HPV Positive Oropharyngeal Squamous Cell Carcinoma research hub
7 indexed studies · 5 currently recruiting
- recruitingPHASE1, PHASE2
Safety and Efficacy of VB10.16 and Pembrolizumab in Patients with Head-Neck Squamous Cell Carcinoma
This study is for people with a certain type of advanced head and neck cancer linked to HPV. It's testing a new 'vaccine-like' treatment called VB10.16 combined with an existing medicine, pembrolizumab, to see if it's safe and effective.
Czechia · France · Germany - recruitingPHASE1, PHASE2
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
This study is looking at a new drug called MCLA-158 for advanced cancers like bowel and head and neck cancer. It aims to find the safest dose and see how well it works alone or with other treatments. It's for patients whose cancer has spread or come back.
United States · Belgium · France - recruitingPHASE1
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
This study is testing a new drug, OKN4395, alone and with an existing cancer treatment, pembrolizumab, for various solid tumours. The main goals are to check its safety, how well it's tolerated, and if it helps fight cancer.
United States · Australia · United Kingdom - active not recruitingPHASE2
Trial Evaluating the Tolerance and Safety of Durvalumab - RT Combination for Treatment in SCCHN
This study looks at a new way to treat certain head, neck, and throat cancers. It combines a drug called durvalumab with a different type of radiation therapy. The aim is to see if this new approach controls cancer just as well as standard treatment, with fewer side effects.
France - active not recruitingPHASE3
Chemo-radiotherapy Versus Radiotherapy in the Treatment of Salivary Glands and Nasal Tumors (IMRT or Protontherapy)
This study compares chemotherapy combined with radiotherapy against radiotherapy alone for certain head and neck cancers, like those in the salivary glands or nose. It aims to see if adding chemotherapy improves treatment results for these rare cancers.
France - recruiting
Clinical Benefit and Biomarker Analysis of Combination of PD-1/PD-L1 Immune Checkpoint Inhibitors and Radiotherapy
This study looks at combining special cancer drugs (PD-1/PD-L1 inhibitors) with radiation. It aims to see how well this works for various cancers and if we can find new ways to predict who will benefit most from this treatment.
Germany - recruitingPHASE1, PHASE2
First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
This study is testing a new drug called TUB-030 for adults with advanced solid cancers. Researchers want to see if it's safe, how well it works, and find the right dose. It's a first step to understand if TUB-030 could be a future treatment.
United States · Canada · Romania