- RecruitingPHASE2
A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
This study is testing a new combination of medicines for advanced bowel cancer. It aims to see how safe and effective a new drug, telisotuzumab adizutecan, is when given with standard treatments. The study will look at side effects and whether the cancer activity changes.
For: Metastatic Colorectal CancerUnited States · Australia · Austria - RecruitingPHASE1
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
This study is looking at a new medicine, AMG 410, for cancers with a specific change called KRAS. We want to see how safe it is, how it works in the body, and if it helps shrink tumors, both on its own and with other medicines.
For: KRAS Altered Advanced or Metastatic Solid TumorsUnited States · Australia · Belgium - RecruitingPHASE3
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
This study is for people with advanced bowel cancer that has spread and has a specific gene change called KRAS p.G12C. It compares a new combination of treatments to standard treatment to see if it can better stop the cancer from growing.
For: Metastatic Colorectal CancerUnited States · Argentina · Australia - RecruitingPHASE1, PHASE2
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
This study is testing a new medicine called S241656 for people with certain advanced cancers, including lung, bowel, and pancreatic cancers. It aims to find a safe and effective dose, either alone or with other treatments, for cancers with specific genetic changes.
For: Non-small Cell Lung Cancer · Histiocytic Neoplasm · HistiocytosisUnited States · Denmark · Hong Kong - Active not recruitingPHASE1
Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)
This study is looking into new ways to treat advanced cancers that have a specific genetic change called KRAS p.G12C. It's testing a drug called sotorasib, either by itself or with other treatments, to see how safe and effective they are for adults.
For: Advanced Solid Tumors · Kirsten Rat Sarcoma (KRAS) pG12C MutationUnited States · Australia · Austria - RecruitingPHASE2
A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation
This study looks at continuing treatment with sotorasib, sometimes with a drug called panitumumab, for people with advanced cancers that have a specific genetic change (KRAS p.G12C). It checks how safe the treatments are and if they're well-tolerated.
For: Advanced Solid TumorsUnited States · Australia · France - RecruitingPHASE1
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
This study is testing a new drug, ASP5834, for adults with certain solid cancers. It aims to find the right dose and check for side effects, sometimes given with another cancer drug called panitumumab, especially for bowel cancer.
For: Solid Tumor · Non-Small-Cell Lung Cancer · Pancreatic Ductal AdenocarcinomaUnited States · France · Japan - RecruitingPHASE3
Systemic Oxaliplatin or Intra-arterial Chemotherapy Combined With LV5FU2 +/- Irinotecan and an Target Therapy in First Line Treatment of Metastatic Colorectal Cancer Restricted to the Liver
This study is looking at a new way to treat bowel cancer that has spread only to the liver. It combines standard chemotherapy with newer targeted drugs, and a special way of delivering chemotherapy directly to the liver, to see if it works better.
For: Colorectal NeoplasmsBelgium · France - RecruitingPHASE3
The Sagittarius Trial
This study looks at new ways to treat colon cancer after surgery to stop it coming back. It uses advanced tests called 'liquid biopsies' to help doctors choose the best treatment for each person, aiming for better results and fewer side effects.
For: Colon Cancer Stage II · Colon Cancer Stage IIIGermany · Italy · Spain