- active not recruitingPHASE3
A Long-term Extension Study of Ustekinumab in Pediatric Participants
This study looks at the long-term safety of a treatment called ustekinumab for children and young people with conditions like Crohn's disease or certain types of arthritis. It's for those already taking part in an earlier study of this medicine.
United States · Argentina · Belgium - recruiting
Nutrition and Clinical Outcomes in IBD
This study looks at how nutrition and body health affect people with Crohn's disease and ulcerative colitis. We want to find better ways to check for poor nutrition and understand how it impacts treatment, surgery, and overall well-being in IBD patients.
United Kingdom - recruitingPHASE4
VECTORS - A Study to Evaluate Transmural Healing as a Treatment Target in Crohn's Disease
This study looks at new ways to treat Crohn's disease using a gentle scan called intestinal ultrasound. It aims to see if targeting 'transmural healing' – healing all layers of the bowel wall – alongside other measures, works better than standard care for people with moderately to severely active Crohn's.
United States · Australia · Belgium - recruiting
NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study
This study compares body markers linked to inflammation in people with Crohn's disease or ulcerative colitis (IBD) and healthy individuals. It aims to understand IBD better and find ways to predict treatment responses, ultimately leading to improved care.
United Kingdom - recruitingNA
The CROCO Study: CROhn's Disease COhort Study
The CROCO Study looks at how Crohn's disease changes over time in people getting the latest treatments. We hope to understand the disease better and find ways to predict its impact, ultimately improving care for patients.
Belgium · Cyprus · Czechia - recruiting
PIBD-SETQuality: the Inception Cohort and Safety Registry
This study looks at how well current treatments work and their safety for children and teenagers with Inflammatory Bowel Disease (IBD). It wants to understand how individual factors might affect treatment outcomes and serious complications.
Netherlands · United Kingdom - recruiting
Diagnostic Concordance of MR Enterography and Ultrasound for Treatment Response Assessment in Crohn's Disease (MANTRA)
This study looks at how well two types of scans – MR Enterography (MRE) and intestinal ultrasound (IUS) – work to check if Crohn's disease treatment is effective. We want to see if they give similar results and if one scan is better or if they can be used interchangeably.
United Kingdom - recruitingPHASE2, PHASE3
A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine, icotrokinra, for people in the UK with moderately to severely active Crohn's disease. Researchers want to see if it helps reduce symptoms and if it's safe to use, compared to a dummy medicine.
United States · Argentina · Australia - recruitingPHASE3
A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
This study compares two medicines, guselkumab and risankizumab, for people with moderate to severe Crohn's disease. Researchers want to see which one works better to reduce inflammation in the gut and improve symptoms.
United States · Austria · Belgium - active not recruitingPHASE2
A Study to Evaluate the Long-Term Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease
This study is looking at a new medication, TEV-48574, for adults with moderate to severe Crohn's disease or ulcerative colitis. It aims to see how well different doses work over the long term and if they are safe.
United States · Austria · Bulgaria - recruitingPHASE3
Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)
This study looks at a medicine called tulisokibart for Crohn's disease and ulcerative colitis. It's for people who were in earlier trials and found benefit from it. The aim is to check its long-term safety and how well it works over time.
United States · Czechia · France - active not recruitingNA
Implementing a Multimodal RCT Intervention to Improve the Transition of Patients With Crohn's Disease From Pediatric to Adult Care
This study looks at a new support program for young people with Crohn's or ulcerative colitis who are moving from children's to adult healthcare. It aims to make this move smoother and improve their health and well-being.
Canada - recruitingPHASE4
Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease
This study looks at how a treatment called anti-TNF works for children aged 6-17 with newly diagnosed Crohn's disease. Researchers want to understand why some children get better and others don't, helping doctors offer more tailored care.
United States · Canada - recruitingPHASE3
Comparison of Azathioprine to Methotrexate in Combination Therapy With Adalimumab in Crohn's Disease: an Open-label Randomized Controlled Trial
This study compares two common medicines, azathioprine and methotrexate, when used with adalimumab for Crohn's disease. Researchers want to see which combination works best to improve symptoms and healing in the gut, hoping to find a safer and more effective treatment.
France - active not recruitingPHASE4
Stopping Aminosalicylate Therapy in Inactive Crohn's Disease
This study looks at whether people with Crohn's disease in remission can safely stop taking a common medicine called 5-ASA. It compares stopping the medicine with continuing it to see if symptoms stay away for at least two years.
Canada · Italy · Ukraine - recruitingNA
KONO-S Anastomosis Compared to Conventional Ileocolonic Anastomosis to Reduce Recurrence in Crohn's Disease
This study compares two surgical techniques for Crohn's disease: the Kono-S method and a standard method. It aims to see which is better at preventing the disease from returning after surgery.
France - recruiting
Analysis of Therapeutic Management Strategies for Anal Suppurations of Crohn's Disease
This study looks at the best ways to treat anal Crohn's disease, specifically focusing on infections and abscesses. We want to find out which treatments, combining medication and surgery, work best to completely heal these problems and keep them away for a long time.
France - recruitingPHASE1, PHASE2
Dose Escalation of Allogeneic Adipose Derived Stroma/Stem Cells for the Treatment of Crohn's Fistula
This study is testing a new cell treatment, called CellReady®, for difficult-to-treat Crohn's fistulas. It aims to see if different doses of these special cells can help heal fistulas when usual treatments haven't worked.
France - recruiting
Study on the Treatment of Anal Fistulas Using Alofisel Versus Fat Autologous Stem Cells
This study compares two treatments for anal fistulas in people with Crohn's disease: a new cell therapy called Alofisel and a treatment using your own body fat (fat stem cells). It aims to see which is more effective for these complex fistulas.
France - recruiting
Fibrosis Associated Protein Inhibitor (FAPI) Radiotracer-based Imaging to Identify Fibrotic Intestinal Crohn's Disease
This study is testing a new way to see gut scarring in Crohn's disease using a special 'dye' and scans. Current treatments help inflammation, but not scarring. This new method could help doctors find scarring early and develop treatments to stop it.
United Kingdom - recruiting
Robotic Inflammatory Bowel Disease Development, Learning and Efficacy Study
This study looks at using robotic surgery for inflammatory bowel disease (IBD) like Crohn's disease and ulcerative colitis. Researchers want to see if robots can help surgeons operate more effectively and how this new method compares to traditional keyhole surgery for IBD.
United Kingdom - recruitingNA
The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.
This study looks into why some people get migraines, especially those with other health conditions like autoimmune diseases. Researchers are examining how chemicals in the body, called cytokines, and special immune cells, called Treg cells, might be linked to migraine pain. They hope to better understand migraine causes.
France - recruitingNA
Biologics and Partial Enteral Nutrition Study
This study looks at whether adding special milkshakes to half your normal diet can help adults with Crohn's disease respond better to their usual medicine. It's for people starting a biologic injection for the first time.
United Kingdom - active not recruitingNA
DWI MR-enterography Without or With Bowel Cleansing to Assess Intestinal Inflammatory Activity in the Follow-up of Crohn's Disease
This study looks at a new, faster way to use MRI for Crohn's disease without needing a bowel cleanse. It aims to see if this simpler method can still effectively check bowel inflammation.
France - active not recruitingNA
OptiMized REsistaNt Starch in Inflammatory Bowel Disease: The MEND Trial
This study, called MEND, aims to see if a special plant-based fibre, called resistant starch, can help children and teenagers with Inflammatory Bowel Disease (IBD). We want to find out if it can make their gut healthier and tackle the root cause of their condition.
Canada - recruiting
Predicting IBD Treatment Outcomes With Gut Microbiome Analysis
This study looks at gut bugs (microbiome) in people with Crohn's disease to see if they can predict how well treatments will work. They will collect samples during colonoscopies and follow people for a year.
Canada - recruitingNA
Reverse-Engineering of Exclusive Enteral Nutrition (RE-EEN) in Crohn's Disease: A Multi-Center Trial
This study looks at two ways to use a special diet (EEN) for children and young people with Crohn's. We're comparing a standard liquid diet with a new smoothie made from real foods to see which works best and is easiest to stick to.
United States · Canada - not yet recruiting
Spondylo-arthritis Screening Tool Among Patient Suffering From Inflammatory Bowel Disease
This study is translating two questionnaires from English to French. These questionnaires help doctors identify if people with inflammatory bowel disease might also have a type of arthritis called spondyloarthritis, so they can get the right care.
France - recruitingNA
Threonine Requirement in Adult Males With Crohn's Disease Using IAAO
This study looks at how much of an important nutrient called threonine people with Crohn's disease need. Researchers want to see if this amount is different from healthy adults, hoping to improve dietary advice for Crohn's patients.
Canada - recruiting
AI-enabled Endoscopic Prediction of Post-operative Recurrence in Crohn's Disease
This study uses new technology and AI during a colonoscopy to better predict when Crohn's disease might return after surgery. The goal is to find patients at high risk so they can get early treatment.
Belgium · Canada · Germany - recruitingPHASE2
A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease
This study is looking at new treatments for Crohn's disease. Researchers are testing a new drug, LY4395089, with an existing drug, mirikizumab, to see if they work better together than mirikizumab alone. They want to find out if this combination is safe and effective for adults.
United States · Belgium · Brazil - active not recruitingNA
Small Bowel Deep Learning Algorithm Project
This study uses a special computer program to help doctors find Crohn's disease in the small bowel more easily on MRI scans. It compares how well the computer does compared to experienced doctors looking at the scans.
United Kingdom - recruitingPHASE3
Fecal Microbiota Transplantation in Crohn's Disease as Relay After Anti-TNF Withdrawal
This study is looking at whether a 'stool transplant' (Fecal Microbiota Transplantation) can help people with Crohn's disease stay well after stopping other strong medicines called anti-TNFs. We want to see if it can keep their symptoms away for longer.
France - recruitingNA
Safety of Mesentery-embedding Surgery in Patients With Ileocolic Crohn's Disease on Biotherapy
This study looks at a new surgical approach for Crohn's disease that might reduce how often the disease comes back. We're comparing it to the usual surgery to see if it's safe and helps people on certain medications stay healthier longer.
France - recruitingPHASE4
Bowel Preparation for Colonoscopy Among Individuals With Crohn's and Ulcerative Colitis Disease.
This study compares two bowel preparations, KleanLyte and Bi-PegLyte, for colonoscopies in people with Crohn's disease or ulcerative colitis. It aims to find out which is more effective at cleaning the bowel and easier to use before a colonoscopy.
Canada - recruitingNA
Evaluation of Sleep Changes in Inflammatory Bowel Diseases (IBD) Patients.
This study looks at how sleep changes in people with Inflammatory Bowel Diseases (IBD) who are currently feeling well. We want to see if changes in sleep patterns might predict when their IBD symptoms could return or 'flare up'.
France - recruitingPHASE2
Impact Of The Gut Microbiota On Host Cells Energy Metabolism in Health And In Inflammatory Bowel Disease
This study looks at how gut germs affect energy in healthy people and those with Inflammatory Bowel Disease (IBD). We want to understand if changes in these germs contribute to IBD. Healthy people get antibiotics, while IBD patients are tested once. We'll use special fiber to see how gut germs break it down.
France