- authorisedTherapeutic exploratory (Phase II)
Randomized, controlled, double-blind trial to investigate the effect of colchicin on the endothelial function in patients with CHIP mutations and chronic heart failure with reduced left ventricular function (CHIP-HF)
This study looks at whether a medicine called colchicine can help people with a specific type of heart failure. It compares colchicine to a dummy pill to see impacts on blood vessel health, especially in those with certain genetic changes.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A trial to learn if itraconazole and carbamazepine affect how AZD5462 moves throughout the bodies of healthy adults
This study is looking at how a new medicine, AZD5462, moves through the body when healthy adults also take common medicines for fungal infections (itraconazole) or epilepsy/nerve pain (carbamazepine). It will help us understand how these medicines interact.
Germany - not yet recruitingNA
VItamiN D treatIng Chronic heArT Failure (the Effect of Vitamin D Supplementation in Patients With Heart Failure)
This study looks at whether a daily vitamin D supplement can help people with long-term heart failure and low vitamin D. Patients will receive either vitamin D or a dummy pill to see if it reduces hospital stays or improves their health over several years.
United Kingdom - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIb Two-cohort, Randomised, Placebo-controlled, Double-blind, Multi-centre, Dose-ranging Study of AZD5462 in Stable Patients with Chronic Heart Failure
This study is testing a new medicine, AZD5462, for people with long-term heart failure. Researchers want to see if it improves how well the heart pumps, using ultrasound scans. It's a key step to understanding if this medicine could help patients.
Bulgaria · Czechia · Poland - authorisedHuman Pharmacology (Phase I)- Other
A Randomized Study in Healthy Participants to Identify the Optimal Subcutaneous Injection Strategy for COR-1167
This early-stage study is looking for healthy volunteers to help researchers figure out the best way to give a new medication, COR-1167, by injection under the skin. It's not for people with heart failure yet, but aims to make future treatments for chronic heart failure better.
Netherlands - active not recruitingNA
Heart Failure Patient Management and Interventions Using Continuous Patient Monitoring Outside Hospitals and Real-world Data
This study uses smart devices to track heart failure, heart transplant or LVAD patients at home. The goal is to help doctors make better decisions, aiming to reduce hospital stays and improve quality of life.
Germany · Greece · Italy - recruitingNA
CHF-COV Reduced (Chronic Heart Failure With Reduced Ejection Fraction - COngestion eValuation)
This study looks for better ways to spot and track fluid build-up in people with heart failure. We want to find clearer signs, using check-ups, blood tests, and ultrasound scans, to help manage heart failure and prevent hospital stays.
France - recruitingNA
Impact of YOGA on the Quality of Life and Well-being of Heart Failure Patients
This study looks at how yoga affects the quality of life and general well-being of people living with long-term heart failure. Participants will either attend yoga classes or storytelling groups to see if yoga can help them feel better and improve their health.
France - recruitingNA
Chronic Heart Failure With Preserved Ejection Fraction - COngestion eValuation
This study aims to find ways to better monitor chronic heart failure, especially when the heart's pumping ability is still good but there's a build-up of fluid (congestion). We're looking at different tests to see which ones best predict future health problems like hospital stays or death.
France - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Assess the Safety and Effectiveness of Tovinontrine in Patients With Chronic Heart Failure With Preserved Ejection Fraction
This study is testing a new medicine, Tovinontrine, for people with a type of chronic heart failure. It aims to see if the medicine is safe and if it can improve how the heart works according to blood tests, compared to a dummy pill.
Czechia · Bulgaria · Netherlands