- ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of linagliptin/metformin
This study is checking if two different versions of a medicine for type 2 diabetes, containing linagliptin and metformin, work in the same way in healthy people. It's a first step to make sure any new version is just as good as the original.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of linagliptin/metformin.
Researchers are comparing two versions of a blood sugar lowering medicine. This study is for healthy volunteers to see if the body uses these two versions in the same way. It helps ensure new medicines work as expected.
Spain - recruiting
EarMetrics®-Oximeter - a targeted oxygenation observation study
This study tests a new ear device, the EarMetrics®-Oximeter, to measure blood oxygen levels. It aims to be more accurate for people with darker skin. Healthy adults will have their oxygen levels monitored during a temporary, controlled reduction of oxygen.
United Kingdom · England - recruitingPHASE1
A Study to Evaluate Novel KarX and KarT Prototypes Versus the KarXT and KarX-EC Reference Following Single Doses, and to Explore the Effect of Food After Multiple Doses of Selected Prototypes in Healthy Adult Participants
This study is testing new versions of a medicine called KarXT and KarX-EC in healthy adults. Researchers want to see how these new versions work after a single dose and if food changes how they act after several doses. It's about finding out how medicines are absorbed by the body.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Randomized, open-label clinical trial (Phase 1) to evaluate safety, tolerability, pharmacokinetics and food effects of a single dose of IM-250 in healthy volunteers
This early-stage study is looking for healthy volunteers to test a new medicine called IM-250. We want to see if it's safe, how well the body handles it, and if food changes how it works. This is the first time it will be given to people.
Bulgaria - authorisedHuman Pharmacology (Phase I)- Other
A study investigating the safety, absorption, and elimination of RO7795068, a new compound that may potentially be used in the treatment of obesity
This study is looking into a new medicine, RO7795068, which might help treat obesity. We want to understand how safe it is and how the body takes it in and gets rid of it. We're inviting healthy volunteers to take part.
Netherlands - completedPhase I
A 2-part study to investigate the safety, tolerability and effect of MB272 in healthy volunteers
This study, called MB272, looked at a new drug (GS-0272) in healthy volunteers. It checked if the drug was safe, how well people tolerated it, and how it acted in the body when given in different ways and doses. The goal was to gather early information about this potential new medicine.
United Kingdom · Wales - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study on Oral and Intranasal Forms in Healthy Volunteers using Pharmacokinetic Modeling
This study is looking at how two different ways of taking a medicine – by mouth and through the nose – work in healthy people. It's an early-stage study to understand how the body handles the medicine.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of linagliptin
This study is looking at two versions of a diabetes medicine called linagliptin to see if they work the same way in healthy people. It's a very early-stage study to check how the medicines are absorbed by the body.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of edoxaban 60 mg tablets versus edoxaban 60 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.
This study is checking if a new version of the edoxaban 60 mg tablet works the same way as the current one. Healthy volunteers take a single dose of each tablet on different days to see if they are medically equivalent.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Investigation of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Subcutaneous Injections of NNC0582-0001 in Healthy Adults
This study is looking at a new medicine called NNC0582-0001, given as a single injection under the skin. It aims to check if it's safe and how the body handles it in healthy adults. This is the very first time this medicine is being tested in people.
Austria - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of loperamide.
This study is testing if two different versions of a common medicine, loperamide, work the same way in the body. We need healthy volunteers to help us understand how the medicine is absorbed.
Spain - recruitingPHASE1
Multiple Dose Study for a New Medication to Potentially Treat Liver Diseases
This study looks at a new medicine for liver conditions, including fatty liver disease. It checks if the medicine, given as an injection, is safe and how the body handles it. Participants will either get the new medicine or a dummy treatment over 3 months.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
OPEN-LABEL PALATABILITY STUDY OF A NOVEL ORODISPERSIBLE PARACETAMOL/IBUPROFEN FORMULATION AFTER A SINGLE ORAL ADMINISTRATION IN HEALTHY SUBJECTS
This study is testing a new type of painkiller that mixes paracetamol and ibuprofen in one easy-to-take form. Researchers want to find out how it tastes and how pleasant it is to take for healthy adults. It's an early-stage study to gather initial feedback.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of edoxaban.
This study is looking at two versions of a medicine called edoxaban in healthy volunteers. It wants to see if both versions act the same way in the body. This helps ensure new medicines work just as well as existing ones.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to compare the pharmacokinetics of salbutamol administered via metered dose inhalers containing propellants HFA-152a (test) or HFA-134a (reference) in healthy participants aged 18 to 55 inclusive.
This study is looking at two types of asthma inhalers to see how a medicine called salbutamol is absorbed by the body. We need healthy people aged 18 to 55 to help us understand if a new version of the inhaler medicine works similarly to the current one.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of dapagliflozin.
This study is looking at two versions of a diabetes medicine called dapagliflozin in healthy people. It wants to check if they act the same way in the body. This is a very early stage of testing.
Spain - recruitingPhase I
Phase I Study (QSC303441)
This early-stage study is looking for healthy volunteers aged 18-55. It's a 'Phase 1' trial, which usually tests new medicines for safety. Full details will be shared later, after the trial finishes.
United Kingdom · England - recruitingPhase I
Deferred registration: Quotient Sciences code: QSC303996
This is an early-stage study (Phase I) for healthy men aged 25 to 55. It's too early to share all the details, but they will be made public soon. This type of study mainly checks the safety of a new treatment.
United Kingdom · England - recruitingPHASE1, PHASE2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
This study is testing a new medicine, BMS-986470, for people with sickle cell disease and healthy volunteers. Researchers want to see if it's safe, how it works in the body, and if it helps with sickle cell symptoms. It's an early-stage study.
United States · Canada · France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of bilastine.
This study is testing if two versions of a hay fever medicine called bilastine work the same way in healthy people. It's a very early stage of testing to make sure new medicines are just as good as existing ones.
Spain - recruitingPHASE1
A Study to Evaluate ALN-4285 in Adult Healthy Volunteers
This study is looking into a new medication called ALN-4285. It aims to see how safe it is and what happens to it in the body when given to healthy adults. Some participants will receive the medication, others a dummy treatment.
United Kingdom - recruitingPHASE1
A Study to Evaluate ALN-4915 in Adult Healthy Volunteers
This study is looking into a new medicine called ALN-4915. It's for healthy adults aged 18-65. The main aim is to check if the medicine is safe and how it affects the body.
United Kingdom - recruitingPhase I
Phase I trial, HS-25-802
This early-stage study is looking for healthy adults aged 18 to 55. Not much information is available about it yet, as the details will be shared later once the study finishes, as approved by the Health Research Authority.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Randomized, crossover, two-period, comparative bioavailability study of two ibuprofen (arginate) formulations, administered as solutions in single oral dose of 400 mg to healthy subjects under fasting conditions.
This study is looking at two types of liquid ibuprofen arginate. We want to see how well they get into the body and if they work the same way. It's for healthy adults who haven't eaten, and they'll get a single dose of 400 mg.
Spain - not yet recruitingPhase I
Deferred registration - Phase I trial - Quotient Sciences code: QSC303633
This early-stage study is looking for healthy volunteers aged 18-55. It's a 'Phase 1' trial, which means it's one of the first times a new treatment is tried in people. We're waiting for more details, but it's important for understanding how new medicines work safely.
United Kingdom · England - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of pregabalin 300 mg tablets versus pregabalin 300 mg hard capsules, after a single oral dose administration to healthy volunteers under fasting conditions.
This study compares two different forms of pregabalin 300mg – a tablet and a capsule – to see how similarly the body absorbs them. It's for healthy adults and helps ensure medicines work the same way. We're testing if they're interchangeable.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of rosuvastatin/ezetimibe 20 mg/ 10 mg film-coated tablets versus rosuvastatin/ezetimibe 20 mg/ 10 mg hard capsules, after a single oral dose administration to healthy volunteers under fasting conditions.
This study is comparing two versions of a combined heart medication in healthy volunteers. It checks if a new tablet form works the same way as an existing capsule form when taken once, on an empty stomach. The goal is to ensure both deliver the medication equally well.
Spain - completedPhase I
Phase I trial HMR code: 25-004
This early-stage study is looking for healthy women to help test a new treatment. We don't have all the details yet, but the aim is to see if the treatment is safe in people. More information will be shared after the study is finished.
United Kingdom · England - active not recruitingPHASE1, PHASE2
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
This study is looking at a new drug called ELE-101 for depression. It checks how safe it is and how it works in healthy people first, then in people with depression, to see if it could be a helpful new treatment.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of loperamide.
This study is looking at how two different versions of a common medicine for tummy troubles, called loperamide, work in healthy people. We want to see if these two versions are absorbed in the body in the same way, to make sure they'll have the same effect.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase 1 clinical trial to evaluate the safety, tolerability and pharmacokinetics of multiple daily doses of IM-250 in healthy volunteers.
This study is testing a new medicine called IM-250 in healthy adult volunteers for the first time. We want to see if it's safe, how well people tolerate it, and what happens to the medicine in the body after taking multiple doses. It's an early-stage study.
Bulgaria - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of dapagliflozin/metformin
This study is looking at two different versions of a common diabetes medicine, dapagliflozin/metformin. We want to see if they work the same way in healthy people. This helps make sure new medicines are just as good as existing ones.
Spain - ongoing, recruitingTherapeutic use (Phase IV)
YF_PROTECT: Prophylactic Treatment with Sofosbuvir for Yellow fever Exemption Circumstances and Travel
This study is looking at whether a medicine called Sofosbuvir could help people who can't have the Yellow Fever vaccine. It's testing if the medicine can stop the Yellow Fever virus from being detected in the body after vaccination, acting as a 'protective' treatment.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of apixabán 5 mg film coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.
This study is testing if a new version of the blood thinner apixaban works the same way as the original. Healthy adults take a single dose of both medicines to see how they behave in the body.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of dapagliflozin/metformin
This study is looking at how two different versions of a common medicine, dapagliflozin/metformin, are absorbed and used by the body. It involves healthy adults and aims to check if they work in the same way.
Spain - recruitingNA
Identifying Wearable Biomarkers to Monitor Dietary Intake
This study explores if wearable devices can accurately measure what people eat. Researchers will monitor healthy volunteers after high and low-calorie meals to see how their bodies react, hoping to create a better way to track diet than current methods.
United Kingdom - authorisedHuman Pharmacology (Phase I)- Other
Thorough QT/QTc study with GLPG3667, placebo, and active comparator in healthy subjects
This study is testing a new medicine, GLPG3667, in healthy people to see how it affects the heart's electrical activity. This is an early-stage study to check for any heart-related side effects before the medicine can be tested in people with the actual illness it’s designed to treat.
Netherlands - ongoing, recruitingTherapeutic use (Phase IV)
Effects of promethazine and altered gravity on bimanual coordination
This study looks at how a common anti-sickness medicine (promethazine) and changes in gravity might affect how well people use both hands together. We're inviting healthy adults to help us understand this better.
France - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence clinical trial of two formulations of ezetimibe/atorvastatin
This study is looking at how well two different versions of a medicine called ezetimibe/atorvastatin are absorbed by the body. This medicine is used to help lower cholesterol. We need healthy volunteers to take part and help us understand if the new version works the same as the established one.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Randomized, crossover, comparative bioavailability study of two Paracetamol-Ibuprofen 25-20 mg/ml oral suspension, administered in single dose to healthy subjects under fasting conditions.
This study is looking at two different liquid medicines that contain paracetamol and ibuprofen. We want to see how well and how quickly your body absorbs each medicine. It's for healthy adults and involves taking a single dose of each medicine on separate occasions.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase I clinical trial to evaluate the pharmacokinetics, safety and tolerability of repeated topical application of PARENTIDE in healthy volunteers
This study is testing a new cream called PARENTIDE on healthy people. We want to see how the cream is absorbed, if it's safe, and if people can tolerate it when used repeatedly. It's an early-stage study to understand the new treatment better.
Spain - ongoing, recruitingHuman Pharmacology (Phase I)- Other
RANDOMIZED, CROSSOVER, TWO-PERIOD, COMPARATIVE BIOAVAILABILITY STUDY OF TWO IBUPROFEN FORMULATIONS, AFTER A SINGLE ORAL DOSE OF 400 MG IN SOLUTION FORM TO HEALTHY SUBJECTS UNDER FASTING CONDITIONS
This study compares two different ibuprofen medicines to see how well they are absorbed by healthy people. Participants will take a single dose of ibuprofen on two separate occasions to help researchers understand which one gets into the body best.
Spain - recruitingPHASE1
A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults
This study looks at a new drug, MSP-2020, to understand how it works in the brain. We want to see how it connects with specific brain chemicals and how the body handles it. This research is for healthy men aged 23-55 and aims to help people with depression.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Drug-Drug Interaction Study With BIA 28-6156 and Clarithromycin, Midazolam, and Dabigatran Etexilate in Healthy Participants
This study is looking at how a new drug, BIA 28-6156, reacts with three common medicines: clarithromycin (an antibiotic), midazolam (a sedative), and dabigatran etexilate (a blood thinner). We want to see if they affect each other when taken together, to make sure future patients can take them safely.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, PHASE I STUDY TO ASSESS THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF SINGLE ANDMULTIPLE ASCENDING DOSES OF THN391 IN HEALTHY SUBJECTS
This early-stage study is looking for healthy volunteers to test a new medicine called THN391. We want to see if it's safe, how well the body handles it, and how it moves through the body after single and repeated doses. It's the first time this medicine will be given to people.
Netherlands - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
Jim Beam Cumulative Irritation Patch Test
This study is looking at how skin reacts to a product called Jim Beam when applied repeatedly. It's a very early-stage trial, just testing on healthy volunteers to see if it causes any irritation. They're checking skin responses to make sure it's safe for people.
Germany - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study to Evaluate the Safety and Tolerability of JNJ-77730614 When Given as Single and Multiple Doses to Healthy Participants to Assess How Long JNJ 77730614 Stays in the Body (Pharmacokinetics) and How the Body Responds to it (Pharmacodynamics)
This study is looking at a new medicine called JNJ-77730614. We want to find out if it's safe for healthy people and how their bodies react to it. It's an early-stage study to learn more about the medicine. We'll check how long it stays in the body.
Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A study to investigate JNJ-80202135 (nipocalimab) delivered subcutaneously via prefilled syringe autoinjector and via normal syringe
This study is testing a new way to give a medicine called nipocalimab. It's looking at two different ways to inject it under the skin to see if they are safe and work well in healthy adults.
Belgium - not yet recruitingPHASE1
A Study to Compare How CHF10196 (Florensocatib) is Absorbed Into the Blood When Given Alone and With a Drug That Reduces Stomach Acid in Healthy Male Participants
This study is looking at how a new medicine, called Florensocatib (CHF10196), is taken up by the body. We want to see if taking it with a common stomach acid-reducing drug changes how much gets into the blood of healthy men. This helps us understand how medicines work together.
United Kingdom