- AuthorisedTherapeutic exploratory (Phase II)
Autologous Bone Marrow derived cells for the treatment of chronic arterial Limb Ischemia in patients with high risk of amputation
This study looks at using a person's own bone marrow cells to help people with severe leg circulation problems. The aim is to see if these cells can help improve blood flow, reduce pain, heal wounds, and potentially save a leg from amputation.
For: advanced chronic ischemia (fontaine III-IV class and Rutherford IV-V), with risk of amputation of at least one limbSpain - Not yet recruitingNA
Nebulised Hypertonic Saline to Decrease Respiratory Exacerbations in Neuromuscular Disease or Neurodisability
This study looks at whether breathing in salty water (hypertonic saline) can help people with certain muscle or brain conditions avoid frequent chest infections. Participants will use a nebuliser twice a day for a year to see if this treatment reduces the need for antibiotics.
For: Neuromuscular Diseases · Neurodevelopmental Disorders · Cerebral PalsyUnited Kingdom - RecruitingNA
Reproductive Hormones During Sustained Administration of Kisspeptin
This study looks at how a hormone called kisspeptin affects other hormones (LH, FSH, testosterone, oestradiol) linked to fertility. We test different doses of kisspeptin or a dummy treatment over 8 days each month, for four months, to understand its effects.
For: Fertility Disorders · Hypothalamic DysfunctionUnited Kingdom - Active not recruitingPHASE1
Intranasal Insulin and Olanzapine Study in Healthy Volunteers
This study looks at how a common medicine called olanzapine affects sugar levels and brain function, and if a nasal spray insulin can help. It's for healthy volunteers and aims to better understand medicine side effects.
For: Healthy ControlsCanada - RecruitingNA
Lung Immune Challenge Study: Controlled Exposure to Inhaled Resiquimod (R848)
This study looks at how people's lungs respond to a harmless mist that acts like a virus. It aims to understand lung inflammation better, especially in people with asthma, to help develop new treatments for respiratory infections without causing actual illness.
For: Innate Immunity · Mucosal Immunity · AsthmaUnited Kingdom - RecruitingPHASE4
Impact of Administration of Esmolol on Nociception Level-guided Control of Nociception.
This study looks at whether a heart medication called esmolol can help reduce pain meds during and after surgery. It combines esmolol with special monitoring to see if it makes a difference for patients having certain abdominal surgeries.
For: Opioid Use, Unspecified · Anesthesia · Nociceptive PainCanada - RecruitingPHASE3
PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST)
This study looks at the best way to stop dangerous blood clots forming in people with severe head injuries. It compares a special massage for the legs with massage plus a blood-thinning medicine called Dalteparin, to see which is safer and more effective at preventing clots without causing more bleeding in the brain.
For: Traumatic Brain InjuryCanada - RecruitingPHASE4
3 mL Inhaled Methoxyflurane for Intrauterine Device (IUD) Insertion
This study is looking at whether inhaled Methoxyflurane (like the Penthrox inhaler) can help reduce pain and anxiety when having an IUD fitted. We want to see if it makes the experience more comfortable for patients.
For: IUDCanada