- ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3 Multicenter, Randomized, Openlabel, Active-controlled Study of Sotorasib and Panitumumab Versus Investigator’s Choice (Trifluridine and Tipiracil, or Regorafenib) for the Treatment of Previously Treated Metastatic Colorectal Cancer Subjects with KRAS p.G12C Mutation
This study looks at new treatments for bowel cancer that has spread and has a specific gene change (KRAS p.G12C mutation). It compares a new drug combination (sotorasib and panitumumab) with standard treatments to see which works best and is safest.
Italy · Germany · Greece - recruiting
Advances in Imaging to Assess Response in Rectal Cancer
This study looks at using advanced MRI scans to plan radiotherapy for rectal cancer more precisely. It aims to see if getting these detailed scans over time is practical and helpful for improving treatment planning.
United Kingdom - active not recruitingPHASE1, PHASE2
GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
This study is testing a new cancer medicine, GEN1042, both by itself and with other treatments. It's for people with certain advanced solid tumours where standard treatments haven't worked or aren't available. The main goals are to check its safety and see how well it fights cancer.
United States · Denmark · France - recruitingPHASE1
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
This study is testing a new drug, OKN4395, alone and with an existing cancer treatment, pembrolizumab, for various solid tumours. The main goals are to check its safety, how well it's tolerated, and if it helps fight cancer.
United States · Australia · United Kingdom - recruitingPHASE1
Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors
This study is testing a new drug, zanzalintinib, alone and with other medicines, for people with advanced cancers like kidney, prostate, and lung cancer. It's looking at safety and if the treatment shrinks tumours.
United States · Australia · Austria - recruiting
Faecal Immunochemical Tests (FIT) for Surveillance After Colorectal Cancer (CRC) Study
This study looks at a simple poo test (FIT) to see if it can accurately find bowel cancer returning after surgery. It aims to see if this test could offer a gentler option than colonoscopies for some patients, helping them avoid unpleasant procedures.
United Kingdom - recruitingPHASE1, PHASE2
Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors
This study is testing a new medicine, TH9619, for people with advanced cancers like bowel, head and neck, lung, and stomach cancer. It's the first time TH9619 is being given to people, and doctors want to find the safest and most effective dose.
France · Spain · United Kingdom