Latest studies
- Completed
A study of potential treatment-responsive biomarkers and clinical outcomes in Hunter syndrome
This study looked at how Hunter Syndrome affects people over time, including changes in behaviour, thinking abilities, and levels of certain signs in the body. It aimed to understand the condition better and find ways to measure if future treatments are working, without giving any new medicines.
Mucopolysaccharidosis IIUnited States of America - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaUnited States of America - RecruitingPhase III
A long-term extension (LTE) study of guselkumab in pediatric participants
This study looks at the long-term safety of a medicine called guselkumab for children and young people aged 2-17 with Crohn's disease, ulcerative colitis, or a type of arthritis called juvenile psoriatic arthritis. It's for those who have already benefited from guselkumab in a previous study.
Moderately to severely active ulcerative colitis (UC), moderately to severely active Crohn's disease (CD), Juvenile psoriatic arthritis (jPsA)United States of America - RecruitingPhase III
Astria STAR-0215-302 trial for Navenibart in Hereditary Angioedema
This study looks at a new medicine called navenibart for hereditary angioedema (HAE). It aims to see how safe it is and how well people tolerate it over a long time. Navenibart might help prevent HAE attacks, which can be severe and painful.
Hereditary angioedemaUnited States of America - Recruiting
The international ‘100 DU’ study
This study looks at how painful finger and toe sores (digital ulcers) of systemic sclerosis (a rare long-term condition) affect people's daily lives. Researchers want to create a new questionnaire to better understand how these sores make patients feel and function.
Systemic sclerosis (SSc) with active digital ulceration (DU)United States of America - RecruitingPhase III
A study comparing JNJ-79635322 and an anti-B-cell maturation antigen (BCMA)xCD3 bispecific antibody in participants with relapsed or refractory multiple myeloma (Trilogy-4)
This study looks at a new injection called JNJ-79635322 for multiple myeloma that has come back or isn't responding to treatment. We're comparing it to another approved drug, teclistamab, to see if it helps patients aged 18 and over who have tried other therapies.
Relapsed or refractory multiple myelomaUnited States of America - RecruitingPhase I/II
Study of EN-374 gene therapy in participants with X-linked chronic granulomatous disease
This study is testing a new gene therapy called EN-374 for X-linked chronic granulomatous disease (X-CGD). It aims to see if EN-374 is safe and effective in adults first, and then in children. We hope to improve the health of people with this rare immune condition.
X-linked chronic granulomatous diseaseUnited States of America - Completed
Transatlantic registry of type A aortic dissection
This study looks at how people recover after surgery for a serious heart condition called Type A Aortic Dissection. Researchers are collecting information from patients across different hospitals to understand the best ways to treat it and improve outcomes.
Type A aortic dissectionUnited States of America - Recruiting
An international study of therapist-supported online cognitive behavioural therapy for the reduction of repetitive negative thought (overthinking, rumination, worry) in adults: the Calming Minds study
This study explores how online talking therapy (CBT) can help reduce overthinking, worry, and rumination in adults. It compares different versions of CBT to find the most effective parts, aiming to improve mental well-being for many people.
Repetitive negative thought (overthinking, rumination, worry)United States of America - Not yet recruiting
Trial investigating the effects of a brief online uncertainty tolerance training for young people
This study looks at an online training for young people aged 18-24 to help them cope better with everyday uncertainties. It compares two online programs to see if one can reduce worry and improve how young adults handle unsure situations.
Reduction of intolerance of uncertainty and anxiety symptoms in an unselected population (i.e., with or without a psychiatric condition).United States of America - RecruitingPhase I
An early safety study testing a drug combination given before possible surgery for people with pancreatic cancer that can’t be easily removed yet or hasn’t spread far
This study looks at new drug combinations for pancreatic cancer that hasn't spread but is hard to remove. It combines standard chemotherapy with three new medicines to see if they can shrink the cancer before surgery and if they are safe.
Borderline resectable or locally advanced pancreatic ductal adenocarcinoma (PDAC)United States of America - RecruitingPhase I
Safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple doses of ANB033 - Part 1c
This study is testing a new medicine called ANB033 for a condition called Eosinophilic Esophagitis (EoE). Researchers want to check if it's safe, how it works in the body, and if it could help stop the immune system from overreacting in people with EoE.
Eosinophilic Esophagitis (EoE)United States of America - CompletedPhase II
A study of JNJ-95475939 in the treatment of participants with moderate to severe atopic dermatitis
This study is testing a new medicine, JNJ-95475939, for moderate to severe eczema (atopic dermatitis). Researchers want to see how well it works and if it's safe compared to a dummy treatment and an existing medicine. It involves adults aged 18 and over.
Atopic dermatitis (AD)United States of America - CompletedPhase III
A study comparing JNJ-77242113 and ustekinumab in adult participants with moderate to severe plaque psoriasis
This study compares a new medicine, JNJ-77242113, with an existing one, Stelara, for adults with moderate to severe plaque psoriasis. It aims to see how well the new drug works to reduce red, scaly skin patches by targeting a protein involved in inflammation.
Plaque psoriasisUnited States of America - Not yet recruiting
Multi-centre MRI study of the heart microstructure in healthy volunteers
This study uses special MRI scans to look at tiny details of the heart in healthy people. Researchers want to understand how these scans work best and improve them. This information could help spot heart problems earlier and develop new treatments in the future.
Evaluation of cardiac microstructure with cardiac DTIUnited States of America - RecruitingPhase III
A study of nipocalimab in adults with moderate to severe systemic lupus erythematosus
This study is testing a new drug called nipocalimab for adults with moderate to severe lupus (SLE). Researchers want to see if it works better than a dummy drug to reduce symptoms. It involves regular visits and monitoring over several years.
Systemic lupus erythematosusUnited States of America - Not yet recruitingPhase II
A study testing two targeted medicines, bomedemstat, which helps normalise blood cell development, and momelotinib, which reduces symptoms and anaemia, to see whether the combination is safe and effective for people with myelofibrosis
This study looks at combining two medicines, bomedemstat and momelotinib, for people with myelofibrosis. It aims to see if this combination is safe and helps more than momelotinib alone, especially for those whose first treatment isn't working well.
MyelofibrosisUnited States of America - Recruiting
Evaluation of self-initiated humour protocol
This study explores a new digital humour program called SIHP to boost your emotional well-being. It involves daily exercises and weekly lessons over eight weeks, using a virtual coach to help you laugh more and feel better.
Emotional well-beingUnited States of America - RecruitingPhase III
JNJ-90301900 (NBTXR3) activated by radiotherapy with or without cetuximab in LA-HNSCC
This study looks at a new treatment called JNJ-90301900 with radiotherapy, sometimes with another drug called cetuximab. It's for older patients with a type of head and neck cancer who can't have standard chemotherapy.
Locally advanced head & neck squamous cell carcinomaUnited States of America - CompletedNot Applicable
Strength gel with Kaempferia Parviflora Extract for improving the appearance of cellulite.
This study is testing a new body gel designed to improve the look of cellulite. We want to see if the gel can really make cellulite less noticeable and if it's safe to use. Women aged 25-75 with cellulite can take part.
CelluliteUnited States of America - CompletedPhase II
A long-term extension study of JNJ-81201887 (AAVCAGsCD59) parent studies in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD)
This study looks at the long-term safety of a new gene therapy, JNJ-81201887, for Geographic Atrophy (GA), a severe eye condition. It involves people who previously took part in earlier studies of this treatment, to see how they are doing over several years.
Geographic Atrophy, secondary to age-related macular degenerationUnited States of America - Recruiting
Improving hormonal infertility treatment for men with hypogonadotropic hypogonadism
This study looks back at records of men with hypogonadotropic hypogonadism, a type of male infertility. Doctors want to find the best hormone treatment to help these men and their partners get pregnant. No new patients are needed for this study.
Infertility due to hypogonadismUnited States of America - Recruiting
Security and effectiveness assessment of locking systems in ventriculostomy for traumatic brain injury
This study looks at new ways to treat serious head injuries by comparing two methods for draining fluid from the brain. It aims to make a procedure called ventriculostomy safer and more effective, especially for preventing complications like infections or the drain moving out of place.
Intracranial compartment syndrome in traumatic brain injury patientsUnited States of America - RecruitingPhase I
A study of JNJ-78278343 in combination with JNJ-95298177 for treatment of prostate cancer
This study is testing two new medicines, JNJ-78278343 and JNJ-95298177, together for advanced prostate cancer. Researchers want to find the safest and most effective dose in men whose cancer has spread and is no longer responding well to standard hormone treatments.
Prostate cancerUnited States of America - Completed
Does removing both ovaries prior to menopause reduce breast cancer risk in BRCA1 and BRCA2 mutation carriers?
This study looks at existing health records to see if removing ovaries and fallopian tubes before menopause reduces breast cancer risk for women with BRCA1 or BRCA2 gene changes. It aims to understand if these operations help prevent cancer in these women.
Breast cancerUnited States of America - CompletedPhase I
A study of Pasritamig (JNJ-78278343) in combination with JNJ-86974680 for treatment of prostate cancer
This study is testing two new drugs, Pasritamig and JNJ-86974680, together for men with advanced prostate cancer. Researchers want to find the safest dose and see if it helps fight the cancer. It's a very early-stage trial.
Prostate cancerUnited States of America