- recruiting
Quality of Pediatric Resuscitation in a Multicenter Collaborative
This study looks at how the quality of CPR given to children during a cardiac arrest affects their recovery. Researchers are observing children in hospitals to see if better CPR techniques and after-care improve survival and brain function.
United States · Australia · Brazil - authorisedTherapeutic confirmatory (Phase III)
Use of Isoprenaline with Epinephrine During Out-of-Hospital Cardiac Arrest with Non-Shockable Rhytm (EPISO)
This study looks at using isoprenaline with epinephrine for adults experiencing a cardiac arrest outside of a hospital, when their heart rhythm can't be corrected with an electric shock. It aims to see if this combination of medicines helps get the heart beating again and improves survival.
Denmark - authorisedTherapeutic exploratory (Phase II)
CardioPulmonary resuscitation with Argon (CPAr) trial
This study is looking into whether a special gas mixture (Argon and Oxygen) can protect the brain and heart after a cardiac arrest. It's an early-stage study to see if this treatment could help people recover better.
Italy - recruitingNA
Emergency Resuscitative Endovascular Balloon Occlusion of the Aorta in Out of Hospital Cardiac Arrest
This study looks at using a special balloon device (REBOA) in the main artery to help people who have a sudden heart stop outside of hospital. It aims to see if this method is practical and helpful alongside standard emergency care to improve survival.
United Kingdom - not yet recruitingNA
Sustained Inflation and Chest Compression vs 3:1 C:V Ratio in Asphyxiated Newborns
This study is looking at the best way to help newborn babies who need CPR straight after birth. We're comparing a new technique called CC+SI with the usual method (3:1 C:V) to see which is safer and more effective in helping babies survive and thrive.
Canada - not yet recruitingNA
Optimizing Ventilation to Improve Survival From Out-of-hospital Cardiac Arrest: the OPTIVO Randomized Controlled Trial
This study looks at the best way to help people breathe during CPR after their heart stops. Researchers want to find out if giving a little or a lot of air makes a difference in survival and recovery for adults.
Canada - recruitingNA
Cardiac Arrest Bundle of cARE Trial
This study looks at new technology to help people who have a sudden heart stop outside of hospital. It combines three devices to improve blood flow during CPR, hoping to boost survival rates and protect the brain. It's a pilot study to see if using these devices together is practical and helpful.
United Kingdom - recruitingPHASE2
Efficacy of Early Intravenous High-dose Vitamin C in Post-cardiac Arrest Shock.
This study looks at whether giving high-dose vitamin C and vitamin B1 early can help patients who have a serious medical problem called 'shock' after a cardiac arrest. Doctors want to see if these vitamins can improve recovery and reduce harm to organs.
France - recruiting
Brain Heart InterActioNs in Cardiac Arrest. Ancillary Study of the HEAVENwARd Trial
This study looks at how the brain and heart work together after someone has a cardiac arrest. It aims to find new ways to predict how well people will recover by studying the electrical signals between the brain and heart.
France - not yet recruitingNA
Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients
This study looks at how certain antibiotics, called beta-lactams, work in very sick patients on a special life support machine called VA-ECMO. Doctors want to find the best way to give these antibiotics to help fight infections effectively.
France - recruiting
Early Neuroprognostication After OHCA
This study looks at new ways to predict how well people recover after a cardiac arrest, focusing on brain health. Doctors hope to find out earlier if someone will have long-term brain issues using new tests like brain scans and blood tests, rather than waiting a few days.
Finland · Germany · Sweden - recruitingNA
Impact of Aerosol Box Use During Cardiopulmonary Arrest: A Multicenter Study
This study looks at how a special box, called an aerosol box, helps protect healthcare workers during CPR for patients who might have COVID-19. It aims to see if the box stops tiny virus particles from spreading in the air, making it safer for staff.
United States · Canada - recruiting
Respiratory Parameters Using Advanced Airways During In-hospital Cardiac Arrest
This study looks at how much air gets into patients' lungs during CPR in hospital. We're comparing different breathing tubes used in emergencies to see which ones deliver air most effectively, helping doctors understand how to best support patients during a cardiac arrest.
United Kingdom