- active not recruitingNA
Minimally-invasive Non-surgical and Surgical Periodontitis Treatment
This study compares two ways to treat severe gum disease where bone around teeth is damaged. One is a gentle, special cleaning, and the other is a small gum operation. We want to see which one helps repair the bone and improves gum health better.
United Kingdom - not yet recruitingNA
Endo-perio Disease - Treatment Outcomes Using Conventional and Hydraulic Calcium Silicate Sealer With or Without LPRF
This study looks at new ways to treat a complex dental problem where both the tooth's inside (pulp) and surrounding gums/bone are affected. It compares existing treatments with new materials and a special healing boost from your own blood to see which works best.
United Kingdom - recruitingNA
Hyaluronic Acid and Octenidine Gel as an Adjunct to Non-surgical Periodontal Treatment
This study looks at a new gel for gum disease. It combines hyaluronic acid and octenidine with standard gum treatment to see if it helps gums heal better. We'll check healing signs, bacteria, and how patients feel over three months.
United Kingdom - recruiting
PERIODONTAL HEALTH IN PATIENTS ACUTELY ADMITTED FOR MYOCARDIAL INFARCTION: A CASE CONTROL STUDY
This study looks into whether gum disease might be linked to heart attacks. Researchers will compare the gum health of people who recently had a heart attack with those who haven't, to see if there's a connection. This could help find new ways to prevent heart attacks.
United Kingdom - authorisedHuman Pharmacology (Phase I)- Other
A monocentric Phase I pivotal pharmacology study for the determination of the local and systemic exposure of locally applied Minocycline in periodontal pockets via a newly developed pharmaceutical formulation for the treatment of patients with recurrent or persistent periodontitis
This study is testing a new minocycline gel to treat gum disease (periodontitis). It's looking at how much of the medicine gets into the gums and the body. The goal is to see if this new treatment works well and is safe for adults with ongoing gum problems.
Germany - recruiting
Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodontal Disease (PostNCT07164573)
This study checks new ways to spot gum disease early. It compares different tests like questionnaires, photos, and saliva tests against a thorough dental check-up. The goal is to find better, simpler ways to diagnose gum problems for people aged 18 and over.
China · Italy · United Kingdom - recruitingNA
MICRO-SURG: Subgingival Microbiome in Peri-Implantitis, Regenerative, and Resective Periodontal Surgery
This study looks at how mouth bacteria change after gum surgery for gum disease or issues around dental implants. We want to see if different surgeries cause different changes to these bacteria, hoping to improve future treatments.
Germany - recruitingNA
A Pilot Study to Test the Efficacy of a Commercial Toothpaste (Cosmetic Product)
This study is testing a new toothpaste for gum disease. It aims to see if a normal-looking toothpaste with a special ingredient can help keep your mouth healthy and reduce problems with gum disease over three months.
Germany - not yet recruitingNA
Inflammation-resolution Therapy in MINST of Periodontal Intrabony Defect: a Pilot Randomised Controlled Trial
This study looks at whether a special mouthwash, combined with deep cleaning, can better treat severe gum disease. We want to see if it helps gums heal more effectively by reducing inflammation.
United Kingdom - active not recruitingNA
Non-surgical vs. Surgical Therapy for Periodontal Furcations
This study looks at the best way to treat advanced gum disease affecting the roots of back teeth (molars). Researchers are comparing non-surgical and surgical treatments to see which works best at saving these teeth from being lost.
United Kingdom - not yet recruitingNA
PROSpECT-PRIOR-2-CHEMO: PRIOR Dental Intervention Before Chemo to Reduce Chemotherapy Complications
This study looks at whether checking and treating dental problems before chemotherapy for blood cancers can reduce side effects like mouth sores and infections. It aims to see if this dental care plan, called PRIOR, is safe and can work in hospitals.
United Kingdom - recruiting
Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control Study
This study looks at the germs in the mouths of older people, comparing those with and without Alzheimer's disease. Researchers hope to find a link between mouth germs and Alzheimer's to help with early detection and understanding of the disease.
France