- ongoing, recruitingTherapeutic exploratory (Phase II)
Safety and efficacy of once-weekly subcutaneous and once-daily oral NNC0487-0111 in participants with type 2 diabetes – a dose finding study
This study is testing a new medicine, NNC0487-0111, for people with type 2 diabetes. It's looking at different ways to take the medicine (once a week shot or once a day pill) to see how safe and effective it is at controlling blood sugar.
Romania · Spain · Poland - recruiting
Pancreas lipotoxicity in type 2 diabetes: Edinburgh Diabetes Remission Study (EDRS)
This study, the Edinburgh Diabetes Remission Study (EDRS), is looking at how fat in the pancreas affects type 2 diabetes. It wants to see if losing weight can reverse the condition. Participants will follow a special low-calorie diet to help researchers understand these changes.
United Kingdom · Scotland - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase 1 study assessing the pharmacokinetics of NEX-22A in subjects with T2D
This early-stage study is for people with type 2 diabetes. It's looking at how a new medicine, NEX-22A, moves through the body. The main goal is to understand how the body handles this new treatment.
Germany - ongoing, recruitingTherapeutic use (Phase IV)
DiEtary Sodium Intake effects on ertugliflozin-induced changes in GFR, reNal oxygenation and systemic hemodynamics: the DESIGN study, a randomized, placebo-controlled, cross-over study with ertugliflozin in people with type 2 diabetes.
This study looks at how different salt levels in your diet affect a type 2 diabetes drug called ertugliflozin (Steglatro) and your blood pressure. We're comparing recommended salt intake with a higher salt diet in people with type 2 diabetes who are overweight or obese.
Netherlands - recruitingNA
Low EnerGy DiEt iN Adolescents With Obesity and Type 2 Diabetes: The LEGEND Study
This study looks at how a special low-energy diet helps teenagers with obesity and type 2 diabetes. It aims to see if they can lose enough weight to reverse their diabetes and how easy it is for them to stick with the diet.
United Kingdom - completed
Women’s Wellness Type 2 Diabetes Programme in the UK
This study looks at a 12-week online programme for women aged 45-65 with Type 2 diabetes in the UK. It aims to see if the programme helps improve their health, wellbeing, and diabetes management through an e-Book, podcasts, and peer support.
United Kingdom · England - ongoing, recruitingTherapeutic confirmatory (Phase III)
A 40-week study comparing the efficacy, safety and patient-reported outcomes of once weekly IcoSema and once or twice daily insulin degludec/insulin aspart 100 units/mL, both treatment arms with or without oral anti-diabetic drugs, in participants with type 2 diabetes inadequately controlled with daily pre-mixed insulin. COMBINE 5
This 40-week study looks at two different insulin-based treatments for adults with type 2 diabetes that isn't well-controlled. It compares a new once-weekly injection (IcoSema) with an existing daily or twice-daily insulin (Ryzodeg) to see which is more effective and safer.
Poland - recruiting
The effect of text reminders on the uptake of type 2 diabetes screening test after gestational diabetes
This study looks at whether sending text messages helps women who've had diabetes in pregnancy (gestational diabetes) remember to get their yearly check-up for type 2 diabetes. Catching it early can help keep them healthier in the long run.
United Kingdom · England - active not recruitingPHASE4
A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
This study looks at a new treatment called tirzepatide for people with type 2 diabetes. It's compared to standard care to see how well it works and if it's safe when started early. The goal is to improve blood sugar control for those with type 2 diabetes.
United States · Argentina · Canada - recruitingPHASE3
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)
This study looks at a new medicine for adults with overweight or obesity and type 2 diabetes. It aims to see if the medicine helps with weight loss and is safe. The medicine is given as a weekly injection under the skin.
United States · Argentina · Bulgaria - recruitingPHASE2
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
This study is looking into a new medication, LY3457263, for people with Type 2 Diabetes whose blood sugar levels are still high despite taking other common diabetes medicines like semaglutide or tirzepatide. It will compare the new drug with a dummy treatment (placebo).
United States · Canada · Germany - recruiting
Nottingham Community Liver Biomarkers Cohort
This study in Nottingham looks at improving how we find liver disease early in the community. It involves people with risk factors like heavy alcohol use, obesity, or diabetes, to see if new blood and scan tests can help identify liver problems before they become serious.
United Kingdom - completed
How a low-carbohydrate diet affects blood sugar and health in people living with type 2 diabetes: results from a real-life study
This study looks at how a low-carbohydrate diet helps people with type 2 diabetes manage their blood sugar and improve their health over 6 months. It involves an online program and checks on diet, weight, and blood sugar levels.
United Kingdom · England - authorisedTherapeutic use (Phase IV)
A multicenter, register-based, randomized, controlled trial comparing dapagliflozin with metformin treatment in early stage type 2 diabetes patients by assessing mortality and macro- and microvascular complications
This study compares two common diabetes medicines, dapagliflozin and metformin, for people recently diagnosed with type 2 diabetes. We want to see how these medicines affect serious health problems like heart attacks, strokes, kidney issues, and overall health over time.
Sweden - authorisedTherapeutic use (Phase IV)
EFFectiveness of once-weekly insulin ICodec versus once-daily basal Insulin analogues in an insulin-naïve type 2 diabEtes population in real-world cliNical pracTice- The EFFICIENT pragmatic study
This study looks at different insulin treatments for people with type 2 diabetes who are just starting insulin. It compares a new once-weekly insulin called Icodec with other daily insulins people usually take. The aim is to see how well they work in real life and how easy they are to use.
Germany · Italy - recruitingNA
Pancreas Lipotoxicity in T2D: Edinburgh Diabetes Remission Study (EDRS)
This study in Edinburgh looks at how fat in the pancreas affects type 2 diabetes and if losing weight can reverse it. Participants will follow a special diet to lose weight, helping researchers understand how the body changes and improves.
United Kingdom - enrolling by invitation
Sweet Sensing in Type 2 Diabetes
This study looks at how people with type 2 diabetes and prediabetes sense sweetness. We want to understand if changes in taste and brain activity affect sugar cravings. This could help develop new ways to manage blood sugar.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4/2.4 mg and 1.0/1.0 mg once weekly versus semaglutide 2.4 mg and 1.0 mg, cagrilintide 2.4 mg and placebo in participants with type 2 diabetes inadequately controlled on metformin with or without an SGLT2 inhibitor
This study is testing a new combination medicine, CagriSema, for people with type 2 diabetes. It's looking at whether this combined medicine is better at controlling blood sugar and helping with weight loss than existing treatments, including its individual components, semaglutide and cagrilintide.
Denmark · Sweden · Slovakia - active not recruitingNA
Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure
This study looks at a new way to find hidden heart failure in people with diabetes who are at higher risk. We're testing if checking a specific blood marker helps doctors discover heart problems earlier, so people can get the right care sooner.
United Kingdom - recruiting
Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction
This study looks at why people with a type of heart failure called HFpEF, especially those with Type 2 Diabetes, get so unwell. Using special MRI scans and dyes, researchers want to see how their hearts handle calcium and energy, comparing them to healthy volunteers.
United Kingdom - ongoing, recruitingTherapeutic confirmatory (Phase III)
J2A-MC-GZGW: A Phase 3, Randomized, Double-Blind Study to Investigate the Efficacy and Safety of Once Daily Oral Orforglipron Compared with Placebo in Adult Participants with Type 2 Diabetes and Inadequate Glycemic Control with Insulin Glargine, with or without Metformin and/or SGLT-2 Inhibitor (ACHIEVE-5)
This study is looking into a new daily tablet, orforglipron, for adults with type 2 diabetes. We want to see if it's better than a dummy pill at helping control blood sugar when taken with insulin glargine and other diabetes medicines.
Romania - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Investigation of safety, tolerability and pharmacokinetics of multiple doses of NNC0113‑6856 in healthy participants, including a subset of healthy Japanese participants
This study is testing a new medicine, NNC0113-6856, in healthy people, including some of Japanese background. We want to see how safe it is, how well bodies handle it, and what happens to the medicine inside the body after taking different doses.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
A 40-week study comparing the efficacy and safety of once weekly IcoSema and daily insulin glargine 100 units/mL in participants with type 2 diabetes inadequately controlled on oral anti diabetic drugs. COMBINE 4
This study looks at a new once-a-week insulin treatment, IcoSema, for people with type 2 diabetes whose blood sugar isn't well controlled by their current medicines. It compares IcoSema to a daily insulin, glargine, to see which is better and safer.
Greece · Italy · Poland - ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4 mg/2.4 mg and 1.0 mg/1.0 mg once weekly versus placebo in participants with type 2 diabetes as add on to once-daily basal insulin with or without metformin
This study is looking at a new combination medicine, CagriSema, for people with type 2 diabetes. We want to see how well it helps control blood sugar and manage weight, alongside their usual insulin and other diabetes medicines.
Slovakia - ongoing, recruitingHuman Pharmacology (Phase I)- Other
Investigating how CagriSema, semaglutide and cagrilintide regulate insulin effects in the body of people with type 2 diabetes.
This study looks at how new medicines, CagriSema and its parts (semaglutide and cagrilintide), work in people with type 2 diabetes. Researchers want to understand how these medicines affect the body's use of insulin and sugar.
Germany - ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4 mg/2.4 mg and 1.0 mg/1.0 mg once weekly versus placebo in participants with type 2 diabetes inadequately controlled on diet and exercise.
This study is testing a new combination medicine for people with type 2 diabetes who haven't fully managed their blood sugar with diet and exercise. It looks at how well the medicine works to lower blood sugar and help with weight loss over 40 weeks.
Italy · Hungary · Poland - ongoing, recruitingTherapeutic confirmatory (Phase III)
PIONEER TEENS Efficacy and safety of oral semaglutide versus placebo both in combination with metformin and/or basal insulin in children and adolescents with type 2 diabetes.
This study is looking at a medicine called Rybelsus for teenagers with type 2 diabetes. It wants to see if Rybelsus, taken with other common diabetes medicines, helps control blood sugar and is safe. The study compares Rybelsus to a dummy pill to understand its effects better.
Greece · Czechia · Portugal - enrolling by invitation
PDE3B in Metabolic Regulation
This study looks at how a protein called PDE3B affects how our bodies handle sugar and fat. Researchers want to understand if changes in this protein could protect people from conditions like type 2 diabetes and heart disease, potentially leading to new treatments.
United Kingdom - enrolling by invitationNA
Free Fatty Acid Effects In Type 2 Diabetes
This study looks at how omega-3 fatty acids, found in oily fish, might help people with type 2 diabetes and heart problems. Researchers want to see if omega-3s can improve blood sugar and reduce the risk of heart disease, as they are a natural and potentially safe option.
United Kingdom - ongoing, recruitingTherapeutic use (Phase IV)
A Phase 4, Randomized, Open-Label, Active-Controlled Study to Investigate the Efficacy and Safety of Switching From Weekly Dulaglutide to Weekly Tirzepatide in Adults With Type 2 Diabetes
This study is looking at how well a new medicine, Tirzepatide, works for adults with type 2 diabetes when they switch from another medicine called Dulaglutide. Researchers want to see if the new medicine helps lower blood sugar and improve other health markers like weight.
Romania · Germany · Belgium - ongoing, recruitingHuman Pharmacology (Phase I)- Other
A research study comparing the effect of different dosing conditions on blood levels of semaglutide in a new tablet composition in healthy participants
This study is looking at a new tablet for type 2 diabetes. It aims to see how different amounts of the medicine, semaglutide, affect its levels in the blood of healthy male volunteers.
Germany - recruitingNA
Targeting Risk Factors for Diabetes in Subjects With Normal Blood Cholesterol Using Omega-3 Fatty Acids
This study looks at how omega-3 from fish oil might help prevent type 2 diabetes. Researchers are exploring if lowering 'bad cholesterol' in a certain way can increase diabetes risk, and if omega-3 can help counteract this in some people.
Canada - recruitingNA
Improving Insulin Sensitivity in Patients With Type 2 Diabetes Via Repeated Cold-induced Shivering Thermogenesis
This study looks at whether getting a little cold and shivery could help people with Type 2 Diabetes manage their blood sugar and heart health better. Researchers believe regular, mild shivering might improve how the body uses insulin, offering a new way to support health alongside diet and exercise.
Canada - authorisedPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2 Open-Label, Single Ascending Dose, First-In-Human Study to Assess Safety and Tolerability of Endoscopic Ultrasound-Guided Pancreatic Infusion of RJVA-001 in Adults With Inadequately Controlled Type 2 Diabetes on Multiple Glucose-Lowering Agents.
This study is testing a new treatment, RJVA-001, for adults with Type 2 diabetes that isn't well-controlled. It's the first time this treatment is being given to people. Doctors want to see if it's safe, what dose works best, and how it affects blood sugar.
Netherlands - recruitingNA
Improving Kidney Care in Type 2 Diabetes: A Study of Pharmacist Prescribing Versus Usual Care
This study checks if pharmacists using special guides can help people with type 2 diabetes and early kidney damage get the right medicines. It compares this to standard care for those without a regular doctor, aiming to improve long-term health.
Canada - active not recruitingPHASE4
Combined Active Treatment in Type 2 Diabetes with NASH
This study is looking at new ways to treat a liver condition called NASH in people with type 2 diabetes. We're testing two medicines, empagliflozin and semaglutide, to see if they can help improve liver health. This is important because there are currently no specific treatments for NASH.
Austria · Germany - recruiting
The European NAFLD Registry
This study aims to understand fatty liver disease (NAFLD) better. Researchers collect information and samples from patients across Europe to find new ways to detect and monitor the disease, especially how it progresses from fatty liver to more serious conditions like fibrosis.
Belgium · Finland · France - not yet recruitingNA
Community-integrated Nutrition Education to Prevent Type 2 Diabetes in Peel
This study in Peel, Ontario, explores if healthy eating and community gardening can lower the risk of type 2 diabetes. It teaches a special diet and includes gardening to help people stay healthy and prevent this condition.
Canada - recruitingNA
Glucose Monitoring After Acute Myocardial Infarct in People With Diabetes
This study looks at how using a special glucose monitor (Dexcom ONE) might help people with type 2 diabetes manage their blood sugar after a heart attack. It aims to see if better blood sugar control improves health over six months.
United Kingdom - recruitingNA
GLycaemic Outcomes With Whey Protein in ageING
This study looks at whether whey protein taken before meals can help older adults (75-90) with Type 2 Diabetes manage their blood sugar levels better. Participants will try different doses of whey protein and a harmless dummy powder.
United Kingdom - recruiting
Global Research Initiative for Patients Screening on MASH
This study aims to improve how doctors find serious liver conditions like MASH in people with health problems like diabetes or obesity. It brings together healthcare providers across Europe to use new care guidelines and raise awareness about these liver diseases.
Belgium · Czechia · France - recruitingNA
taRgeting bEtA-Cell Function To achIeVe Remission of Type 2 diAbeTEs
This study looks at a new way to help people with newly diagnosed Type 2 diabetes. It compares a special automated insulin device with standard care to see if it can help put diabetes into remission, meaning you might not need medication.
United Kingdom - recruitingNA
PROTeIn-rich Meals to Control Glucose
This study looks at how different eating patterns might help people with prediabetes or type 2 diabetes manage their blood sugar. Researchers are comparing two diets to see which is better for controlling sugar levels and body inflammation.
Germany - recruiting
Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass
This study looks at how a medicine called semaglutide (Ozempic/Wegovy®) affects your heart and muscles over a year. Researchers use special scans and tests to understand if it helps keep your muscles healthy, especially if you have type 2 diabetes or obesity.
Canada - not yet recruitingNA
Effects of HIIT Following PTR Programme
This study looks at whether a home-based exercise program (HIIT) can help people who have put their Type 2 diabetes into remission to stay diabetes-free for longer. It compares this special exercise with usual care after completing the NHS Path to Remission program.
United Kingdom - active not recruitingPHASE3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
This study is looking at a new medicine called orforglipron for people with obesity or who are overweight and have type 2 diabetes. It wants to see how well it helps control blood sugar compared to a dummy medicine, called a placebo.
United States · Argentina · China - enrolling by invitationNA
Effects of Dried Whole Fruits on Metabolism in Diabetes
This study looks at whether eating dried Saskatoon berries can help people with prediabetes or new type 2 diabetes manage their blood sugar and gut health, compared to eating dried apple slices.
Canada - recruitingNA
Time Restricted-EAting for Type 2 Diabetes and MEtabolic Health: the TEA TIME Trial
This study looks at how 'time-restricted eating' (eating only within certain hours) affects type 2 diabetes. Researchers want to see if it helps manage blood sugar and improves how the body uses insulin, especially for people recently diagnosed with type 2 diabetes.
Canada - recruiting
Capillary OGTT Study
This study is looking for new, easier ways to test for diabetes (Type 1 and Type 2) in children and young people. Instead of tricky hospital blood tests, we want to see if finger-prick tests at home or skin sensors can give reliable results.
United Kingdom - not yet recruitingNA
A Multi-centre Trial to Assess the Efficacy and Safety of the Omnipod 5 System in People With Type 2 Diabetes Undergoing Haemodialysis
This study looks at a new automated insulin system, Omnipod 5, for people with type 2 diabetes and advanced kidney failure on dialysis. It aims to see if it improves blood sugar control and quality of life compared to usual care.
United Kingdom