- RecruitingPHASE2
A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis
This study is looking into a new medicine called Ianalumab for people in the UK with a specific type of scleroderma called diffuse cutaneous systemic sclerosis. It aims to see if the drug is safe and helps with symptoms, compared to a dummy treatment.
For: Diffuse Cutaneous Systemic SclerosisUnited States · Argentina · Austria - Not yet recruitingNA
The YOU-Fish Study: Fish and Omega 3 Supplementation in Young Adults
This study looks at how eating more fish or taking omega-3 supplements can improve heart health in young adults. We want to see if these changes can boost your body's omega-3 levels, which are linked to a lower risk of heart disease later in life.
For: Cardiovascular PreventionUnited Kingdom - Active not recruitingPHASE2
A Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's Disease
This study is looking into a new treatment called prasinezumab for people in the early stages of Parkinson's disease. Researchers want to see if it's safe and helps improve symptoms. Participants will either receive the new medicine or a dummy treatment, called a placebo.
For: Parkinsons DiseaseUnited States · Austria · Canada - Active not recruitingPHASE2
Trial of Efficacy and Safety of NS-229 Versus Placebo in Patients With Eosinophilic Granulomatosis With Polyangiitis
This study is looking into a new medication called NS-229 for Eosinophilic Granulomatosis with Polyangiitis (EGPA), also known as Churg-Strauss Syndrome. We want to see if NS-229 is safe and effective compared to a dummy treatment (placebo) when added to usual care.
For: Eosinophilic Granulomatosis With Polyangiitis · Churg-Strauss SyndromeUnited States · Canada · France - Active not recruitingPHASE3
Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD
This study is looking into a new medication called Pelacarsen. It aims to see if this medicine can help people with heart disease who have high levels of a specific type of 'bad' cholesterol (Lipoprotein(a)) reduce their risk of future heart problems.
For: Cardiovascular Disease and Lipoprotein(a)United States · Argentina · Australia - RecruitingPHASE3
Efficacy, Safety, and Tolerability Study of Lunsekimig Compared With Placebo in Adult Participants With Inadequately Controlled Chronic Obstructive Pulmonary Disease (COPD) Characterized by an Eosinophilic Phenotype
This study is testing a new medicine, lunsekimig, for adults aged 40-80 with COPD that's not well-controlled. We want to see if it helps improve breathing, is safe, and has manageable side effects compared to a dummy medicine.
For: Chronic Obstructive Pulmonary DiseaseUnited States · Argentina · Brazil - RecruitingPHASE3
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
This study looks at a new medicine called zilebesiran for people with high blood pressure that isn't well controlled, especially if they also have heart problems or are at high risk of developing them. The aim is to see if zilebesiran can reduce serious heart-related events like heart attacks or strokes.
For: High Risk Cardiovascular Disease · Hypertension · High Cardiovascular RiskUnited States · Argentina · Australia - RecruitingPHASE2
Trial of Mirtazapine for Depression in IBD
This study is testing if it's practical to run a larger trial for people with both depression and a bowel condition. We'll see if a depression tablet called mirtazapine helps, compared to a dummy pill. It's a first step to understand if this treatment could be useful.
For: Major Depressive Disorder · Inflammatory Bowel DiseasesUnited Kingdom - Active not recruitingPHASE2, PHASE3
A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
This study investigates an injection called litifilimab for adults with active lupus that mainly affects the skin, known as cutaneous lupus erythematosus (CLE). Researchers want to see if it helps reduce skin symptoms and is safe, especially for those whose current treatments aren't working well.
For: Subacute Cutaneous Lupus Erythematosus · Chronic Cutaneous Lupus ErythematosusUnited States · Argentina · Belgium - Active not recruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Zilganersen (ION373) in Patients With Alexander Disease (AxD)
This study is testing a new medicine, zilganersen, for people with Alexander Disease. It aims to see if the medicine is safe and if it can help improve or steady movement abilities. It's a large study, comparing the medicine to a dummy treatment (placebo).
For: Alexander DiseaseUnited States · Australia · Canada - RecruitingPHASE2
Brivekimig for the Treatment of Moderate to Severe Hidradenitis Suppurativa
This study is testing a new medicine called brivekimig for moderate to severe hidradenitis suppurativa (HS). It compares brivekimig to a dummy medicine (placebo) to see if it's safe and helps reduce HS symptoms.
For: Hidradenitis SuppurativaUnited States · Australia · Canada - RecruitingPHASE3
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
This study looks at an inhaled medicine called treprostinil for people with progressive pulmonary fibrosis. It aims to see if it's safe and effective in slowing down this lung condition over 52 weeks. Half get the medicine, half get a dummy treatment.
For: Progressive Pulmonary Fibrosis · Interstitial Lung DiseaseUnited States · Argentina · Australia - RecruitingPHASE3
Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
This study is testing a new medicine called iptacopan for people aged 12-60 with a kidney disease called C3 Glomerulopathy (C3G). It aims to see if the medicine is safe and helps improve kidney function compared to a dummy pill.
For: C3GUnited States · Argentina · Belgium - Active not recruitingPHASE3
A Study of Ramucirumab (LY3009806) in Combination With Erlotinib in Previously Untreated Participants With EGFR Mutation-Positive Metastatic NSCLC (RELAY)
This study looks at new ways to treat advanced non-small cell lung cancer with a specific genetic change. It aims to see if combining a drug called ramucirumab with existing treatments like erlotinib, gefitinib, or osimertinib can work better than current approaches.
For: Metastatic Non-Small Cell Lung CancerUnited States · Canada · France - RecruitingPHASE3
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy
This study looks at a new drug called Leriglitazone for adult men with a brain condition called cerebral adrenoleukodystrophy (cALD). Researchers want to see if it's safe and helps improve or slow down the disease.
For: Cerebral Adrenoleukodystrophy (cALD)United States · Argentina · Brazil - RecruitingPHASE1
A Phase 1b Study to Investigate Safety and Tolerability of ARGX-119 in Adult Participants With DOK7-Congenital Myasthenic Syndromes (CMS)
This study is testing a new medicine, ARGX-119, for adults with a specific type of muscle weakness called DOK7-Congenital Myasthenic Syndrome (CMS). It's looking at how safe the medicine is, if it causes side effects, and if it helps people feel better.
For: Congenital Myasthenic Syndrome · CMSUnited States · Canada · France - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)
This study investigates a new treatment, CAEL-101, for a serious heart condition called AL amyloidosis. Researchers want to see if CAEL-101 can help patients live longer and reduce hospital stays, alongside their usual medicine, compared to a dummy drug.
For: AL AmyloidosisUnited States · Australia · Austria - Active not recruitingPHASE3
A Safety and Efficacy Study of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-Severe Symptom State
This study is looking at a new medicine called Dazodalibep for people with Sjögren's Syndrome. It aims to see how well it helps with symptoms and whether it's safe to use, especially for those with moderate to severe symptoms.
For: Sjögren's Syndrome (SS)United States · Argentina · Australia - Active not recruitingPHASE3
Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)
This study looks at a new combination of drugs, pembrolizumab and enzalutamide, for men with advanced prostate cancer that has spread and no longer responds to hormone therapy. It compares this combination to enzalutamide alone to see if it helps men live longer and stops the cancer from growing.
For: Prostatic NeoplasmsUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Women With Breast Cancer Who Are Having Hormone Therapy
This study looks at whether fezolinetant can reduce hot flashes in women with breast cancer who are having hormone therapy. These hot flashes are a common side effect, and current treatments like HRT aren't suitable. We want to see if fezolinetant helps more than a dummy pill.
For: Hot FlashesCanada · Czechia · Denmark - RecruitingPHASE3
Ivosidenib and Azacitidine With or Without Venetoclax in Adult Patients With Newly Diagnosed IDH1-Mutated AML or MDS/AML Considered Ineligible for Intensive Chemotherapy
This study looks at a new way to treat a specific type of leukaemia (AML) with a gene change called IDH1. It adds a drug called venetoclax to standard treatment (ivosidenib and azacitidine) to see if it works better. It's for patients who can't have strong chemotherapy.
For: Acute Myeloid LeukemiaAustria · Belgium · Denmark - Active not recruitingPHASE3
Assess Efficacy & Safety of Selumetinib in Combination With Docetaxel in Patients Receiving 2nd Line Treatment for v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Positive NSCLC
This study looks at a new drug, selumetinib, combined with standard chemotherapy (docetaxel) for a specific type of advanced lung cancer. It aims to see if this combination works better than chemotherapy alone for patients whose cancer has the KRAS gene mutation.
For: Locally Advanced or Metastatic Non Small Cell Lung Cancer Stage IIIb - IVUnited States · Argentina · Australia - Active not recruitingPHASE3
Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)
This study is testing a new medicine, pembrolizumab, for people in the UK with a type of skin cancer called melanoma that has been removed by surgery but is considered high-risk. It aims to see if the medicine can stop the cancer from coming back.
For: MelanomaUnited States · Australia · Belgium - Active not recruitingPHASE3
A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis
This study is testing new drug combinations, pozelimab and cemdisiran, for adults with a muscle-weakening condition called generalised myasthenia gravis (gMG). It looks at how safe these drugs are and how well they help improve muscle function.
For: Generalized Myasthenia GravisUnited States · Belgium · Brazil - RecruitingPHASE3
A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking into a new medication called Afimkibart for people aged 16-80 with ulcerative colitis that is moderately to severely active. It aims to see how well it works and if it's safe compared to a dummy drug. We hope it could be a new treatment option.
For: Moderately to Severely Active Ulcerative ColitisUnited States · Argentina · Australia - Active not recruitingPHASE2
Study of Bepirovirsen in Participants Living With Human Immunodeficiency Virus and Chronic Hepatitis B Virus Infection (B-Focus)
This study is looking into a new medication called Bepirovirsen for people who have both HIV and long-term Hepatitis B. It will compare Bepirovirsen to a dummy treatment (placebo) to see if it's safe and effective in improving their health.
For: Hepatitis BUnited States · Argentina · Brazil - RecruitingPHASE3
Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation
This study looks at a new medicine called ravulizumab for adults receiving a kidney transplant from a deceased donor. It aims to see if this medicine can help their new kidney start working well faster, reducing the need for dialysis after the operation.
For: Delayed Graft Function · DGF · Kidney TransplantUnited States · Argentina · Australia - Active not recruitingPHASE3
A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)
This study is looking at different ways of giving a medicine called donanemab for early Alzheimer's disease. Researchers want to see how different doses affect side effects and which patients might be more likely to experience them. It's for adults aged 60-85.
For: Alzheimer's Disease · Dementia · Brain DiseasesUnited States · United Kingdom - RecruitingPHASE3
A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]
This study looks at a new medicine for muscle-weakening conditions called dermatomyositis (DM) and polymyositis (PM). It aims to see how well the medicine, called dazukibart, works to help people with these conditions and if it’s safe.
For: MyositisUnited States · Argentina · Bulgaria - RecruitingNA
Effects of 8 Weeks of Turmeric Ingestion on Physiology and Wellbeing in Healthy Older Adults
This study looks at how drinking turmeric shots for 8 weeks affects the health and well-being of older adults. We want to see if turmeric, known for its natural health benefits, can make a difference compared to a dummy drink.
For: Turmeric · PlaceboUnited Kingdom - RecruitingPHASE3
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
This study is looking at a new drug, Saruparib, for men with high-risk prostate cancer and a faulty BRCA gene. It aims to see if adding Saruparib to standard treatments can help prevent the cancer from spreading.
For: Prostate CancerUnited States · Argentina · Australia - Active not recruitingPHASE2
A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body
This study is testing a new under-the-skin injection, REGN7999, for adults with non-transfusion dependent beta-thalassemia and too much iron. It aims to check if the drug is safe, works well, and lowers iron levels, using MRI scans to measure iron.
For: Non-Transfusion Dependent Beta-Thalassemia (NTDT)United States · Georgia · Greece - Active not recruitingPHASE3
A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery
This study looks at new drug combinations (fianlimab with cemiplimab) versus a standard drug (pembrolizumab) to see if they can stop melanoma from coming back after surgery. It's for people at high risk of their melanoma returning.
For: MelanomaUnited States · Argentina · Australia - Active not recruitingPHASE1
A Study to Investigate Andexanet Dosing and the Interaction Between Andexanet and Subsequent Enoxaparin in Healthy Participants
This study is testing a new medicine called Andexanet. It's for healthy people aged 18 to 55. We want to see how Andexanet works with common blood thinners like Rivaroxaban and Apixaban, and if it affects another blood thinner called Enoxaparin. This helps doctors understand how to use Andexanet safely.
For: Healthy ParticipantsGermany · United Kingdom - Active not recruitingPHASE3
A Study of Elafibranor in Adults With Primary Biliary Cholangitis and Inadequate Response or Intolerance to Ursodeoxycholic Acid.
This study investigates a new drug, elafibranor, for adults with Primary Biliary Cholangitis (PBC). It aims to see if elafibranor can improve liver health in people whose current treatment isn't working well or who can't tolerate it. It compares elafibranor to a dummy treatment.
For: Primary Biliary CholangitisUnited States · Czechia · France - Active not recruitingPHASE3
ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE
This study looks at a new medicine called ravulizumab for people with kidney disease having heart surgery. It aims to see if the medicine can prevent serious kidney problems after the operation. It's for adults aged 18-90.
For: Chronic Kidney Disease · CKD · Cardiac DiseaseUnited States · Argentina · Australia - Active not recruitingPHASE3
Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)
This study looks at new treatments for HER2-positive breast cancer that has spread. It compares an experimental drug, trastuzumab deruxtecan (T-DXd), alone or with another drug, pertuzumab, to standard care, to see if they work better and are safe.
For: Breast Cancer; HER2-positive; MetastaticUnited States · Argentina · Belgium - Active not recruitingPHASE3
A Study to Assess Safety, Tolerability and Efficacy of Garetosmab Versus Placebo Administered Intravenously (IV) in Adult Participants With Fibrodysplasia Ossificans Progressiva (FOP)
This study is looking into a new drug, garetosmab, for adults with Fibrodysplasia Ossificans Progressiva (FOP). We want to find out if it's safe, how well it works, and if it helps with FOP symptoms. It's a Phase 3 trial, meaning it's in the later stages of testing.
For: Fibrodysplasia Ossificans ProgressivaUnited States · Australia · Brazil - Active not recruitingPHASE2
A Phase 2 Trial of ENV-101 in Patients With Lung Fibrosis (WHISTLE-PF Trial)
This study is testing a new medicine, ENV-101, for people with lung scarring conditions like Idiopathic Pulmonary Fibrosis (IPF). It aims to see if it improves breathing and is safe to use. Patients might continue their usual treatments.
For: Idiopathic Pulmonary Fibrosis · Progressive Fibrosing Interstitial Lung DiseaseArgentina · Australia · Austria - Active not recruitingPHASE3
A Study of Obexelimab in Patients With Warm Autoimmune Hemolytic Anemia (SApHiAre)
This study investigates a new medicine, obexelimab, for Warm Autoimmune Hemolytic Anemia (wAIHA). It aims to see how well it works and if it's safe for people who haven't responded to previous treatments.
For: Warm Autoimmune Hemolytic AnemiaItaly · Poland · Spain - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Escalation, Proof-of-Concept Study Evaluating the Safety, Tolerability, Efficacy and Pharmacokinetics of INT-787 in Subjects with Severe Alcohol-Associated Hepatitis
This study looks into a new medication called INT-787 for people with severe liver damage caused by alcohol. Doctors want to see if it's safe, if patients tolerate it well, and if it helps improve their condition more than a dummy treatment.
For: Severe Alcohol-Associated HepatitisFrance - Active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy
This study looked at new treatments for HER2-positive breast cancer that had already been treated but still showed signs of cancer after surgery. Researchers wanted to see if adding certain drugs could prevent the cancer from coming back.
For: Breast CancerUnited States · Australia · Austria - Active not recruitingPHASE3
An Investigational Immuno-therapy Study of Nivolumab, Compared to Placebo, in Patients With Bladder or Upper Urinary Tract Cancer, Following Surgery to Remove the Cancer
This study looks at a new immune-boosting medicine called Nivolumab for people who have had surgery for bladder or kidney drainage system cancer. It compares Nivolumab to a dummy drug to see if it's safe and helps stop the cancer from coming back.
For: Various Advanced CancerUnited States · Argentina · Australia - RecruitingPHASE3
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)
This study looks at a new medicine, BI 764198, for people aged 12 and over with a kidney condition called FSGS. It aims to see if this medicine helps improve kidney health. Participants will take a tablet daily and have their kidney function checked regularly.
For: Focal Segmental GlomerulosclerosisUnited States · Argentina · Australia - Active not recruitingNA
Prebiotic Effects on Anxiety, Cortisol, and Emotional Processing in Mild-to-Moderately Stressed Adults
This study looks at how a special fibre called a prebiotic might help adults deal with mild to moderate stress. Researchers want to see if taking a prebiotic supplement like Bimuno® can improve mood, sleep, and reduce stress levels.
For: Mild-to-Moderate StressUnited Kingdom - RecruitingPHASE3
Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)
This study looks at a new medicine, fazirsiran, for people with a genetic liver condition called Alpha-1 Antitrypsin Deficiency, who have early liver scarring. It aims to see if the medicine is safe, well-tolerated, and can help reduce the abnormal protein buildup that causes liver damage.
For: Alpha1-Antitrypsin DeficiencyUnited States · Austria · Belgium - Active not recruitingPHASE4
A Study of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease
This study is looking at a new treatment called guselkumab for people with psoriatic arthritis that affects the spine and pelvis. It aims to see how well it reduces pain and inflammation in these areas. Participants will receive either the study drug or a dummy treatment.
For: Arthritis, PsoriaticUnited States · Argentina · Australia - RecruitingPHASE3
A Study of Zolbetuximab Together With Pembrolizumab and Chemotherapy in Adults With Gastric Cancer
This study looks at a new drug, zolbetuximab, alongside usual treatments for stomach or gullet cancer that has spread or can't be removed. It aims to see if this combination helps people live longer by targeting specific proteins on cancer cells.
For: Locally Advanced Unresectable Gastroesophageal Junction (GEJ) Adenocarcinoma or Cancer · Locally Advanced Unresectable Gastric Adenocarcinoma or Cancer · Metastatic Gastric Adenocarcinoma or CancerUnited States · Australia · Belgium - Active not recruitingPHASE1
A Study to Assess THN391 in Subjects With Alzheimer's Disease
This study is for people aged 65-85 with early Alzheimer's and small vessel disease. It tests a new drug, THN391, or a dummy drug, over 6 months to see if it's safe and how it behaves in the body. It involves clinic visits, scans, and memory tests.
For: Alzheimer Disease, Early OnsetNetherlands · United Kingdom - Active not recruitingPHASE2
A Dose Finding Study With an Anti-TSLP Antibody (GSK5784283) in Adults Aged 18 to 75 Years of Age With Uncontrolled Asthma
This study is looking for the right dose of a new medicine, GSK5784283, for adults aged 18 to 75 with asthma that isn't fully controlled by their current treatments. It aims to see how it affects breathing and overall asthma control.
For: AsthmaUnited States · Bulgaria · Canada