- ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase I First Time in Human Open Label Study of GSK3745417 Administered With and Without Anticancer Agents in Participants With Advanced Solid Tumors
This early-stage study is testing a new medicine, GSK3745417, for the first time in people with advanced cancers. Researchers want to see if it's safe and what doses are best, sometimes combined with other cancer drugs. Anyone aged 18 or over, male or female, with advanced cancer may be considered.
Spain · France - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2 First-Time-in-Human, open-label, multicenter, dose escalation and expansion study of the oral DNA Polymerase Theta Inhibitor (POLQi) GSK4524101 and the PARP inhibitor (PARPi) niraparib in adult participants with solid tumors.
This study looks at a new drug, GSK4524101, combined with an existing cancer drug, niraparib (Zejula), for adults with solid tumours. It aims to find a safe dose and see how well the combination shrinks tumours and manages cancer.
Estonia · Czechia · Spain - recruitingPHASE1
A Study to Evaluate the Safety,Tolerability, Pharmacokinetics and Clinical Activity of Mocertatug Rezetecan for Injection in Participants With Advanced Solid Tumors (BEHOLD-1)
This study is looking at a new medicine called GSK5733584 for people with advanced solid tumours. It aims to see if the treatment is safe, how well the body handles it, and how much of the medicine is in the body over time at different doses.
United States · Argentina · Australia - recruitingPHASE1
A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD)
This study is testing a new drug, Ris-Rez, for people with advanced cancers. Researchers want to see if it's safe, how it works, and if it can help stop cancer growth, both alone and with other medicines.
United States · Argentina · Canada - active not recruitingPHASE1
First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors
This study looks at a new treatment called remzistotug for advanced cancers that haven't responded to usual treatments. It's the first time it will be tested in people to check if it's safe and how it works in the body.
United States · Australia · Canada - active not recruiting
Anticoagulation in Patients With Venous Thromboembolism and Cancer
This study looks back at patient records to understand how different blood-thinning medicines work for people with cancer who have also had blood clots. It compares medicines like Apixaban, Rivaroxaban, and Dabigatran to see which are most effective and safe.
United Kingdom - enrolling by invitation
A Study to Follow Paediatric Participants With Growth Hormone Deficiency Treated With Somapacitan for Long Term Safety Information and Clinical Parameters
This study looks at the long-term safety and effects of a medicine called somapacitan in children with growth hormone deficiency. It involves children already taking this medicine and follows them over a long period to see how they get on.
United Kingdom - recruitingNA
Imperial Prostate 7 - Prostate Assessment Using Comparative Interventions - Fast Mri and Image-fusion for Cancer
This study looks at new ways to find prostate cancer using MRI scans and biopsies. Researchers want to see if a shorter, simpler MRI is as good as the usual one, and if guiding biopsies with a computer is better than relying on a doctor’s eye.
United Kingdom - recruitingPHASE1
A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms
This study is testing a new medicine, JNJ-88549968, for people with specific types of blood cancers called myeloproliferative neoplasms (MPNs) that have a CALR gene mutation. It aims to find the safest dose and see how well it works, sometimes given with other existing treatments.
United States · Canada · China - enrolling by invitationPHASE1
A Rollover Study for Continued Study Treatment and Ongoing Safety Monitoring
This study helps us understand the long-term safety of new treatments for certain cancers like leukemia and lymphoma. People who have already been in an earlier drug trial for these conditions will continue to be monitored to see how they respond over time.
Australia · Belgium · France - active not recruitingPHASE2
Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Untreated Advanced (Metastatic or Unresectable) Synovial Sarcoma and Myxoid/Round Cell Liposarcoma
This study is looking at a new T-cell therapy called Lete-Cel for people with advanced synovial sarcoma or myxoid/round cell liposarcoma. It aims to see how safe and effective this treatment is in fighting these cancers.
United States · Canada · France - active not recruitingPHASE2
Extended Access of Momelotinib in Adults With Myelofibrosis
This study offers ongoing access to a medication called momelotinib for adults with myelofibrosis. It checks how safe the medicine is long-term and tracks its effects on survival for those already taking part in specific earlier studies and benefiting from the treatment.
United States · Australia · Austria - recruiting
IMMUNO-FIT Observational Study
This study looks at how immunotherapy for cancer affects your fitness, quality of life, and side effects. We want to see if being fitter helps you cope better and understand how your fitness changes during treatment. It's an observation study, so your cancer treatment won't change.
United Kingdom - active not recruitingPHASE2
Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Solid Tumors
This study looks at a new treatment called lete-cel for certain advanced cancers like synovial sarcoma and myxoid/round cell liposarcoma. It uses specially modified immune cells to fight cancer, testing how safe and effective it is for people with specific cancer markers.
United States · Canada · France - recruiting
OSPREY is a Post-market, Global, Multicentre, Observational, Prospective Registry.
The OSPREY Registry is looking at how a device called OncoSil™ works in people with locally advanced pancreatic cancer in normal hospital care. It watches how well the device performs and if there are any side effects when used with standard chemotherapy.
Spain · United Kingdom - recruitingPHASE1
Adoptive Cell Therapy Long-term Follow-up (LTFU) Study
This study is checking on the long-term safety of people who've had ADP adoptive cell therapy. It will follow them for up to 15 years to see how they are doing and make sure the treatment continues to be safe.
United States · Australia · Canada - recruitingPHASE2
A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
This study is a research programme looking at new ways to treat cancer in children and young adults aged 1 to 39. It tests different medicines to find out how well they work and if they are safe.
United States · Australia · Belgium - recruiting
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The MOMENTUM Study is tracking how a new type of advanced radiotherapy, called MR-Linac, works for people with different cancers. It aims to see if this treatment improves survival, controls cancer better, and enhances quality of life by using highly precise radiation guidance.
United States · Australia · Belgium - active not recruitingPHASE3
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
This study looks at new drug combinations for advanced bowel cancer that has spread and has a specific gene change (BRAF). It compares these new combinations with standard chemotherapy to see which works best for people who haven't had treatment for their spread cancer.
United States · Argentina · Australia - active not recruitingPHASE1
Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors
This study is testing a new drug called dostarlimab for people with advanced cancers that haven't responded to other treatments. It aims to find the safest and most effective dose, and see how well it works against different types of advanced solid tumours.
United States · Brazil · Canada - recruitingPHASE2, PHASE3
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
This study keeps an eye on people who have had a special treatment called gene-modified T-cell therapy for cancer. It aims to check their health and how well the treatment worked over a long time, making sure it's safe and effective.
United States · Australia · Austria - active not recruitingPHASE1, PHASE2
Investigation of a Therapeutic Vaccine (ACIT-1) in Cancer
This study is testing a new treatment called ACIT-1, which is a therapeutic vaccine for cancer. Researchers are looking at different doses to see if it's safe and helps the body's immune system fight cancer, including pancreatic cancer and other types.
United Kingdom - recruitingNA
Beyond TME Origins
This study looks at a new way to classify advanced bowel cancer that has come back in the pelvis. We’re using special scans to help doctors plan the best treatment and understand why cancer might return, ultimately aiming to improve care.
Norway · United Kingdom - active not recruitingPHASE1
A First Time in Human (FTIH) Study of GSK3745417 Administered to Participants With Advanced Solid Tumors
This study is testing a new medicine, GSK3745417, alone or with another drug, dostarlimab, for people with advanced cancers. The aim is to see if it's safe, how well it's tolerated, find the right dose, and check its early effects against cancer.
United States · Australia · Canada - active not recruitingNA
Alberta Cancer Exercise Hybrid Effectiveness-Implementation Study
This study looks at how a cancer and exercise programme called ACE can help people with cancer in Alberta, Canada. It aims to improve their well-being and health by offering exercise programmes in local centres and homes.
Canada - not yet recruitingNA
Finding My Way-UK: Promoting Positive Psychological Outcomes in People Living With and Beyond Curatively Treated Cancer
This study looks at an online program, "Finding My Way-UK", for people who have finished cancer treatment. It checks if the program is easy to use and helpful for improving feelings like hope and resilience after cancer.
United Kingdom - recruitingPHASE1, PHASE2
HTL0039732 in Participants With Advanced Solid Tumours
This study is testing a new drug, HTL0039732, alone and with another cancer medicine, atezolizumab. It's for people with advanced solid tumours, aiming to see if blocking certain signals can help the immune system fight cancer. The goal is to find the right dose and see how well it works.
United Kingdom - recruitingPHASE1, PHASE2
Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer
This study looks at new drug combinations (Elacestrant and Abemaciclib) for people with breast cancer that has spread to the brain. It aims to find the right dose and see how well the new combination works for ER-positive, HER-2 negative breast cancer.
United States · Belgium · France - recruitingNA
Evaluation of an Interactive E-learning Environment to Enhance Digital Health Literacy in Cancer Patients
This study tests an online tool to help people with cancer find reliable health information. Some will use the tool, others a PDF, or receive no help, to see if the tool improves their ability to understand online health details.
Germany - active not recruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723283, an Anti-PD-1 Monoclonal Antibody, in Participants With Advanced Cancers
This study is looking at a new drug called JNJ-63723283 for people with advanced cancers. It aims to find the right dose and see how well it works. This drug is designed to help the body's immune system fight cancer.
United States · Moldova · Poland - active not recruitingPHASE2
Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Treated Advanced (Metastatic or Unresectable) Synovial Sarcoma or Myxoid/Round Cell Liposarcoma
This study looks at a new cell therapy called Lete-Cel for certain advanced cancers like synovial sarcoma and myxoid/round cell liposarcoma. It aims to see how safe and effective this treatment is for people whose cancer hasn't responded to previous treatments.
United States · Canada · France - authorisedHuman Pharmacology (Phase I)- First administration to humans
First time in human (FTIH) study to investigate the safety and preliminary activity of GSK5533524 alone or in combination in adult participants with advanced solid tumors
This study is a first step to see if a new medicine, called GSK5533524, is safe for adults with advanced cancers. Researchers will also check if it shows any signs of helping people, either on its own or with other treatments.
Spain · Denmark · Finland - recruiting
Anatomical-Clinical Base of Adenocarcinoma Pancreatic
This study is building a collection of samples and information from people with pancreatic cancer. It aims to help scientists better understand the disease, find new ways to spot it early, and develop more effective treatments. It's about gathering resources for future vital research.
France - recruitingPHASE1
A Phase I Trial to Establish the Safety and Maximum Tolerated Dose of High-affinity Autologous BCMA-targeting Chimeric Antigen Receptor (CAR) T-cells in Patients With Relapsed and Refractory B-cell Malignancies
This early-stage study is testing a new cell therapy called MDC-CAR-BCMA001. It aims to find the safest dose for people with certain types of blood cancers, like some lymphomas and multiple myeloma, that have come back or not responded to other treatments.
Germany - active not recruitingPHASE3
A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer
This study looks at new ways to treat advanced or returning womb cancer. It compares a drug called dostarlimab, with or without another drug called niraparib, alongside standard chemotherapy, against chemotherapy plus a dummy drug, to see if these new treatments work better and are safe.
United States · Belarus · Belgium - recruitingNA
Prehab for Lung and Esophageal Cancer
This study looks at a special 8-week health coaching programme for people having surgery for lung or gullet (oesophageal) cancer. It helps them get ready for surgery by improving their fitness, nutrition, and well-being, hoping for better recovery and quality of life.
Canada - active not recruitingPHASE1
A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer
This study looks at new ways to treat advanced cancer. It tests a new drug, BI 765179, alone or with established treatments like ezabenlimab and pembrolizumab. We want to find out how safe these treatments are and if they can help people with different types of advanced cancer.
United States · Australia · Belgium - recruitingPHASE2
A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer
This study looks at a new medicine, LY3537021, to see how well it stops sickness and vomiting caused by chemotherapy. It also checks if the medicine is safe for adults with cancer undergoing treatment.
United States · Australia · China - active not recruitingPHASE1
A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies
This study is looking at a new way to give an existing cancer medicine, amivantamab, as an injection under the skin. It aims to find the safest and most effective dose for this new delivery method, for people with advanced solid cancers.
United States · Canada · South Korea - active not recruitingPHASE1
Study of the Safety and Effectiveness of GSK6097608 in Participants With Advanced Solid Tumors
This study is testing new medicines for advanced cancers that have grown. It particularly looks at how safe these new drugs are and how well they work, both alone and with existing treatments. The research also wants to understand how the body uses these new drugs.
United States · Canada · Japan - recruitingNA
Program to Establish the Genetic and Immunologic Profile of Patient's Tumor for All Types of Advanced Cancer
This study looks at the genetic and immune makeup of advanced cancers to help doctors choose more personalised treatments. Researchers collect blood and tumour samples to understand how different cancers behave and guide therapy for patients.
France - recruitingPHASE1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)
This study is looking at a new drug, RO7673396, for advanced cancers with a specific gene change (RAS mutation). We want to check if it's safe and how the body handles it. We'll also see if it helps shrink tumors.
United States · Australia · Canada - active not recruitingPHASE1, PHASE2
A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor
This study is testing a new drug, E7386, alongside other cancer medicines. It aims to find the safest and most effective dose for people with various solid tumours, especially endometrial cancer, and to understand how these combinations work.
United States · Canada · China - not yet recruitingPHASE1, PHASE2
A Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of LRK-4189 Alone and in Combination in Patients With Solid Tumors
This study is testing a new medicine called LRK-4189 for adults with solid cancers that have spread. It aims to see if LRK-4189 is safe and helps shrink tumours, especially bowel cancer, either alone or with normal chemotherapy. Participants will take the drug and have regular check-ups.
France · United Kingdom