Latest studies
- Active not recruitingPHASE2, PHASE3
A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
This study investigates an injection called litifilimab for adults with active lupus that mainly affects the skin, known as cutaneous lupus erythematosus (CLE). Researchers want to see if it helps reduce skin symptoms and is safe, especially for those whose current treatments aren't working well.
Subacute Cutaneous Lupus ErythematosusChronic Cutaneous Lupus ErythematosusSlovakia - Ongoing, recruitingTherapeutic exploratory (Phase II)
Safety and efficacy of once-weekly subcutaneous and once-daily oral NNC0487-0111 in participants with type 2 diabetes – a dose finding study
This study is testing a new medicine, NNC0487-0111, for people with type 2 diabetes. It's looking at different ways to take the medicine (once a week shot or once a day pill) to see how safe and effective it is at controlling blood sugar.
Type 2 DiabetesSlovakia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
An Open-label Extension Study for Participants who Completed Study IMVT-1401-3201 or Study IMVT-1401-3202 to Assess the Efficacy and Safety of Batoclimab for the Treatment of Thyroid Eye Disease (TED)
This study looks at a new medicine called batoclimab for Thyroid Eye Disease (TED). It’s for people who have already taken part in similar batoclimab studies. We want to see how long their eyes stay improved after stopping the medicine and if it helps those who didn't respond before.
Thyroid Eye Disease (TED)Slovakia - Recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
This study looks at how well Medtronic heart devices, like pacemakers and defibrillators, perform over a long time. It helps ensure these devices are reliable and safe for people with heart conditions such as irregular heartbeats or heart failure.
ArrhythmiaBradycardiaHeart FailureSinus TachycardiaSlovakia - Active not recruitingPHASE3
Safety and Efficacy Study of Enzalutamide Plus Leuprolide in Patients With Nonmetastatic Prostate Cancer (EMBARK)
This study looks at a new combination of medicines, enzalutamide and leuprolide, for men with prostate cancer that hasn't spread but is considered high-risk. The goal is to see how safe and effective this combination is in slowing down the cancer.
Hormone Sensitive Prostate CancerProstate CancerCancer of the ProstateSlovakia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase I/III, Multi-center, Randomized, Double-blind Study of BAT3306 plus Chemotherapy versus Keytruda® plus Chemotherapy to Evaluate Pharmacokinetics, Efficacy, and Safety in Participants with Stage IV Non-squamous Non-small Cell Lung Cancer.
This study is testing a new drug (BAT3306) against an existing one (Keytruda®) in people with advanced non-small cell lung cancer. Both drugs are given with standard chemotherapy. We want to see how safe and effective the new drug is, and how it acts in the body.
Stage IV Non-squamous non-small cell lung cancerSlovakia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study to Assess Efficacy and Safety of Atuliflapon Given Orally Once Daily for Twelve Weeks in Adults with Moderate to Severe Uncontrolled Asthma
This study is testing a new medicine, Atuliflapon, for adults whose moderate-to-severe asthma isn't well controlled by their usual treatments. We want to see if it reduces asthma flare-ups and improves breathing, compared to a dummy pill, over 12 weeks.
Moderate-to-Severe Uncontrolled AsthmaSlovakia - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaSlovakia - Ongoing, recruitingTherapeutic exploratory (Phase II)
Interventional, randomized, double-blind, parallel-group, placebo-controlled, dose-finding trial of Lu AG09222 for the prevention of migraine in participants with episodic and chronic migraine. Lundbeck trial no: 20297A
This study is testing a new medicine, Lu AG09222, to see if it can help prevent migraines. It's for people who get migraines often, including those with episodic (comes and goes) and chronic (very frequent) migraine. Researchers want to find the best dose to reduce migraine days.
MigraineSlovakia - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Study to Evaluate the Effects of Various Degrees of Hepatic Impairment on the Pharmacokinetics of A Single Subcutaneous Dose Of RO7434656, an Antisense Inhibitor of Complement Factor B
This study is looking at how a new medicine, called RO7434656, is handled by the body in people with different levels of liver problems. It's a very early stage study to understand how this medicine works and whether liver health affects it.
Hepatic ImpairmentSlovakia - RecruitingPHASE3
A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis
This study is looking into a new medication called Afimkibart for people aged 16-80 with ulcerative colitis that is moderately to severely active. It aims to see how well it works and if it's safe compared to a dummy drug. We hope it could be a new treatment option.
Moderately to Severely Active Ulcerative ColitisSlovakia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
IOCYTE AMI-3: A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Intravenous FDY-5301 in Patients with an Anterior ST-Elevation Myocardial Infarction
This study is testing a new medicine, FDY-5301, for people who have had a severe type of heart attack called an anterior ST-elevation myocardial infarction. Researchers want to see if the medicine can help prevent serious heart problems or death in the year after the heart attack.
Anterior ST-Elevation Myocardial InfarctionSlovakia - RecruitingPHASE3
A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
This study looks at a new drug, sevabertinib, for advanced lung cancer with a specific genetic change (HER2 mutation). It compares sevabertinib to standard treatments to see if it works better and is safe.
Advanced Non-small Cell Lung Cancer, HER2 MutationSlovakia - Ongoing, recruitingPhase II and Phase III (Integrated)
Multicenter, Prospective, Open-label, Randomized, Crossover Study to Evaluate Pharmacokinetics (PK), Safety, and Tolerability of TAK-881 in Primary Immunodeficiency Diseases (PIDD)
This study is looking at a new treatment called TAK-881 for people with primary immunodeficiency diseases (PIDD). Researchers want to understand how the body uses TAK-881, if it's safe, and if it helps prevent infections. It compares TAK-881 to an existing treatment, HyQvia.
Primary Immunodeficiency DiseasesSlovakia - RecruitingPHASE3
A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]
This study looks at a new medicine for muscle-weakening conditions called dermatomyositis (DM) and polymyositis (PM). It aims to see how well the medicine, called dazukibart, works to help people with these conditions and if it’s safe.
MyositisSlovakia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2b, Multi-center, Randomized, Quadruple-blind, Placebo-controlled Study of Batoclimab Treatment in Adult Participants with Active Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This study is testing a new medicine, Batoclimab, for adults with a condition called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Researchers want to see if this medicine can stop CIDP symptoms from getting worse, compared to a dummy medicine. It's an important step to find better treatments.
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)Slovakia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Multicentre, Double-masked, Randomised Study to Evaluate the Efficacy and Safety of Intravitreal OPT-302 in Combination with Aflibercept, Compared with Aflibercept Alone, in Participants with Neovascular Age-related Macular Degeneration (nAMD)
This study is testing a new treatment called OPT-302, given alongside an existing treatment (Eylea), for a serious eye condition called 'wet' Age-related Macular Degeneration (AMD). Doctors want to see if combining these treatments helps people see better than Eylea alone.
Neovascular Age-related Macular Degeneration (wet AMD)Slovakia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2, Multicenter, Randomized, Double-Blind, Placebo Controlled, Parallel Group Study to Evaluate the Clinical Efficacy and Safety of VTX002 in Subjects with Moderately to Severely Active Ulcerative Colitis
This study is testing a new medicine, VTX002, for people with moderate to severe ulcerative colitis. Researchers want to see if it helps reduce symptoms and improve the condition, compared to a dummy pill.
Moderately to Severely Active Ulcerative ColitisSlovakia - Active not recruitingNA
Coating to Optimize Aneurysm Treatment In The New Flow Diverter Generation
This study looks at a new type of device for treating brain aneurysms. It compares a new version of the device with a coating, used with one blood-thinning medicine, against an older version, used with two blood-thinning medicines. The aim is to see how safe and effective the new device is.
Intracranial AneurysmSlovakia - Active not recruiting
Observation of Clinical Routine Care for Heart Failure Patients Implanted With BIOTRONIK CRT Devices
This study looks at how well a special device for heart failure, called a CRT, works for people in their everyday lives. It also checks for future heart problems and aims to make the device even better.
Heart FailureSlovakia - Active not recruitingPHASE3
Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6)
This study is testing a new drug, AZD9833, for advanced breast cancer. It's for people whose cancer has a specific gene change (ESR1 mutation) and are already on certain treatments. Researchers want to see if adding AZD9833 works better than current medicines.
ER-Positive HER2-Negative Breast CancerSlovakia - Ongoing, recruitingTherapeutic exploratory (Phase II)
C4391025_AN INTERVENTIONAL, OPEN-LABEL, RANDOMIZED, MULTICENTER, PHASE 2 STUDY OF PF-07220060 PLUS LETROZOLE COMPARED TO LETROZOLE ALONE IN POSTMENOPAUSAL WOMEN 18 YEARS OR OLDER WITH HORMONE RECEPTOR-POSITIVE, HER2-NEGATIVE BREAST CANCER IN THE NEOADJUVANT SETTING
This study is looking at a new medicine (PF-07220060) combined with a standard breast cancer drug (Letrozole). It's for women after menopause with a specific type of breast cancer, to see if the combination helps shrink the cancer before surgery. We want to know how well it works and if it's safe.
HORMONE RECEPTOR-POSITIVE, HER2-NEGATIVE BREAST CANCERSlovakia - Not yet recruitingPHASE3
Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment
This study is for people who were in a previous trial for a medicine called anifrolumab (Saphnelo) and found it helpful. It lets you keep taking the medicine to see if it continues to work and monitor your safety.
Systemic Sclerosis Cutaneous Lupus E Myopathies Systemic Lupus ErythematosusSlovakia - RecruitingPHASE3
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)
This study looks at a new medicine, BI 764198, for people aged 12 and over with a kidney condition called FSGS. It aims to see if this medicine helps improve kidney health. Participants will take a tablet daily and have their kidney function checked regularly.
Focal Segmental GlomerulosclerosisSlovakia - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
A Double-Blind Placebo-Controlled Randomised Phase 1b Study of the Pharmacokinetics of ALE.F02 in Patients with Advanced Liver Fibrosis and/or with Mild Cirrhosis
This study is testing a new medicine, ALE.F02, in adults with advanced liver scarring or early-stage liver disease. It aims to understand how the body uses the medicine, comparing it to a dummy treatment, to see if it could help. This is an early trial to check its effects and safety.
Advanced liver fibrosis and/or mild liver cirrhosisSlovakia - Active not recruitingPHASE4
A Study of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease
This study is looking at a new treatment called guselkumab for people with psoriatic arthritis that affects the spine and pelvis. It aims to see how well it reduces pain and inflammation in these areas. Participants will receive either the study drug or a dummy treatment.
Arthritis, PsoriaticSlovakia - AuthorisedTherapeutic exploratory (Phase II)
Effects of GLP-1 analogue in multiple sclerosis
This study is looking at how a specific type of medicine, usually for diabetes, might affect the brains of people with multiple sclerosis (MS). Researchers want to see if it can slow down brain changes and improve memory or thinking skills.
Slovakia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase Ilb, Randomized, Double-blind, Placebo controlled and Open-label Active Comparator Study to Evaluate the Efficacy, Safety, and Tolerability of AZD5004 in Adults with Type 2 Diabetes Mellitus
This study is looking at a new medicine called AZD5004 for adults with Type 2 Diabetes. Researchers want to see how well it lowers blood sugar (HbA1c) and if it's safe, compared to a widely used medicine (Rybelsus) or a dummy pill.
Type 2 Diabetes MellitusSlovakia - Active not recruitingPHASE3
An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis
This study is an extension for people in the UK with moderately to severely active ulcerative colitis who have already taken part in a specific etrasimod trial. It aims to gather more information on the long-term safety and effectiveness of etrasimod for this condition.
Ulcerative ColitisSlovakia - RecruitingPHASE3
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
This study investigates if a new drug, vicadrostat, combined with empagliflozin, can help adults with heart failure and a weakened heart pump. Participants will take study medications for up to 3.5 years, alongside their usual care.
Heart FailureSlovakia - RecruitingPHASE3
A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.
This study is looking into a new drug, PF-06821497, combined with an existing drug, enzalutamide, for men with advanced prostate cancer. It wants to see if this combination works better than enzalutamide alone for those who haven't had certain other treatments.
Metastatic Castration-Resistant Prostate CancerSlovakia - RecruitingPHASE3
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
This study looks at a new medicine, vicadrostat, for people with type 2 diabetes, high blood pressure, and heart disease. It aims to see if taking vicadrostat alongside empagliflozin can help reduce heart problems. Half the participants will get the study medicine, and half will get a dummy pill.
Diabetes Mellitus, Type 2HypertensionCardiovascular DiseasesSlovakia - RecruitingPHASE2, PHASE3
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
This study looks at a new medicine called ponsegromab for advanced pancreatic cancer that has spread, especially when patients have lost a lot of weight and feel very tired. It aims to see if adding ponsegromab to standard chemotherapy helps more than chemotherapy alone.
CachexiaMetastatic Pancreatic Ductal AdenocarcinomaSlovakia - RecruitingPHASE3
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
This study looks at a new drug, mevrometostat, combined with enzalutamide for men with prostate cancer that has spread. It compares this combination to enzalutamide alone, to see if it works better for those not yet treated with specific hormone therapies.
Metastatic Castration Sensitive Prostate Cancer (mCSPC)Hormone Sensitive Prostate CancerProstate CancerCancer of the ProstateSlovakia - RecruitingPHASE3
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
This study is looking into a new medicine, BI 1291583, for people with bronchiectasis. It aims to see if this medicine can help reduce flare-ups, which are common with the condition. Participants will take a tablet daily and be monitored for up to 1 year and 8 months.
BronchiectasisSlovakia - RecruitingPHASE2
A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema
This study tests a new medicine, BI 1815368, for people with diabetic macular edema (DME), an eye condition linked to diabetes. It aims to see if the medicine improves sight and to find the best dose. Participants take tablets for about 11 months.
Macular EdemaSlovakia - Active not recruitingPHASE3
Research Study to Look at How Well the Drug Concizumab Works in Your Body if You Have Haemophilia Without Inhibitors
This study looks at a new medicine called concizumab for people with haemophilia A or B without inhibitors. It aims to see how well it prevents bleeding and if it's safe. Participants will take the medicine daily, usually by injection under the skin, for up to 8 years.
Haemophilia A Without InhibitorsHaemophilia B Without InhibitorsSlovakia - Recruiting
Registry for Patients With X-Linked Hypophosphatemia
This study is gathering information on people with X-Linked Hypophosphatemia (XLH) to understand how it progresses and how different treatments work over a long time. It's for all ages and genders, whether they are on treatment or not.
X-Linked HypophosphatemiaSlovakia - RecruitingPHASE3
Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
This study looks at a new weekly injection, MET097, for adults who are overweight or have obesity. It checks how well it helps with weight loss and if it's safe. The study lasts for 84 weeks, focusing on participants without type 2 diabetes.
Obesity and OverweightSlovakia - Active not recruitingPHASE3
Extension Study to Assess Effects of Non-interrupted Versus Interrupted and Long Term Treatment of Two Dose Regimes of Secukinumab in Subjects With Hidradenitis Suppurativa
This study is for people with moderate to severe Hidradenitis Suppurativa who have already been treated with Secukinumab in previous studies. It looks at whether continuing this medicine or stopping it works best long-term, and how safe it is.
Hidradenitis SuppurativaSlovakia - RecruitingPHASE3
A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
This study is testing a new medicine, PF-07248144, with an existing one, fulvestrant, for advanced breast cancer that has grown despite previous treatment. It aims to see if this combination is safe and effective.
Breast CancerSlovakia - RecruitingPHASE3
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)
This study is looking into a new medication called KarXT for people with memory problems like Alzheimer's who also experience psychosis. It compares KarXT to a dummy pill to see if it can prevent these symptoms from returning and if it's safe to use.
Psychosis Associated With Alzheimer's DiseaseSlovakia - Active not recruitingPHASE3
A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2
This study looks at a new medicine called ritlecitinib for people with vitiligo. It wants to see if this medicine can safely and effectively help treat the white patches on the skin caused by vitiligo. It's for adults aged 18 and over.
Stable Nonsegmental VitiligoActive Nonsegmental VitiligoSlovakia - AuthorisedTherapeutic confirmatory (Phase III)
A Double-blind, Randomized,Placebo-controlled, Multicenter Study Assessing Olpasiran Use to Prevent First Major Cardiovascular Events in Participants with Elevated Lipoprotein(a)
This study is looking at a new medicine called Olpasiran. It aims to see if Olpasiran can help prevent serious heart problems like heart attacks in people who have high levels of a specific fat in their blood called lipoprotein(a).
Cardiovascular DiseaseSlovakia - RecruitingPHASE3
Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN
This study is testing a new medicine, iptacopan, for a kidney disease called IC-MPGN. It wants to see if the medicine can help improve kidney function and reduce protein in the urine, compared to a dummy medicine, in people aged 12 to 60.
IC-MPGNSlovakia - AuthorisedTherapeutic use (Phase IV)
A pragmatic, phase IV, randomized, open-label, multinational, multicentre, 2-arm parallel group, prospective study comparing efficacy and safety of Single Inhaler ICS/LABA/LAMA (beclometasone/formoterol fumarate/glycopyrronium bromide [87/5/9 pMDI {BD/FF/GB - 100/6/12.5 µg}]) vs Single Inhaler ICS/LABA (beclometasone dipropionate plus formoterol fumarate [200/6 pMDI {BD/FF - 200/6 µg}]) in asthma subjects.
This study compares two inhalers, Trimbow and Fostair, for adults with asthma. It looks at how well they control asthma symptoms and prevent flare-ups over a year, as well as their safety.
AsthmaSlovakia - RecruitingPHASE3
A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
This study looks at the long-term safety of a medicine called vedolizumab for children and young people with Crohn's disease or ulcerative colitis. It's for those who have already taken part in a previous study with vedolizumab.
Ulcerative ColitisCrohn's DiseaseSlovakia - AuthorisedTherapeutic exploratory (Phase II)
Phase II study of dornase alpha and cisplatin in refractory germ cell cancer.
This study is looking at a new way to treat germ cell cancer that hasn't responded to other treatments. It combines a standard chemotherapy drug called cisplatin with a medicine called Pulmozyme. The study wants to see if this combination can stop the cancer from growing for at least 12 weeks.
germ cell cancerSlovakia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Multicenter, Randomized, Double-Masked, Vehicle-Controlled Study to Assess the Safety and Efficacy of SYD-101 Ophthalmic Solution for the Treatment of Myopia in Children
This study is testing a new eye drop called SYD-101 to see if it can slow down the worsening of short-sightedness (myopia) in children. Researchers want to know if it's safe and how well it works compared to a dummy eye drop over two years.
MyopiaSlovakia - AuthorisedPhase II and Phase III (Integrated)
Phase 2/3, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of EXV-802 and EXV-801 in the Treatment of Agitation in Participants with Alzheimer’s Disease Dementia
This study is testing two new medicines, EXV-802 and EXV-801, for people with Alzheimer's disease who experience agitation. It compares these medicines to a dummy pill (placebo) to see if they can help reduce agitation and if they are safe.
Agitation in Alzheimer's Disease DementiaSlovakia