- recruiting
A global study of pleural infection causes, management, and outcomes
This global study, INTERMITTENT, aims to understand why and how lung infections (pleural infections) happen, how they're treated around the world, and what helps patients recover best. Researchers hope to improve care for this serious condition.
United Kingdom · England - active not recruiting
Pleural Fluid Neutrophil Extracellular Traps Exacerbate Disease Severity and Risk of One-year Mortality in Pleural Infection (TORPIDS-3)
This study looks at how certain tiny particles in fluid around the lungs, called neutrophil extracellular traps, affect how serious a lung infection is and the risk of dying within a year. It's an international study observing people with lung infections.
United Kingdom - completed
A randomised study to assess the feasibility of treating patients with pleural infection according to the RAPID score, compared with usual care based on the British Thoracic Society Pleural Disease Guidelines
This study looks at how best to treat a serious chest infection called pleural infection. Researchers are comparing standard care with a new method using a scoring system called RAPID to guide treatment, aiming for better patient outcomes.
United Kingdom · England - not yet recruitingPhase IV
The Fourth Multicentre Intrapleural Sepsis Trial (MIST-4) - a randomised clinical randomised effectiveness study comparing early video assisted thoracic surgery and early intrapleural enzyme therapy in adult patients with pleural infection
This study compares two treatments for lung infection: enzyme therapy and keyhole surgery. Both aim to clear fluid around the lungs. This trial will help doctors understand which treatment works best, ensuring patients get the most effective care for this serious condition.
United Kingdom · England