- active not recruiting
The SUMMIT Study: A Cancer Screening Study
The SUMMIT study is looking at better ways to find cancer early. It will test a blood test for many cancers and offer special lung scans to people at higher risk in London who have smoked. The goal is to improve how we check for cancer.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
A Phase II Open Label Study of Brentuximab Vedotin in Combination with CHEP in Patients with Previously Untreated CD30-expressing Peripheral T-cell Lymphomas (PTCL)
This study is looking at a new combination of medicines, including Brentuximab Vedotin (Adcetris), for adults with a type of cancer called CD30-expressing Peripheral T-cell Lymphoma (PTCL) that hasn't been treated before. We want to see how well this new treatment shrinks the cancer.
Czechia - enrolling by invitation
SMS 2: Impact of Cancer Therapy on the Somatic Mutational Landscape of Normal Tissues
This study looks at how cancer treatments, like chemotherapy or radiotherapy, affect tiny changes (mutations) in healthy body cells. We're collecting samples such as blood, cheek swabs, and urine from adult cancer patients to understand these changes better.
United Kingdom - authorisedHuman Pharmacology (Phase I)- Other
Artesunate, sulfasalazine polyunsaturated fatty acids, and iron in patients with solid tumors.
This study is looking at how a combination of different drugs like artesunate and sulfasalazine, along with healthy fats (omega-3s) and iron, affects people with solid cancers. It's an early-stage study to understand how these treatments work in the body.
Spain - authorisedTherapeutic exploratory (Phase II)
Early intervention and recovery of sexual function in men and women after treatment of rectal cancer–a randomized controlled study with tadalafil compared to standard care
This study looks at how Cialis (a medication) might help men and women who've had bowel cancer treatment. It focuses on improving sexual function and quality of life after surgery, comparing Cialis to standard care over two years.
Sweden - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1 /2 study for the safety, efficacy, pharmacokinetic and pharmacodynamics evaluation of amcenestrant (SAR439859 ), administered orally as monotherapy, then in combination with other anti-cancer therapies in postmenopausal women with estrogen receptor-positive advanced breast cancer
This study looks at a new drug, amcenestrant, for postmenopausal women with advanced breast cancer. It tests its safety and how well it works, both alone and with other common cancer medicines.
Belgium · Spain - active not recruiting
Mixed Methods Study to Assess Family Members Unmet Needs in an Oncology Setting
This study looks into what support family members of cancer patients might need, especially in the Swansea area. Researchers want to understand where current support falls short and how to improve it, by asking family members about their experiences.
United Kingdom - active not recruitingPHASE3
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)
This study is for cancer patients who are already taking osimertinib (Tagrisso) in another AstraZeneca study and are still benefiting from it. It allows them to keep taking the drug to see if it continues to help.
China · France · Japan - recruitingNA
Integrated Short-Term Palliative Rehabilitation in Incurable Cancer
This study looks at a special support program called 'palliative rehabilitation' for people with incurable cancer. It aims to see if adding this program to usual care helps improve their quality of life more than just usual care alone.
Denmark · France · Italy - active not recruiting
BIOMARKER and IMAGING CHARACTERISATION of INFLAMMATORY ATHEROMA in PATIENTS RECEIVING IMMUNOTHERAPY and ANGIOGENESIS INHIBITORS
This study looks at how new cancer drugs, called immunotherapies and anti-angiogenesis medicines, affect your blood vessels and heart. We want to understand why some patients get heart problems or strokes when taking these important cancer treatments.
United Kingdom - active not recruitingPHASE1
A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors
This study is looking into a new medication called ALTA2618 for adults with certain advanced cancers that have a specific genetic change (AKT1 E17K mutation). The main goal is to check its safety and find the right dose.
United States · Australia · France - authorisedTherapeutic use (Phase IV)
MetAddon: Methadone as co-analgesic for patients with metastatic bone pain: a double-blind randomized controlled trial
This study is looking at how well a medicine called methadone works alongside usual pain relief for people with cancer pain that has spread to their bones. It compares methadone with morphine to see which is better at reducing pain.
Netherlands - recruiting
The Shared Safety Net Action Plan (SSNAP): Exploring the viability of a safety-netting tool in primary care that encourages partnership between patients and staff to support earlier diagnosis of cancer
This study looks at a new tool called SSNAP to help doctors and patients work together for an earlier cancer diagnosis. It helps patients understand symptoms to watch for and when to see the doctor again, especially for unclear symptoms like tiredness or weight loss.
United Kingdom · England - active not recruitingPHASE1
AZD6244 (ARRY-142886) Solid Oral Dosage Formulation in Participants With Advanced Solid Malignancies
This study is testing a new capsule called AZD6244 for people with advanced cancers. It aims to check how safe it is, whether people can tolerate it well, and how the body handles the medicine. This is an early-stage study to understand the drug better.
United States · Netherlands · United Kingdom - recruiting
A population-based digital study offering people testing for cancer genes, to identify people at increased risk of cancer so they can take steps to prevent it or detect it early
This study offers a genetic test for cancer risk to people in the UK. It uses a saliva sample to check for genes linked to breast, ovarian, bowel, and womb cancers. The aim is to find people at higher risk so they can take steps to prevent cancer or detect it early.
United Kingdom · England · Northern Ireland - recruiting
Heuristics, Algorithms and Machine Learning: Evaluation & Testing in Radiation Therapy
This study aims to predict side effects from radiotherapy for cancer using computer models. It collects information from patients having image-guided radiotherapy to help develop better ways to understand and manage treatment risks, making radiotherapy safer and more effective for everyone.
United Kingdom - recruiting
A Platform Study for solId orgaN CancERs
This study aims to collect tiny samples of tissue and blood from cancer patients undergoing surgery or biopsy. These samples will help researchers understand solid organ cancers better and develop new ways to diagnose and treat them. It's designed to make it easier for researchers to get high-quality samples.
United Kingdom - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
Phase 1/2, Open-label, Dose Escalation and Dose Expansion Study of TransCon TLR7/8 Agonist Alone or in Combination with Pembrolizumab in Participants with Locally Advanced or Metastatic Solid Tumor Malignancies
This study is testing a new cancer medicine, TransCon TLR7/8 Agonist, sometimes given with another drug called Keytruda. It's for adults with advanced cancer. Researchers want to see if it's safe, what dose works best, and if it can shrink tumours.
Spain · Netherlands - active not recruitingPHASE1
Study of RP2 Monotherapy and RP2 in Combination With Nivolumab in Patients With Solid Tumors
This study is testing a new treatment called RP2, alone and with nivolumab, for adults with advanced cancers. It aims to find the safest dose and see how well it works. RP2 is a modified virus designed to fight cancer.
Spain · United Kingdom - active not recruiting
CCP Cancer UK Companion Study
This study looks at how COVID-19 affects people with cancer in the UK. We want to understand their symptoms, treatment, and recovery, comparing them to people without cancer. This helps us learn how to better care for cancer patients during outbreaks.
United Kingdom - recruiting
APACE - Feasibility of Using Accelerometers to Measure Physical Activity in Cancer Patients on Early Phase Clinical Trials
This study looks at how we can better measure physical activity and sleep in cancer patients using a wearable device. It helps us understand if these devices are useful for people with advanced cancer participating in early clinical trials, potentially improving care and support.
Italy · Spain · United Kingdom - recruitingNA
RESCUE: A Workplace Dietary Intervention for UK Firefighters
This study looks at how diet affects firefighters' health, especially their cancer risk. Firefighters often have unhealthy eating habits due to their demanding jobs. Researchers are testing a new education programme called RESCUE to help them eat better and improve their long-term health.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A PHASE 1 STUDY TO ASSESS THE MASS BALANCE, PHARMACOKINETICS, AND METABOLISM OF ORAL [14C]-ZIPALERTINIB IN HEALTHY ADULT MALE SUBJECTS
This early-stage study in healthy adult men looks at how a new cancer drug called zipalertinib is handled by the body. We want to understand how it's absorbed, changed, and leaves the body, and check for any side effects.
Netherlands - recruitingPHASE4
The STOP-MED CTRCD Trial
This study looks at whether it's safe for cancer survivors to stop heart failure medicines if their heart has recovered well. It's for people whose hearts were affected by cancer treatment but are now working normally again.
United States · Australia · Canada - active not recruitingPHASE3
Study to Continue Treatment With Darolutamide in Patients Who Have Been Participating in Previous Darolutamide Studies Supported by Bayer
This study is for men with cancer who are already taking darolutamide in another Bayer study and are doing well. It lets them keep taking the same medicine at the same dose, continuing their treatment journey under medical supervision.
United States · Argentina · Australia - recruiting
Circulating Tumour DNA (ctDNA) in Patients With Colorectal Cancer and the Relationship to Imaging Features of Extramural Venous Invasion
This study looks at a new way to understand bowel cancer spread. We're taking blood samples from patients having surgery for bowel cancer to see if blood changes can tell us more about how the cancer might spread through blood vessels. This could help improve how we treat bowel cancer in the future.
United Kingdom - active not recruitingNA
Does Screening With the Galleri Test in the NHS Reduce the Likelihood of a Late-stage Cancer Diagnosis in an Asymptomatic Population? A Randomised Clinical Trial
This study is looking at a new blood test called the Galleri test. It aims to see if using this test with usual NHS care can help find many types of cancer earlier in people aged 50-77 who don't have symptoms. Finding cancer early often makes it easier to treat.
United Kingdom - recruitingNA
Introduction of Y90-PET-CT Post Radioembolisation Therapy Scans
This study looks at a new type of scan for liver cancer patients having a treatment called Y-90 radioembolisation. We want to see if this new scan, Y90-PET-CT, gives clearer pictures than the usual scan, to better understand how the treatment works.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
Open-label, Phase 2 study of tusamitamab ravtansine (SAR408701) combined with pembrolizumab and tusamitamab ravtansine (SAR408701) combined with pembrolizumab and platinum-based chemotherapy with or without pemetrexed in patients with CEACAM5-positive expression advanced/metastatic nonsquamous non-small-cell lung cancer (NSQ NSCLC)
This study is testing new combinations of medicines for a type of advanced lung cancer. It combines an experimental drug (tusamitamab ravtansine) with existing treatments like pembrolizumab (Keytruda) and chemotherapy to see how safe and effective they are. It's for adults whose cancer has a specific marker called CEACAM5.
France - recruitingNA
Glasgow Low-dose CT and AI-based Diagnostics to Case Find Lung Cancer and Other Cardio-respiratory Long-term Conditions - Feasibility Study
This study offers a Lung Health Check for those at higher lung cancer risk. It includes a low-dose CT scan, plus heart and breathing tests, aiming to find lung cancer early and check for other conditions like heart disease and emphysema, all in one visit.
United Kingdom - enrolling by invitation
Investigating the Role of Genetics in Disease Predisposition
This study looks at how tiny changes in the sperm and eggs we inherit can affect our health, especially the risk of certain cancers and rare diseases in our children. Researchers want to understand where these changes come from and how they pass them on.
United Kingdom - recruitingPHASE3
A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study
This study offers continued treatment to cancer patients already in certain Genentech/Roche studies. It's for those still benefiting from their current treatment and who can't get it elsewhere. The aim is to bridge care for these patients.
Belgium · Canada · China - recruiting
Public Survey on Breath Testing for Health and Disease
This survey asks what people think about using an easy breath test to check their health and find illnesses like cancer. Your answers will help researchers understand how to make health checks better and guide future studies.
United Kingdom - not yet recruiting
Chemotherapy-Induced Hearing Loss and Health Inequality
This study looks at how chemotherapy for cancer can cause hearing loss, especially in people from poorer backgrounds. It also checks if hearing loss affects memory and thinking, to help improve care for cancer patients in the North West of England.
United Kingdom - active not recruiting
Digital Monitoring in Cancer Survivors
This study looks at how digital tools, like smartwatches and questionnaires on phones, can help monitor cancer survivors' well-being after treatment. It aims to see if these tools are easy to use and helpful for keeping track of symptoms and quality of life.
United Kingdom - recruitingNA
Effects of a Second-generation Mindfulness-based Intervention on Quality of Life, Pain Management, and Psycho-spiritual Wellbeing in Cancer Patients: A Randomised Controlled Trial
This study explores if Meditation Awareness Training (MAT) can improve well-being, pain management, and quality of life for cancer patients. It combines traditional spiritual ideas with mindfulness to offer deeper support beyond standard approaches.
United Kingdom - recruiting
Breaking Barriers to Research Access
This study aims to understand why some cancer patients, especially those from certain backgrounds, find it hard to join research studies. By finding out what these barriers are, we hope to make sure more people can take part in research, leading to fairer and better cancer care for everyone in Cheshire and Merseyside.
United Kingdom - recruiting
Neurobehavioural and Cognitive Changes in Cancer Cachexia (CANCOG)
This study looks at how cancer, specifically weight loss due to cancer, affects the brain and body signals. Researchers want to understand changes in appetite, motivation, and brain activity to help develop new treatments for cancer-related weight loss.
United Kingdom - ongoing, recruitingPhase I and Phase II (Integrated)- Other
An open-label, multicenter Phase 1/2 dose escalation and expansion study of THOR-707 as a single agent and as a combination therapy in adult subjects with advanced or metastatic solid tumors
This study is testing a new medicine, THOR-707, for people with advanced cancer. It aims to find the safest and most effective dose, and see how well it works alone or with other treatments to shrink tumours and improve health.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1, open-label, multiple-ascending dose study to investigate the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of KD033 (SAR445710) in subjects with metastatic or locally advanced solid tumors
This study is testing a new medicine, KD033, for people with advanced cancer. It's a very early-stage trial focusing on how safe the medicine is, how it moves through the body, and if it shows any signs of working.
France · Spain - active not recruitingPHASE3
A Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezolizumab Study (IMbrella A)
This study is for people with cancer who are already receiving specific cancer treatments in another study. It allows them to continue their treatment if their original study ends and they can't get the medicine elsewhere. It's about safely extending access to these important cancer drugs.
United States · Argentina · Australia - active not recruiting
LEVANTIS-0093A: GAGomes for Multi-Cancer Early Detection in High-Risk Adults (LEV93A)
This study looks for early signs of many cancers in people aged 55-80 who have a history of smoking. It uses blood samples from existing screening programmes in Yorkshire to find new ways to detect cancer sooner.
United Kingdom - ongoing, recruitingPhase I and Phase II (Integrated)- Other
Phase 1/2 trial evaluating isatuximab in combination with pegenzileukin in relapsed or refractory multiple myeloma (RRMM) previously exposed to anti-CD38 and anti-BCMA
This study is looking at a new combination of treatments for multiple myeloma that has come back or isn't responding to current treatments. It aims to find the safest dose of these new drugs and see how well they work together to shrink the cancer or stop it from growing.
Greece · Germany · Italy - recruiting
Testing a digital, comprehensive, standardised assessment approach to improve the management of people with cancer
This study is testing a new digital tool called MyPath to help people with cancer. It lets patients record their symptoms on a phone or tablet, so doctors can better understand how they are feeling and give more personalised care. The aim is to make cancer treatment better for everyone.
United Kingdom · England · Scotland - recruiting
Palliative Care and Oncology Survey on Terminology
This study asks people with cancer how they feel about words used to describe them, like 'cancer survivor'. We want to understand if these terms are helpful, especially for those receiving palliative care or active cancer treatment. Your views can help improve how care is given.
Ireland · United Kingdom - enrolling by invitationPHASE3
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Durvalumab
This study is for cancer patients who have already been in another durvalumab drug trial and are still benefiting from the treatment. It lets them continue receiving the drug to see if it keeps helping them.
United States · Argentina · Australia - active not recruiting
Epidemiology of Complications After Solid Organ Transplantation - EpCOT Study
This study looks at health problems, especially cancer, after organ transplants in the UK. Researchers are combining existing patient information to better understand why cancer happens and how it affects people after a transplant, to help improve care.
United Kingdom - recruiting
RDC Biomarker Study
This study aims to find new, simple tests, like breath, blood, or saliva tests, to help doctors quickly find cancer in patients at Rapid Diagnostic Centres. It also wants to identify people at higher risk of cancer to help them get screenings or monitoring.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingPHASE2
Pan Tumor Rollover Study
This study looks at the long-term safety of different cancer treatments, including nivolumab, alone or combined with other medicines. It's for people with various types of cancer who are already receiving treatment in a related study, aiming to see how these treatments work over time.
United States · Argentina · Australia