Latest studies
- Active not recruitingPHASE2
Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL)
This study is testing a new medicine, Selinexor, for people in the UK with a type of cancer called Diffuse Large B-cell Lymphoma (DLBCL) that has come back or not responded to previous treatments. It aims to see if Selinexor can help when other options haven't worked.
Diffuse Large B-cell LymphomaNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Randomized, double-blind, placebo-controlled, three-way cross-over study to assess the pharmacodynamic effects of an authorised and a new compound on nerve excitability threshold tracking in healthy male subjects.
This study is looking at how a new medicine, compared to an existing one and a dummy pill, affects nerve signals in healthy men. It aims to see if the new medicine could help with nerve pain in the future by understanding how it works in the body.
neuropathic painNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study of the Bruton’s Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Combination with Rituximab versus Placebo in Combination with Rituximab in Treatment Naïve Subjects with Follicular Lymphoma
This study is looking at a new way to treat follicular lymphoma, a type of cancer. It compares a drug called Ibrutinib with a standard treatment, Rituximab. The aim is to see if adding Ibrutinib helps people live longer without their cancer getting worse.
Follicular LymphomaNetherlands - Ongoing, recruitingPhase III and phase IV (Integrated)
The bilateral sentinel node detection rate of fluorescent indocyanine green compared to 99mTc and blue dye in the sentinel node procedure in stage I-IIA cervical cancer
This study compares different ways to find 'sentinel lymph nodes' in women with early cervical cancer. These nodes are the first ones cancer might spread to. We're looking at a new dye called indocyanine green against older methods to see which is best at finding these important nodes on both sides of the body.
cervical cancer stage I-IIANetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Finding Study to Assess the Safety and Effectiveness of Tovinontrine in Patients With Chronic Heart Failure With Reduced Ejection Fraction
This study is testing a new medicine, Tovinontrine, for people with a type of heart failure where the heart struggles to pump blood effectively. It aims to see if different doses are safe and if the medicine helps improve heart health over 12 weeks.
Heart failure (HF) with reduced ejection fraction (HFrEF)Netherlands - Ongoing, recruitingTherapeutic use (Phase IV)
The PHENOSAR trial: Antibiotic treatment of biopsy confirmed phenotypes in sarcoidosis: a proof of concept clinical trial.
This study looks at how well two common antibiotics, Doxiclat and Azithran, might help reduce inflammation in people with sarcoidosis. It's an important step to see if these medicines could offer a new way to manage this condition.
sarcoidosisNetherlands - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
Study of Pembrolizumab combined with Ataluren in Patients with metastatic pMMR and dMMR colorectal cancer adenocarcinomas or metastatic dMMR endometrial carcinoma: the ATAPEMBRO study
This study is testing a new combination of two cancer drugs, pembrolizumab and ataluren, for people in the UK with advanced bowel cancer or advanced womb cancer that has spread. It's an early-stage study to see if this combination is safe and works.
metastatic colon cancer, advanced cancer of the colonNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A Phase 1 study to evaluate IK-930 in subjects with advanced solid tumors
This early-stage study is looking at a new medicine called IK-930 for people with advanced cancers. It's the very first time this medicine is being given to people, to check if it's safe and how it works in the body.
Advanced Solid TumorsNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Phase 3, Multicenter, Randomized, Double-Masked, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Tinlarebant in the Treatment of Stargardt Disease in Adolescent Subjects
This study is looking into a new medication called Tinlarebant for young people with Stargardt disease. It aims to see if the medication is safe and can slow down the development of the condition over about two years, compared to a dummy treatment.
Stargardt DiseaseNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Adenoassociated Virus Serotype 8-mediated Gene Transfer of Glucose-6-phosphatase in Patients With Glycogen Storage Disease Type Ia.
This study looks at a new gene therapy called Pariglasgene brecaparvovec for people with a rare liver condition called GSDIa. It aims to see if this new treatment can help reduce the amount of cornstarch they need to eat daily to keep their blood sugar stable.
Glycogen Storage Disease Type Ia (GSDIa)Netherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Monitoring the AD effects of ketamine in MDD patients
This study is looking at how a medicine called ketamine affects people with severe depression. Researchers want to understand its effects better to see if it could be a helpful treatment. It’s an early-stage study, meaning they are carefully checking how the body reacts to the medicine.
Major depressive disorderNetherlands - Active not recruitingPHASE2, PHASE3
International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma
This study looks at new ways to treat medulloblastoma, a type of brain tumour, in children and young people. It aims to find the best treatments based on the tumour's specific characteristics, hoping to improve the chances of recovery with fewer side effects.
Brain TumorsNetherlands - Active not recruitingPHASE2
An Extension Study to Evaluate the Long-Term Safety and Efficacy of Votoplam in Participants With Huntington's Disease (HD)
This study is looking into the long-term safety and effects of a medicine called Votoplam for people with Huntington's disease. Participants who were already in a previous study with Votoplam will continue to take it to see how it works over a longer time.
Huntington DiseaseNetherlands - Ongoing, recruitingPhase I and Phase II (Integrated)- Other
A Phase 1b/2, Open-label, Randomized Study of Vudalimab in Combination With Chemotherapy or Pembrolizumab in Combination With Chemotherapy as First-line Treatment in Patients With Advanced Non-small Cell Lung Cancer
This study is testing new treatments for advanced non-small cell lung cancer. It combines a new medicine, vudalimab, or an existing one, pembrolizumab, with chemotherapy. Doctors will be looking at how safe and effective these combinations are for patients.
Advanced Non-small Cell Lung CancerNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Tolerability of concurrent EBRT + Lu-PSMA for node-positive prostate cancer (PROQURE-1)
This study looks at a new way to treat prostate cancer that has spread to nearby lymph nodes but not to other parts of the body. It combines two treatments: external radiotherapy and a special type of radiation therapy called Lu-PSMA, given at the same time. Doctors want to see how well people tolerate this combined treatment.
N+M0 prostate cancerNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b Randomized, Double-blind, Placebo-controlled, Repeat-dose, Multicenter Trial to Evaluate the Efficacy, Safety and Tolerability of HZN-825 in Subjects with Idiopathic Pulmonary Fibrosis
This study is testing a new medicine, Fipaxalparant, for a lung condition called Idiopathic Pulmonary Fibrosis (IPF). Researchers want to see if it's safe and helps improve lung function over one to two years compared to a dummy pill.
Idiopathic Pulmonary FibrosisNetherlands - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, adaptive, open-label, single ascending dose to multiple ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of mRNA-3745 in participants with glycogen storage disease type 1a (GSD1a), followed by an open-label extension
This study is testing a new medicine, mRNA-3745, for Glycogen Storage Disease Type 1a (GSD1a). It's looking at how safe it is, how well people tolerate it, and how it works in the body, starting with low doses and gradually increasing them.
Glycogen storage disease type 1a (GSD1a)Netherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
HOVON 139 CLL: A prospective, open-label, multicenter randomized phase-II trial to evaluate the efficacy and safety of a sequential regimen of Gazyvaro (obinutuzumab) followed by obinutuzumab and venetoclax, followed by either standard venetoclax maintenance or MRD guided venetoclax maintenance in first-line patients with CLL and unfit for FCR-like regimens. (GIVE trial).
This study looks at new ways to treat chronic lymphocytic leukaemia (CLL). It combines a medicine called obinutuzumab with venetoclax to see if it helps patients who can't have standard chemotherapy. Researchers want to find out how well it works and if it can clear all signs of the cancer.
Chronic lymphocytic leukemiaNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
Effects of NNC0194-0499 alone and in combination with semaglutide, of semaglutide alone, and of cagrilintide alone and in combination with semaglutide on liver damage and alcohol use in people with alcohol-related liver disease
This study is testing different new medicines, alone or in combination, to see if they can help improve liver damage and reduce alcohol use in people with liver problems caused by alcohol. One of the medicines is similar to a type already used for diabetes.
alcohol-related liver diseaseNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Assess the Safety and Effectiveness of Tovinontrine in Patients With Chronic Heart Failure With Preserved Ejection Fraction
This study is testing a new medicine, Tovinontrine, for people with a type of chronic heart failure. It aims to see if the medicine is safe and if it can improve how the heart works according to blood tests, compared to a dummy pill.
chronic heart failureNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A Randomized, Double-blind, Controlled, Parallel-group, Single Dose, Three arm Study to Compare the Pharmacokinetic Similarity of MAB-22 Versus Prolia® Sourced from the European Union and United States in Healthy Male Participants
This study is looking at a new version of a medicine for bone conditions, called MAB-22. We want to see if it works the same way in the body as an existing medicine, Prolia®. Healthy men will take a single dose of one of these medicines.
Healthy volunteersNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Dose-finding, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Safety and Efficacy of Efavaleukin Alfa Induction Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis
This study is looking at a new medicine called Efavaleukin Alfa for people with moderate to severe Ulcerative Colitis. We want to see if it's safe and helps people feel better and get their condition under control within 12 weeks.
Ulcerative Colitis (UC)Netherlands - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase I/IIa Open-label Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD7789, an anti-PD-1 and anti-TIM-3 Bispecific Antibody, in Participants with Advanced or Metastatic Solid Tumors
This study is testing a new medicine, AZD7789, for people with advanced cancers like stomach or lung cancer. It's looking to see if the medicine is safe, how it works in the body, and if it can help shrink tumors.
Advanced or metastatic gastric and gastro-esophageal junction (GEJ) adenocarcinoma, Advanced or Metastatic Non-small Cell Lung Carcinoma, Advanced or Metastatic Solid TumorsNetherlands - Active not recruitingPHASE2, PHASE3
A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy.
This study looks at a new drug, efgartigimod PH20 SC, for adults with active idiopathic inflammatory myopathy (IIM), a condition causing muscle weakness and inflammation. It compares the drug to a dummy treatment to see if it helps improve muscle strength and overall well-being.
Active Idiopathic Inflammatory MyopathyMyositisDermatomyositisPolymyositisNetherlands - Ongoing, recruitingTherapeutic exploratory (Phase II)
A phase II, randomized, open-label study to assess the efficacy, safety, and pharmacokinetics (PK) of maintenance cabozantinib (XL184) plus best supportive care (BSC) versus BSC in children, adolescents and young adults (AYA) with unresectable residual osteosarcoma either at diagnosis or at first relapse after standard treatment.
This study looks at a new medicine called cabozantinib for young people with a type of bone cancer called osteosarcoma. It compares cabozantinib plus supportive care with supportive care alone to see if it helps stop the cancer from growing.
Osteosarcoma in Children, Osteosarcoma in Adolescents and Young Adults, OsteosarcomaNetherlands - Ongoing, recruitingPhase I and Phase II (Integrated)- First administration to humans
A Phase 1/2, Multicenter, Open-Label Study to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of DNL310 in Pediatric Participants with Hunter Syndrome
This study is testing a new medicine called DNL310 for children with Hunter Syndrome. It's looking at how safe the medicine is, how the body handles it, and if it helps reduce certain substances linked to the condition.
Hunter Syndrome (Mucopolysaccharidosis Type II [MPS II])Netherlands - AuthorisedTherapeutic confirmatory (Phase III)
APECS II: Comparing the efficacy of Pectoral Nerve (PECS II) Block with long-acting liposomal bupivacaine versus levobupivacaine for Mastectomy Surgery: A Multicenter Prospective Randomized Controlled Trial
This study compares two pain medications given during breast cancer surgery (mastectomy) to see which one works better at reducing pain afterwards. It aims to find out if a newer, longer-lasting pain relief注射 (injection) is more effective than a standard one for managing pain in the breast.
Postoperative and chronic pain after breast cancer surgeryNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A 52-week, randomised, double-blind, double-dummy, parallel group, multi-centre, non-inferiority study assessing exacerbation rate, additional measures of asthma control and safety in adult and adolescent severe asthmatic participants with an eosinophilic phenotype treated with GSK3511294 (depemokimab) compared with mepolizumab or benralizumab
This study looks at a new medicine called depemokimab for severe asthma with high eosinophils. It compares it to existing treatments like mepolizumab and benralizumab over a year to see if it's just as good at preventing asthma attacks and improving control.
Severe asthma with an eosinophilic phenotypeNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An open label, single arm, extension trial to examine long-term safety of Iclepertin once daily in patients with schizophrenia who have completed previous Iclepertin Phase III trials.(CONNEX-X)
This study is looking at the long-term safety of a new medicine called Iclepertin for people with schizophrenia. It's for those who have already taken part in earlier studies of this medicine. We want to see how safe it is over a longer period.
SchizophreniaNetherlands - Recruiting
How effective are walk-in mental health centers for young people with psychological distress in Europe and Australia?
This study looks at how well 'walk-in' mental health centres, called YEAHs, help young people aged 12-25 with mental health challenges. It checks if they improve mental well-being, are easy to use, and offer good value, comparing them to usual care.
Prevention and early intervention of mental disorders in youth with psychological distressNetherlands - Recruiting
Effectiveness and public health impact of SELFIE, a blended ecological momentary intervention for improving self-esteem in young people
This study aims to help young people aged 14-25 in the UK and other European countries who have had tough childhoods and now have low self-esteem and mental health problems. It tests a program called SELFIE, combining an app with support from a mental health expert, to see if it can boost self-esteem.
Mental health problemsNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of Daratumumab in Combination with Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) Compared With CyBorD Alone in Newly Diagnosed Systemic AL Amyloidosis
This study is looking at a new way to treat AL amyloidosis, a rare condition where unhealthy proteins build up in your body. It compares a new drug called daratumumab with existing treatments to see if it works better and is safe for people newly diagnosed with the condition.
AL Amyloidosis (Newly Diagnosed Systemic AL Amyloidosis)Netherlands - Ongoing, recruitingTherapeutic use (Phase IV)
A stratification trial to determine key immunological factors predicting Tofacitinib efficacy in Psoriatic Arthritis (PsA); TOFA-PREDICT
This study, called TOFA-PREDICT, looks at how a medicine called Tofacitinib works for people with Psoriatic Arthritis. Researchers want to understand why it helps some people more than others by looking at their body's chemistry before and during treatment.
Psoriatic arthritisNetherlands - Active not recruiting
A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice
This study looks at how a cancer drug called atezolizumab works in real patients. Researchers want to see its effects and safety under normal hospital care, for different types of cancer it's approved for.
Urothelial CarcinomaNon-Small Cell Lung CancerSmall Cell Lung CancerHepatocellular CarcinomaNetherlands - Active not recruitingPHASE3
Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD
This study is looking into a new medication called Pelacarsen. It aims to see if this medicine can help people with heart disease who have high levels of a specific type of 'bad' cholesterol (Lipoprotein(a)) reduce their risk of future heart problems.
Cardiovascular Disease and Lipoprotein(a)Netherlands - Active not recruitingPHASE2
Safety and Efficacy of Pembrolizumab (MK-3475) in Children and Young Adults With Classical Hodgkin Lymphoma (MK-3475-667/KEYNOTE-667)
This study looks at a new drug, pembrolizumab, combined with standard chemotherapy for children and young adults (3-25 years old) with newly diagnosed classical Hodgkin Lymphoma. It specifically focuses on those who aren't responding quickly to initial treatment.
Hodgkin LymphomaNetherlands - Active not recruitingNA
Neural Cardiac Therapy for Heart Failure Study (NECTAR-HF)
This study is looking into a new way to help people with heart failure by stimulating a nerve called the vagal nerve. It involves a small implanted device and aims to improve heart health and quality of life.
Heart FailureCongestive Heart FailureNetherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A First in Human Study of IBC-Ab002 in Persons With Early Alzheimer's Disease (AD)
This study is looking into a new medicine called IBC-Ab002 for people with early Alzheimer's disease. It's the very first time this medicine is being given to humans, to see if it's safe and how it works in the body.
Alzheimer's diseaseNetherlands - RecruitingPHASE1, PHASE2
HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
This study is for children and young adults aged 1-21 with specific types of aggressive blood cancers that have come back or not responded to treatment. It tests new drug combinations to see if they're safe and work well for those with certain genetic changes in their cancer.
Acute Lymphoblastic LeukemiaLymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) RecurrentLymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) RecurrentLymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) RefractoryNetherlands - RecruitingPHASE1, PHASE2
A Trial to Evaluate EP-104GI in Adults With Eosinophilic Esophagitis (EoE).
This study is testing a new treatment, EP-104GI, for adults with eosinophilic esophagitis (EoE). It aims to see if it's safe, how well it works, and how the body handles it. Participants will either receive the treatment or a dummy version.
Eosinophilic EsophagitisNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, adjudicator-blinded, randomised study to evaluate the efficacy and safety of treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with invasive fungal disease (IFD) caused by Aspergillus species
This study looks at a new medicine, olorofim, for serious fungal infections caused by Aspergillus. It compares olorofim to an existing treatment, AmBisome, to see which is safer and more effective for patients in the UK.
Invasive fungal infections due to Aspergillus spp.Netherlands - Active not recruitingPHASE3
Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
This study is for men with a certain type of advanced prostate cancer (mCSPC) that has spread and has specific gene changes. It compares a new drug called talazoparib, given with standard treatment enzalutamide, against enzalutamide alone, to see if it's safe and effective.
Prostate CancerNetherlands - RecruitingPHASE3
An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma
This study looks at a daily tablet called ivosidenib for adults with bile duct cancer that has come back or spread, and has been treated before. It aims to confirm if the treatment is safe and works well, and how it affects quality of life.
CholangiocarcinomaNetherlands - RecruitingPHASE3
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
This study looks at a new medicine called zilebesiran for people with high blood pressure that isn't well controlled, especially if they also have heart problems or are at high risk of developing them. The aim is to see if zilebesiran can reduce serious heart-related events like heart attacks or strokes.
High Risk Cardiovascular DiseaseHypertensionHigh Cardiovascular RiskNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, phase 3 trial with anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) versus placebo for patients with early stage NSCLC after resection and completion of standard adjuvant therapy (PEARLS) KEYNOTE-091
This study looks at a drug called Keytruda after surgery for a type of lung cancer. It aims to see if Keytruda can stop the cancer from coming back for longer than a dummy treatment in patients with non-small cell lung cancer, especially those with certain cancer markers.
Stage IB (T ≥ 4 cm), II and IIIA NSCLCNetherlands - Active not recruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Zilganersen (ION373) in Patients With Alexander Disease (AxD)
This study is testing a new medicine, zilganersen, for people with Alexander Disease. It aims to see if the medicine is safe and if it can help improve or steady movement abilities. It's a large study, comparing the medicine to a dummy treatment (placebo).
Alexander DiseaseNetherlands - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of AMX0035 Versus Placebo for 48-week Treatment of Adult Patients with Amyotrophic Lateral Sclerosis (ALS)
This study is testing a new medicine, AMX0035, for people with Motor Neurone Disease (ALS). It aims to see if the medicine can slow down the disease's progression over 48 weeks, compared to a dummy medicine.
Amyotrophic Lateral Sclerosis (ALS)Netherlands - Ongoing, recruitingTherapeutic use (Phase IV)
GOut TrEatment STrategy (GO TEST) FINALE study, a multicentre pragmatic randomized superiority trial of continuation versus cessation of urate lowering therapies in gout in remission.
This study, called GO TEST FINALE, is looking into the best way to manage gout. If your gout is under control, doctors want to know if it's better to keep taking your gout medication or if you can safely stop. They will compare different treatments over two years.
GoutNetherlands - RecruitingPHASE2
Brivekimig for the Treatment of Moderate to Severe Hidradenitis Suppurativa
This study is testing a new medicine called brivekimig for moderate to severe hidradenitis suppurativa (HS). It compares brivekimig to a dummy medicine (placebo) to see if it's safe and helps reduce HS symptoms.
Hidradenitis SuppurativaNetherlands - AuthorisedTherapeutic exploratory (Phase II)
Neoadjuvant AXITINIB plus AVELUMAB for patients with localized RCC and a moderate to high risk of recurrence (N17JAV)
This study is looking at a new combination of two drugs, axitinib and avelumab, for people with a common type of kidney cancer before surgery. The main goal is to see how well this drug combination shrinks the cancer.
renal cell carcinomaNetherlands