- active not recruitingPHASE3
Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer
This study looks at a drug called abemaciclib, given with standard hormone therapy after surgery for a type of breast cancer. We want to see if it's safe and helps stop the cancer coming back in people with certain high-risk breast cancers.
United States · Argentina · Australia - recruiting
Artificial intelligence to help healthcare professionals detect cancer in the UK breast screening programme
This study looks at how artificial intelligence (AI) can help find breast cancer in mammograms. It compares AI working with human experts to human experts working alone, hoping to improve breast screening for women across the UK.
United Kingdom · England - recruiting
Real-world Evaluation of Patient Outcomes and Experiences With Ribociclib Early Adopters.
This study looks at how well new breast cancer medicines, ribociclib and abemaciclib, work for people with early-stage breast cancer, and what their experiences are like. It helps us understand how these treatments are used in real life.
United Kingdom - ongoing, recruitingTherapeutic use (Phase IV)
Pilot study to explore the diagnostic value of gadopiclenol in pathological and radiological insights with multiparametric MRI enhancement in breast cancer.
This study looks at how a special MRI scan, using a dye called Elucirem, helps doctors see breast cancer. We're checking if what the MRI shows matches what doctors find when they examine breast tissue closely, to better understand and treat the disease.
Spain - recruiting
The DISC Pilot study: testing if taking extra tissue during breast surgery helps make treatment more successful
This study looks at whether removing a small amount of extra tissue during breast cancer surgery for a specific type called DCIS can reduce the need for a second operation. It also checks cosmetic results and patient experiences.
United Kingdom · England - recruitingPHASE4
A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies
This study looks into why some breast cancers stop responding to treatment. We will examine tissue and blood samples from patients with specific types of breast cancer to understand how the cancer becomes resistant and find new ways to help them.
Belgium · Denmark · Finland - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - recruitingNA
Axillary Management in Breast Cancer Patients With Needle Biopsy Proven Nodal Metastases After Neoadjuvant Chemotherapy
This study looks at breast cancer patients whose lymph nodes cleared after chemotherapy. We want to see if skipping further surgery or radiation to their armpit causes fewer side effects like swelling, without making their cancer return more often compared to standard treatment.
Ireland · United Kingdom - active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
This study looked at new treatments for HER2-positive breast cancer that had already been treated but still showed signs of cancer after surgery. Researchers wanted to see if adding certain drugs could prevent the cancer from coming back.
United States · Australia · Austria - authorisedTherapeutic exploratory (Phase II)
A Phase II Open-Label Randomized Controlled Pre-Surgical Feasibility Study of Antibiotic Combinations in Early Breast Cancer – ABC2
This study looks at whether certain antibiotics might help treat early breast cancer before surgery. Researchers want to see if these medicines can slow down cancer cell growth, using a common marker called Ki67 to measure this effect in women undergoing treatment.
Italy - recruitingPHASE3
A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
This study is testing a new medicine, PF-07248144, with an existing one, fulvestrant, for advanced breast cancer that has grown despite previous treatment. It aims to see if this combination is safe and effective.
United States · Australia · Belgium - active not recruiting
Male Breast Cancer: Understanding the Biology for Improved Patient Care
This study looks at breast cancer in men. Researchers are gathering information and samples from men with breast cancer to better understand the disease and improve how it's treated. It's a large international effort to learn more about this rare condition.
United States · Belgium · Brazil - recruitingPHASE3
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
This study is testing a new drug, Elacestrant, against standard hormone treatments for early breast cancer. It's for men and women whose cancer is ER-positive and HER2-negative, and has a high chance of coming back. The aim is to see if Elacestrant works better.
United States · Argentina · Australia - active not recruitingPHASE1
A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors
This study is looking into a new medication called ALTA2618 for adults with certain advanced cancers that have a specific genetic change (AKT1 E17K mutation). The main goal is to check its safety and find the right dose.
United States · Australia · France - authorisedPhase I and Phase II (Integrated)- Other
Evaluation of a [68Ga] Ga-HER2 single domain antibody PET/CT for predicting pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) in HER2-positive early breast cancer
This study looks at a special scan called a PET/CT using a tracer to see if it can predict how well treatment works for HER2-positive early breast cancer before surgery. It's for women aged 18 and over.
France - recruitingPHASE3
Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial
The LOLIPOP trial is studying a common pain medication called lidocaine, given into a vein during and after breast cancer surgery. We want to see if it helps reduce long-term pain and is safe for patients.
Australia · Hong Kong · New Zealand - recruitingPHASE1, PHASE2
Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)
This study looks into a new medicine, patritumab deruxtecan, for HER2-positive breast cancer that has spread and can't be removed by surgery. Researchers want to see if it's safe, how well people tolerate it, and if it can shrink or get rid of the cancer.
United States · Canada · Israel - active not recruitingPHASE2
Chemotherapy-free Trastuzumab and Pertuzumab in HER2-positive Breast Cancer: FDG-PET Response-adapted Strategy.
This study looks at new ways to treat a type of breast cancer called HER2-positive. We're testing if using special drugs (Herceptin and Perjeta) without chemotherapy first can shrink tumours effectively. We're also checking if scans can predict how well treatments work.
Belgium · France · Germany - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - completed
Availability of free door-to-door transport to increase the attendance of breast screening appointments in Yorkshire
This study in Yorkshire looks at whether offering free transport to breast screening appointments helps more women attend. The goal is to catch breast cancer earlier and improve chances of recovery. It involves women aged 50-70 and compares those offered transport to those who aren’t.
United Kingdom · England - active not recruitingPHASE1
To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer
This study looks at a new drug, Inavolisib, for people with solid tumours or breast cancer, focusing on safety and how the body handles it. It's an early-stage study, checking if the drug works alone or with other common cancer treatments.
United States · Canada · France - recruitingPHASE1, PHASE2
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies
This study is testing a new medicine called AZD8205, by itself or with other cancer drugs. It's for people with advanced cancers like breast, ovarian, or lung cancer, to see if it's safe and helps shrink tumours.
United States · Australia · Belgium - active not recruiting
Cancer Surveillance and Support
This study helps people who have had breast or bowel cancer after their treatment. It looks at using an online system for survivors to report health changes from home and get quick advice. The goal is better support and faster help when needed.
United Kingdom - recruiting
Can we safely reduce the number of days of radiotherapy needed to treat people with breast cancer who need boost treatment?
This study looks at whether we can safely give breast cancer patients who need an extra 'boost' of radiotherapy a shorter 5-day treatment instead of the usual 15 days. It compares two different 5-day boost doses with the standard 15-day boost.
United Kingdom · England · Northern Ireland - not yet recruitingNA
EQUITA - A Feasibility Trial of a Faith-placed Intervention to Increase Screening Uptake in Black Adults
This study looks at how faith groups can help Black adults get important cancer and aneurysm screenings. It's a small trial in the North East, Leeds, and Scotland to see if this approach works and is well-received before a larger study.
United Kingdom - active not recruitingPHASE1, PHASE2
Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer
This study looks at new drug combinations for advanced ER+ breast cancer in women aged 18-100. It tests LEE011 and BYL719 with letrozole to find safe and effective doses, hoping to improve treatment for this type of cancer.
United States · Australia · France - active not recruitingPHASE1
DS8201a and Pembrolizumab in Participants With Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer
This study looks at a new combination treatment for advanced breast cancer or a type of lung cancer. It combines two drugs, Trastuzumab deruxtecan and Pembrolizumab, to see if they are safe and effective together.
United States · France · Spain - active not recruitingPHASE1, PHASE2
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.
United States · Australia · Canada - recruiting
Prospective Evaluation of AI R&D Tool for Patient Stratification - MoA Evaluation in Triple Negative Breast Cancer (PEAR-MET)
This study is testing a new tool for people with advanced triple-negative breast cancer. It uses a small sample of your tumour to see how it might react to different treatments. This helps researchers understand how to better choose treatments in the future, aiming to improve care for patients.
United Kingdom - recruitingPHASE2
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
This study is looking at a new treatment called HER3-DXd for people with certain advanced solid tumours that haven't responded to other treatments. It aims to see how well it works and if it's safe for different types of cancer, like melanoma, lung cancer, and breast cancer.
United States · Australia · Belgium - active not recruitingPHASE1, PHASE2
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
This study is testing a new drug, ST101, for people with advanced cancers like breast cancer, melanoma, and glioblastoma. It aims to see if the drug is safe, how much to give, and if it could help shrink tumors. It's for adults whose cancer hasn't responded to other treatments.
United States · United Kingdom - authorisedTherapeutic use (Phase IV)
ENDO-67 project: Investigating ENDOcrine therapy-related questions using Ki67 changes in the window-of-opportunity before breast surgery
This study is looking at how a common breast cancer drug, tamoxifen, works in the body. Researchers want to understand if different levels of a substance called endoxifen affect a patient's response to tamoxifen treatment before surgery, using a marker called Ki67.
Netherlands - active not recruitingPHASE2
Study of Neoadjuvant Olaparib Monotherapy and Olaparib and Durvalumab Combination in HER2 Negative BRCAm Breast Cancer
This study looks at new treatments for a specific type of breast cancer with a BRCA gene change. It tests olaparib, alone or with durvalumab, before surgery. The aim is to find better ways to treat this cancer and reduce the need for strong chemotherapy.
United States · Australia · Austria - recruitingPHASE2
To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer
This study is looking at a new combination of medicines, Inavolisib and Fulvestrant, for people with a specific type of advanced breast cancer. It aims to see how well this combination works and if it's safe after other treatments haven't worked.
United States · Argentina · Australia - authorisedPhase I and Phase II (Integrated)- First administration to humans
SPRAYDYE-Trial - A phase I/II study to assess the efficacy, safety and tolerability of topically applied 6qc-ICG, a cathepsin-activatable fluorescent probe, for real-time intraoperative resection margin assessment in breast conserving surgery
This study looks at a special dye for breast cancer surgery. It's designed to help surgeons see cancer cells more clearly during an operation, aiming to ensure all cancer is removed and reduce the need for more surgery later.
Netherlands - recruitingPHASE2
KORTUC Phase II - Intra-tumoural Radiation Sensitizer in Patients With Locally Advanced/Recurrent Breast Cancer
This study is testing if a very diluted version of a common chemical, hydrogen peroxide, can make radiotherapy work better for large breast cancer lumps. It involves injecting this special gel into the cancer twice a week during a standard course of radiotherapy. Early results from Japan have been promising.
India · United Kingdom - authorisedTherapeutic exploratory (Phase II)
A multicentre, prospective, open-label study with [68Ga]Ga-ABY-025 PET-imaging to characterize HER2-expression and explore the therapy-predictive value for HER2-antibody drug conjugates in patients with metastatic breast cancer (HER2-Ex PET)
This study looks at a new special scan for breast cancer to see how HER2 protein levels affect treatment. It uses a new drug called Enhertu to treat metastatic breast cancer and aims to find out if the scan can predict how well the treatment will work.
Sweden - active not recruitingPHASE3
A Study of Nonsteroidal Aromatase Inhibitors Plus Abemaciclib (LY2835219) in Postmenopausal Women With Breast Cancer
This study looks at a new combination of medicines for postmenopausal women with a certain type of breast cancer. It tests if abemaciclib with standard hormone therapy works better than hormone therapy alone.
United States · Australia · Austria - recruitingPHASE1, PHASE2
A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.
This study is for people with advanced breast cancer that has grown despite previous treatments. It tests a new combination of targeted radiation therapy and chemotherapy to see if it can stop cancer growth and if it's safe. We're looking at different doses to find the best way to use these treatments.
United States · Australia · Canada - recruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
This study is looking at new combinations of medicines for advanced lung or breast cancer. We want to see if they are safe, how much medicine gets into the body, and if they show early signs of working. It's for adults with certain types of advanced cancer.
United States · Australia · Canada - ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1b/2 Open-Label Study of Samuraciclib in Combination with Elacestrant in Participants with Metastatic or Locally Advanced Hormone-Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer
This study looks at combining two drugs, samuraciclib and elacestrant, for people with advanced breast cancer. It aims to find the best dose and see how well the combination works and if it's safe.
France · Spain - recruitingNA
Biological Matrices Versus Synthetic Meshes
This study looks at two types of mesh used in breast reconstruction after cancer surgery: natural (biological) and man-made (synthetic). It aims to see if patients and doctors are comfortable with not choosing which mesh they get, and to check their long-term safety and how happy people are with the results.
United Kingdom - authorisedTherapeutic confirmatory (Phase III)
Assessing Oxytocin's Role in Mitigating Psychosocial Stress in Breast Cancer Survivors
This study looks at whether a nasal spray with a natural hormone called oxytocin can help women who have had breast cancer feel less stressed, anxious, and sad. Researchers will compare it to a dummy spray.
Belgium - active not recruitingPHASE1
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
This early-stage study is testing a new drug, MOMA-313, for advanced solid tumours, including prostate, breast, and pancreatic cancers. It aims to find a safe dose and see how it works, either alone or with another drug called Olaparib, in patients whose tumours have a specific genetic weakness.
United States · Spain · United Kingdom - active not recruiting
The OPBC-07/microNAC Study
This study looks at whether it's safe to skip a full lymph node removal surgery in breast cancer patients who have only tiny traces of cancer left in their armpit lymph nodes after chemotherapy. It checks how these patients have fared over time.
United States · Argentina · Australia - authorisedPhase I and Phase II (Integrated)- Other
Tumour heterogeneity studies based on dedicated breast PET using proliferation radiotracers: early detection of the treatment response.
This study is looking for better ways to spot early signs if breast cancer treatment is working. It uses a special advanced scan called a PET scan, specifically designed for the breast, to see how fast cancer cells are growing.
Spain - ongoing, recruitingTherapeutic confirmatory (Phase III)
A–BRAVE-Trial. ADJUVANT TREATMENT FOR HIGH-RISK TRIPLE NEGATIVE BREAST CANCER PATIENTS WITH THE ANTI-PD-L1 ANTIBODY AVELUMAB: A PHASE III RANDOMIZED TRIAL
This study is looking at a new treatment called Bavencio for a specific type of breast cancer (triple negative). It's a large study to see if adding Bavencio after initial treatment can help people live longer without their cancer coming back.
Italy - active not recruitingPHASE1, PHASE2
Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer
This study is testing a new drug called elacestrant with other breast cancer medicines. It's for people with a specific type of advanced breast cancer that has spread. The main goals are to see if these drug combinations are safe and if they can help shrink the cancer.
United States · Argentina · Australia - active not recruitingPHASE1
A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors
This study is looking into a new medicine, LOXO-783, for breast cancer and other solid tumours with a specific gene change (PIK3CA). It aims to understand if the medicine is safe, what side effects it has, and how well it works.
United States · Australia · Belgium - ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase I/II study to determine the safety and efficacy of Ribociclib in combination with hormone therapy and hypofractionated radiotherapy in breast cancer, with positive hormone receptors and negative HER2 status, in newly diagnosed, not immediately operable (or wishing to avoid surgery), elderly patient
This study looks at a new way to treat specific breast cancers in older women. It combines a drug called Kisqali with hormone therapy and focused radiotherapy. We want to see if this treatment is safe and effective, especially for patients who can't have or prefer to avoid surgery.
France