- ongoing, recruitingTherapeutic exploratory (Phase II)
Evaluation of the efficacy of intra venous dornase alfa (Pulmozyme®) on arterial recanalization in post-thrombectomy angiography in patients managed for ischemic stroke with thrombolysis and eligible for thrombectomy: a single-center phase II trial.
This study looks at whether a drug called Pulmozyme, given through a vein, can help clear blood clots in the brain after a stroke. It's for patients who have had a stroke and are having an operation to remove the clot, to see if Pulmozyme helps blood flow return to normal more quickly.
France - active not recruitingNA
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial
This study looks at whether closing off a small part of the heart called the left atrial appendage (LAA) during heart surgery can help prevent strokes in people at risk. They're comparing it to standard care in those having heart operations.
United States · Australia · Austria - recruitingPHASE2, PHASE3
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
This study is testing a new medicine, DM199, for people who have had a type of stroke called an ischaemic stroke. It aims to see if the medicine is safe and helps people recover better, especially those with fewer treatment options.
United States · Belgium · Canada - recruiting
Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants
This study looks at people who have a stroke while taking blood thinners for an irregular heartbeat. It aims to understand why this happens and what treatments work best afterwards to prevent another stroke. Researchers will collect information from medical records and follow some patients over time.
Croatia · Denmark · Egypt - recruitingNA
Early Closure of Left Atrial Appendage for Patients With Atrial Fibrillation and Ischemic Stroke Despite Anticoagulation Therapy
This study looks at whether a procedure to close off a part of the heart called the left atrial appendage (LAA) in addition to blood thinners can better prevent strokes in people with atrial fibrillation who have already had a stroke despite being on blood thinners.
Belgium · Germany · New Zealand - recruiting
Augmented Renal Clearance in Neurocritical Care
This study looks at how certain serious brain conditions might cause kidneys to work extra fast, which can make medicines less effective. Researchers want to understand this better to help doctors give the right amount of medicine, improving care for patients.
United States · Canada - active not recruiting
Symptomatic Carotid Outcomes Registry
This study looks at how well modern medicines prevent strokes in people with narrowed neck arteries. It wants to see if current treatments can keep the stroke rate below 5% for these patients over one year, building on older research.
United States · Canada - authorisedTherapeutic exploratory (Phase II)
StroKE34 Study Protocol: a randomized Controlled Phase IIa trial of intra-arterial Cd34+ Cells in acute ischemic Stroke
This study looks at a new treatment involving special cells (Cd34+ cells) for people who have recently had a stroke. It aims to see if this treatment can limit the damage to the brain. Researchers will measure the affected brain area three months later.
Portugal - active not recruiting
Observational Study on Determinants of Dementia After Stroke
This study looks at why some people develop memory problems (dementia) after a stroke. Researchers aim to find early signs in the brain and blood that could predict who might be affected, hoping to help develop ways to prevent it.
Germany - recruitingNA
Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke
This study looks at stopping blood-thinning medicine a year after a heart procedure called PFO closure. It's for younger people who had a stroke with no clear cause. We want to see if stopping this medicine is safe and if it lowers the risk of bleeding while still preventing new strokes.
Canada - recruitingNA
Transmission Electron Microscopy Images for Platelet Ultrastructural Criteria Before and After the Onset of an Antiplatelet Agent
This study looks at tiny pictures of blood cells called platelets from stroke patients. Doctors want to see how these cells change before and after starting blood-thinning medicine. This could help them understand how well the medicine works and prevent future strokes.
France - recruitingPHASE3
Combination of Hypothermia and Thrombectomy in Acute Stroke
This study looks at whether cooling the body to 35°C (mild hypothermia) along with standard treatment (like clot removal) can help people who’ve had a severe stroke. Researchers want to see if this cooling leads to a better recovery without serious side effects.
Germany - active not recruitingNA
Distal Ischemic Stroke Treatment With Adjustable Low-profile Stentriever
This study is looking at a new device called the Tigertriever 13 to treat a type of stroke called ischemic stroke. It aims to see if this device is safe and effective at unblocking blood vessels in the brain, compared to standard medical care, for people who have had a stroke recently.
United States · Belgium · Germany - recruiting
Thrombo-inflammation Biomarkers Trial in Acute Cerebral Hypoxia
Researchers are studying whether certain blood markers can help us understand brain damage caused by a lack of oxygen. This study compares these markers in people with serious brain conditions to those with milder, temporary problems, to see how they link to recovery.
France - recruitingNA
Inflammatory faCtors AfteR acUte Ischemic Stroke
This study, called ICARUS, is looking at how the brain reacts after a stroke. It uses special scans and blood tests to understand the body's healing process and how it affects recovery. The goal is to learn more about stroke and how to help people recover better.
Germany - active not recruiting
Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome
This study, SECRETO, looks into why younger adults have strokes when the cause isn't clear. It aims to find out what triggers these strokes, how people recover, and if genetics play a role, to help improve care for patients.
Estonia · Finland · Germany - recruiting
Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants
This study looks at how safe and effective clot-busting medicine (like Alteplase or Tenecteplase) is for people having a stroke who recently took certain blood thinners (DOACs). We want to see if it helps their recovery.
Austria · Belgium · Canada - recruitingNA
Measuring Absolute Brain Flow and Brain Microcirculation Resistance by Continuous Thermodilution
This study looks at a new way to measure blood flow in the brain after a stroke to understand why some patients don't fully recover. It uses a small wire to check how well tiny blood vessels in the brain are working after a clot is removed.
France - recruitingPHASE4
Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Direct Oral Anticoagulants Intake
This study looks at a treatment called 'thrombolysis' for stroke patients who have recently taken certain blood thinners. We want to see if this treatment is safe and helps people recover better after a stroke, compared to standard care.
Belgium · Canada · France - recruitingNA
A Pivotal Study Evaluating Safety and Effectiveness of Adaptative Tip Catheter in Patients With Acute Ischemic Stroke
This study is testing a new device called an 'Adaptive Tip Catheter' for people who have had a stroke caused by a blood clot. It aims to see if this device is safe and effective in removing the clot and helping patients recover.
Belgium · France · Germany - recruiting
Cerebral Embolization During Pulmonary Vein Isolation
This study looks at how tiny blockages might form in the brain during a common heart procedure for atrial fibrillation. Researchers will use ultrasound to monitor brain activity and compare different ways of doing the procedure to see which is safest.
Germany - not yet recruitingNA
Stroke Cerebral Reorganization Pathways (SPECTRE)
The SPECTRE study looks at how the brain recovers after a stroke, especially for arm and hand movement. Researchers use special brain scans (fMRI) and arm tests to understand why some people recover better than others, hoping to improve future stroke care.
France - enrolling by invitationPHASE2
Testing of a System for Remote Ischemic Conditioning in Cerebral Small Vessel Disease and Pre-hospital Stroke Care
This study is testing a new device that uses a special arm cuff, like a blood pressure cuff, to help protect the brain after a stroke or in certain brain conditions. It's a small, early study to check if the device is safe, easy to use, and how well it works.
Canada