- authorisedTherapeutic exploratory (Phase II)
Efficacy of Ketamine for the Prevention of Relapse in Patients with Opioid-Use Disorders (OUD)
This study is looking into whether a medicine called ketamine can help people with opioid use disorder (addiction to strong painkillers or drugs like heroin) stay off opioids and reduce their cravings. It's an early-stage study to see how well it works.
Cyprus - recruitingPHASE2
A Study of Brenipatide in Participants With Opioid Use Disorder
This study is testing a new medicine called brenipatide for people with opioid use disorder. It aims to see if brenipatide, when used with buprenorphine, is safe and works better than a dummy medicine (placebo).
United States · Canada · Puerto Rico - recruitingPhase II
A trial to investigate if psilocybin therapy is effective in improving outcomes for people with opioid use disorder
This study looks at whether a special type of therapy using psilocybin (from magic mushrooms) can help people recover from opioid addiction. It combines a single dose of psilocybin with talking support to see if it improves their recovery.
United Kingdom · England - recruitingPHASE4
Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility Trial
This study is testing a new way to start treatment for opioid use disorder. It involves giving a medicine called naloxone to bring on mild withdrawal, then buprenorphine to ease symptoms. It aims to see if this method is safe and works well.
Canada - not yet recruitingPHASE4
Evaluation of Switch to Dolutegravir/Lamivudine (DTG/3TC) From Current Suppressive Antiretroviral Therapy in People Living With HIV (PLWH) Receiving Opioid Agonist Therapy (OAT)
This study looks at switching HIV patients already on opioid addiction treatment to a new HIV medicine called Dovato. We want to see if Dovato keeps their HIV under control and if it's safe for them.
Canada - ongoing, recruitingTherapeutic use (Phase IV)
A Phase IV Longitudinal Study of SUBLOCADE (SUBUTEX Prolonged Release) Clinical Outcomes in Adults with Opioid Use Disorder (Opioid Dependence)
This study looks at how well SUBLOCADE, a long-acting injection, helps adults with opioid use disorder. It aims to see if people achieve and maintain recovery over 3 years while using this treatment, checking for symptom improvement and other important health outcomes.
Sweden - active not recruiting
Biopsychosocial Markers of Addiction in Opioid Users: an Integrated Approach
This study looks at how addiction to opioids affects people in France. Researchers will collect blood, saliva, and hair samples. They want to understand how things like personal experiences, social life, and biology work together to make opioid use disorder worse, hoping to find better ways to help.
France