- authorisedTherapeutic use (Phase IV)
Effect of an adjunctive intervention on the tolerability of semaglutide in overweight adults without diabetes: a prospective, randomised, double-blind, single-centre, placebo-controlled clinical trial (SEMTOL)
This study looks at how well people who are overweight tolerate a medicine called semaglutide. We want to see if adding another medicine helps reduce sickness (nausea) during the first few days of taking semaglutide for weight management.
Estonia - recruitingNA
The Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function.
This study looks at how beetroot juice and a special diet affect brain function and blood vessels in healthy older adults. Some will have a calorie-restricted diet, while others will maintain their weight. It's a pilot study to see if combining these approaches is helpful.
United Kingdom - recruitingPHASE1, PHASE2
A Phase 1/2a Study of WVE-007 in Adults Living With Overweight or Obesity
This study is testing a new medicine, WVE-007, for people who are overweight or have obesity. Researchers want to see if it's safe, how the body handles it, and if it helps with weight or conditions like pre-diabetes and type 2 diabetes.
United States · Moldova · Romania - recruiting
Examining the mechanisms that underlie the biological drive to eat
This study looks at how losing weight quickly or slowly affects your body and health. Healthy adults aged 18-55 with a BMI between 23-40 are invited to take part. It involves a meal replacement diet and lasts up to 11 months, with visits to Leeds for tests.
United Kingdom · England - ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2 Randomized, Placebo-controlled, Double-blind, Dose-ranging Study to Evaluate the Efficacy, Safety, and Tolerability of AMG 133 in Adult Subjects With Overweight or Obesity, With or Without Type 2 Diabetes Mellitus.
This study is testing a new medicine, AMG 133, for adults who are overweight or have obesity, with or without type 2 diabetes. Researchers want to see if it helps with weight loss and if it's safe.
Germany · Spain · Czechia - active not recruiting
Outcome of Overweight AF Patients Following Ablation With a Potential Weight Loss Medication ( GOAL-AF )
This study looks at whether a weight-loss medicine called Liraglutide can help people with an irregular heartbeat (Atrial Fibrillation or AF) who are overweight. The aim is to see if losing weight before a heart procedure called ablation can improve its success and overall health.
United Kingdom - active not recruitingNA
Super-Rehab: a Novel Approach to Treat Atrial Fibrillation
This study looks at 'Super Rehab', a new lifestyle programme combining exercise, diet advice, and regular check-ups, for overweight people with a heart rhythm problem called atrial fibrillation (AF). It aims to see if Super Rehab helps improve AF symptoms when added to usual care.
United Kingdom - recruitingPHASE1, PHASE2
A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
This study looks at a new drug, AZD9550, alone or with another drug, AZD6234, for people who are overweight or living with obesity, with or without Type 2 diabetes. We want to see if it's safe and how it works in the body.
Austria · Canada · Germany - active not recruitingNA
WB-EMS Effects on Cardiometabolic Risk Factors
This study looks at how a type of exercise called whole-body electrical stimulation (WB-EMS) affects blood pressure and other health factors in men over 50. It wants to see if this quick, joint-friendly exercise can help people with slightly high blood pressure.
Germany - recruitingNA
Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness
This study looks at how a drug similar to a natural body chemical (GLP-1) affects brain responses to insulin in people of different weights. Researchers use special brain scans and tests to understand if this drug changes how the brain uses insulin and influences eating habits.
Germany - active not recruitingNA
ARIADNE: A Study of Weight Loss for Diabetes Treatment and Wellbeing
This study looks at how a special low-calorie diet affects people with type 2 diabetes and concerns about their eating habits. We want to see if this diet helps with diabetes without causing problems with their relationship with food. It will help us understand if this diet is safe for everyone.
United Kingdom - recruitingNA
Impact of Microbiome-changing Interventions on Food Decision-making
Researchers are studying how what we eat affects our brains and food choices, especially for people who are overweight. They want to see if special foods or lifestyle changes can help improve how people make decisions about food.
Germany