Standard of care clinical trials
42 indexed studies · 25 currently recruiting
- Active not recruitingPHASE3
A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer
This study compares new drug combinations (dostarlimab and niraparib) with standard care for women newly diagnosed with advanced ovarian cancer. It aims to see if these new treatments can stop the cancer from growing for longer.
For: Ovarian Neoplasms · Ovarian, Fallopian Tube and Primary Peritoneal CarcinomaUnited States · Belarus · Belgium - RecruitingPHASE2, PHASE3
A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer
This study looks at a new drug, telisotuzumab adizutecan, for a type of lung cancer called non-small cell lung cancer. It compares the new drug to standard treatments to see how safe it is and how well it works in adults with advanced lung cancer.
For: Non-Small Cell Lung CancerUnited States · Australia · Austria - RecruitingPHASE3
A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine
This study is looking into a new medication called rimegepant. It's for women who get migraines around their period. We want to see if this medicine can help prevent these 'menstrual migraines' and if it's safe to use.
For: Menstrual MigraineUnited States · Argentina · Canada - RecruitingPHASE4
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
This study looks at a new medicine called tirzepatide for adults with obesity but not diabetes. It compares it to standard care to see how well it helps with weight loss and if it can prevent type 2 diabetes over about five years.
For: ObesityUnited Kingdom - RecruitingNA
The PERSEVERE Study
The PERSEVERE Study is looking at a new device, the FlowTriever System, to treat severe lung blood clots (pulmonary embolism). It compares this new approach to standard NHS care for people with high-risk clots, aiming to see which is more effective.
For: Pulmonary Embolism · Pulmonary ThromboembolismUnited States · France · Germany - RecruitingNA
Trans-coronary Cooling and Dilution for Cardioprotection During Revascularisation for ST-elevation Myocardial Infarction
This study is looking at a new way to protect the heart during a heart attack. We're testing if gently cooling the heart directly through a small tube, instead of the whole body, can reduce damage. This might make the current treatment even better.
For: Myocardial Infarction · Reperfusion Injury, MyocardialUnited Kingdom - Active not recruitingPHASE2
Additional Treatments to the Local Tumour for Metastatic Prostate Cancer: Assessment of Novel Treatment Algorithms
This study looks at new ways to treat prostate cancer that has spread. It compares adding treatments directly to the prostate and other affected areas with standard care, to see if it improves outcomes for men who have recently been diagnosed.
For: Prostate Cancer · Metastatic Prostate CancerUnited Kingdom - Active not recruitingNA
Speech Performance and Clinic Efficiency With Remote Care Compared With Standard of Care in Adults With a Cochlear Implant in the First 12 Months Post-activation
This study compares remote and in-clinic care for people with cochlear implants in their first year. It checks if remote care works well for hearing and saves time/money, offering a convenient alternative to traditional hospital visits.
For: Hearing LossAustralia · Belgium · Italy - Active not recruitingPHASE2
Seal, Stopping Eczema and Allergy Study
This study is for babies under 12 weeks old with early eczema. It compares special skin creams and treatments to standard care to see if they can reduce eczema and prevent food allergies. We want to find the best ways to keep young skin healthy.
For: Eczema, Infantile · Eczema · Atopic Dermatitis EczemaUnited States · United Kingdom - Recruiting
International Registry for Men With Advanced Prostate Cancer (IRONMAN)
This study, called IRONMAN, is collecting information from men with advanced prostate cancer across many countries, including the UK. It aims to understand treatments, how they vary, and what helps men live longer and have a better quality of life.
For: Prostate CancerUnited States · Australia · Barbados - Recruiting
A Study on Hemolytic Disease of the Fetus and Newborn (HDFN) Through Global Registry
This study looks at a blood condition called HDFN, which can affect babies during pregnancy or soon after birth. Researchers want to understand the risk of babies getting anaemia (low red blood cells) when their mothers have HDFN, using information collected from medical records.
For: Hemolytic Disease of the Fetus and NewbornUnited States · Australia · Belgium - Active not recruiting
Global Patient Registry of Inherited Retinal Diseases
This study is gathering information about inherited eye conditions that affect the retina, like X-Linked Retinitis Pigmentosa and Achromatopsia. It aims to better understand how these conditions develop and improve care for people living with them.
For: Inherited Retinal DiseasesUnited States · Australia · Austria - Active not recruiting
Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC)
This study looks at how new patients with severe ulcerative colitis are treated in hospitals across the UK. It aims to understand why some patients get better with standard treatments and why others might need surgery or different medicines.
For: Severe Ulcerative ColitisUnited Kingdom - RecruitingPHASE3
Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC
This study is looking at a new treatment called AAA817, combined with standard prostate cancer drugs, for men with advanced prostate cancer. It compares this new combination to existing treatments to see which works best at slowing the cancer's growth.
For: Prostate CancerUnited States · Australia · Brazil - Not yet recruitingNA
Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour
This study is looking at whether specially designed computer games, using virtual reality, can help young people aged 10-40 who have lost some of their vision (hemianopsia) due to a brain tumour. It aims to improve their sight and daily life.
For: Hemianopsia · Virtual Reality · Visual RehabilitationAustria · Denmark · France - Active not recruiting
Paediatric Sjögren Syndrome Cohort Study and Repository (PaedSSCoRe)
This study looks at Sjögren's syndrome (SS) in children and teenagers in the UK. Researchers want to understand how SS affects young people, gather information on their health, and create better ways to identify the condition. It's hoped this will lead to improved care.
For: Sjogren's Syndrome Childhood-onsetIreland · United Kingdom - Active not recruitingNA
Implementing a Multimodal RCT Intervention to Improve the Transition of Patients With Crohn's Disease From Pediatric to Adult Care
This study looks at a new support program for young people with Crohn's or ulcerative colitis who are moving from children's to adult healthcare. It aims to make this move smoother and improve their health and well-being.
For: Inflammatory Bowel Diseases · Crohn Disease · Ulcerative ColitisCanada - Active not recruitingPHASE2
Belimumab in Patients with Chronic Lymphocytic Leukemia
This study looks at adding a new drug, belimumab, to standard treatment (rituximab/venetoclax) for chronic lymphocytic leukemia (CLL) that has come back or isn't responding. The aim is to make the treatment work better and potentially reduce its overall length.
For: Chronic Lymphoid Leukemia in RelapseGermany - RecruitingNA
ImproviNg rEnal Outcomes Following Coronary angiograPhy and/or percuTaneoUs coroNary intErventions
This study looks at a new way to protect kidneys during heart procedures that use dye. We're testing if giving fluids tailored to each person works better than the usual method to prevent kidney problems, which can sometimes happen after these procedures.
For: Contrast-Induced Acute Kidney InjuryCanada - Not yet recruitingNA
Best Practices Fo Early Diagnosis of Cerebral Palsy
This study aims to improve how doctors diagnose cerebral palsy earlier in premature babies. We want to make sure all clinics follow the best guidelines to help these babies get the right care sooner, which could improve their development.
For: Cerebral Palsy · PrematurityCanada - RecruitingPHASE2
Clinical Trial With Donor Modified Immune Cells in Living Donor Kidney Transplantation
This study looks at a new treatment called MIC for people having a living donor kidney transplant. It checks if MIC is safe and helps prevent the body from rejecting the new kidney, potentially with less strong anti-rejection medicines. We are comparing it to standard care.
For: Kidney TransplantationGermany - RecruitingPHASE2
High Heated Humidity in Stem Cell Transplant
This study looks at using warm, moist air to help people who have had a stem cell transplant for blood cancers. It aims to see if this treatment can reduce sore mouths and throats, which are common side effects, and make hospital stays shorter.
For: Autologous Stem Cell TransplantCanada - Not yet recruitingNA
The LIFT-ECHO Last Mile Project
This study aims to improve care for people with intestinal failure. It involves a learning program called LIFT-ECHO for doctors, helping them learn from specialists. The goal is to see if better doctor knowledge leads to better health and quality of life for patients.
For: Intestinal FailureUnited States · United Kingdom - RecruitingPHASE2
Stereotactic Ablative Radiotherapy for Oligo-Progressive Non Small Cell Lung Cancer
This study looks at a special type of radiation (SABR) for people with lung cancer that has spread a little. It compares SABR with standard treatments to see if it helps control the cancer for longer while continuing current medication.
For: Lung Cancer MetastaticCanada - Active not recruitingNA
Virtual E-health System for Pacemakers
This study looks at using a virtual health system to monitor pacemakers remotely, aiming to make follow-up easier and more affordable. It compares remote check-ups to traditional clinic visits for people with pacemakers.
For: PacemakerCanada - Active not recruitingNA
Reversal of Atrial Substrate to Prevent Atrial
This study looks at how best to prevent atrial fibrillation (AF) recurring. It compares two approaches: an AF treatment called catheter ablation, and catheter ablation combined with an intense programme to improve lifestyle and health factors like diet and exercise.
For: Atrial FibrillationCanada - Active not recruiting
Observational Evaluation of Atopic Dermatitis in Pediatric Patients
This study looks at children aged 0-11 with moderate to severe eczema (atopic dermatitis) that isn't well controlled with usual creams. Researchers want to understand their condition better, how it changes over time, and how current treatments are working in real life. It's an observational study, meaning no new treatments are being tested.
For: Dermatitis AtopicUnited States · Argentina · Australia - Active not recruitingPHASE3
Long-term Safety and Efficacy Extension Trial of Bimatoprost SR
This study looks at the long-term effects of a special eye implant, Bimatoprost SR, for people with glaucoma or high eye pressure. It checks how safe and effective it is over a longer period, continuing from previous studies.
For: Open-Angle Glaucoma · Ocular HypertensionUnited States · Argentina · Belgium - RecruitingNA
Safety of AI-Powered Virtual Assistant in Outpatient Management of Heart Failure
This study looks at whether a special computer program called SIRIO-HF, which is like a virtual assistant, can help people with a new diagnosis of heart failure manage their condition at home after leaving the hospital. We want to see if it's safe and helps reduce clinic visits.
For: Heart FailureUnited Kingdom - Not yet recruitingNA
The REmission of Diabetes Using a PlAnt-based Weight Loss InteRvention (REPAIR) Trial
This study, called REPAIR, explores if a plant-based diet and exercise can help people with type 2 diabetes achieve remission and significant weight loss. It compares this approach to standard diabetes care.
For: Diabetes MellitusCanada - Active not recruitingNA
Fit-for-Fertility Multicenter Randomized Controlled Trial
This study looks into how a healthy lifestyle program, called Fit-for-Fertility, can help women with obesity and infertility. It compares this program to standard fertility treatments to see if it improves chances of pregnancy and having a healthy baby.
For: Obesity · Infertility, FemaleCanada - Active not recruitingNA
Virtual E-health System for Implantable Cardioverter Defibrillators
This study looks at a new way to monitor implanted heart devices remotely, like pacemakers or defibrillators. Instead of regular hospital visits, patients' devices are checked from home using a special e-health system. It compares this new remote monitoring system to the usual care.
For: Cardiac ArrhythmiaCanada - Active not recruitingPHASE3
Efficacy and Safety of Encaleret Compared to Standard of Care in Participants With ADH1
This study is looking at a new medicine called encaleret for a condition called Autosomal Dominant Hypocalcemia Type 1 (ADH1). It compares encaleret to the usual treatment to see if it's safe and works better for patients.
For: Autosomal Dominant Hypocalcemia (ADH)United States · Australia · Canada - Enrolling by invitationPHASE3
Long-term Efficacy and Safety Extension (LTE) Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria
This study looks at the long-term effects and safety of a drug called barzolvolimab for chronic hives (CSU). It's for adults who have already completed earlier studies with this drug, aiming to see how well it works over a longer time and to give ongoing access to treatment if needed.
For: Chronic Spontaneous UrticariaUnited States · Australia · Bulgaria - Not yet recruitingPHASE2
A Dose Optimization Study of Enzalutamide in Elderly Patients With Advanced Prostate Cancer
This study looks at different doses of a prostate cancer drug called enzalutamide, especially for older men. We want to find the best dose that works well but causes fewer side effects like tiredness, to help improve their quality of life.
For: Prostate Cancer Patients · Elderly Patients · Pharmacokinetic StudyCanada - RecruitingNA
Short Antibiotic Treatment in High Risk Febrile Neutropenia
This study looks at treating fevers in cancer patients with low white blood cells (febrile neutropenia). We're testing if stopping antibiotics sooner is as safe as longer treatment, to help fight antibiotic resistance and other issues from overuse. It's for adult cancer patients currently on chemotherapy.
For: Febrile NeutropeniaCanada - RecruitingNA
Evaluating the Use of Educational Videos in Newly Diagnosed Patients in a Medical Oncology Sarcoma Clinic
This study looks at whether short videos can help people newly diagnosed with sarcoma understand their condition and treatment better before their first hospital appointment. We want to see if these videos improve their knowledge and make them feel more prepared for their medical oncology visit.
For: SarcomaCanada - Recruiting
Hospitalised COVID-19 Patients Cohort Study in the EuCARE Project
This study looks at hospitalised COVID-19 patients across the world. Researchers want to understand how different types of the virus and vaccination affect how ill people get and how they recover. They're collecting patient information and some blood samples to learn more.
For: COVID-19Germany · Italy · Kenya - Active not recruitingPHASE3
Prostate-cancer Treatment Using Stereotactic Radiotherapy for Oligometastases Ablation in Hormone-sensitive Patients
This study looks at a new way to treat prostate cancer that has spread to a few other places. It compares standard hormone therapy with adding special focused radiation (SBRT) to shrink these small cancer sites.
For: Oligometastatic Hormone Sensitive Prostate CancerFrance · Martinique - RecruitingNA
App-based Recording and Optimization of the Nutritional Status in Patients With Head and Neck Tumors During and After Radio(Chemo)Therapy
This study looks at how an app can help people with head and neck cancer manage their nutrition during and after treatment. It aims to reduce weight loss and poor nutrition by using app reminders and checking in on how people are eating.
For: Squamous Cell Carcinoma of Head and NeckGermany - RecruitingNA
Effects of Neoadjuvant Prehabilitation on Post-Interventional Physical and Psychological Outcomes in Oncology Patients With Solid Tumors
This study looks at how a special program of exercise and emotional support before cancer treatment might help people with solid tumours, especially breast cancer. Researchers want to see if this program improves how people feel, both physically and emotionally, compared to usual care.
For: Breast Cancer · Solid TumorGermany - Not yet recruitingPHASE3
Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease
This study looks at whether adding a medicine called lidocaine to usual pain relief helps people with sickle cell disease during a painful crisis. We want to see if it reduces the amount of strong pain medication they need.
For: Vaso-Occlusive Pain Episode in Sickle Cell DiseaseFrance · Guadeloupe