- ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Phase 1 study on SAR443122 bioavailability and food effect in healthy adults
This early-stage study is looking at a new medicine called SAR443122 in healthy adults. It aims to understand how much of the medicine the body absorbs and if food affects this. We hope this research will eventually help people with ulcerative colitis.
Netherlands - active not recruitingPHASE3
A Long-term Extension Study of Ustekinumab in Pediatric Participants
This study looks at the long-term safety of a treatment called ustekinumab for children and young people with conditions like Crohn's disease or certain types of arthritis. It's for those already taking part in an earlier study of this medicine.
United States · Argentina · Belgium - recruitingPHASE2, PHASE3
A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis
This study is testing a new medicine, ozanimod, for children aged 2-17 with moderate to severe ulcerative colitis that hasn't responded well to other treatments. We want to see if it helps them feel better and stay well.
United States · Australia · Belgium - recruiting
A Study to Observe Real-world Evidence of Guselkumab Treatment in Participants With Ulcerative Colitis and Crohn's Disease in the United Kingdom (UK)
This study looks at how well a medicine called guselkumab works for adults with moderate to severe Ulcerative Colitis or Crohn's Disease in the UK. Researchers want to see its real-world benefits and how different groups of patients respond.
United Kingdom - recruitingPHASE3
A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis
This study is testing a new medicine called Icotrokinra for teenagers and adults with moderate to severe ulcerative colitis. It aims to see how well it works, if it's safe, and if people can tolerate it, compared to a dummy pill.
United States · Argentina · Australia - active not recruitingPHASE2
A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease
This study is looking at a new medication, TEV-48574, for adults with moderate to severe Crohn's disease or ulcerative colitis. It aims to see how well different doses work over the long term and if they are safe.
United States · Austria · Bulgaria - recruiting
A Study to Learn About the Effectiveness of Etrasimod in People With Ulcerative Colitis
This study looks at how well a medicine called etrasimod works for people in the UK with a bowel condition called ulcerative colitis. It follows patients receiving etrasimod as part of their usual care to see how their health changes over time.
Canada · Germany · United Kingdom - recruitingPHASE3
Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)
This study looks at a medicine called tulisokibart for Crohn's disease and ulcerative colitis. It's for people who were in earlier trials and found benefit from it. The aim is to check its long-term safety and how well it works over time.
United States · Czechia · France - active not recruitingPHASE2
Dose-finding Study of SAR443122 in Adult Participants With Ulcerative Colitis
This study is testing a new medicine, SAR443122, for adults with moderate to severe Ulcerative Colitis. We want to see how well it works and if it's safe compared to a dummy drug, and find the best dose.
United States · Argentina · Chile - active not recruitingPHASE1
A First-time in Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK4528287 in Healthy Participants
This study is testing a new medicine, GSK4528287, for bowel conditions like ulcerative colitis for the very first time in people. We want to see if it's safe, how the body handles it, and if it works as expected. We'll start with small doses in healthy volunteers.
United Kingdom - recruitingPHASE2
A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis
This study looks at a medicine called Etrasimod for children aged 2-11 with a gut condition called ulcerative colitis. It aims to see if the medicine is safe, works well, and how the body handles it. Some children might continue taking it for a longer time.
Canada · France · Germany - recruiting
A Study to Generate Real-world Evidence of Guselkumab Effectiveness in Inflammatory Bowel Disease in Germany
This study looks at how a medicine called guselkumab works for people in Germany with Crohn's disease or ulcerative colitis in real life. It also checks how this medicine affects their quality of life, tiredness, and daily activities.
Germany - active not recruitingPHASE4
Determination of the Optimal Treatment Target in Ulcerative Colitis
This study is looking for the best way to treat ulcerative colitis (UC). We're testing different treatment goals to see which one works best at keeping your symptoms away, healing your gut, and improving your quality of life. Understanding this can help doctors treat UC more effectively.
United States · Belarus · Belgium - recruitingPHASE2
A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Ulcerative Colitis
This study is looking into a new medication called SAR441566 for people aged 18-75 with moderate to severe ulcerative colitis. It aims to see if the medication is safe and effective in improving symptoms compared to a dummy drug.
United States · Argentina · Australia - active not recruitingPHASE3
A Study of Guselkumab Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
This study looks at a new drug, guselkumab, for people in the UK with moderate to severe ulcerative colitis. It aims to see if the drug can help improve their symptoms and lead to remission, compared to a dummy treatment. It's a key step in understanding this potential new medicine.
United States · Argentina · Australia - active not recruitingPHASE2
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis
This study looks at new ways to treat ulcerative colitis, a condition causing gut inflammation. We're testing a combination of medicines (JNJ-78934804) for people whose current treatments aren't working well. The goal is to see if these new approaches are safe and effective.
United States · Argentina · Australia - recruitingPHASE3
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
This study looks at the long-term safety of a medicine called guselkumab for children and young people with Crohn's disease, ulcerative colitis, or a type of arthritis called juvenile psoriatic arthritis. It's for those who have already seen benefits from the medicine in an earlier study.
United States · Argentina · Australia - recruitingPHASE2
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
This study is testing new long-acting medicines for adults with moderate to severe ulcerative colitis. It aims to see how well they work and if they are safe, both on their own and in combinations, compared to a dummy treatment.
United States · Argentina · Australia