Diabetes mellitus, Type 1 research hub
22 indexed studies · 14 currently recruiting
- ongoing, recruitingTherapeutic exploratory (Phase II)
A randomised, double-blind, placebo controlled, parallel group, multi-centre trial in adult subjects with newly diagnosed type 1 diabetes mellitus investigating the effect of Verapamil SR on preservation of beta-cell function (VER-A-T1D)
This study looks at whether a drug called Verapamil can help people newly diagnosed with type 1 diabetes keep their bodies making some insulin. Researchers want to see if it preserves the 'beta cells' that produce insulin, which could be an important step for future treatments.
France · Germany · Belgium - recruiting
TrialNet Pathway to Prevention of T1D
This study helps us understand how type 1 diabetes develops by screening relatives of people with the condition. We look for early signs in the blood. If detected, we offer close monitoring and a chance to join studies working on prevention or early treatment.
United States · Australia · Canada - recruiting
Chronotype of Patients With Diabetes and Effect on Glycaemic Control
This study looks at how your natural sleep patterns, called chronotype, are linked to managing diabetes and your overall heart health. We want to understand how different sleep timings affect blood sugar levels and other health factors in people with type 1 and type 2 diabetes.
United Kingdom - recruitingPHASE3
A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
This study is looking into whether a medicine called baricitinib can delay Type 1 Diabetes in children and adults who are at a high risk of developing it. It's a key step in preventing the condition.
United States · Australia · Belgium - recruitingPHASE3
A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
This study investigates if a drug called baricitinib can protect the body's insulin-making cells in children and adults newly diagnosed with type 1 diabetes. It aims to see if preserving these cells helps manage the condition better.
United States · Australia · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to test how insulin NNC0471-0119 H works in the body in participants with type 1 diabetes when given by an insulin pump.
This study is looking at a new type of insulin, called NNC0471-0119 H, for people with type 1 diabetes. Researchers want to understand how it works in the body when delivered using an insulin pump. It's an early-stage study to learn more about this new treatment.
Germany - ongoing, recruitingTherapeutic exploratory (Phase II)
Glucagon enhanced insulin absorption in Diabetes Mellitus type 1
This study is looking into whether a hormone called glucagon can help people with type 1 diabetes absorb their insulin better. It's an early-stage study to see how glucagon affects blood sugar and insulin levels in the body over a few hours.
Norway - recruitingNA
RT-CGM in Young Adults at Risk of DKA
This study looks at how a special device called real-time continuous glucose monitoring (RT-CGM) helps young adults, aged 18-25, manage their type 1 diabetes. We want to see if it improves blood sugar control and reduces hospital visits for high blood sugar.
United Kingdom - recruitingPHASE3
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
This study looks at a new treatment called VX-880 for people with Type 1 diabetes. We want to see if it's safe, if people can tolerate it well, and if it helps those who often have severe low blood sugar and don't realise it.
United States · Canada · France - not yet recruitingPHASE2
Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia
This study looks at a new drug, sotagliflozin, to see if it can protect kidneys in people with type 1 diabetes. Researchers want to understand how it affects kidney oxygen levels and overall kidney health over 12 weeks.
Denmark · United Kingdom - recruitingNA
Healthy Outcomes for Muscle with Exercise in T1D
This study looks at how exercise affects muscles and blood vessels in people with Type 1 Diabetes (T1D). Researchers want to understand if exercise can help prevent health problems linked to T1D and if men and women respond differently to exercise.
Canada - active not recruitingPHASE1
Safety of ENC-201-CED ENCRT
This study is looking at a new treatment called ENC-201-CED for people with Type 1 diabetes. We want to see if it's safe and if people can tolerate it well when placed under the skin. This is an early-stage study to understand how it works.
Canada - recruitingPHASE4
Anti-viral Action Against Type 1 Diabetes Autoimmunity
This study is testing if a COVID-19 vaccine can help prevent type 1 diabetes in young children who are at a higher risk. It involves giving children, aged 6 months and older, either the vaccine or a dummy shot to see if it reduces their chance of developing certain signs of diabetes.
Austria · Belgium · Germany - active not recruitingNA
Supplementation With B. Infantis for Mitigation of Type 1 Diabetes Autoimmunity
This study looks at whether giving a special good bacteria (B. infantis) to very young babies at higher risk of type 1 diabetes can help prevent their immune system from attacking their own body, which is what causes the condition.
Belgium · Germany · Poland - not yet recruiting
Mapping Diabetes in Quebec: Validating Medico-administrative Algorithms for Type 1 Diabetes, Type 2 Diabetes and LADA
This study looks at health records in Quebec, Canada, for people aged 1 to 40 with diabetes until 2024. It aims to improve how we identify different types of diabetes (Type 1, Type 2, and LADA) using existing healthcare data. This helps us better understand diabetes in the community.
Canada - active not recruitingPHASE1
A Study to See the Effect of NNC0194-0499 Alone or in Combination With Semaglutide on Blood Sugar Control in People Living With Type 1 Diabetes
This study is testing a new medicine, NNC0194-0499, for people with type 1 diabetes. Researchers want to see how it affects blood sugar when taken alone or with semaglutide, alongside your usual insulin.
Germany - not yet recruitingNA
Quantifying Artificial Pancreas-related Changes in Diabetic Neuropathy
This study looks at how new insulin delivery systems, like insulin pumps and 'artificial pancreases', might help people with type 1 diabetes who have nerve damage (neuropathy) by improving blood sugar control. It compares them to standard insulin injections.
United Kingdom - active not recruitingNA
Children's Hospital Academic Medical Organization (CHAMO) MyChart Study
This study looks at how a new online form (MyChart Questionnaire) used before appointments could improve care for children with Type 1 Diabetes. It aims to make clinic visits more helpful by letting families share information ahead of time.
Canada - recruitingNA
Closed Loop and Education for Hypoglycemia Awareness Restoration
This study looks at new ways to help people with type 1 diabetes better recognise when their blood sugar is going too low. It tests special insulin pumps and educational programmes to see which ones work best to improve awareness and reduce dangerous low blood sugar episodes.
United States · Australia · United Kingdom - active not recruiting
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
This study looks at the long-term safety of a treatment called teplizumab for young people with recent Type 1 diabetes. It follows participants from a previous study, PROTECT, for an extra 42 months to see how they're doing without giving new medication.
United States · Belgium · Canada - recruiting
Monogenic Diabetes Misdiagnosed as Type 1
This study aims to find out how many people diagnosed with Type 1 diabetes actually have a different type called monogenic diabetes. It also hopes to discover new genes that cause this condition, which could lead to better diagnoses and treatments.
Canada - recruiting
Prospective Study on Diabetes Mellitus and Its Complications in Newly Diagnosed Adult Patients
This study looks closely at adults newly diagnosed with diabetes to understand why and how the condition develops. It aims to identify different types of diabetes and track how it changes over time, comparing them to healthy individuals. This helps us learn more about managing diabetes.
Germany