Latest studies
- Ongoing, recruitingTherapeutic confirmatory (Phase III)
A randomized, phase 3 trial with anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) versus placebo for patients with early stage NSCLC after resection and completion of standard adjuvant therapy (PEARLS) KEYNOTE-091
This study looks at a drug called Keytruda after surgery for a type of lung cancer. It aims to see if Keytruda can stop the cancer from coming back for longer than a dummy treatment in patients with non-small cell lung cancer, especially those with certain cancer markers.
Stage IB (T ≥ 4 cm), II and IIIA NSCLCSlovenia - Recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
This study looks at how well Medtronic heart devices, like pacemakers and defibrillators, perform over a long time. It helps ensure these devices are reliable and safe for people with heart conditions such as irregular heartbeats or heart failure.
ArrhythmiaBradycardiaHeart FailureSinus TachycardiaSlovenia - Ongoing, recruitingTherapeutic exploratory (Phase II)
A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study to Assess Efficacy and Safety of Atuliflapon Given Orally Once Daily for Twelve Weeks in Adults with Moderate to Severe Uncontrolled Asthma
This study is testing a new medicine, Atuliflapon, for adults whose moderate-to-severe asthma isn't well controlled by their usual treatments. We want to see if it reduces asthma flare-ups and improves breathing, compared to a dummy pill, over 12 weeks.
Moderate-to-Severe Uncontrolled AsthmaSlovenia - Recruiting
Exploring the hidden burden of living with Glanzmann thrombasthenia
This study wants to hear from people living with Glanzmann thrombasthenia (GT) and their caregivers. We want to understand the daily challenges and feelings of those affected. Your stories can help improve support and understanding for everyone with GT.
Glanzmann thrombastheniaSlovenia - Active not recruitingPHASE3
A Safety and Efficacy Study of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-Severe Symptom State
This study is looking at a new medicine called Dazodalibep for people with Sjögren's Syndrome. It aims to see how well it helps with symptoms and whether it's safe to use, especially for those with moderate to severe symptoms.
Sjögren's Syndrome (SS)Slovenia - Active not recruiting
Minimal SN Tumor Burden
This study is gathering information on people with a certain type of melanoma to see if they can avoid a big surgery. We want to find out if removing fewer lymph nodes is safe for patients with very small amounts of cancer in their nodes.
Cutaneous MelanomaSlovenia - Ongoing, recruitingTherapeutic exploratory (Phase II)
Cytomegalovirus Prophylaxis with Letermovir in Heart Transplant Recipients: A Non-randomized Cohort Pilot Study
This study looks at a new medicine called PREVYMIS in people who have had a heart transplant. It's to see how well it prevents a common infection called Cytomegalovirus (CMV) after their surgery. We want to find out how many people get CMV and if the medicine causes any side effects.
CMV infection in heart transplant recipientsSlovenia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A double blind, randomized, placebo-controlled trial evaluating the efficacy and safety of BI 1015550 over at least 52 weeks in patients with Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)
This study is testing a new medicine, BI 1015550, for people with progressive fibrosing interstitial lung diseases (PF-ILDs). Researchers want to see if it helps improve lung function and is safe to use over about a year.
Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)Slovenia - Ongoing, recruitingPhase III and phase IV (Integrated)
Lowering of LDL-C with rosuvastatin or single-pill combination rosuvastatin/ezetimibe in high/very high-risk patients with hyperlipidaemia – LEASH
This study looks at how well different medications (Sorvasta and Sorvitimb) lower 'bad' cholesterol (LDL-C) in people who have high cholesterol and are at high risk of heart problems. It checks if patients reach their target cholesterol levels after 12 weeks.
HyperlipidaemiaSlovenia - RecruitingPHASE3
A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast
This study looks at a long-term treatment called nerandomilast for people with pulmonary fibrosis. It's for those who've used it in a past study. We'll see how safe and effective it is over time, checking if it helps lung function and slows down the disease.
Idiopathic Pulmonary FibrosisProgressive Pulmonary FibrosisSlovenia - RecruitingPHASE3
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
This study looks into a new treatment for adults with heart failure. It combines two medicines, vicadrostat and empagliflozin, to see if they can improve heart health in people with a specific type of heart failure. Participants take tablets daily and are closely monitored.
Heart FailureSlovenia - Recruiting
Registry for Patients With X-Linked Hypophosphatemia
This study is gathering information on people with X-Linked Hypophosphatemia (XLH) to understand how it progresses and how different treatments work over a long time. It's for all ages and genders, whether they are on treatment or not.
X-Linked HypophosphatemiaSlovenia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
RANDOMISED DOUBLE-BLIND PLACEBO-CONTROLLED PHASE 3 TRIAL OF TRIUMEQ IN AMYOTROPHIC LATERAL SCLEROSIS - LIGHTHOUSE II
This study is looking at a medicine called Triumeq for people with Amyotrophic Lateral Sclerosis (ALS), also known as Motor Neuron Disease. Researchers want to see if Triumeq can help people live longer and improve their daily lives. We are comparing it to a dummy pill to see how well it works.
AMYOTROPHIC LATERAL SCLEROSISSlovenia - AuthorisedTherapeutic use (Phase IV)
A Randomized Trial of the I-BFM-SG for the Management of Childhood non-mature-B Acute Lymphoblastic Leukemia
This study is looking at new treatments for a type of childhood leukaemia. It aims to see if adding Riximyo to standard chemotherapy helps children live longer without the leukaemia coming back. The study also checks for side effects.
Childhood non-mature-B Acute Lymphoblastic LeukemiaSlovenia - RecruitingPHASE2
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
This study is testing a new drug, SAB-142, for people with recently diagnosed Type 1 Diabetes. It aims to see if SAB-142 can slow down the disease, and if it's safe to use. Participants will receive high dose, low dose, or a dummy drug.
Type 1 DiabetesSlovenia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Crossover, Open-Label, Active-Controlled Study of Sepiapterin versus Sapropterin in Participants With Phenylketonuria ≥2 years of Age
This study looks at a new medicine called sepiapterin for people aged 18 and over with phenylketonuria (PKU). It compares sepiapterin to an existing medicine, sapropterin, to see how well it lowers levels of a substance called phenylalanine in the blood, which is important for managing PKU.
PhenylketonuriaSlovenia - Recruiting
A Multi-Country Observational Study of Safety and Effectiveness of Elfabrio® in Fabry Patients
This study looks at how a medicine called Elfabrio® works and if it's safe for people with Fabry disease in a real-world setting. It watches patients receiving their usual care to understand the treatment better.
Fabry DiseaseSlovenia - RecruitingNA
Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
This study compares two ways to remove stage II melanoma, using different-sized safety borders (1cm vs. 2cm). It aims to see if a smaller border is just as safe and improves quality of life, without increasing the chance of cancer returning.
Cutaneous Melanoma, Stage IISlovenia - RecruitingPHASE3
Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass
This study looks at a medicine called Atenativ for people having heart surgery who don't respond well to standard blood thinners. It checks if Atenativ helps their blood thin properly and if it's safe to use.
Acquired Antithrombin DeficiencySlovenia - Recruiting
Registry for Patients With Lipodystrophy
This registry collects information about different types of lipodystrophy. It aims to help doctors and researchers better understand these rare conditions, how they progress, and how they affect patients' lives, ultimately leading to improved care.
Lipodystrophy AcquiredLipodystrophy CongenitalSlovenia - Active not recruitingPHASE3
A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer)
This study compares a new drug, Giredestrant, with standard hormone therapy for early breast cancer. It's for people with a specific type of breast cancer (ER-positive, HER2-negative) who have already had surgery.
Early Breast CancerSlovenia - RecruitingPHASE3
A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)
This study is looking into the long-term safety of a new medicine called dazodalibep for people with Sjögren's Syndrome. It involves individuals who have already taken part in previous studies of this medicine.
Sjögren's SyndromeSlovenia - Recruiting
EFESO: Study on Juvenile Onset Eosinophilic Fasciitis
This study, called EFESO, is looking into a rare condition called Eosinophilic Fasciitis in children. We want to understand it better, improve how we diagnose it, and see which treatments work best for young people. It's about helping kids with this condition live healthier lives.
Eosinophilic FasciitisSlovenia - Recruiting
Personalized Monitoring of Non-foveal, Non-vision Compromising Atrophic Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression
This study looks at how a specific type of age-related macular degeneration (AMD) progresses. It uses AI and eye scans to understand changes over two years, aiming to personalize future monitoring for people with this AMD.
Age-Related Macular DegenerationGeographic AtrophySlovenia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, 24-week, Placebo-controlled, Double-blind Study to Assess the Efficacy, Safety, and Tolerability of Rocatinlimab (AMG 451) in Combination With Topical Corticosteroids and/or Topical Calcineurin Inhibitors in Adult Subjects With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-SHUTTLE)
This study is looking into a new treatment called rocatinlimab for adults with moderate to severe eczema. It wants to see if this new medicine, when used with usual eczema creams, can help clear up skin and reduce itching compared to a dummy treatment.
Atopic DermatitisSlovenia - Active not recruitingPHASE3
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
This study looks at a new medicine called ziltivekimab for people with heart failure and inflammation. It aims to see if monthly injections of ziltivekimab can help, compared to a dummy medicine, over a few years.
Heart FailureSlovenia - RecruitingPHASE3
A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease
This study looks at combining two medicines, vedolizumab and upadacitinib, for adults with moderate to severe Crohn's Disease. It aims to see if this combination better reduces bowel inflammation and ulcers compared to vedolizumab alone, and to check its safety.
Crohn's DiseaseSlovenia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A multicenter, single-arm, open label trial to evaluate efficacy and safety of oral, twice daily LNP023 in adult aHUS patients who are naive to complement inhibitor therapy
This study is looking at a new medicine called IPTACOPAN for adults who have a rare kidney disease called atypical hemolytic uremic syndrome (aHUS). It wants to see if the medicine helps improve blood and kidney problems without needing other common treatments.
Atypical hemolytic uremic syndromeSlovenia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A controlled, open-label post-authorisation efficacy and safety study in imlifidase desensitised kidney transplant patients with positive crossmatch against a deceased donor prior to imlifidase treatment, including non-comparative registry and concurrent reference cohorts
This study looks at a new medicine called Idefirix for people with severe kidney disease waiting for a kidney transplant. It aims to see how well Idefirix helps them receive a transplant and if the new kidney works well for a year after the transplant.
End stage chronic kidney disease (CKD) patients who are highly sensitised and on the kidney transplant list awaiting a kidney transplantSlovenia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Phase 3, Randomized, Double-Masked, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Efgartigimod PH20 SC Administered by Prefilled Syringe in Adult Participants With Thyroid Eye Disease
This study is looking at a new medicine called Vyvgart for people with Thyroid Eye Disease. It aims to see if the medicine can help reduce bulging eyes and improve eye health, compared to a dummy medicine, over 24 weeks.
Thyroid Eye Disease (TED)Slovenia - Recruiting
Lysosomal Acid Lipase (LAL) Deficiency Registry
This study is gathering information on a rare genetic condition called LAL Deficiency. It aims to understand the disease better and improve care for affected individuals, from babies to adults. It's a worldwide effort to collect health data over time.
Lysosomal Acid Lipase DeficiencyCholesterol Ester Storage DiseaseWolman DiseaseAcid Cholesteryl Ester Hydrolase Deficiency, Type 2Slovenia - RecruitingPHASE2
Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
This study is testing a new medicine, Imeroprubart, for adults with a nerve condition called Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). Researchers want to see if it's safe and helps improve symptoms compared to a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathySlovenia - Ongoing, recruitingTherapeutic exploratory (Phase II)
EORTC 2120-HNCG: Radiotherapy plus xevinapant or placebo in older patients with locally advanced head and neck squamous cell carcinoma: a randomized phase II study (Ravina)
This study looks at a new drug, xevinapant, given with radiotherapy for older patients with advanced head and neck cancer. We want to see if this combination helps more people live longer without their cancer coming back. It's a Phase II study, meaning we're testing its effectiveness and safety.
Squamous cell carcinoma of head and neckSlovenia - RecruitingPHASE3
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
This study, called REMAP-CAP, looks at different treatments for serious lung infections like pneumonia, flu, and COVID-19 in adults needing intensive care. It aims to find out which treatments work best to help patients recover.
Community-acquired Pneumonia, Influenza, COVID-19Slovenia - Recruiting
A Global Prospective Observational Registry of Patients With Pompe Disease
This study is gathering information on people with Pompe disease, both those receiving treatment and those not yet treated. It aims to understand how treatments affect health and daily life over time, and what happens when the disease is untreated.
Pompe DiseaseSlovenia - Recruiting
Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation
This study is looking at a new way to understand what's happening in kidney transplants. It combines different tests, like looking at cells and using new technology, to give doctors a clearer picture. The aim is to help doctors make better decisions about treatment for patients.
Validation Study of Molecular Diagnostic SystemDevelopment of Reporting System for Molecular DiagnosisIncorporate Molecular Diagnosis Into Diagnostic StandardsSlovenia - Authorised (with conditions)Therapeutic confirmatory (Phase III)
A prospective, multicenter, randomised, double-blind, placebo-controlled, parallel groups, phase 3 Trial to compare the efficacy and safety of masitinib in combination with standard of care versus placebo in combination with standard of care in the treatment of patients suffering from Amyotrophic Lateral Sclerosis (ALS)
This study is testing a new drug called masitinib for people with Motor Neurone Disease (ALS). It compares masitinib with a dummy pill (placebo) alongside standard treatment to see if it's safe and helps slow down the disease.
Amyotrophic Lateral SclerosisSlovenia - Recruiting
The CATALINA Study
The CATALINA study aims to understand lung flare-ups (exacerbations) in people with COPD. We're collecting health information and samples from patients across Europe to help develop better treatments and predict future flare-ups.
Chronic Obstructive Pulmonary Disease ExacerbationSlovenia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4/2.4 mg and 1.0/1.0 mg once weekly versus semaglutide 2.4 mg and 1.0 mg, cagrilintide 2.4 mg and placebo in participants with type 2 diabetes inadequately controlled on metformin with or without an SGLT2 inhibitor
This study is testing a new combination medicine, CagriSema, for people with type 2 diabetes. It's looking at whether this combined medicine is better at controlling blood sugar and helping with weight loss than existing treatments, including its individual components, semaglutide and cagrilintide.
Type 2 diabetesSlovenia - RecruitingPHASE3
A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy
This study looks at a new medicine called mezagitamab for a kidney problem called IgA nephropathy. It compares mezagitamab to a dummy medicine to see if it lowers protein in the urine and helps protect kidneys. All adults over 18 with this condition can take part.
Kidney DiseaseSlovenia - RecruitingNA
Duroplasty for Injured Cervical Spinal Cord With Uncontrolled Swelling
This study looks at a surgery called duroplasty for severe spinal cord injuries in the neck. It aims to see if opening the tough outer layer around the spinal cord helps improve recovery, such as regaining movement, compared to standard surgery alone.
Spinal Cord InjuriesSlovenia - Active not recruitingPHASE2
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease
This study is looking at a new combination treatment, JNJ-78934804, for people aged 18-65 with Crohn's disease that is moderate to severe. It compares this new treatment to existing medicines, guselkumab and golimumab, to see how well it works over 48 weeks.
Crohn's DiseaseSlovenia - AuthorisedTherapeutic exploratory (Phase II)
Effect of perioperative intravenous infusion of lidocaine on the postoperative course and the immune response in patients undergoing surgery for colon cancer - the PILDI study
This study is looking at whether giving a common pain medication called lidocaine through a drip during colon cancer surgery can help reduce strong painkiller use afterwards. Researchers want to see if lidocaine can help patients recover better and need less opioid medication.
Colon cancerSlovenia - Active not recruiting
The OPBC-07/microNAC Study
This study looks at whether it's safe to skip a full lymph node removal surgery in breast cancer patients who have only tiny traces of cancer left in their armpit lymph nodes after chemotherapy. It checks how these patients have fared over time.
Breast CancerSlovenia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Single Arm, Open Label Multicentre Extension Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Patients with Multiple Sclerosis Previously Enrolled in A F. Hoffmann-La Roche Sponsored Ocrelizumab Phase IIIb/IV Clinical Trial
This study looks at how well a medicine called ocrelizumab works and if it's safe for people with multiple sclerosis (MS). It's for patients who have already been in similar studies with the same medicine.
Multiple sclerosis (MS)Slovenia - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Randomized Study of Andexanet Alfa Compared to Usual Care in Patients Receiving a Factor Xa Inhibitor who Require Urgent Surgery or Procedure (ANNEXA-RS)
This study is comparing a new medication called Andexanet Alfa to usual care. It's for patients who are taking blood thinners (like apixaban, rivaroxaban, or edoxaban) and need urgent surgery. The aim is to see if Andexanet Alfa helps stop bleeding during their operation.
Reversal of anticoagulation effect in patients on a FXa inhibitor (apixaban, rivaroxaban, or edoxaban) who require urgent surgery or procedure, and who have a major risk of bleeding.Slovenia - AuthorisedPhase I and Phase II (Integrated)- First administration to humans
CELL-BASED IMMUNOTHERAPY FOR TREATMENT OF TRIPLE NEGATIVE BREAST CANCER STAGES II AND III
This study is testing a new cell-based treatment for breast cancer that doesn't respond to usual hormone therapies or targeted drugs (called triple-negative breast cancer). It's an early-stage trial trying to find out if the treatment is safe and if it works for patients with stages II and III of this type of cancer.
TRIPLE NEGATIVE BREAST CANCERSlovenia - RecruitingNA
Surgical vs Transcatheter Aortic Valve Replacement in YOUNG Patients
This study compares two ways to fix a common heart problem called severe aortic stenosis in people aged 65 to 75. It aims to see if a newer 'keyhole' procedure is as good as traditional open-heart surgery.
Symptomatic Severe Aortic StenosisSlovenia - Ongoing, recruitingPhase III and phase IV (Integrated)
Effects of single-pill combination of telmisartan/amlodipine and telmisartan/amlodipine/hydrochlorothiazide on 24-hour blood pressure (BP) reduction, 24-h BP variability and office BP control in patients with arterial hypertension – SATELLITE
This study looks at how new combination medicines affect high blood pressure over 24 hours. Researchers want to see how well these pills lower blood pressure and keep it steady throughout the day in people with high blood pressure.
Arterial hypertensionSlovenia - RecruitingPHASE3
Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 Studies
This study looks at the long-term safety of a medicine called inclisiran for people aged 12-100 with high cholesterol due to a genetic condition (HeFH or HoFH). It's for those who have already been in earlier inclisiran studies.
Heterozygous or Homozygous Familial HypercholesterolemiaSlovenia