- Ongoing, recruitingTherapeutic exploratory (Phase II)
Myocarditis Therapy with IL-1 inhibitor (MYTH-1): a double-blind, phase IIa, placebo controlled, randomized clinical trial to evaluate the efficacy and safety of anakinra in addition to standard of care for the treatment of virus-negative myocarditis.
This study looks at a new treatment called anakinra for a heart condition called myocarditis. It aims to see if anakinra, given alongside usual care, can help improve heart function in adults whose myocarditis isn't caused by a virus.
For: endomyocardial biopsy (EBM)-proven virus-negative myocarditisItaly - RecruitingNot Applicable
Assessing changes in an inflammation signal (interleukin 1) in vestibular schwannoma
This study looks at how a drug called anakinra might help people with a type of brain tumour called vestibular schwannoma. We want to find the best ways to see if the drug is working by checking inflammation markers and tumour changes before and after treatment.
For: Vestibular schwannomaUnited Kingdom · England - RecruitingPHASE3
Randomised Evaluation of COVID-19 Therapy
The RECOVERY trial looks at treatments for serious lung infections like pneumonia, including COVID-19. It helps doctors find the best ways to help hospitalised patients get better and reduce their risk of dying. Many treatments have been tested, and some have been found to be very helpful.
For: PneumoniaBelgium · Estonia · France - RecruitingPHASE3
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
This study, called REMAP-CAP, looks at different treatments for serious lung infections like pneumonia, flu, and COVID-19 in adults needing intensive care. It aims to find out which treatments work best to help patients recover.
For: Community-acquired Pneumonia, Influenza, COVID-19United States · Australia · Belgium - Not yet recruitingPHASE3
COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"
This study looks at two existing drugs, anakinra and tocilizumab, to treat a rare, severe seizure condition called NORSE. It aims to find out which drug works better and when it should be given, as NORSE doesn't respond to usual treatments.
For: New Onset Refractory Status Epilepticus · New-Onset Refractory Status Epilepticus · Febrile Infection-Related Epilepsy Syndrome (FIRES)United States · Canada · France - AuthorisedTherapeutic exploratory (Phase II)
THRILL: Treat Hyperinflammation in child oncology study - A single arm, historically controlled, open label phase II study on the efficacy and safety of the recombinant interleukin (IL)-1R antagonist anakinra in pediatric cancer patients admitted to the intensive care with sepsis and signs of hyperinflammation
This study is investigating a new treatment called anakinra for seriously ill children with cancer who have dangerous inflammation and infection. It aims to see if anakinra, given early, can help more children survive compared to standard care, by calming the body's overreaction.
For: Hyperinflammation, SepsisNetherlands - RecruitingPHASE3
Randomized Controlled Trial in Patients on Long-term Colchicine With Colchicine-resistant Familial Mediterranean Fever (FMF) to Evaluate the Efficacy of On-demand Anakinra Treatment for Painful Attacks in Patients Who Refuse Continuous Daily Therapy
This study looks at a new way to treat painful flare-ups in Familial Mediterranean Fever (FMF) for people whose usual medicine, colchicine, isn't enough. It tests if taking Anakinra only when an attack happens, along with colchicine, helps more than just pain relief.
For: FMFFrance - RecruitingPHASE2
A Study to Evaluate Safety and Efficacy of Subcutaneous Administration of Anakinra in Patients With CF
This study is testing a medicine called anakinra for people aged 12 and over with cystic fibrosis (CF). Researchers want to see if it helps improve lung health and is safe to use. It's an early-stage study to understand its effects better.
For: Cystic Fibrosis, 10011762Germany - Recruiting
Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants
This study looks at how medicines mothers take get into breast milk and affect their babies. We need breastfeeding mums taking common drugs to help us learn more about drug levels in milk and babies, to ensure safer choices for mums and their infants.
For: Lactating Women on Select DOI · Breastfed Infants of Mothers on Select DOIUnited States · Canada