Non-small-cell lung cancer research hub
50 indexed studies · 17 currently recruiting
- ongoing, recruitingTherapeutic confirmatory (Phase III)
A study to compare efficacy, safety, and immune response of GME751 and EU-authorized Keytruda in adult participants with untreated metastatic lung cancer
This study is looking at a new medicine called GME751 for advanced lung cancer that hasn't been treated before. It's comparing GME751 with a common cancer drug, Keytruda, to see which works best and if it's safe. It's for adults with non-small cell lung cancer.
Spain · Romania · Germany - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
An open-label, multi-centre, phase I/IIa study evaluating the safety and clinical activity of neoantigen reactive T cells in patients with advanced non-small cell lung cancer
This study is looking at a new treatment for advanced lung cancer. It combines a special cell therapy (ATL001) with existing treatments like KEYTRUDA. The main goal is to check how safe these treatments are and if they help shrink tumours. It's for adults with non-small cell lung cancer.
Spain · Germany · France - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase 1b Study of Dato-DXd in Combination with Pembrolizumab with or without Platinum Chemotherapy in Advanced or Metastatic Non-Small Cell Lung Cancer
This study is looking at a new combination of medicines for people with advanced lung cancer. It combines an experimental drug, Dato-DXd, with pembrolizumab, a common cancer medicine, sometimes also with chemotherapy. It's an early-stage study to see if it's safe and how it works.
Spain · Italy - active not recruiting
A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice
This study looks at how a cancer drug called atezolizumab works in real patients. Researchers want to see its effects and safety under normal hospital care, for different types of cancer it's approved for.
Argentina · Austria · Belgium - recruitingPHASE1
A Study of MGC026 in Participants With Advanced Solid Tumors
This study is testing a new medicine called MGC026 for people with advanced cancers that have come back or spread. Doctors want to see if it's safe, what side effects it causes, and if it can help slow down or shrink tumors.
United States · Australia · United Kingdom - recruitingPHASE3
ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
This study looks at a new drug, gotistobart, for advanced non-small cell lung cancer that has worsened after previous PD-1/PD-L1 treatment. It compares gotistobart to standard chemotherapy (docetaxel) to see if it can help people live longer.
United States · Australia · Belgium - ongoing, recruitingTherapeutic exploratory (Phase II)
Precision Immuno-Oncology for advanced Non-small cell lung cancer patients with PD-1 ICI Resistance (PIONeeR clinical study)
This study is for adults with a type of advanced lung cancer (non-small cell lung cancer) that has stopped responding to previous immune-boosting treatments. It's testing new combinations of medicines to see if they can help control the cancer, looking at how many people's cancer stops growing or shrinks after 12 weeks.
France - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Global, Randomized, Phase 3, Open-Label Study of REGN2810 (Anti-PD-1 Antibody) versus Platinum-Based Chemotherapy in First-Line Treatment of Patients with Advanced or Metastatic PD-L1 + Non-Small Cell Lung Cancer
This study looks at a new drug (REGN2810) compared to standard chemotherapy for advanced non-small cell lung cancer. It aims to see if the new drug helps people live longer and stops cancer from growing, especially for those whose cancer has a specific protein called PD-L1.
Czechia · Poland · Greece - ongoing, recruitingTherapeutic confirmatory (Phase III)
A Two-Part Randomized, Phase 3 Study of Combinations of Cemiplimab (Anti- PD-1 Antibody) and Platinum-based Doublet Chemotherapy in First-line Treatment of Patients with Advanced or Metastatic Non-Small Cell Lung Cancer
This study is testing new combinations of anti-cancer medicines for people with advanced non-small cell lung cancer. It aims to see if these new approaches can help people live longer and improve their quality of life, compared to standard treatments.
France · Poland · Ireland - active not recruitingPHASE1, PHASE2
Dose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumors
This study is testing a new discovery drug called RO7247669 for advanced cancers. It aims to find the safest and most effective dose, and see if it can shrink certain tumours like melanoma, lung, and oesophageal cancer. The drug works by boosting the body's own immune system to fight cancer.
Denmark · Georgia · Israel - authorisedHuman Pharmacology (Phase I)- Other
Phase I clinical trial of TG4050 combined with nivolumab in patients with Non-Small Cell Lung Cancer.
This study is testing a new combination of treatments, TG4050 and nivolumab, for people with a type of lung cancer called Non-Small Cell Lung Cancer. It's an early-stage study to see if the new combination is safe and how it works in the body.
France - recruitingPHASE2, PHASE3
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
This study is for people with a type of lung cancer that has a specific gene change (EGFR mutation) and has not responded to previous treatment. It compares a new medicine called Iza-bren with standard chemotherapy (carboplatin or cisplatin plus pemetrexed) to see which works better.
United States · Argentina · Belgium - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
An open-label, dose-escalation, phase I/II study to assess the safety, the tolerability, the immunogenicity and the preliminary clinical activity of the therapeutic cancer vaccine, PDC*lung01, associated or not with anti-PD-1 treatment in patients with non-small-cell lung cancer (NSCLC)
This study is testing a new cancer 'vaccine' called PDC*lung01 for non-small-cell lung cancer. It checks if it's safe, how well people can tolerate it, and if it helps fight the cancer, sometimes with another drug called anti-PD-1.
France · Germany · Netherlands - ongoing, recruitingTherapeutic exploratory (Phase II)
I4C-MC-JTBB: A Randomized, Controlled Phase 2 Study Evaluating LY2875358 plus Erlotinib versus Erlotinib as First-Line Treatment in Metastatic NSLC Patients with Activating EGFR Mutations Who Have Disease Control after an 8-Week Lead-In Treatment with Erlotinib
This study looks at a new drug, LY2875358, combined with an existing lung cancer treatment, erlotinib, for people with a specific type of advanced non-small cell lung cancer. It compares this combination to using erlotinib alone to see if it helps patients live longer without their cancer growing.
Spain · Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
IFCT-1701 DICIPLE A randomized phase 3 trial comparing continuation Nivolumab-Ipilimumab doublet immunotherapy until progression versus observation in treatment-naive patients with stage IV Non-Small Cell Lung Cancer (NSCLC) after Nivolumab-Ipilimumab induction treatment
This study looks at a new way to treat advanced lung cancer. It compares continuing a combination of two immunotherapy drugs (Nivolumab and Ipilimumab) after initial treatment with simply watching to see what happens. The goal is to find out which approach works better at keeping the cancer from growing.
France - ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, open-label, controlled phase III trial comparing the pembrolizumab platinum based chemotherapy combination with pembrolizumab monotherapy in first line treatment of non small-cell lung cancer (NSCLC) patients with PD L1 expression ≥50% on tumor cells : PERSEE TRIAL
This study is looking at a new way to treat a type of lung cancer called non-small cell lung cancer. It compares two different treatment plans using a medicine called pembrolizumab to see which works best for people with a specific marker on their cancer cells.
France - recruitingPHASE2, PHASE3
A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer
This study looks at a new drug, telisotuzumab adizutecan, for a type of lung cancer called non-small cell lung cancer. It compares the new drug to standard treatments to see how safe it is and how well it works in adults with advanced lung cancer.
United States · Australia · Austria - recruitingPHASE3
Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations
This study is for adults with a certain type of lung cancer (Stage II-IIIB non-small cell lung cancer) that has a specific genetic change (HER2 mutation) and has been fully removed by surgery. It compares a new daily tablet called zongertinib with standard treatments to see if it can stop the cancer from coming back.
United States · Argentina · Australia - recruitingPHASE3
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
This study is looking at a new treatment for non-small cell lung cancer after surgery. It combines two medicines, sacituzumab tirumotecan and pembrolizumab, to see if they work better together than pembrolizumab alone in preventing the cancer from coming back.
United States · Argentina · Australia - active not recruitingPHASE3
A Study of Selpercatinib (LY3527723) in Participants With Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer
This study looks at a new drug, selpercatinib, for people with a type of lung cancer that has spread. It compares this new drug to standard treatments to see if it's safe and works well for their specific cancer type.
Argentina · Australia · Belgium - active not recruitingPHASE3
Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
This study compares a new drug, Sacituzumab Govitecan, with a standard treatment, Docetaxel, for people in the UK with advanced non-small cell lung cancer that has already spread and hasn't responded to previous treatments.
United States · Australia · Austria - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Study of PF-08046031 in Adults With Advanced Melanoma and Other Solid Tumors
This study is testing a new medicine, PF-08046031, for adults with advanced melanoma (a type of skin cancer) and other solid cancers like lung, head and neck, and oesophageal cancer. This is an early-stage study to see if the medicine is safe and how it works in the body.
Germany · Sweden · France - active not recruitingPHASE3
Study of DS-1062a Versus Docetaxel in Previously Treated Advanced or Metastatic Non-small Cell Lung Cancer With or Without Actionable Genomic Alterations (TROPION-LUNG01)
This study compares a new drug, DS-1062a, with a standard chemotherapy, docetaxel, for advanced lung cancer. It's for people whose cancer has grown after previous treatments. We want to see if DS-1062a is safer and works better.
United States · Argentina · Australia - active not recruitingPHASE1
Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
This study is testing two anti-cancer drugs, cabozantinib and atezolizumab, alone and together, for various advanced cancers. It aims to find a safe combination dose and see how well it works and any side effects.
United States · Australia · Belgium - authorisedTherapeutic exploratory (Phase II)
The Expression of Fibroblast Activation Protein in Patients with Non-Small Cell Lung Cancer Patients
This study is looking at a new way to find and measure non-small cell lung cancer using a special scan called a FAPI PET scan. They want to see how well it lights up areas of cancer in patients.
Finland - recruitingPHASE3
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
This study is testing new treatments for a type of lung cancer called non-small cell lung cancer. Researchers want to see if a combination of two medicines, calderasib and pembrolizumab, works better than pembrolizumab with chemotherapy to slow down cancer growth.
United States · Argentina · Australia - active not recruitingPHASE1, PHASE2
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
This study is testing a new drug, BT5528, for advanced cancers like ovarian, lung, and breast cancer. We want to find a safe dose, understand side effects, and see how well it works, sometimes given with another drug called nivolumab.
United States · Belgium · South Korea - recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - active not recruitingPHASE3
Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic Non-Small Cell Lung Cancer
This study is testing new combinations of medicines (Zimberelimab and Domvanalimab with chemotherapy) against a standard treatment (Pembrolizumab with chemotherapy) for people with advanced non-small cell lung cancer that hasn't been treated yet. We want to see which combination helps people live longer.
United States · Argentina · Austria - recruitingPHASE3
Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer
This study looks at treating brain tumours from melanoma or lung cancer. It compares standard treatments (like immunotherapy) plus focused radiation to standard treatments alone, aiming to find the best way to improve lives and reduce side effects.
Italy · Netherlands · Spain - ongoing, recruitingTherapeutic exploratory (Phase II)
C4221008 - A Phase 2, Open-label Study of Encorafenib + Binimetinib in Patients with BRAFV600-mutant Non-small Cell Lung Cancer
This study is looking at two drugs, encorafenib and binimetinib, for a type of lung cancer called non-small cell lung cancer. It's for patients whose cancer has a specific change called a BRAFV600 mutation. Researchers want to see how well these drugs shrink the cancer.
Netherlands · Spain · Italy - active not recruitingPHASE2
Study of Zirconium Zr 89 Crefmirlimab Berdoxam PET/CT in Subjects With Advanced or Metastatic Malignancies
This study uses a special scan called a PET/CT with a medicine called zirconium Zr 89 crefmirlimab berdoxam. It’s for people with advanced melanoma, Merkel cell cancer, kidney cancer, or lung cancer. We want to see if this scan can help predict how well immunotherapy will work for their cancer.
United States · Australia · Belgium - recruitingPHASE1
A Platform Study of Novel Agents in Combination With Radiotherapy in NSCLC
This study looks at combining radiotherapy with new drugs to treat non-small cell lung cancer that hasn't spread widely. Researchers want to find the safest and most effective dose of these new drugs, which help radiotherapy work better by making it harder for cancer cells to repair themselves.
United Kingdom - active not recruitingNA
Assessment of Precision Irradiation in Early NSCLC and Interstitial Lung Disease
This study looks at a special type of radiation (SABR) for early-stage lung cancer in people who also have a lung scarring condition (ILD). The goal is to see how well it works and if it's safe for this group, especially if surgery isn't an option.
Canada · United Kingdom - recruitingPHASE3
JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer
This study compares two treatments for early-stage lung cancer: special radiation (SAbR) and a smaller surgery (sublobar resection). It aims to see if SAbR helps people live longer and healthier, especially those who might find full surgery too risky.
United States · Australia · Canada - active not recruitingPHASE1, PHASE2
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This study is looking into a new drug, AZD5305, by itself or with other cancer treatments, for advanced solid cancers like ovarian, breast, and lung cancer. It aims to see if it's safe, tolerable, and effective.
United States · Australia · Canada - recruitingPHASE3
Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer
This study is looking at a new combination of medicines for a type of lung cancer that has spread or can’t be removed by surgery. It compares a drug called trastuzumab deruxtecan plus pembrolizumab to standard chemotherapy plus pembrolizumab.
United States · Argentina · Belgium - authorisedTherapeutic exploratory (Phase II)
A randomized phase II study of Pembrolizumab (MK-3475) as maintainance therapy in patients with unresectable stage III non-small cell lung cancer treated with definitive chemo-radiotherapy (MP-LALC- Maintainance Pembrolizumab in Locally Advanced Lung Cancer).
This study looks at a medicine called Pembrolizumab (Keytruda) for people with a type of lung cancer that can't be removed by surgery. It aims to see if this medicine helps people live longer after they've had chemotherapy and radiation.
Italy - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
First-in-human phase I/IIa study investigating inhaled CIS-DPI as add-on treatment in Stage IV NSCLC patients
This study is testing a new inhaled medicine called CIS-DPI for people with advanced non-small cell lung cancer. It's an early-stage trial looking at whether the medicine is safe and how well it works when added to usual treatments.
Belgium · France · Spain - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A study to investigate the safety and tolerability of intravenous QEQ278 in patients with advanced solid tumors
This study is looking into a new medicine called QEQ278 for people with advanced cancers like lung, oesophageal, kidney, or head and neck cancer. It's the very first time this medicine is being given to people, and the main aim is to see if it's safe to use and how well people tolerate it.
France · Italy · Germany - recruiting
Cardiopulmonary Toxicity of Thoracic Radiotherapy
This study looks at how radiotherapy for lung and oesophageal cancer might affect your heart and lungs. We want to see if a condition called pulmonary hypertension, which affects blood flow in the lungs, is a common side effect so we can improve care.
Belgium · Netherlands · United Kingdom - active not recruitingPHASE1
Combination Study of Guadecitabine/ASTX727 and Pembrolizumab
This study looks at combining two medicines, Guadecitabine/ASTX727 and Pembrolizumab, for people with advanced solid tumours, including a type of lung cancer. The main aim is to check if this new combination is safe and what doses work best.
United Kingdom - recruitingPHASE3
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)
This study is testing a new drug, daraxonrasib, for people with a specific type of advanced lung cancer (non-small cell lung cancer, or NSCLC) that has a RAS gene change. It compares the new drug to an existing chemotherapy, docetaxel, to see if it works better or has fewer side effects.
United States · Australia · Belgium - recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
This study looks at new drug combinations for a specific type of advanced lung cancer. It compares a new drug, Divarasib, with Pembrolizumab, against standard treatments to see which works best and is safest for patients with KRAS G12C-mutated non-small cell lung cancer.
United States · Argentina · Australia - recruitingPHASE1
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
This study is testing a new drug, LY4052031, for people with advanced cancers like bladder, breast, and lung cancer. It aims to see if the drug is safe, what dose works best, and if it helps shrink tumors. It's an early-stage study to gather important information.
United States · Australia · China - recruitingPHASE1
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
This study is testing a new drug, OKN4395, alone and with an existing cancer treatment, pembrolizumab, for various solid tumours. The main goals are to check its safety, how well it's tolerated, and if it helps fight cancer.
United States · Australia · United Kingdom - authorisedTherapeutic exploratory (Phase II)
Phase II single arm study with CABozantinib in Non-Small Cell Lung Cancer patients with MET deregulation
This study is looking at a new drug called Cabozantinib for a type of lung cancer called non-small cell lung cancer (NSCLC). It's for people whose cancer has specific genetic changes related to a protein called MET. Researchers want to see how well the drug shrinks tumours.
Italy - authorisedTherapeutic exploratory (Phase II)
Improved baseline staging with 68Ga-FAPI-46 PET in non-small cell lung cancer – a pilot study
This study looks at a new type of body scan (called 68Ga-FAPI-46 PET) for people with a type of lung cancer. It compares how well this new scan finds cancer spread compared to the usual scans, hoping to find better ways to understand the cancer.
Netherlands - available
Expanded Access Program of Neladalkib (NVL-655) for Patients With Advanced ALK+ NSCLC or Other ALK+ Solid Tumors
This program offers people with advanced ALK-positive lung cancer or other ALK-positive tumours an opportunity to receive an investigational medicine called neladalkib (NVL-655). It is for those who can't join a regular trial and have run out of other good treatment options.
United States · Australia · Canada - ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase I/IIa, Open-label, Multi-centre Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of AZD0022 Monotherapy and in Combination with Anti-cancer Agents in Participants with Tumours Harbouring a KRASG12D Mutation (ALAFOSS-01)
This study looks at a new drug, AZD0022, for people with certain types of lung, bowel, and pancreatic cancer. Doctors want to see if it's safe, how the body handles it, and if it can help shrink tumours, both on its own and with other cancer drugs.
Belgium · Poland · Italy