Major Depressive Disorder research hub
23 indexed studies · 20 currently recruiting
- recruitingPHASE2
Trial of Mirtazapine for Depression in IBD
This study is testing if it's practical to run a larger trial for people with both depression and a bowel condition. We'll see if a depression tablet called mirtazapine helps, compared to a dummy pill. It's a first step to understand if this treatment could be useful.
United Kingdom - recruiting
Mitochondrial DAMPs as Mechanistic Biomarkers of Mucosal Inflammation in Crohn's Disease and Ulcerative Colitis
The MUSIC study looks for better ways to check gut inflammation in Crohn's disease and ulcerative colitis. We're testing new markers in blood, poo, and gut samples to see if they can show how well your gut lining is healing, without always needing an endoscopy.
United Kingdom - recruiting
Nutrition and Clinical Outcomes in IBD
This study looks at how nutrition and body health affect people with Crohn's disease and ulcerative colitis. We want to find better ways to check for poor nutrition and understand how it impacts treatment, surgery, and overall well-being in IBD patients.
United Kingdom - recruiting
NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study
This study compares body markers linked to inflammation in people with Crohn's disease or ulcerative colitis (IBD) and healthy individuals. It aims to understand IBD better and find ways to predict treatment responses, ultimately leading to improved care.
United Kingdom - recruiting
PIBD-SETQuality: the Inception Cohort and Safety Registry
This study looks at how well current treatments work and their safety for children and teenagers with Inflammatory Bowel Disease (IBD). It wants to understand how individual factors might affect treatment outcomes and serious complications.
Netherlands · United Kingdom - recruitingNA
Colectomy Reconstruction for Ulcerative Colitis, Ileorectal Anastomosis vs Ileal Pouch-Anal Anastomosis in Ulcerative Colitis.
This study compares two common surgeries to reconnect your gut after removing most of your large bowel for Ulcerative Colitis. It aims to see which one, an ileal pouch or an ileorectal anastomosis, offers the best quality of life, satisfaction, and fewer complications for patients in the UK.
Sweden · United Kingdom - recruitingPHASE3
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
This study looks at a medicine called Mirikizumab for children and teenagers aged 2 to 19 with Ulcerative Colitis or Crohn's Disease. It checks how well the medicine works over a long time to help manage these conditions.
United States · Austria · Belgium - active not recruitingNA
Implementing a Multimodal RCT Intervention to Improve the Transition of Patients With Crohn's Disease From Pediatric to Adult Care
This study looks at a new support program for young people with Crohn's or ulcerative colitis who are moving from children's to adult healthcare. It aims to make this move smoother and improve their health and well-being.
Canada - recruitingPHASE2
FAecal Microbiota Transplantation in primaRy sclerosinG chOlangitis
The FARGO trial is investigating if a 'healthy gut bacteria transplant' (Faecal Microbiota Transplant, or FMT) can help people in the UK with the liver condition Primary Sclerosing Cholangitis (PSC) who also have Inflammatory Bowel Disease (IBD). Half of the participants will receive FMT, and the other half a dummy treatment, to see if it improves their condition.
United Kingdom - recruitingNA
AIRE-2 Device for Study of Breath Analysis in IBD
This study looks at how diet, gut bugs, and symptoms affect people with Inflammatory Bowel Diseases (IBD) and their household members. It uses a device called AIRE-2 and a phone app to track breath, symptoms, and food. The aim is to understand these links better.
Canada - recruiting
Pathogenic Study of Adult Immune Enteropathies
This study looks into why certain gut conditions, like coeliac disease and inflammatory bowel diseases, happen. Researchers want to understand how the immune system in the gut goes wrong and how it might lead to other problems, including those affecting the liver.
France - recruiting
ACTIVE-IBD Study: Physical Activity and Sleep in Paediatric Inflammatory Bowel Disease
This study looks at how active children and teenagers with Inflammatory Bowel Disease (IBD) are. We're using questionnaires and special wrist trackers to understand their activity levels and how they might link to their health.
United Kingdom - recruiting
Robotic Inflammatory Bowel Disease Development, Learning and Efficacy Study
This study looks at using robotic surgery for inflammatory bowel disease (IBD) like Crohn's disease and ulcerative colitis. Researchers want to see if robots can help surgeons operate more effectively and how this new method compares to traditional keyhole surgery for IBD.
United Kingdom - not yet recruiting
IBDminds - Mapping the Influence of aNxiety and DepreSsion on IBD
This study, IBDminds, explores how anxiety and depression affect treatment success for Inflammatory Bowel Disease (IBD). We're asking people with IBD taking advanced treatments to complete questionnaires to see if their mental health impacts how well their medication works over time.
United Kingdom - recruiting
Longitudinal Study on Bacterial Production of LPC and LPA in Patients With Inflammatory Bowel Disease
This study looks at whether gut bacteria in people with Crohn's and ulcerative colitis cause ongoing tummy pain, even when their condition is calm. They want to find out if certain fats produced by these bacteria, called LPC and LPA, are the culprits.
Canada - active not recruitingNA
OptiMized REsistaNt Starch in Inflammatory Bowel Disease: The MEND Trial
This study, called MEND, aims to see if a special plant-based fibre, called resistant starch, can help children and teenagers with Inflammatory Bowel Disease (IBD). We want to find out if it can make their gut healthier and tackle the root cause of their condition.
Canada - recruiting
Predicting IBD Treatment Outcomes With Gut Microbiome Analysis
This study looks at gut bugs (microbiome) in people with Crohn's disease to see if they can predict how well treatments will work. They will collect samples during colonoscopies and follow people for a year.
Canada - not yet recruiting
Spondylo-arthritis Screening Tool Among Patient Suffering From Inflammatory Bowel Disease
This study is translating two questionnaires from English to French. These questionnaires help doctors identify if people with inflammatory bowel disease might also have a type of arthritis called spondyloarthritis, so they can get the right care.
France - recruiting
Mechanism of Chronic Pain in Patients With IBD
This study looks into why some people with Inflammatory Bowel Disease (IBD) still get tummy pain even when their IBD is settled. Researchers want to find out what factors, including body and mind, might contribute to this ongoing pain.
United Kingdom - recruitingPHASE3
Transfer of FRozen Encapsulated Multidonor Stool Filtrate for Active Ulcerative COlitis
This study is looking at new treatments for Ulcerative Colitis. We're testing if special capsules made from healthy donor stool can help people with active Ulcerative Colitis feel better. It involves comparing these capsules to a dummy pill to see if they are safe and effective.
Germany - recruitingPHASE2
A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease
This study is testing a new medicine called MORF-057 for adults with moderate to severe Crohn's disease. It compares different doses of the medicine to a dummy pill to see if it's safe and helps improve symptoms.
United States · Australia · Austria - recruitingPHASE2
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
This study is testing new long-acting medicines for adults with moderate to severe ulcerative colitis. It aims to see how well they work and if they are safe, both on their own and in combinations, compared to a dummy treatment.
United States · Argentina · Australia - active not recruiting
West Hertfordshire Inflammatory Bowel Disease Technology Study
This study looks at how we diagnose and monitor Inflammatory Bowel Disease (IBD). We're exploring new ways to measure IBD using information from existing tests. The goal is to improve how we track these conditions and help doctors make more accurate decisions for patients.
United Kingdom