- ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase IIa, randomised, double-blind, placebo-controlled trial to evaluate the safety, efficacy, pharmacokinetics and pharmacodynamics of BI 706321 orally administered for 12 weeks in patients with Crohn`s Disease (CD) receiving ustekinumab induction treatment
This study is looking into a new medication (BI 706321) for Crohn's disease. It aims to see if it's safe and effective when taken alongside an existing treatment called Stelara, and how it works in the body.
Italy · Spain · Czechia - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Multicenter, Open-Label Extension (OLE) Study to Observe the Long-Term Efficacy, Safety, and Tolerability of Repeated Administration of Upadacitinib (ABT-494) in Subjects with Crohn's Disease
This study looks at how safe and effective a drug called Upadacitinib is over a long time for people with Crohn's disease. It checks if the drug helps people feel better and if they stay better, as well as any side effects.
Slovakia · Netherlands · France - recruitingPHASE3
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Crohn's Disease (CD)
This study looks at a medicine called vedolizumab for children and teenagers with moderate to severe Crohn's disease. It aims to see if the medicine can make their symptoms better and heal inflammation in their gut.
United States · Australia · Belgium - active not recruitingPHASE3
Study Comparing Intravenous (IV)/Subcutaneous (SC) Risankizumab to IV/SC Ustekinumab to Assess Change in Crohn's Disease Activity Index (CDAI) in Adult Participants With Moderate to Severe Crohn's Disease (CD)
This study compares two treatments, risankizumab and ustekinumab, for adults with moderate to severe Crohn's disease. Researchers want to see which treatment works best to reduce Crohn's symptoms. Both treatments are given initially by IV, then by injection.
United States · Argentina · Australia - recruitingNA
Biologics and Paediatric Enteral Nutrition in Crohn's Disease Study
This study looks at how a liquid-only diet (specialised milkshakes) might help children and young people with Crohn's disease when they start new biologic medicines. We want to see if combining these treatments helps them feel better and stay well for longer.
United Kingdom