Prevention of stroke and systemic embolism in adult patients with non-valvular atrial fibrillation (NVAF), with one or more risk factors, such as prior stroke or transient ischaemic attack (TIA) research hub
35 indexed studies · 24 currently recruiting
- ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A randomized, open-label, single dose, 2-way crossover bioequivalence study comparing apixaban 5 mg hard capsules (PG412 [Celon Pharma]) vs apixaban 5 mg film-coated tablets (Eliquis [Bristol-Myers Squibb]) under fasting conditions in healthy volunteers
This study compares two different versions of a medicine called apixaban (one is PG412, the other is Eliquis). Both help prevent blood clots. We want to see if the new version works in the body in the same way as the established one.
Poland - active not recruiting
Continuous Glucose Monitoring in People With Diabetes on Dialysis
This study looks at how blood sugar levels change in people with diabetes who are on dialysis, using a device called a continuous glucose monitor (CGM). It aims to see if these changes are linked to dialysis itself or to long-term health problems like hospital stays.
United Kingdom - active not recruiting
Genetic Determinants of Kidney Disease in People of African Ancestry With HIV
This study looks at why kidney problems are more common in people of African heritage living with HIV in the UK. It found that certain genes can increase this risk. The research aims to better understand these factors to improve care.
United Kingdom - recruiting
Convenient Home Access for Routine Monitoring in Diabetes (Charm-D Study)
This study looks at making diabetes monitoring easier. We're testing if people can accurately do their blood tests (for blood sugar, cholesterol, and thyroid) at home instead of going to a clinic. This could save time and make regular check-ups more convenient.
United Kingdom - recruitingNot Applicable
Characterisation of sensor accuracy performance for Continuous Glucose Monitoring (CGM) systems
This study looks at how well different glucose monitors work for people with diabetes. If you're over 18 with Type 1 or Type 2 diabetes, you could help us understand these devices better by wearing some sensors and doing regular finger-prick tests.
United Kingdom · England · Scotland - recruitingNA
Automated Insulin Delivery in Adults With Advanced Kidney Disease
This study looks at a new system called automated insulin delivery (AID) for people with diabetes and advanced kidney disease. It checks if AID can improve blood sugar control and quality of life compared to usual care. It's a small study in London for people injecting insulin.
United Kingdom - active not recruitingNA
Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure
This study looks at a new way to find hidden heart failure in people with diabetes who are at higher risk. We're testing if checking a specific blood marker helps doctors discover heart problems earlier, so people can get the right care sooner.
United Kingdom - recruiting
Understanding Beta Cell Disorders Through the Study of Rare Genotypes (ENDURE)
This study, called ENDURE, wants to understand how rare changes in our genes affect cells that control blood sugar. We're looking for people with and without these gene changes to help us learn more about diabetes and other sugar-related conditions, hoping to find new ways to help patients.
United Kingdom - recruitingNA
Streamlined Denervation With spYral For an Optimized Treatment (SPYRAL SWYFT) in Subjects With Uncontrolled Hypertension
This study looks at a procedure called renal denervation to treat high blood pressure. It aims to see if a simpler way of doing the procedure is just as good, and possibly quicker, than older methods. This could offer a new option for people whose blood pressure is hard to control.
Australia · Belgium · Germany - enrolling by invitation
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
The EuroSIDA study looks at how HIV affects people in Europe and how treatments work over time. It helps us understand health changes and the impact of new medicines for HIV and related conditions like hepatitis.
Argentina · Austria · Belarus - active not recruitingNA
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
This study looks at a treatment called renal denervation (RDN) for high blood pressure. It uses a device called Symplicity Spyral to see how well it works and if it's safe in the long term, especially for people whose blood pressure is hard to control.
United States · Australia · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A study comparing the new drug PG413 produced by Celon Pharma SA with the drug Eliquis available on the market in healthy volunteers.
This study is testing a new medicine, PG413, to see how it compares to an existing medicine called Eliquis. Both medicines are used to prevent strokes and treat blood clots. This early study helps us understand how PG413 works in healthy people.
Poland - active not recruitingPHASE4
ASCEND: A Study of Cardiovascular Events iN Diabetes
The ASCEND study looked at whether daily aspirin or omega-3 tablets could prevent serious heart problems and strokes in people with diabetes who hadn't had them before. It found aspirin helped but also increased bleeding. Omega-3s didn't make a difference.
United Kingdom - recruitingNA
RT-CGM in Young Adults at Risk of DKA
This study looks at how a special device called real-time continuous glucose monitoring (RT-CGM) helps young adults, aged 18-25, manage their type 1 diabetes. We want to see if it improves blood sugar control and reduces hospital visits for high blood sugar.
United Kingdom - recruiting
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
This study aims to understand why common medicines don't work the same for everyone in the UK, especially for people from different backgrounds. It will look at many health conditions, hoping to improve how we treat them and make healthcare fairer for all.
United Kingdom - recruitingNA
Is Community Based Monitoring of Diabetic Maculopathy and Pre-proliferative Diabetic Retinopathy Safe?
This study looks at whether opticians in your local area can help check for eye problems caused by diabetes, using special scans. It aims to make it easier to get checked and reduce hospital visits, while making sure it's safe and effective.
United Kingdom - recruitingPHASE2, PHASE3
Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide
This study looks into whether a weekly injection, Semaglutide, combined with an 'artificial pancreas' system, can help people with Type 1 Diabetes manage their blood sugar without needing to count carbohydrates every meal.
Canada - recruiting
Deep Phenotyping of Peripheral Blood Cells and Circulating Factors in Metabolic Diseases
This study looks at blood cells and other substances in people with obesity, diabetes, and fatty liver disease. Researchers want to understand how these differ in people with and without these conditions to learn more about how they develop.
Germany - active not recruiting
StartRight: Getting the Right Classification and Treatment From Diagnosis in Adults With Diabetes
This study, called StartRight, wants to better understand diabetes right from when it's first diagnosed in adults. Researchers hope to find ways to tell different types of diabetes apart earlier and predict who might need insulin treatment sooner. This could help people get the right care faster.
United Kingdom - recruiting
French Prospective Multicentric Study in Real World
This study looks at how a device called Omnipod 5 helps people with Type 1 diabetes in France. It checks blood sugar control, how it affects their daily lives, and how happy they are with the system, over 12 months.
France - recruiting
Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI
This study looks at how heart attacks affect people with and without diabetes. We want to understand more about metabolism, how bodies use energy, and their link to heart health to help improve treatments for people who've had a heart attack.
Germany - recruitingNA
Role of High-Throughput Whole Genome Sequencing for the Diagnosis and Care of Atypical Diabetes
This study looks at how new DNA testing (whole genome sequencing) can help diagnose unusual types of diabetes. It compares this advanced test to current methods to see if it leads to better understanding and care for patients with difficult-to-diagnose diabetes.
France - recruitingNA
Early Percutaneous Transluminal Angioplasty in Diabetic Foot Syndrome (PTA-DFS)
This study looks at treating diabetic foot ulcers with a procedure called angioplasty. Researchers want to know if having this treatment quickly makes a bigger difference to healing than having it later. It's about finding the best timing for care.
Germany - not yet recruitingNA
SCORE! Non-Physician Health Worker (NPHW) Implementation Protocol (SIP)
This study helps people in the SCORE! Cohort with high blood pressure, unhealthy cholesterol, or blood sugar issues. We're using trained health workers, not doctors, to support better health through lifestyle advice and check-ups over 12 months.
Canada - recruiting
Cryopreserved Hair Follicles for Disease and Cell Replacement
This study explores using cells from hair to help treat conditions like diabetes and injuries. Researchers are looking into growing these cells in the lab to create new ways of understanding and treating diseases.
Canada - recruiting
Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes
This study looks for early warning signs of kidney problems in people with diabetes undergoing heart procedures. We want to find new ways to predict and prevent kidney damage caused by the dye used in these important tests, aiming to make them safer for more patients.
United Kingdom - recruiting
Paraoxonase and HDL Qualities in Glycaemia and Inflammation
This study looks at how weight loss surgery and diabetes affect 'good' cholesterol (HDL), inflammation, and blood sugar. We want to understand how HDL works to protect your heart and how this changes with diabetes or after weight loss surgery to reduce heart disease risk.
United Kingdom - active not recruitingNA
Assessment of HGI (Hemoglobin Glycation Index) Variability Over Time in Patients Living With Diabetes Using Continuous Glucose Monitoring ( GAP OUEST )
This study looks at how a measurement called Hemoglobin Glycation Index (HGI) changes over time in people with diabetes. Researchers will use continuous glucose monitors to track this, helping us understand diabetes management better.
France - not yet recruitingNA
The REmission of Diabetes Using a PlAnt-based Weight Loss InteRvention (REPAIR) Trial
This study, called REPAIR, explores if a plant-based diet and exercise can help people with type 2 diabetes achieve remission and significant weight loss. It compares this approach to standard diabetes care.
Canada - recruitingNA
The Use of Ultrasound Detection of Lipohypertrophy to Improve Glycemic Control
This study looks at how injecting insulin into certain fatty areas under the skin, called lipohypertrophy, affects blood sugar control in people with diabetes. It uses ultrasound to find these areas and aims to see if avoiding them can improve health.
Canada - active not recruitingNA
Reconfirming the Safety and Performance of the Glyconics-DS System in Known Populations With and Without Diabetes
This study is checking a new way to test for diabetes using your fingernails. It uses a special light to look for sugar levels in your nails. Researchers want to make sure it's safe and works well for people with and without diabetes, comparing it to a standard blood test.
United Kingdom - enrolling by invitationPHASE4
Semaglutide vs Sitagliptin
This study looks at two diabetes medicines, Semaglutide and Sitagliptin, in people who have had a liver transplant. It checks how well they control blood sugar and body weight, and if they are safe.
Canada - recruitingNA
Surveillance of Pancreatic Health After Diabetes Diagnosis
This study, called SAFE-D, is looking for a new blood test, Avantect, to find pancreatic cancer early in people newly diagnosed with type 2 diabetes. Early detection can lead to better treatment options. Participants will give blood samples and fill out a questionnaire over 12 months.
United Kingdom - recruiting
AI Screening for Diabetic Retinopathy
This study looks at using a computer program (AI) to check for eye problems in people with diabetes. It aims to see how good the AI is at spotting diabetic retinopathy, a condition that can affect your sight.
Germany - recruitingPHASE1
Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes
This study looks at a new medicine, NNC0487-0111, for adults with Type 2 diabetes. It aims to understand how this medicine affects how your body uses insulin and how well your pancreas works to control blood sugar.
Germany