- recruitingPHASE1, PHASE2
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
This study is testing a new drug, rezatapopt, for advanced cancers with a specific gene change (TP53 Y220C). It's also looking at rezatapopt with another drug, pembrolizumab, to see how safe and effective they are. It’s for people who have already had cancer treatment.
United States · Australia · France - active not recruitingPHASE1, PHASE2
A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.
This study is looking at new drug combinations for advanced cancers like ovarian, breast, lung, and stomach cancer. It checks how safe and effective they are, and how they work in the body.
United States · France · Israel - recruiting
Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS)
This study is looking at a new way to give radiotherapy using a special machine called ETHOS. It aims to make radiotherapy more accurate by adjusting treatment daily for cancers like prostate or head and neck, potentially improving how well it works and reducing side effects.
Germany - recruitingPHASE1, PHASE2
First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
This study is testing a new drug called TUB-030 for adults with advanced solid cancers. Researchers want to see if it's safe, how well it works, and find the right dose. It's a first step to understand if TUB-030 could be a future treatment.
United States · Canada · Romania