- recruiting
Development of Novel MR Techniques Using Volunteer Participants
This study is developing new ways to use MRI scanners to get better and faster pictures of the body. We need healthy volunteers to help test these new scanning methods safely. It's about improving the technology, not about your health.
United Kingdom - recruiting
Who Fares Best With Mindfulness Meditation
This study looks at how mindfulness meditation affects different people. It aims to find out who benefits most and who might experience problems. Researchers want to understand why mindfulness works for some and not for others, especially those with past trauma or negative thinking.
Belgium · United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A TQT Study to Investigate the Effect of Enpatoran on Cardiac Repolarization in Healthy Participants
This study is looking at how a new medicine, called Enpatoran, affects the electrical activity of your heart. It's for healthy people aged 18 and over, and it's one of the first tests in humans to make sure the medicine is safe and doesn't cause heart problems.
Germany - recruiting
Development of a Non-invasive Screening Tool to Predict Metabolic Dysfunction-associated Steatotic Liver Disease
This study aims to develop a simple way to find liver disease commonly linked to weight and lifestyle, called MASLD (Fatty Liver Disease). We're looking at healthy volunteers and people with known MASLD to create a tool that can easily predict the condition without needing complicated tests.
United Kingdom - active not recruitingNA
Trimethylamine N-oxide Effects of a Pomegranate Supplement Simultaneously With Carnitine (TESSA)
This study looks at whether pomegranate extract can lower a substance called TMAO in healthy adults. TMAO is made when your body processes certain foods like meat and dairy, and high levels might be linked to heart disease. Researchers want to see if adding pomegranate can help reduce it.
United Kingdom - recruitingPHASE3
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
The BEATRIX study is looking at a vaccine for Group B Streptococcus (GBS) in pregnant women and their babies. It aims to understand if the vaccine is safe and how well it works to protect against GBS, a common bacteria that can sometimes cause serious infections.
United States · Argentina · Brazil - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A pivotal, randomized, open-label, two-treatment, two-sequence, four periods, crossover clinical trial to evaluate the bioequivalence of single doses of Test product Sacubitril/Valsartan, film-coated tablets 97 mg/103 mg (Manufacturer: JSC «Farmak», Ukraine) and Reference Entresto®, film-coated tablets 97 mg/103 mg (Novartis Europharm Limited, Ireland) in healthy subjects under fasted conditions
This study compares a new heart medicine from Ukraine with an existing one called Entresto. It aims to check if they work the same way in healthy people. Volunteers take both medicines, one after the other, to see how well their bodies absorb them when not eaten with food.
Poland - recruitingPHASE1
Single and Multiple Dose Pharmacokinetics (PK) of Aramchol From an Aramchol Meglumine Tablet
This study looks at a new medicine called Aramchol, in tablet form, for healthy adults. We want to see how the body absorbs and uses different doses of Aramchol and how much stays in the body over time. This helps us find the best way to give the medicine.
United Kingdom - recruitingNA
The Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function.
This study looks at how beetroot juice and a special diet affect brain function and blood vessels in healthy older adults. Some will have a calorie-restricted diet, while others will maintain their weight. It's a pilot study to see if combining these approaches is helpful.
United Kingdom - not yet recruiting
Clinical and Radiographic Outcomes of the JointMedica Custom-Made Resurfacing Device
This study looks at a special custom-made hip cap for people with hip pain. It checks how well it works and if it's safe, especially how long it lasts and if it helps people move better and feel less pain. It gathers information from everyday patient experiences.
United Kingdom - recruiting
Genetic Variants and Regulation of Specialized Pro-resolving Mediator
This study looks at how tiny changes in our genes might affect how our bodies handle inflammation. We're trying to understand why some people get long-term inflammatory diseases like arthritis and heart conditions, hoping to find new ways to treat them.
United Kingdom - recruitingPHASE1
Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs
This study looks at how digital programs can prepare healthy people for a single 25mg psilocybin session. It compares a meditation program with a music program, checking if they are practical and how they affect the experience and well-being.
United Kingdom - recruitingNA
De-stressing the Brain: Can Eating Grapes During Periods of Mental Stress Protect Brain and Vascular Health in Young Adults
This study looks at whether eating grapes before stressful tasks can protect your brain and blood vessels. Researchers want to see if special compounds in grapes called flavonoids help young adults handle stress better, improving mood and thinking abilities.
United Kingdom - enrolling by invitation
Do Daily Disposable Soft Contact Lenses Require Frequent Checks After the Initial Fitting is Complete in Adults Under 40 With No Contraindications
This study looks at whether adults under 40 who wear daily disposable contact lenses really need lots of check-up appointments after their first fitting. Researchers want to find out the best number of visits. We're interested in healthy people new to lenses or who already wear them.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A PHASE 1 STUDY TO ASSESS THE EXCRETION BALANCE, PHARMACOKINETICS, AND METABOLISM OF 14CDC806 IN HEALTHY VOLUNTEERS
This study is looking at how a new drug, DC-806, moves through the body in healthy men. It aims to understand how much of the drug gets absorbed, how it's processed, and how it leaves the body, primarily through urine and faeces.
Netherlands - recruitingPHASE1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
This study is looking at how two different forms of a new medicine, survodutide, are taken up by the body in healthy people who are overweight or have obesity. It aims to see if both forms work in a similar way.
United Kingdom - recruitingNA
Sex Hormones as Regulators of the Age- and Sex-dependent Benefits of Caloric Restriction
This study looks at how hormones, age, and sex affect weight loss from dieting. We want to understand why some people find it harder to lose weight and how diet affects women's health to help fight obesity.
United Kingdom - recruitingNA
The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease.
This study looks at how a natural supplement, 7-keto lithocholic acid (7-KLCA), might improve your gut health. We want to see if it helps good bacteria in your gut grow and if this could lead to better overall health.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to test how well different doses of BI 1815368 are tolerated by healthy men
This study is looking for healthy men aged 18 and over to test a new medicine chiamato BI 1815368. The main goal is to see how different doses are handled by the body and if they are safe. It's a very early stage of testing new medicines.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I, open-label trial in two parallel parts to investigate mass balance, metabolism, and basic pharmacokinetics of BI 1810631 (C-14) administered as oral solution (part A) and to investigate absolute bioavailability of BI 1810631 administered as film-coated tablet together with an intravenous microtracer dose of BI 1810631 (C-14) (part B) in healthy male volunteers
This study looks at how a new medicine, BI 1810631, travels through the body and how much reaches the bloodstream. It helps us understand how the body processes the medicine when taken as a liquid or a tablet.
Netherlands - recruitingNA
Investigating the Clinical Utility of the Oxford Virtual Autism Assessment Tool (OVAAT)
This study is testing a new online tool, the Oxford Virtual Autism Assessment Tool (OVAAT), to see how well it can spot signs of autism in young people aged 13-18. Researchers want to know if it's as good as or better than existing assessments.
United Kingdom - recruiting
A Study Measuring Markers of Airway Inflammation in Breath Samples From People With Respiratory Diseases and Healthy Volunteers.
This study looks for early signs of lung cancer and other lung problems by testing breath. We're trying to find a simple, quick way to help doctors decide who needs more tests, especially for people with ongoing breathing issues.
United Kingdom - recruitingNA
Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA
This study explores how gut bacteria, specifically those making GABA, might affect our brains and behavior. We're looking to see if taking a special probiotic can change GABA levels in the brain and improve how people perform on certain tasks.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I, open-label, two-arm, non-randomised trial to investigate the metabolism and pharmacokinetics of a single dose of BI 764198 (C-14) administered as oral solution using two different approaches in healthy male volunteers.
This early-stage study looks at how a new medicine, BI 764198, moves through and leaves the body. Healthy men will take a single dose, allowing researchers to track where it goes and how much leaves in their urine and faeces.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study in healthy people to test how well repeated doses of BI 3032950 are tolerated
This study is looking for healthy men aged 18 and over to test a new medicine called BI 3032950. The main goal is to see how well people tolerate repeated doses of the medicine and if it causes any unwanted side effects when given over time. It's a very early stage of testing.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Physiologically based pharmacokinetic modelling of oral and intranasal formulations of zolmitriptan in healthy volunteers
This study is looking at how a specific migraine medicine, zolmitriptan, works in the body when taken as a tablet or a nose spray. It involves healthy adult volunteers to understand how the medicine is absorbed and processed.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to investigate the pharmacokinetics of remibrutinib in CSF in healthy participants.
This study is looking at how a new drug, remibrutinib, moves into the brain and spinal fluid in healthy people. We want to understand how it works in the body, which helps us learn about potential future treatments.
Netherlands - recruitingNA
Effect of Exercise on Appetite in Response to Meals
This study looks at how short or long bursts of exercise affect men's appetite and hormones that control hunger after eating. We want to see if exercise changes how much food they want to eat later.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Randomised Double-Blinded, Placebo-Controlled, Single and Multiple Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY3876602 in Healthy Participants.
This study is an early test of a new medicine called LY3876602 in healthy adults. We want to see if it's safe, how much the body can handle, and how it moves through the body. This is the first time it will be given to people.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study in healthy people to test whether iclepertin has an effect on cardiac safety
This study is looking at a new medicine called iclepertin. It's for healthy people and checks if the medicine affects the heart. Researchers want to make sure it's safe before it's given to people with illnesses. Your participation could help us understand this new medicine better.
Germany - recruitingPHASE1
Study to Evaluate Pharmacokinetics, Relative Bioavailability, Palatability of Obefazimod Minitablet Formulation
This study is looking at a new, smaller tablet form of a medicine called Obefazimod. It checks if the new tablet works in the body like the current capsule version and if people find it easy to take, especially with different foods.
United Kingdom - recruitingNA
Low-carbohydrate Diet and Low-Density Lipoprotein - Cholesterol (LDL-c) Interindividual Variability
This study looks at how a low-carbohydrate (keto) diet affects cholesterol levels differently in healthy people. We want to find out why some people might see their 'bad' cholesterol go up, to help offer personalised diet advice.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A phase I, open-label, single dose, mass balance trial to investigate metabolism and pharmacokinetics of BI 1291583(C-14) administered as oral solution in healthy male subjects
This study is looking at a new medicine called BI 1291583. It wants to understand how the body uses and gets rid of this medicine. Healthy men will take a single dose, and scientists will follow the medicine's journey through their bodies.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A Randomized, Open-label, Single Dose, 3-Period, 6-Sequence Cross-Over Trial to Investigate the Relative Bioavailability of Apraglutide Versus the Reference Formulation Following Subcutaneous Administrations.
This study is looking at a new medicine called apraglutide. We want to see how well the body takes in this medicine when given in two different ways. It's for healthy adults and helps us understand the best way to give apraglutide.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Effect of itraconazole on the pharmacokinetics of a single oral dose of BI 1815368 in healthy male subjects (an open-label, two-period fixed-sequence design study)
This study looks at how a drug called Sempera affects another medicine, BI 1815368, in healthy men. Researchers want to see if Sempera changes how much BI 1815368 gets into the body and how quickly it reaches its highest level.
Germany - recruitingNA
A Multidisciplinary Investigation of Cardiovascular Benefits of Wild Rice
This study looks at whether eating a small amount of wild rice daily for 28 days can improve heart health in healthy adults. Researchers will check health indicators at the start and end of the study.
Canada - enrolling by invitationPHASE2
Topical Menthol For Tear Secretion
This study is looking into whether applying a menthol solution to your cheek can help your eyes make more tears naturally. It aims to see if the menthol vapour can gently encourage your eyes to feel more comfortable, especially if they sometimes feel dry.
Canada - active not recruitingPHASE1
A Study in Healthy People to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
This study is looking at a new version of a medicine called survodutide, which may help people with obesity or liver conditions. We want to see how the new version is absorbed by the body in healthy people aged 18-65 with a BMI between 27 and 39.9.
Germany - recruitingPHASE1
A Study of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus (T1DM)
This study looks at a new medicine called LY3938577 for type 1 diabetes. We want to see how it works in the body and if it helps control blood sugar, comparing it to existing insulin treatments. Safety is also a key focus.
Germany - active not recruitingNA
The Effects of Protein Supplementation With or Without Urolithin A During Single-leg Immobilization
This study looks at how protein drinks, with or without a natural ingredient called Urolithin A, can help protect muscles when someone can't use their leg, like after an injury. Researchers want to see if these drinks can stop muscle weakening during this time.
Canada - active not recruitingPHASE1
A Study in Healthy People or Otherwise Healthy With Overweight or Obesity to Compare 2 Formulations of Survodutide Given in Different Ways, Either as a Pre-filled Syringe or a Pen-like Injector
This study looks at a new medicine called survodutide for people who are healthy or have overweight/obesity. We want to see if two different versions of the medicine, given with different types of injectors, work similarly in the body. It's an early-stage study.
Germany - recruitingPHASE1
A Study in Healthy Men to Test How Well Different Doses of BI 3821001 Are Tolerated
This study is looking at a new medicine called BI 3821001 in healthy men. Scientists want to see if it's safe, how well people tolerate different doses, and how the body handles the medicine.
Germany - recruitingNA
Effect of Smoking and Time of Day on Eosinophils
This study looks at how smoking and time of day affect immune cells called eosinophils in healthy smokers. Researchers will compare blood samples from smokers and non-smokers both with and without recent smoking.
Germany - recruitingPHASE1
A Study in Healthy People to Test How Vicadrostat Affects the Heart
This study is looking at how a new medicine, Vicadrostat, affects the heart in healthy adults. Researchers will compare Vicadrostat to a dummy medicine (placebo) to see if there are any differences. Moxifloxacin, another medicine, will also be used in some people.
Germany - recruitingNA
Personalized Responses to Dietary Composition Trial 3
This study, PREDICT 3, aims to understand how different foods affect individuals. By looking at how people respond to meals in their everyday life, it helps create more personalised eating advice to improve health for conditions like diabetes and heart problems.
United States · United Kingdom - recruitingPHASE1
A Study to Test How Well Different Doses of BI 3031185 Are Tolerated by Healthy Men and Women
This study is testing a new medicine, BI 3031185, to see how safe it is and how the body handles different doses. It involves healthy men and women.
Germany - not yet recruitingNA
Pre-analytical Processing of Human Samples for Microbiota Analysis Quality
This study aims to find the best ways to collect and store poo samples for studying the tiny living things (microbes) in your gut. It compares different collection methods to make sure the science is accurate.
France - enrolling by invitationNA
Effects of Reactive Hypoglycaemia on Cognition in Earlier or Later Chronotypes
This study looks at how certain breakfasts affect memory and attention in university students. We want to see if a quick drop in blood sugar after eating (called reactive hypoglycaemia) impacts thinking skills, especially for those who naturally prefer going to bed and waking up later.
Germany - recruitingPHASE1
Phase 1 Single Ascending Doses (SAD) of M5542 in Healthy Participants
This study is testing a new medicine called M5542 in healthy volunteers. It checks how safe it is, whether people can tolerate it, and how the body handles it after a single dose. This is an early stage of testing new medications.
Germany - not yet recruitingNA
Light-Based Monitoring (SR-NIRS) for Suspected Testicular Torsion in Children
This study uses a special light to check blood flow in boys' testicles. It aims to find a quick, easy way to spot twisted testicles (testicular torsion) which need urgent treatment. It looks at healthy boys and boys with sudden pain to see if this new method works.
Canada