Neurodegenerative Diseases research hub
50 indexed studies · 39 currently recruiting
- recruiting
Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR
This study looks into how inflammation might play a role in Parkinson's disease. Researchers will use special scans and tests to understand why inflammation happens and how it affects the disease, hoping to find new ways to help patients in the future.
United Kingdom - recruitingNA
Frontosubthalamic Networks in Parkinson's Disease.
This study looks at how deep brain stimulation (DBS) for Parkinson's disease affects brain networks, especially concerning changes in impulsive behaviour. We want to see if different DBS settings can help reduce impulsivity.
United Kingdom - recruiting
Digital App for Speech & Health Monitoring
This study is using a smartphone app to record and analyse speech from people with conditions like dementia, MND, MS, and Parkinson's. The goal is to see if speech changes can help diagnose and monitor these conditions, comparing them to healthy individuals, using simple digital technology.
United Kingdom - active not recruitingPHASE1
A Trial to Determine the Safety and Tolerability of Transplanted Stem Cell Derived Dopamine Neurons to the Brains of Individuals With Parkinson's Disease
This study is testing a new stem cell treatment for Parkinson's disease. Surgeons will place special cells into the brain to see if they are safe and can help replace damaged cells. It's hoped this could improve movement for people with Parkinson's.
Sweden · United Kingdom - enrolling by invitationNA
TUS to Disrupt Pathological Oscillations
This study explores a new, gentle sound wave method to correct faulty brain signals in Parkinson's. We're testing if this non-invasive technique can improve symptoms, offering a safer alternative to current brain surgery. It could also help treat other brain conditions in the future.
United Kingdom - recruiting
Observational Case Series of Patients With Parkinson's Disease (PD) Attending a Complementary Medicine Neuro-degenerative Disease (NDD) Clinic.
This study looks at how people with Parkinson's disease experience complementary therapies like homeopathy and herbalism in a London clinic. Researchers want to understand if these treatments help and how they are used alongside regular medical care.
United Kingdom - recruiting
DBS and Respiration
This study looks at how deep brain stimulation (DBS) for Parkinson's disease might affect breathing. Researchers want to see if DBS in a specific brain area causes breathing problems and understand why, using questionnaires, tests, and activity trackers.
United Kingdom - recruiting
Radiofrequency (RF) Ablation Prospective Outcomes Study for Central Nervous System - RAPID for CNS
This study looks at how well a treatment called radiofrequency ablation works for certain brain conditions, like Parkinson's. Researchers are collecting information from people who are already having this treatment in real life to see how it helps them.
Germany · United Kingdom - authorisedHuman Pharmacology (Phase I)- Bioequivalence Study
Bioequivalence study 1 to compare pharmacokinetics of Parkinson´s disease drugs in healthy volunteers
This study is looking at how two different versions of a Parkinson's disease medicine are handled by the body in healthy adult volunteers. It's a first step to make sure new medicines work in the same way as existing ones.
Czechia - not yet recruiting
AI-PROGNOSIS - Digital Biomarkers Development Study (dBM-DEV)
This study looks at whether smartwatches can help spot early signs of Parkinson's disease. Researchers are testing if these watches can pick up sleep problems linked to brain conditions. They hope to find an easier way to check for these issues than current complex tests.
France · Germany · Spain - active not recruitingNA
Validation of a Novel Functional Food Designed to Meet the Nutritional Needs of People Living With Parkinson's Disease
This study looks at a special drink for people with Parkinson's disease who have constipation. The drink contains helpful fibres and vitamins. Researchers want to see if it improves gut health and overall well-being over 12 weeks.
United Kingdom - recruiting
Molecular and Functional Imaging in Monogenic PD.
This study uses special brain scans to understand Parkinson's disease better, especially in people with a genetic link. The goal is to find ways to measure the disease and help develop new medicines to slow down symptoms.
United Kingdom - recruiting
Longitudinal Investigation of I2BS in PD
This study aims to find ways to measure Parkinson's disease progression using special brain scans and spinal fluid tests. Researchers hope to understand the disease better and help develop new treatments to slow down its effects. It involves multiple visits over a year in London.
United Kingdom - recruitingPHASE2
A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease
This study is looking into a new medication called NEU-411 for people aged 40-80 with early Parkinson's disease. It focuses on those with a specific genetic marker. The aim is to see if the drug is safe and effective in slowing the disease's progress.
United States · Israel · Italy - recruiting
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
This study aims to understand how Parkinson's disease progresses by tracking changes in people with Parkinson's, those at risk, and healthy volunteers. Scientists hope to find new ways to measure the disease's progression, which will help develop better treatments.
United States · Austria · Canada - active not recruitingNA
ExAblate Pallidotomy for Medically-Refractory Dyskinesia Symptoms or Motor Fluctuations of Advanced Parkinson's Disease
This study is looking at a new way to treat symptoms of advanced Parkinson's disease, like uncontrolled movements or 'on-off' periods, when medicines aren't working well. It uses focused sound waves to target a small area of the brain.
United States · Canada · Israel - recruitingPHASE2
A Trial to Test the Use of Dapansutrile, an Anti-inflammatory Medication, in People With Parkinson's Disease
This study is testing a new drug called dapansutrile for people with Parkinson's disease. Researchers want to see if it's safe, reduces inflammation in the brain and body, and helps with Parkinson's symptoms. Inflammation is thought to play a role in the disease.
United Kingdom - active not recruitingPHASE2
A Study to Evaluate the Effects of ACI-7104.056 in Patients With Early Stages of Parkinson's Disease
This study is looking for people with early Parkinson's disease to test a new treatment called ACI-7104.056. We want to see if it's safe, how the body reacts to it, and if it could help. Participants will receive either the study medicine or a dummy treatment (placebo) by injection.
Germany · Spain · United Kingdom - recruitingPHASE2
A Study of AAV2-GDNF in Adults With Moderate Parkinson's Disease (REGENERATE-PD)
This study is testing a new gene therapy, AAV2-GDNF, for people with moderate Parkinson's disease. We want to see if it's safe and helps improve symptoms. It involves a single surgery and comparing the gene therapy to a control surgery.
United States · Germany · Poland - recruiting
Mobilise-D: Extension Study
This study looks at how Parkinson's disease affects movement and how our movement changes as we get older. Researchers will use a special device to track how people move, hoping to understand the condition better and improve ways to measure it in daily life.
United Kingdom - enrolling by invitation
An Observational Study of Patients With Moderate Parkinson's Disease
This study watches people with moderate Parkinson's disease to see how their symptoms change over time. Participants continue their usual medicine, but doctors might suggest adjustments. It helps us understand the condition better.
United States · Japan · Sweden - recruiting
Non-invasive Detection of Volatile Metabolites in Parkinson's Disease
This study is looking for a new, simple way to diagnose Parkinson's disease earlier. Researchers are checking if a breath test can spot early signs of the condition by looking at tiny molecules in your breath, combined with changes in gut bacteria.
United Kingdom - recruitingNA
Exercise to Improve Sleep in Parkinson's Disease
This study looks at how different types of exercise – cardio, strength, or a mix – can improve sleep for people with Parkinson's disease. Researchers want to see if better sleep also improves their quality of life.
Canada - enrolling by invitationNA
Brain-Machine Interface for Freezing of Gait
This study explores a new brain-machine interface to help people with Parkinson's disease who experience "freezing of gait." Researchers want to understand brain activity during freezing and test if gentle brain stimulation can stop it, hoping to develop better treatments.
Canada - recruiting
Prodromal Alpha-Synuclein Screening in Parkinson's Disease Study
This study is looking for people aged 50-99 to understand who might be at higher risk of developing Parkinson's disease in the future. Researchers will follow these individuals for five years to learn more about early signs and how the condition develops. There are no treatments involved, only observation and investigation.
Germany - recruitingNA
CANadian Adaptive DBS TriAl
This study looks at a new type of deep brain stimulation (DBS) called 'adaptive DBS' for Parkinson's disease. It aims to see if this smarter, adjustable DBS can better help with problems like walking difficulties and speech issues compared to standard DBS.
Canada - active not recruitingNA
Towards Noninvasive DBS of the Basal Ganglia in Parkinson's Disease Using TUS
This study is looking at a new, gentle way to stimulate the brain called Focused Ultrasound (TUS) for people with Parkinson’s disease or dystonia. It uses sound waves to deliver a treatment similar to deep brain stimulation (DBS) and aims to understand how it works.
Canada - recruiting
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
This study looks at how well Abbott's Deep Brain Stimulation (DBS) systems work and how safe they are over time for people with movement problems like Parkinson's or essential tremor. It helps doctors understand the long-term benefits.
United States · Australia · Finland - recruitingNA
Home-based Gait and Balance Training in Patients With Movement Disorders
This study looks at how a home-based exercise programme can help people with Ataxia or Parkinson's disease improve their walking and balance. It compares two training schedules to see which works best.
Germany - recruitingNA
Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity
This study looks at how increasing physical activity might help slow down memory and thinking problems in people with a condition called REM sleep behaviour disorder (iRBD). This condition can sometimes lead to Parkinson's disease. Participants will use a smartphone app to boost their activity levels.
Germany - recruitingNA
Brain Training to Improve Balance in Parkinson's Disease
This study looks at new ways to help people with Parkinson's improve their balance and prevent falls. It tests a special 'brain training' exercise game to see if it can change brain activity and lead to better balance.
United Kingdom - recruiting
Serotonin Release in Premotor and Motor PD
This study aims to better understand Parkinson's disease by using special brain scans. Researchers hope to find a 'biomarker' – a sign of the disease – which could help develop new medicines to slow down Parkinson's symptoms.
United Kingdom - recruiting
Influence of Glucose on Metabolism and Clinical Symptoms of Patients With Parkinson's Disease
This study looks at how sugar affects people with Parkinson's and why some crave sweet foods. Researchers will see how blood sugar levels change after sweet drinks and measure how it affects their Parkinson's symptoms, both movement and non-movement related.
Germany - recruiting
Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases
This study looks at how swallowing and voice box problems affect people with conditions like Parkinson's and Motor Neuron Disease. Researchers will observe existing medical checks to understand more about these issues. This could help find better ways to diagnose and treat these conditions early.
Austria · Germany · Israel - active not recruitingNA
New Approaches in MRI at 3T Dedicated to Targeting Subthalamic Nucleus on Parkinsonian Patients
This study looks at new ways to use powerful MRI scans to better pinpoint specific brain areas in people with Parkinson's disease. This is important for improving a treatment called Deep Brain Stimulation (DBS), which can help reduce movement problems.
France - not yet recruiting
Trial Evaluating the Efficacy of Pimavanserin, a Selective Serotonin 5-HydroxyTryptamine-2A (5HT2A) Inverse Agonist, to Treat Impulse Control Disorders in Parkinson's Disease.
This study is looking into a new medication called pimavanserin for people with Parkinson's disease who also experience impulse control disorders (ICDs). The aim is to see if this medicine can help manage these behaviours safely and effectively.
France - recruitingNA
Evaluation of the Safety of Electrical Spinal Cord Stimulation in Parkinson's Patients Presenting With Painful Camptocormia
This study looks at a treatment called electrical spinal cord stimulation for people with Parkinson's disease who have painful camptocormia (a bent-over posture). It wants to see if this treatment is safe and helps with pain and posture when other treatments haven't worked.
France - active not recruitingPHASE2
Safety and Pharmacodynamic Effects of BIIB122 in Participants With LRRK2-Associated Parkinson's Disease (LRRK2-PD)
This study is testing a new medicine called BIIB122 for people with a specific type of Parkinson's disease linked to a gene. We want to see if it's safe and how it affects the body.
United States · Germany · Israel - available
Compassionate Use for BIA 28-6156 in Patients With Parkinson's Disease (PD) Who Have a Pathogenic Variant in the GBA1 Gene (GBA-PD) and Completed the ACTIVATE Study
This programme offers continued access to an investigational drug, BIA 28-6156, for people with a specific type of Parkinson's disease (related to the GBA1 gene) who have already completed a previous study. It provides the medicine free of charge on compassionate grounds.
United States · Italy · Portugal - recruitingPHASE3
Ambroxol to Slow Progression in Parkinson Disease
This UK study is testing if a drug called ambroxol, already used for colds, can slow the progression of Parkinson's disease. Participants will take either ambroxol or a dummy pill, then all take ambroxol. We want to see if it's safe and effective.
United Kingdom - not yet recruitingNA
Early Biomarkers of Neurodegeneration in Parkinsonian Syndromes
This study uses advanced MRI scans to find early signs of Parkinson's disease and a similar condition called PSP. The goal is to discover ways to diagnose these diseases earlier and help patients get better treatment.
France - recruitingNA
Interdisciplinary + Intersectoral Telemedicine Evaluation, Coordination + Treatment in RhineMain+ Parkinson's Network
This study looks at new ways to support people with Parkinson's disease in the RhineMain+ area of Germany. It uses a special nurse and online tools to help manage care, aiming to improve health and treatment coordination.
Germany - recruitingNA
Exercise & Brain Energetics in PD
This study looks at how exercise might help the brain use energy better in people with Parkinson's disease. We're using special brain scans before and after an exercise programme to see if it makes a difference to brain energy.
Canada - active not recruitingNA
Remote Optimization, Adjustment and Measurement for Deep Brain Stimulation
This study looks at how a new remote system for Deep Brain Stimulation (DBS) in Parkinson's disease might help patients get their treatment settings adjusted faster. It compares in-clinic visits with a mix of in-clinic and virtual visits.
United States · Germany · Spain - recruitingNA
Patient Engagement Investigation of NMS Assist
This study looks at a new digital helper called NMS Assist for people with Parkinson's. It aims to help manage common non-motor symptoms like pain and sleep problems, which can really affect daily life. We want to see if it helps people feel more confident and knowledgeable about their symptoms.
United Kingdom - recruitingNA
Network-based biOmarker Discovery of Neurodegenerative Diseases Using Multimodal Connectivity
This study aims to find new, simple ways to spot early signs of Alzheimer's and Parkinson's diseases. Researchers will use special brain scans to look at how different parts of the brain connect, hoping to find unique patterns that point to these conditions sooner.
France - not yet recruitingNA
Minimal Electrophysiology and Imaging Enhanced Deep Brain Stimulation
This study looks at making Deep Brain Stimulation (DBS) surgery for Parkinson's disease simpler and safer. Researchers are testing a new method that uses less invasive techniques during surgery, hoping to improve results and make the process easier for patients.
Canada - active not recruitingNA
MST for Parkinson's Disease
This study is testing a new treatment called Magnetic Seizure Therapy (MST) for depression in people with Parkinson's disease. It wants to see if MST is a practical and safe option before it's compared to other treatments in the future. The trial is happening in Canada and involves 20 patients.
Canada - recruitingNA
Study in Parkinson Disease of Exercise
This study looks at how treadmill exercise affects people with early Parkinson's disease who haven't started medication. Participants will walk on a treadmill at different intensities four times a week for a year to see if it slows down their Parkinson's symptoms.
United States · Canada - not yet recruitingNA
Prevention of Medical, Social, and Psychosocial Risks Following a Parkinson's Disease Diagnosis: A Pilot Study
This study looks at a new way to support people newly diagnosed with Parkinson's disease and their families. It uses questionnaires and tools like booklets and a website to help manage the medical, social, and emotional challenges that can come with the diagnosis.
France