- ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c. 1.0 mg/1.0 mg and 1.7 mg/1.7 mg) once-weekly in participants with overweight or obesity
This study is looking at a new combination medicine, CagriSema, for adults who are overweight or have obesity. It wants to see if this weekly injection helps people lose weight and if it's safe to use. Researchers hope it can lead to meaningful weight loss.
France · Germany - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Defining the Glucagon Unit: Investigating the Impact on Energy Expenditure and Glucose Level Deviation in healthy volunteers
This study for healthy men aged 18 and over investigates how different substances, including medicines for weight loss and hormones, affect the body's energy use and blood sugar levels. Researchers want to understand these effects to help treat conditions like obesity.
Latvia - authorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Active- and Placebo-Controlled, Partially-Blinded Study to Compare the Efficacy and Safety of KAI-9531 Administered Once Weekly Versus Semaglutide and Placebo in Participants Living with Obesity Who Do Not Have Diabetes
This study is looking at a new medicine, KAI-9531, to help people living with obesity who don't have diabetes. It compares KAI-9531 with an existing medicine (Wegovy) and a dummy treatment to see how well it helps with weight loss and if it's safe.
Poland · Bulgaria - recruitingNA
The Effect of Exercise in Patients Awaiting Bariatric Surgery
This study looks at how a 4-week online exercise programme helps people preparing for weight-loss surgery. It aims to see if exercise before surgery can improve fitness and how the body uses energy, compared to not exercising.
United Kingdom - ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE ASCENDING DOSE PHASE 1 STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, PHARMACOKINETIC, AND PHARMACODYNAMIC PROFILE OF RES-010 IN HEALTHY, OVERWEIGHT, AND MODERATELY OBESE SUBJECTS
This study is testing a new medicine, RES-010, for obesity in healthy, overweight, and moderately obese adults. It's an early-stage study to check its safety, how well bodies handle it, and its effects, compared to a dummy pill.
Netherlands - recruiting
Periodontal Assessment of a Bariatric Care Population
This study looks at gum health in people considering weight-loss surgery. It explores the link between obesity, gum disease, and genetic factors, and examines bacteria in the mouth to understand these connections better.
United Kingdom - recruitingNA
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.
This study explores if losing weight can improve the heart's health and quality of life for people with a specific type of heart failure. Participants will follow a supervised diet plan or continue their usual care.
Jersey · United Kingdom - recruitingPHASE2
A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight
This study is testing a new medicine, BI 3034701, to see if it helps adults with obesity or overweight lose weight. Participants will get either the medicine or dummy medicine, plus advice on diet and exercise.
United States · Australia · Canada - recruitingPHASE3
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
This study is looking into a new medicine, NNC0487-0111, to help people who have lost weight keep it off. Participants will get either the new medicine or a dummy medicine by injection once a week to see if it's safe and effective for weight management.
United States · Argentina · Australia - recruitingPHASE3
AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight
This study, AMAZE 1, is testing a new medicine called NNC0487-0111 to see if it helps people with excess body weight lose weight. It involves weekly injections, with some participants receiving the active medicine and others a dummy treatment (placebo).
United States · Argentina · Australia - recruitingNA
Bariatric Surgery and Exercise Interventions: Effects on Muscle
This study looks at how weight loss surgery affects muscles. It also checks if a special exercise programme after surgery can help improve muscle strength. We're inviting people having weight loss surgery at Royal Derby Hospital to take part.
United Kingdom - active not recruitingNA
Adults Regulating Their Weight Everyday With Mobile Internet Support
This study, called ARTEMIS, is exploring if a mobile app can help adults in the UK manage their weight. It focuses on using the app to help people make daily healthy choices and build lasting habits for weight control, without needing in-person meetings.
United Kingdom - recruiting
Effect of Obesity, Diabetes and Bariatric Surgery on Pregnancy Outcomes
This study looks at how being overweight or having diabetes affects mothers and babies during pregnancy in the UK. Researchers are also comparing mums who've had weight loss surgery with those who haven't, to understand the different effects on pregnancy.
United Kingdom - recruitingPHASE4
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
This study looks at a new medicine called tirzepatide for adults with obesity but not diabetes. It compares it to standard care to see how well it helps with weight loss and if it can prevent type 2 diabetes over about five years.
United Kingdom - recruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - recruitingPHASE3
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
This study looks at a medicine called tirzepatide for teenagers aged 12-17 who are overweight and have related health problems. Researchers want to see if it helps with weight and heart health when combined with healthy eating and exercise.
United States · Argentina · Australia - active not recruiting
Genetic Determinants of Kidney Disease in People of African Ancestry With HIV
This study looks at why kidney problems are more common in people of African heritage living with HIV in the UK. It found that certain genes can increase this risk. The research aims to better understand these factors to improve care.
United Kingdom - active not recruitingPHASE3
EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
This study looks into a new medicine called Setmelanotide for people aged 6 to 65 with obesity caused by specific genetic changes. Researchers want to see if this medicine helps with weight and appetite in people whose obesity is linked to faults in the MC4R pathway.
United States · Canada · France - active not recruitingPHASE3
Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
This study is looking at a new medicine called Maridebart Cafraglutide to see if it helps adults who are overweight or have obesity lose weight. It compares the medicine to a dummy treatment (placebo) to find out if it's more effective.
United States · Argentina · Australia - authorisedHuman Pharmacology (Phase I)- Other
A research study to see how NNC0487-0111 affects the body’s energy use after a weight loss in adults living with obesity, compared to a low-calorie diet or placebo
This study looks at a new treatment, NNC0487-0111, for adults who have lost weight but are still living with obesity. It compares this treatment to a low-calorie diet or a dummy medicine, to see how it affects the body's energy use after weight loss.
Netherlands · Denmark - recruiting
Nottingham Community Liver Biomarkers Cohort
This study in Nottingham looks at improving how we find liver disease early in the community. It involves people with risk factors like heavy alcohol use, obesity, or diabetes, to see if new blood and scan tests can help identify liver problems before they become serious.
United Kingdom - active not recruitingNA
Intensive Weight Loss Intervention Versus Usual Care for Adults With Obesity
This study compares an intense weight loss plan against standard care for adults with obesity. The intense plan involves special diets, support, and medication. Researchers want to see which approach works best and is most cost-effective for health.
Denmark · United Kingdom - ongoing, recruitingTherapeutic use (Phase IV)
Young adults with early-onset obesity treated with semaglutide -The RESETTLE study - a randomized double blind placebo-controlled clinical trial
This study, called RESETTLE, is looking at how a medicine called semaglutide helps young adults with obesity. It compares semaglutide to a dummy medicine to see if it makes a difference to their weight and overall health.
Denmark - ongoing, recruitingTherapeutic exploratory (Phase II)
A PilOt dose-escalation trial with EMP16 in preparation for Phase III – the POEM trial
This study is looking at a new way to help people with obesity manage their weight. It compares a new treatment called EMP16 with a common weight-loss medicine, Orlistat, to see how they affect tummy troubles.
Sweden - recruitingPHASE3
A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
This study is for children and teenagers aged 6-17 who are overweight or have obesity. It's testing a new medication called Orforglipron to see if it's safe and helps with weight management, compared to a dummy medicine. It aims to find better ways to help young people manage their weight.
United States · Brazil · Israel - recruitingPHASE3
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
This study is looking into a new medication called Eloralintide for people who are overweight or have obesity but don't have type 2 diabetes. It aims to see how well it works and if it's safe to help with weight management.
United States · Argentina · Australia - recruiting
Biomarkers in Patients With Suspected HFpEF
This study looks for better ways to spot heart failure, especially in people with obesity or low levels of a common blood test. Researchers hope to find new blood markers to help doctors diagnose heart failure more accurately and earlier.
United Kingdom - recruitingNA
Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity
This study compares an intensive weight loss programme, including special diets and support, with standard NHS weight management for adults with severe obesity. It aims to see which works best for health and cost.
Denmark · United Kingdom - recruitingPHASE3
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
This study looks at a new medicine, Maridebart cafraglutide, for people with heart failure and obesity. It aims to see if the medicine can reduce heart-related problems like hospital stays, improve symptoms, and help people live longer, alongside their usual heart failure care.
United States · Argentina · Australia - recruitingNA
Gut Hormone LEAP2 in Metabolism and Eating Behaviour: Fixed Meal Testing
This study looks at how different sized liquid meals affect hunger hormones and feelings of fullness in healthy adults, both with and without obesity. We want to see if meal size changes these hormones and how much people eat afterwards.
United Kingdom - authorisedTherapeutic exploratory (Phase II)
Weight management with orismilast alone or in combination with s.c. semaglutide (WELOSITI)
This study looks at a new medicine called orismilast, sometimes with semaglutide, to help adults aged 18 and over manage their weight. Researchers want to see how much weight people lose over 16 weeks.
Denmark - recruitingPHASE1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
This study is looking at how two different forms of a new medicine, survodutide, are taken up by the body in healthy people who are overweight or have obesity. It aims to see if both forms work in a similar way.
United Kingdom - authorisedHuman Pharmacology (Phase I)- Other
A Study of Eloralintide (LY3841136) in Participants With Overweight or Obesity
This study is looking into a new medication called Eloralintide (LY3841136) for adults who are overweight or obese. It's an early-stage study to understand how the medicine works in the body and if it's safe.
Germany - active not recruitingPHASE3
A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)
This study looks at a new medicine called survodutide for people who are overweight or obese. It checks if survodutide helps with heart health problems. Participants take the medicine weekly for up to 2 years, alongside diet and exercise advice.
United States · Argentina · Australia - ongoing, recruitingTherapeutic exploratory (Phase II)
Dapiglutide for the treatment of obesity (DREAM): a randomised, double-blind, placebo-controlled, investigator-initiated trial
This study, called DREAM, is looking into a new medication called dapiglutide for treating obesity. It's in an early stage (Phase II) and aims to see how much dapiglutide can help people lose weight, compared to a dummy pill. Researchers will also check its effects on gut health and inflammation.
Denmark - recruitingPHASE3
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight
This study looks at new treatments, CagriSema and cagrilintide, for children and teenagers aged 8-18 who are overweight. It compares these new drugs to an existing medicine (semaglutide) or a dummy drug (placebo) to see how well they help with weight loss.
United States · Australia · Austria - enrolling by invitation
A Two-year Prospective, Observational Study of Wegovy in Real-world Clinical Practice
This study looks at how a medicine called Wegovy (semaglutide) is used in real life to help people with obesity. It will follow participants for two years to see how it affects weight, body size, and quality of life.
Spain · Switzerland · United Kingdom - recruiting
Weight Loss in Adults Using Semaglutide (Real-world Study)
This study looks at how a medicine called semaglutide helps adults lose weight in real-life settings. Doctors decide who receives the treatment. It aims to see how effective semaglutide is for people who are overweight or obese, following their usual healthcare.
United States · United Kingdom - authorisedTherapeutic use (Phase IV)
Efficacy and safety of pharmacological therapy of obesity in liver transplant candidates
This study looks at how a medicine called Mounjaro helps people with obesity who are waiting for a liver transplant. Researchers want to see if it helps them lose weight and if it's safe to use, carefully checking for any side effects and how it affects their health after a transplant.
Czechia - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A research study to look at how CagriSema influences food intake, appetite and emptying of the stomach in people with excess body weight
This study is looking at a new medicine called CagriSema to see how it affects eating, hunger, and how quickly your stomach empties if you are overweight. It's an early study to understand how it works in the body.
Germany - active not recruitingNA
Evaluation of Lifestyle Modification on Cardiovascular Risk
This study looks at how exercise, and a healthy Mediterranean diet, might help women aged 45-65 who are overweight or obese and have gone through menopause. It aims to improve heart health and metabolic health (like blood sugar and cholesterol) over 8 weeks.
United Kingdom - recruitingPHASE4
Fibrosis Lessens After Metabolic Surgery
This study looks at how well weight-loss surgery compares to new medicines for treating liver disease. It focuses on a condition called MASH, which is linked to being overweight and can cause liver damage.
United States · Brazil · Canada - authorisedTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living with Obesity or Overweight with Weight-Related Comorbidities Who Do Not Have Diabetes
This study is testing a new medicine, KAI-9531, for people who are overweight or have obesity and other health issues, but don't have diabetes. We want to see if it helps with weight loss and is safe to use over about 18 months.
Bulgaria · Hungary · Spain - recruitingPHASE3
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
This study looks at a new medicine, NNC0487-0111, for people with heart failure and obesity. It compares the medicine to a dummy treatment (placebo) to see if it's safe and helps improve heart health.
United States · Argentina · Australia - ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Control Of BioEquivalence with Xenical (COBEX): A Phase I, randomized, active-control study to evaluate EMP22 pharmacodynamics and EMP16 pharmacokinetics versus Xenical® in healthy volunteers.
This study is comparing two new medicines (EMP22 and EMP16) for obesity with an existing one (Xenical). We want to see how much fat is passed in your poo when taking these medicines. It's a first step to understand how they work in healthy adults.
Sweden - recruiting
Support for weight loss for adults from the dental team when attending routine appointments at dental practices
This study looks at whether dental teams can help adults with weight management. If you join, your height and weight will be measured at your dental check-up, and you'll discuss healthy habits with your dental team to see if this helps improve health.
United Kingdom - enrolling by invitation
A Study to Evaluate Safety of Exposure to Wegovy During Pregnancy
This study looks at how babies and mothers are doing when the mother has taken Wegovy for obesity or being overweight during pregnancy. It compares their health outcomes with mothers who didn't take Wegovy but had similar health conditions.
United States · Spain · United Kingdom - not yet recruitingNA
Group Skills Training for Body Awareness and Managing Emotions
This study aims to help people with obesity improve their awareness of body signals and manage emotions better. It tests a new group program, based on polyvagal theory, to see if it helps people understand their body's messages and respond in healthier ways.
United Kingdom - recruiting
A UK Registry for Metabolic and Bariatric Endoscopic Interventions
This UK study is collecting information on new, less invasive procedures using a camera on a thin tube (endoscope) to help people with obesity and type 2 diabetes lose weight. It aims to see how safe and effective these treatments are in real-life settings.
United Kingdom - active not recruitingPHASE3
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
This study is looking at how a medication called Tirzepatide might help people living with obesity. Researchers want to see if it can reduce serious health problems and improve overall health in adults.
United States · Argentina · Australia