Latest studies
- Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaNorth Macedonia - RecruitingPhase III
Astria STAR-0215-302 trial for Navenibart in Hereditary Angioedema
This study looks at a new medicine called navenibart for hereditary angioedema (HAE). It aims to see how safe it is and how well people tolerate it over a long time. Navenibart might help prevent HAE attacks, which can be severe and painful.
Hereditary angioedemaNorth Macedonia - Recruiting
Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry
This international study looks at how a type of medicine called SGLT2 inhibitors is used in adults with heart problems they were born with. Researchers want to see how safe these medicines are, if people tolerate them well, and if they help improve heart failure.
Adult Congenital Heart DiseaseCongenital Heart DiseaseSystemic Right VentricleTransposition of the Great ArteriesNorth Macedonia - Active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
This study compares a new drug, Giredestrant, with standard hormone therapy for early breast cancer. It's for people with a specific type of breast cancer (ER-positive, HER2-negative) who have already had surgery.
Early Breast CancerNorth Macedonia - Active not recruitingPHASE3
A Study of Navenibart in Participants With Hereditary Angioedema
This study is testing a new medicine, navenibart, for people with Hereditary Angioedema (HAE). Researchers want to see if it safely and effectively prevents swelling attacks in adults and teenagers with HAE.
Hereditary Angioedema (HAE)North Macedonia - Active not recruitingPHASE3
An Open-label Extension Trial to Evaluate the Long-term Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)
This study is looking into the long-term safety of a new medication, KVD900 (Sebetralstat), for teenagers and adults with Hereditary Angioedema (HAE). It is an extension of a previous study, continuing to monitor participants who have already been taking the drug.
Hereditary AngioedemaNorth Macedonia - Active not recruitingPHASE3
A Research Study on How Well Concizumab Works for You if You Have Haemophilia A or B With or Without Inhibitors
This study is testing a new medicine, concizumab, for people with haemophilia A or B, with or without 'inhibitors'. It aims to see if concizumab can prevent bleeds and if it's safe to use. Participants will inject the medicine daily under their skin.
Haemophilia A and B With and Without InhibitorsNorth Macedonia - Active not recruitingPHASE3
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
This study looks at a new medicine called ziltivekimab for people with heart failure and inflammation. It aims to see if monthly injections of ziltivekimab can help, compared to a dummy medicine, over a few years.
Heart FailureNorth Macedonia - RecruitingNA
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
This study looks at two types of heart bypass surgery for women: using one or multiple healthy arteries. Researchers want to see if using more arteries leads to better long-term health, quality of life, and fewer future heart problems for women.
Heart DiseasesCoronary Artery DiseaseCoronary Artery Bypass GraftingNorth Macedonia - Enrolling by invitationPHASE3
Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat Studies
This study offers ongoing access to a medicine called berotralstat for people with Hereditary Angioedema (HAE) who have already taken part in previous berotralstat studies. It aims to check the long-term safety of the treatment.
Hereditary AngioedemaHAENorth Macedonia - Active not recruitingPHASE2
A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent Studies
This study is for people with cancer that has spread, who are already benefiting from a specific medicine called trastuzumab emtansine (T-DM1) or other similar treatments in an earlier study. It allows them to keep receiving these important treatments for longer to see if they continue to help.
Neoplasm MetastasisNorth Macedonia - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis
This study is comparing two medicines, fenebrutinib and ocrelizumab, to see which is safer and better at slowing down primary progressive multiple sclerosis (PPMS). It's for adults with PPMS and aims to understand how these treatments affect the disease progression.
Multiple Sclerosis, Primary ProgressiveNorth Macedonia - Recruiting
Computerized Registry of Patients With Venous Thromboembolism (RIETE)
The RIETE study is building a large database of information from patients with blood clots (venous thromboembolism). It helps doctors better understand and treat patients, especially those with other health problems, to improve care and understand what medicine works best for different groups.
Venous ThromboembolismNorth Macedonia - Recruiting
Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants
This study looks at people who have a stroke while taking blood thinners for an irregular heartbeat. It aims to understand why this happens and what treatments work best afterwards to prevent another stroke. Researchers will collect information from medical records and follow some patients over time.
Ischemic StrokeOral AnticoagulationAtrial Fibrillation (AF)Outcome AssessmentNorth Macedonia - RecruitingPHASE2
A Clinical Study to Evaluate DNTH103 in Adults With Multifocal Motor Neuropathy
This study is testing a new medicine, Claseprubart, for adults with Multifocal Motor Neuropathy (MMN). We want to see if it's safe, how it works in the body, and if it can help improve symptoms. Participants will receive either the new medicine or a placebo.
Multifocal Motor NeuropathyNorth Macedonia - Active not recruitingPHASE2
A Phase 2 Study to Evaluate DNTH103 in Adults With Generalized Myasthenia Gravis (MAGIC)
This study is testing a new medicine, Claseprubart (also called DNTH103), for adults with a condition called generalized myasthenia gravis (gMG). We want to see if the medicine is safe, well-tolerated, and helps improve symptoms. Some people will get the new medicine, and others a placebo.
Myasthenia Gravis, GeneralizedNorth Macedonia - RecruitingPHASE4
Nuwiq for Perioperative Management Of Patients With Haemophilia A on Emicizumab Regular Prophylaxis Study
This study looks at how well a medicine called Nuwiq works to prevent bleeding during surgery in people with severe haemophilia A who are already taking another medicine called emicizumab. It's for males aged 12 and over undergoing major operations.
Severe Hemophilia ANorth Macedonia - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)
This study is looking at a new medicine called fenebrutinib for people with relapsing multiple sclerosis (RMS). It wants to see if fenebrutinib is safe and works better than an existing medicine, teriflunomide, at slowing down the disease and reducing flare-ups.
Relapsing Multiple SclerosisNorth Macedonia - Enrolling by invitationPHASE3
A Long-Term Study of Navenibart in Participants With Hereditary Angioedema
This study looks at a new medicine called navenibart for people with hereditary angioedema (HAE). It checks how safe and effective it is over a long time. Only people who were in a previous study with this medicine can join.
Hereditary Angioedema (HAE)North Macedonia - Active not recruitingPHASE2, PHASE3
A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
This study looks at a new medicine called guselkumab for adults with moderately to severely active Crohn's disease. Researchers want to see how well it works and if it's safe compared to other treatments or a dummy medicine.
Crohn's DiseaseNorth Macedonia - Active not recruitingPHASE2
A Study to Evaluate INCB099280 in Participants With Advanced Cutaneous Squamous Cell Carcinoma
This study is looking at a new medicine called INCB099280 for people with advanced skin cancer (cutaneous squamous cell carcinoma). We want to find out if it's safe, how well people can tolerate it, and if it helps treat this type of cancer.
Cutaneous Squamous Cell CarcinomaNorth Macedonia - Active not recruitingPHASE1
A PK Study to Compare GME751 (Proposed Pembrolizumab Biosimilar) and US-licensed and EU-authorized Keytruda® in Participants With Stage II and III Melanoma
This study compares a new medicine called GME751 to an existing treatment, Keytruda, for people with melanoma that has been removed by surgery. It checks if GME751 works similarly and is safe.
MelanomaNorth Macedonia - Active not recruitingPHASE3
A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer
This study compares a new drug, alectinib, with standard chemotherapy for people with a certain type of lung cancer (ALK-positive non-small cell lung cancer) after surgery. We want to see if alectinib is better at stopping the cancer from coming back and if it's safe.
Carcinoma, Non-Small-Cell LungNorth Macedonia - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)
This study looks at a new drug, claseprubart, for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). It aims to see if the drug helps people with CIDP and if it's safe. Some participants will receive the drug, and others a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathyNorth Macedonia