Latest studies
- Recruiting
A study to find out if a new blood test (microRNA) can be used to monitor people after surgery for seminoma or dysgerminoma cancer
This study looks at a new blood test to see if cancer has come back in people treated for specific early-stage cancers like seminoma or dysgerminoma. It aims to reduce the need for scans by seeing if a simple blood test can do the job and help find cancer recurrence earlier.
Seminoma and dysgerminomaWales - CompletedPhase I
Phase I Trial: 36414 (SUDO-550-102)
This early-stage study is looking for healthy women aged 18-55 to help test a new medicine or treatment. The full details are not yet public, but it's an important step in making sure new healthcare options are safe and effective.
N/A - healthy volunteersWales - Recruiting
Timing of nutrition in emergency laparotomy
This study looks at the best time to give special liquid food directly into a vein to adults having urgent belly surgery. It aims to see if starting this feeding early helps reduce problems and speeds up recovery after the operation.
Hospital complications in adults undergoing emergency laparotomyWales - Recruiting
A study of home-use brain stimulation to treat bipolar depression
This study looks at whether a home-use device using mild electrical current can help people with bipolar depression. It aims to see if it's effective, safe, and easy to use at home, compared to a dummy treatment.
Bipolar Disorder; Mental healthWales - Recruiting
Comparing large chest drains with small chest drains to explore the best treatments for chest injury
This study compares two types of tubes, small and large, used to drain air or blood from the chest after an injury. It aims to find out which one works best and is safer for patients, and if it could save the NHS money.
Specialty: Trauma and Emergency Care, Primary sub-specialty: Emergency Medicine; Health Category: Injuries and accidents, Respiratory; Disease/Condition: Injuries to the thoraxWales - Recruiting
Evaluating The Skill Mill programme to lower violence and offending in young people
This study looks at 'The Skill Mill' programme, which gives young people aged 16-18 with a past offending history a 6-month paid job. The aim is to see if this helps reduce re-offending and improves their life skills and job prospects. It's funded by the Youth Endowment Fund.
Prevention of re-offending by young people with an offending history with one or multiple convictions of any type of offenceWales - Recruiting
Pharmacogenetics to avoid loss of hearing UK
This study uses a quick genetic test to protect newborn babies from hearing loss. Some babies given a common antibiotic, gentamicin, can become deaf if they have a certain gene. This test identifies those babies quickly so they can receive a safer treatment. It's being tested across the UK.
Use of a genetic test to detect the m.1555A>G variant associated with aminoglycoside-induced hearing loss in neonatal care unitsWales - RecruitingPhase IV
Digital multi-component intervention to improve the care of older people living with diabetes and chronic kidney disease
This study looks at whether computer reminders can help GPs give better care to older people with kidney problems caused by diabetes. The aim is to slow down kidney damage and improve health for people in the UK. Researchers will test a digital tool in GP practices.
Diabetic kidney disease (DKD)Wales - Recruiting
Investigating the use of a breathing device in older people with broken ribs
This study looks at a breathing device for older people with broken ribs. It aims to see if an incentive spirometer can help prevent chest infections and other problems, making recovery smoother after a rib injury.
Rib fracturesWales - CompletedPhase I
Phase 1 Trial: 36342 (DT-101/102)
This is a very early stage clinical trial, called a Phase 1 study, looking into a new treatment marked as DT-101/102. The aim is to understand how safe the treatment is and if it has any side effects. Full details about it will be shared later, after the study finishes.
The Health Research Authority (HRA) has approved deferral of publication of the full details of the trial. The full details will be added to the study record within 30 months after the trial has ended.Wales - Completed
Evaluating CBT Bytesize: a mixed-methods feasibility trial of a blended digital CBT intervention for adolescent anxiety and low mood
This study tested a new digital programme called CBT Bytesize for young people aged 11-17 with anxiety. It combines online learning with therapist support to see if it helps reduce anxiety and is easy to use.
Anxiety disorders in children and young peopleWales - CompletedPhase I
A 2-part study to investigate the safety, tolerability and effect of MB272 in healthy volunteers
This study, called MB272, looked at a new drug (GS-0272) in healthy volunteers. It checked if the drug was safe, how well people tolerated it, and how it acted in the body when given in different ways and doses. The goal was to gather early information about this potential new medicine.
Healthy volunteersWales - Completed
Evaluating the feasibility of a samba percussion intervention for people with Parkinson’s disease
This study looks at a fun samba drumming activity for people with Parkinson's disease. It wants to see if weekly drumming sessions can help with movement, thinking, and mood. The aim is to check if a future, bigger study would be possible.
Parkinson's diseaseWales - Recruiting
A study evaluating whether immobilisation or no immobilisation affects pain scores in toddlers fractures
This study looks at how best to treat toddlers' shin bone breaks. It compares using a cast or boot with no cast, to see which helps children with pain, convenience, and recovery. It aims to find the safest and most practical approach for families and the NHS.
Toddler's fractures - non-displaced spiral fractures of the tibiaWales - Recruiting
A brief psychosocial therapy intervention for dementia carers
This study tests a free online program called Kindred to help family carers of people with dementia who have challenging symptoms. It aims to see if the program makes carers feel more confident and less stressed, and whether it helps the person they care for.
Carers supporting people with dementia who are experiencing neuropsychiatric symptoms (NPS) such as aggression, irritability, depression, anxiety and suspiciousnessWales - Completed
NOMO app and teenage social media use: a randomised controlled trial in England and Wales
This study looks at whether a phone app called NOMO can help teenagers in UK secondary schools use social media less. It aims to see if the app can improve things like concentration, happiness, and sleep by encouraging less screen time and more challenges.
Social media usage, distraction, life satisfaction, sleepWales - RecruitingNot Applicable
Biomarkers for RAtional Investigation for Neurological Decision Support in traumatic brain injury (BRaINS-TBI): cohort study with a nested pragmatic randomised controlled trial
This study looks at a new blood test for people with head injuries in A&E. It aims to see if this test can help doctors make better decisions, reduce unnecessary scans, and improve care. It involves blood samples and follow-up.
Traumatic brain injuryWales - RecruitingPhase IV
A platform trial to identify the best treatments for critically ill children admitted to paediatric intensive care
This study is looking for better ways to care for very sick children in intensive care. We are testing common treatments to see which ones work best and are safest, hoping to improve their recovery and future well-being.
Critical illnessWales - RecruitingPhase III
ESTEEM: A clinical trial testing whether testosterone can help improve the quality of life during menopause
This study, called ESTEEM, is looking at whether adding testosterone cream to usual HRT can help women in the UK feel better during menopause. It aims to see if it can ease symptoms like poor sleep, brain fog, or low energy, and whether any side effects are worth it.
Medical condition: Menopause Medical condition in lay language: Menopause Therapeutic areas: Diseases [C] - Female diseases of the urinary and reproductive systems and pregancy complications [C13]Wales - Recruiting
A population-based digital study offering people testing for cancer genes, to identify people at increased risk of cancer so they can take steps to prevent it or detect it early
This study offers a genetic test for cancer risk to people in the UK. It uses a saliva sample to check for genes linked to breast, ovarian, bowel, and womb cancers. The aim is to find people at higher risk so they can take steps to prevent cancer or detect it early.
CancerWales - Recruiting
Cauda equina syndrome early recognition study
This study looks into Cauda Equina Syndrome (CES), a serious spinal condition. It aims to find better ways for doctors in A&E to quickly identify who has CES and who doesn't, to make sure people get the right treatment when they need it most.
Cauda equina syndrome (CES)Wales - Recruiting
A UK study of minimally invasive emergency treatment of sudden bleeding from the lower bowel
This study looks back at records of patients in the UK and other countries who had a special X-ray guided procedure called embolisation to stop sudden bleeding from their bowel. It aims to understand how well this treatment works and to improve care for similar cases in the future.
Patients who have undergone angiography +/- embolisation for acute non-variceal lower GI haemorrhage.Wales - Completed
The impact of trainer behaviour on trainee cognitive load and performance during vascular surgery simulation
This study looks at how a trainer's behaviour affects surgical trainees learning. It compares supportive trainers to rude ones in a simulated operating room. The goal is to improve training and patient safety by understanding this impact.
Surgical trainee intraoperative cognitive load, technical skills and non-technical skillsWales - Recruiting
Impact of having a long lie after a fall
This study looks into what happens when someone falls and can't get up for a long time. It aims to improve how we help people waiting for assistance, making things better for patients, ambulance services, and care homes.
Specialty: Trauma and Emergency Care, Primary sub-specialty: Pre-hospital; Health Category: Disputed Aetiology and OtherWales - RecruitingPhase III
A Phase III randomized, open-label study of pasritamig (JNJ-78278343), a T-cell-redirecting agent targeting human kallikrein 2, with docetaxel versus docetaxel for metastatic castration-resistant prostate cancer
This study is testing a new drug, pasritamig, with an existing treatment for advanced prostate cancer called docetaxel. It aims to see if combining them works better than docetaxel alone for men whose cancer has spread and is resistant to hormone treatment.
Metastatic castration-resistant prostate cancer (mCRPC)Wales - Completed
Evaluating the effectiveness of the RILL literacy with language intervention for primary-aged children in English and Welsh
This study looks at a new version of the RILL programme, an online reading and language support for 7-9 year olds in schools across Wales. It aims to see if RILL helps children who are finding reading difficult improve more than usual classroom lessons.
Lower reading performanceWales - Recruiting
Can we safely reduce the number of days of radiotherapy needed to treat people with breast cancer who need boost treatment?
This study looks at whether we can safely give breast cancer patients who need an extra 'boost' of radiotherapy a shorter 5-day treatment instead of the usual 15 days. It compares two different 5-day boost doses with the standard 15-day boost.
Breast cancerWales - Recruiting
Under stress: Why women of black African-Caribbean heritage are at elevated risk of stroke
This study looks at why Black African and Caribbean women might be more likely to have a stroke, especially at a younger age. We're exploring how stress affects blood pressure and brain health in these women, and comparing it to White European women.
HypertensionWales - RecruitingPhase I
Phase 1 Trial: 36024 (SYX-5219-101)
This is a very early-stage medical study, called a Phase 1 trial. Researchers are testing a new treatment, SYX-5219-101. We don't have many details yet because the full information will be made public later, but it involves people aged 18 to 65. Its main goal is to check safety.
The Health Research Authority (HRA) has approved deferral of publication of the full details of the trial. The full details will be added to the study record within 30 months after the trial has ended.Wales - Recruiting
FORENSIC-UK: Fusion versus Best Conservative Care
This study looks at whether an operation called spinal fusion helps people with ongoing severe lower back pain better than other non-surgical treatments. It also checks if the operation is good value for the NHS.
Low back painWales - Completed
A study exploring healthcare professionals' experiences using a ready-to-use botulinum toxin for cosmetic treatments in UK aesthetic clinics
This study looks at how UK skincare doctors and nurses use a new, ready-to-use treatment for facial lines like frown lines and crow's feet. It aims to see if this new product is easy to use and helps clinics run smoothly.
Facial lines, specifically glabellar (frown) lines and lateral canthal (crow’s feet) linesWales - Recruiting
Can we reduce the environmental impact of nitrous oxide anaesthesia without affecting patient care?
This study looks at different ways to give a gas called nitrous oxide during surgery. It checks if using gas from small cylinders is as safe for patients and better for the environment than the usual way, which uses pipes.
Method of nitrous oxide delivery in patients requiring surgery under general anaesthetic.Wales - CompletedPhase II
Evaluation of a novel bowel cancer blood test to prioritise the colonoscopy waiting list
This study is testing a new blood test that could help prioritise people waiting for a colonoscopy after having bowel cancer or polyps. It aims to see how well the blood test can identify those most likely to have a recurrence, so they can get their colonoscopy sooner.
Colorectal cancer, high risk polyp and genetic colorectal cancer predispositionsWales - Recruiting
A trial to expand the IRIS (Identification and Referral to Improve Safety) domestic abuse programme to include men, children and young people
This study looks at how GP practices can better support people experiencing domestic abuse, including men, women, and children. It compares a new, expanded support program (IRIS+) with the current one (IRIS) to see which is more effective and offers better value for money in keeping people safe and healthy.
Domestic violence and abuseWales - Not yet recruiting
Multi-centre MRI study of the heart microstructure in healthy volunteers
This study uses special MRI scans to look at tiny details of the heart in healthy people. Researchers want to understand how these scans work best and improve them. This information could help spot heart problems earlier and develop new treatments in the future.
Evaluation of cardiac microstructure with cardiac DTIWales - Recruiting
Introducing diabetes checks in dental settings: a study to explore whether dental settings can be used to identify new cases of prediabetes and diabetes
This study looks at whether dentists can help spot early signs of diabetes in their patients. Dentists are often seen regularly, which might make them a good place to check for diabetes early. It involves a simple questionnaire and a finger-prick test.
DiabetesWales - Recruiting
QuicDNA Max Research Programme – multi site, multi-centre, non-interventional, biomarker platform study. Assessing blood based ctDNA (circulating tumour) testing to guide cancer care across multiple cancer types
The QuicDNA Max study is exploring a new blood test (liquid biopsy) for people with advanced cancer. It aims to see if this test, which looks for cancer DNA in the blood, can help doctors make better treatment decisions and track cancer changes, offering a simpler alternative to traditional biopsies.
Individuals with radiologically suspected or confirmed advanced cancers, or those who have developed resistance to existing therapies and have radiological evidence of disease progressionWales - CompletedNot Applicable
REFUEL-MS: Clinical and Cost-Effectiveness RCT
This study looks into an app called REFUEL-MS to help people with Multiple Sclerosis (MS) manage fatigue. The app offers exercises and coping strategies. We want to see if it reduces tiredness more than usual care and if it's safe.
Multiple sclerosisWales - Recruiting
A national perioperative platform trial to improve outcomes for surgical patients (PROTECT)
The PROTECT study aims to improve care for surgical patients in the UK. It's a new type of study that can test many treatments quickly. Patients aged 18 and over, having surgery, can participate. We'll collect health information after surgery to find better ways to help people recover.
All adult patients (≥18 years) being treated within a surgical care pathway at the recruitment sites will be eligible for the trial.Wales - RecruitingPhase IV
Examining antibiotics for ulcerated skin cancer surgical excision
This study looks at whether antibiotics can prevent infections after surgery for ulcerated skin cancer. People will either get an antibiotic or a dummy pill to see if it reduces wound infections, helping doctors decide if antibiotics are needed for this surgery.
Antibiotic treatment for the prevention of surgical site infection in participants receiving ulcerated skin cancer excisionWales - Recruiting
SPRING study: a study to design and evaluate the clinical and cost effectiveness of the SPRING prehabilitation and early rehabilitation interventions for people undergoing shoulder replacement surgery compared to NHS usual care
This study aims to improve support for people having shoulder replacement surgery. It’s testing new support packages before and after surgery to see if they help people recover better and feel more prepared than usual NHS care.
Self management after shoulder replacementWales - RecruitingPhase III
SPOT-IT: prevention of the cutaneous squamous cell carcinoma in immunosuppressed patients using topical treatment
This study looks at new cream treatments to prevent a type of skin cancer called squamous cell carcinoma (SCC) in people with weakened immune systems. It compares existing treatments with new combinations, aiming for more effective and tolerable options.
Cutaneous Squamous cell carcinoma (SCC) is a type of skin cancer. Some SCC may develop from areas of sun-damaged skin called actinic keratoses (AK), which arise on skin areas exposed to sunlight.Wales - Completed
The effect of 8 weeks probiotic supplementation on sleep quality in adults aged 18 years and over
This study looks into whether taking a probiotic supplement for eight weeks can improve sleep for adults who aren't happy with their sleep. Researchers will compare those taking the probiotic to those taking a dummy pill.
Healthy adults with dissatisfaction with their current sleepWales - Recruiting
A UK-wide study to find out which routine top-up feeds for extremely preterm babies when there is insufficient own mother’s milk, reduce the likelihood of necrotising enterocolitis and improve survival and brain development
This study looks at the best way to feed very early babies, specifically those born before 29 weeks. It compares donor breast milk to special formula and different ways of fortifying milk to see which helps babies survive, grow, and avoid serious gut and brain problems.
Necrotising enterocolitis, mortality, and cognitive impairment in preterm babies born below 29 weeks gestationWales - RecruitingPhase I
Phase I Trial: 36540 (DF-PK-01)
This is an early-stage study (Phase I) looking into a new treatment. The full details are not yet available but will be shared within 30 months after the study finishes. It involves people aged 20 to 65.
The Health Research Authority (HRA) has approved deferral of publication of the full details of the trial. The full details will be added to the study record within 30 months after the trial has ended.Wales - Recruiting
Repeat surgery for recurrent glioblastoma
This study looks at whether a second operation for glioblastoma brain cancer, when it returns, helps people live longer and have a better quality of life. Patients will be randomly put into two groups: one has another surgery, and the other does not. Both groups then receive other treatments.
Repeat surgery for patients with recurrent glioblastomaWales - CompletedPhase IV
An 8-week study to investigate the benefits of a blue LED facial mask device on acne
This 8-week study looks at whether a blue LED light mask helps improve acne. We need around 30 healthy volunteers aged 14-75. It involves clinic visits for skin checks and photos, and using the mask at home. The goal is to understand how this device works for future users.
AcneWales - Not yet recruiting
The National Unified Renal Translational Research Enterprise for biosampling patients with rare kidney disease
This study collects samples and health details from children aged 0-16 with rare kidney diseases like glomerulonephritis, and healthy children. Researchers hope to better understand these conditions, find early signs of problems, and develop improved, personalised treatments by studying blood, urine, and medical records.
Children and young people with rare kidney diseases. Glomerulonephritis (GN): Including subtypes such as IgA Vasculitis Nephritis (IgAVN), IgA Nephropathy (IgAN), Idiopathic Nephrotic Syndrome (iNS), C3 Glomerulopathy/Membranoproliferative GN (MPGN), Post-infectious Glomerulonephritis (PIGN), Lupus Nephritis (LN), ANCA-associated vasculitis (AAV), and Membranous Nephropathy (MN)Wales - Completed
Erythropoietic protoporphyria life impact and genetic health trajectory (EPP LIGHT): a survey of adults and adolescents in Europe living with EPP
This study is gathering information through an online survey about how living with Erythropoietic Protoporphyria (EPP) or X-linked Protoporphyria (XLP) affects people in Europe. It looks at daily life, symptoms, and healthcare, helping us understand the condition better for future improvements.
Erythropoietic protoporphyria and X-linked protoporphyria (collectively referred to as EPP)Wales - Recruiting
A-PATH: A path towards healing and support for older women
This study, A-PATH, aims to create better support for women aged 60-74 in England and Wales who have experienced domestic abuse. It will adapt an existing programme to suit their unique needs, helping them on their path to healing and recovery.
Domestic abuseWales