recurrence after atrial fibrillation ablation. Multicenter, open-label, randomized phase II controlled trial.
This study looks at whether breathing a special gas containing hydrogen can help people who have had a procedure called 'ablation' for an irregular heartbeat (atrial fibrillation). It checks if fewer people have their irregular heartbeat come back soon after and if their quality of life improves.
France - recruitingNA
Rate or Rhythm Control in CRT: the RHYTHMIC Study
This study looks at two ways to control an irregular heart rhythm called Atrial Fibrillation (AF) in people with heart failure who have a special pacemaker (CRT). It compares AF ablation (a procedure to correct the rhythm) with AV node ablation (a procedure to slow the heart rate).
United Kingdom - active not recruiting
Realistic Computational Electrophysiology Simulations for the Targetted Treatment of Atrial Fibrillation
This study aims to find better ways to treat Atrial Fibrillation (AF), a condition causing an irregular heartbeat. Researchers are using computer models to understand the heart's electrical problems in AF, hoping to create more personalised treatments for each patient.
United Kingdom - active not recruiting
High Gastrointestinal Bleed Risk Outcomes in Patients With Non-valvular Atrial Fibrillation (NVAF) in France
This study looks back at French health records to understand how different blood-thinning medicines affect people with an irregular heartbeat (atrial fibrillation) who are at higher risk of stomach bleeding. It compares older medicines like warfarin with newer ones to see how safe and effective they are.
United Kingdom - active not recruitingNA
Stroke Prevention and Rhythm Control Therapy STEEER-AF
This study aims to improve care for people with an irregular heartbeat called atrial fibrillation (AF). It's testing if training healthcare professionals helps them better manage AF and prevent strokes, ensuring patients get the best possible treatment according to guidelines.
France · Germany · Italy - recruitingNA
Ablation of Focal Activation in Atrial Fibrillation
This study investigates if a new mapping technique, RETRO-Mapping, can accurately find specific electrical 'drivers' of persistent atrial fibrillation (AF). We aim to see if treating these drivers, in addition to standard treatment, improves outcomes for people living with persistent AF.
United Kingdom - active not recruitingNA
CHAMPION-AF Clinical Trial
This study compares a small heart device (WATCHMAN FLX) with standard blood-thinning medicines (such as DOACs) for people with an irregular heartbeat called atrial fibrillation. It aims to see if the device can prevent strokes just as well as the medicines.
United States · Australia · Belgium - active not recruiting
Preventing Recurrent Cardioembolic Stroke (The PRECISE Study)
This study aims to improve how we check for a heart condition called atrial fibrillation (AF) after a stroke. By finding better ways to identify who needs checking, we hope to prevent more second strokes for people in the UK.
United Kingdom - active not recruiting
A Study of the Acceptability and Performance of Wearables for Atrial Fibrillation Screening in Older Adults
This study looks at how well wearable devices like smartwatches and chest patches can find an irregular heartbeat called atrial fibrillation (AF) in older adults. It also checks if people find these devices easy and comfortable to use, to help prevent strokes.
United Kingdom - active not recruitingNA
Adjunctive Ganglionated Plexus Ablation in Redo-Pulmonary Vein Isolation
This study looks at a new way to treat atrial fibrillation (AF) that keeps coming back after initial treatment. It focuses on disrupting specific nerve bundles in the heart that might be triggering AF, aiming to improve treatment success for people who need a second procedure.
United Kingdom - active not recruitingPHASE3
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation
This study is comparing two medicines, milvexian and apixaban, for people with an irregular heartbeat called atrial fibrillation. We want to see if milvexian is just as good as apixaban at stopping serious problems like strokes, which can happen with this condition.
United States · Argentina · Australia - authorisedTherapeutic use (Phase IV)
An open-label, randomized clinical trial comparing Etacizin versus Propafenone in Atrial Fibrillation
This study compares two medicines, Etacizin and Propafenone, for people with a heart condition called atrial fibrillation. Doctors want to see which medicine is better at keeping the heart's rhythm normal for six months after it has been reset.
Latvia - authorisedTherapeutic use (Phase IV)
Waiting on Atrial fibrillation Intervention Therapy (WAIT) Study
The WAIT Study is looking at whether a drug called Wegovy can help people who have had a procedure for an irregular heartbeat (atrial fibrillation) stay free from it. Researchers want to see if the drug reduces episodes of this irregular heartbeat over 12 months.
Sweden - authorisedTherapeutic use (Phase IV)
Optimal Antiplatelet Treatment to Achieve Stroke Avoidance and Fall in Bleeding Events following Left Atrial Appendage Closure – Chronic Kidney Disease (SAFE LAAC CKD). Comparative Health Effectiveness Ancillary Study – PILOT
Researchers are comparing two common medicines, aspirin and clopidogrel, after a procedure to help people with an irregular heartbeat and kidney disease. They want to find the best way to prevent strokes while also reducing bleeding risks.
Poland - recruitingNA
Hybrid Ablation of Atrial Fibrillation in Heart Failure
This study looks at a new way to treat persistent atrial fibrillation (a type of irregular heartbeat) in people who also have heart failure. It compares a combined treatment (hybrid ablation) with the usual treatment to see which works best at keeping a steady heart rhythm.
United Kingdom - recruitingPHASE2
A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation
This study is testing a new medicine called PKN605 for people with an irregular heartbeat condition called atrial fibrillation. We want to see if it helps reduce how often people have irregular heartbeats and if it's safe to use.
United States · Canada · China - active not recruiting
Outcome of Overweight AF Patients Following Ablation With a Potential Weight Loss Medication ( GOAL-AF )
This study looks at whether a weight-loss medicine called Liraglutide can help people with an irregular heartbeat (Atrial Fibrillation or AF) who are overweight. The aim is to see if losing weight before a heart procedure called ablation can improve its success and overall health.
United Kingdom - active not recruitingNA
Super-Rehab: a Novel Approach to Treat Atrial Fibrillation
This study looks at 'Super Rehab', a new lifestyle programme combining exercise, diet advice, and regular check-ups, for overweight people with a heart rhythm problem called atrial fibrillation (AF). It aims to see if Super Rehab helps improve AF symptoms when added to usual care.
United Kingdom - active not recruiting
Future Innovations in Novel Detection for Atrial Fibrillation (FIND-AF): Pilot Study
This study is testing a new way to find an irregular heartbeat called atrial fibrillation (AF) earlier. It uses a special computer tool and remote heart monitoring for people at higher risk. The goal is to see if this helps detect AF more often and leads to better treatment to prevent strokes.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruiting
An Investigator-initiated Linked Study to OCEANIC-AF
This study aims to understand how a new blood thinner, asundexian, affects the body's natural ability to dissolve blood clots, comparing it to an existing treatment, apixaban. Researchers will use blood samples from patients already in another study.
United Kingdom - recruitingPHASE3
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
This study looks at how best to prevent blood clots and bleeding in people who develop an irregular heartbeat (atrial fibrillation) after bypass surgery. It compares different common blood-thinning treatments.
United States · Brazil · Canada - recruitingNA
Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation Therapy
This study looks at whether a procedure to close off a part of the heart called the left atrial appendage (LAA) in addition to blood thinners can better prevent strokes in people with atrial fibrillation who have already had a stroke despite being on blood thinners.
Belgium · Germany · New Zealand - recruiting
Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation
This study looks at how heart valve problems, called mitral and tricuspid regurgitation, affect people with an irregular heartbeat (atrial fibrillation). Researchers want to understand these conditions better and find out what causes them to get worse.
United Kingdom - recruitingNA
The Fourth Left Atrial Appendage Occlusion Study
This study looks at whether a 'WATCHMAN device' can prevent strokes in people with atrial fibrillation who are already taking blood thinners but still have a high stroke risk. It aims to see if blocking off a small part of the heart called the left atrial appendage helps.
United States · Belgium · Canada - recruitingNA
Anteroposterior Versus Anterolateral Electrode Position for Electrical Cardioversion of Atrial Fibrillation
This study looks into the best way to shock the heart back to a normal rhythm for people with atrial fibrillation. We're testing different pad placements on the chest and if pressing on the pads helps the treatment work better.
Canada - recruitingNA
Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation
This study looks at how different types of exercise, like moderate steady workouts or short bursts of high-intensity activity, affect people with ongoing atrial fibrillation. We want to see if exercise can improve fitness and quality of life for these patients.
Canada - recruitingNA
RAPID AFib Decision Aid for Stroke Prevention in Atrial Fibrillation
This study looks at a new online tool called RAPID AFib. It aims to help people with an irregular heartbeat (atrial fibrillation) and their doctors make good decisions about medicines to prevent strokes. We want to see if this tool is easy to use and helps patients understand their choices better.
Canada - recruiting
Tracking Results of Ablations to Combat AF Registry Generation 2
This study, called TRAC-AF, aims to track the long-term safety and effectiveness of certain heart procedures for people with atrial fibrillation (an irregular heartbeat). It looks at different types of surgery that use special medical devices to help correct the heart's rhythm.
United States · Canada - recruitingNA
Surgical Ablation of AF Efficacy Trial
This study looks at whether a surgical procedure to treat an irregular heartbeat (atrial fibrillation) during heart surgery can help prevent future heart problems, especially heart failure. It compares adding this procedure to not adding it, in people already having heart surgery.
Canada - recruitingNA
BIO|CONCEPT.BIOMONITOR-HF Collect Clinical Data From Heart Failure Patients Using BIOMONITOR Devices With a Study Specific Research Software
This study looks at heart failure patients without special heart devices. We want to understand irregular heartbeats and develop a tool to predict when heart failure might get worse, helping doctors intervene sooner to improve care.
Belgium · Germany - recruiting
Contribution of Computed Tomography and Cardiac-MRI in Atrial Fibrillation Ablation
This study looks at whether special scans (CT and MRI) can help doctors better understand who might benefit most from a common heart procedure called AF ablation. It aims to see if fat in the heart or how the heart muscle moves can predict how well the treatment works.
France - active not recruiting
Tracking Atrial Fibrillation After Intensive Care Admission
This study looks at heart rhythm problems called atrial fibrillation (AF) in people after intensive care. It aims to see how many people develop AF and if it comes back once they leave hospital, to help prevent serious issues like strokes later on.
United Kingdom - not yet recruiting
VOLta Medical AI-software in REal-World During AF Ablation
This study looks at how well a new AI software, Volta AF-Xplorer II, works during a heart procedure called a catheter ablation for atrial fibrillation. We want to see how safe and effective it is in real-life practice over two years.
France - recruitingNA
BaLloon-based PFA Ablation poST Approval Outcomes for PAF and PersAF
This study looks at a new heart treatment called Pulsed Field Ablation (PFA) using the Volt PFA System for people with irregular heartbeats (atrial fibrillation). It aims to see how safe and effective it is in real-world use for different patients.
Austria · Belgium · Denmark - recruitingNA
The Role of Right Atrial Ectopy Triggering Ganglionated Plexuses in AF
This study looks at a new way to treat atrial fibrillation (AF), a common heart rhythm problem. It explores whether targeting specific nerve endings in the right side of the heart can help people whose AF has returned after standard treatments.
United Kingdom - recruitingNA
Smartwatches for Detection of Atrial Fibrillation (AFib) in Secondary Prevention of Cryptogenic Stroke
This study looks at whether smartwatches can reliably find a heart condition called Atrial Fibrillation (AFib) in people who have had a stroke or 'mini-stroke' (TIA). Finding AFib is important to help prevent future strokes.
Germany - recruiting
Observation of Clinical Routine Care for Patients With BIOTRONIK Implantable Cardiac Monitors (ICMs)
This study looks at how well a small heart monitor, called an Implantable Cardiac Monitor (ICM), works in real life for patients in the UK. It helps doctors understand its performance and safety over time, especially for conditions like irregular heartbeats or fainting spells.
Australia · Czechia · France - active not recruitingPHASE4
EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)
This study looks at whether a blood-thinning medicine called edoxaban can reduce the risk of stroke in people with an irregular heartbeat (atrial fibrillation) who have previously had bleeding in the brain. It compares edoxaban to not taking blood thinners.
United States · Argentina · Austria - recruitingPHASE3
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
This study looks at treating an irregular heartbeat called atrial fibrillation (AF) early after a stroke. We want to see if quick treatment of AF can stop future strokes and other heart problems better than the usual care.
Germany - recruitingNA
Ablate and Pace HIS Study
This study looks at a new way of fitting pacemakers for people with a heart condition called atrial fibrillation (AF) who also have signs of heart failure. It compares a standard pacemaker fitting with a newer method called His bundle pacing to see which works best.
United Kingdom - authorisedTherapeutic use (Phase IV)
Optimal Antiplatelet Treatment to Achieve Stroke Avoidance and Fall in Bleeding Events following Left Atrial Appendage Closure (SAFE-LAAC). Comparative Health Effectiveness Randomized Trial – PILOT Study
This study looks at how different blood-thinning medicines, aspirin and clopidogrel, work after a procedure to close off a part of the heart called the left atrial appendage. We want to find the best way to prevent strokes while also reducing bleeding, for people with an irregular heartbeat called atrial fibrillation.
Poland - recruiting
Clinical Cohort Study - TRUST
The TRUST study is looking at heart rhythm problems like atrial fibrillation. It aims to understand how different treatments work over time for people in Hamburg, Germany. Researchers will collect information and samples to learn more about these conditions and improve care.
Germany - active not recruitingNA
Dispersion Stability
This study looks at a treatment called ablation for an irregular heartbeat condition called atrial fibrillation (AF). Researchers are testing if treating specific areas of the heart will stop AF right away and keep it away for a year.
France - recruitingNA
Same-Day Discharge Versus Overnight Stay Following Pulmonary Vein Isolation for Atrial Fibrillation
This study compares going home the same day after a heart procedure for atrial fibrillation with staying overnight. It checks if same-day discharge is as safe and effective, and if it could make recovery easier and cost less.
Germany - recruiting
Atrial Fibrillation in Young Patients: a Prospective Multicentre Registry
This study looks at young people (under 35) with a heart condition called atrial fibrillation (AF). Researchers want to understand what causes it, how it's treated, and what happens to people with AF over time. It's an important step in helping young patients live well with this condition.
France - recruitingNA
B2AD-Risk AFDAS Evolution of Burden of AF
This study looks at people who have had a stroke and then found out they have an irregular heartbeat called atrial fibrillation (AF). We want to understand how this AF changes over time to help improve treatments and prevention for future strokes.
Canada