Latest studies
- Active not recruiting
MYOPROSP - a Prospective Cohort Study in Myositis
This study, MYOPROSP, aims to better understand myositis, a group of rare muscle diseases. We're looking at adults with suspected or confirmed myositis to collect information and samples. This helps us learn more about diagnosing the condition, how it progresses, and how new treatments work.
MyositisIdiopathic Inflammatory MyopathyUnited Kingdom - Not yet recruiting
Immune Responsiveness and Outcome After Aortic Valve Surgery (Measure)
This study looks at how your body's defence system (immune system) reacts during and after heart valve surgery. Researchers want to see if a stronger immune response means a quicker recovery and fewer problems like infections.
Aortic Valve DiseaseSurgery--ComplicationsImmune System DisorderUnited Kingdom - Enrolling by invitation
Use and Opinions of Care Home Medicines Audit Tools
This study looks at how medicines are managed in care homes. We want to understand what helps or hinders staff, residents, and other experts in making sure medicines are given safely and correctly. We'll talk to people and review tools used to check medicine handling.
Medication SystemsQuality ImprovementUnited Kingdom - Active not recruitingPHASE3
Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
This study is for men with a certain type of advanced prostate cancer (mCSPC) that has spread and has specific gene changes. It compares a new drug called talazoparib, given with standard treatment enzalutamide, against enzalutamide alone, to see if it's safe and effective.
Prostate CancerUnited Kingdom - RecruitingPHASE3
An Early Access Study of Ivosidenib in Patients With a Pretreated Locally Advanced or Metastatic Cholangiocarcinoma
This study looks at a daily tablet called ivosidenib for adults with bile duct cancer that has come back or spread, and has been treated before. It aims to confirm if the treatment is safe and works well, and how it affects quality of life.
CholangiocarcinomaUnited Kingdom - Recruiting
Perioperative complications and autonomic function assessed by the COMPASS-31 tool
This study looks at how your body's automatic systems, like heart rate, work before and after big operations. We want to see if a special questionnaire can help predict who might have problems and improve care for people having surgery.
Autonomic function in people undergoing major noncardiac surgery under general anaesthesiaUnited Kingdom - RecruitingPHASE3
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
This study looks at a new medicine called zilebesiran for people with high blood pressure that isn't well controlled, especially if they also have heart problems or are at high risk of developing them. The aim is to see if zilebesiran can reduce serious heart-related events like heart attacks or strokes.
High Risk Cardiovascular DiseaseHypertensionHigh Cardiovascular RiskUnited Kingdom - RecruitingPHASE2
Trial of Mirtazapine for Depression in IBD
This study is testing if it's practical to run a larger trial for people with both depression and a bowel condition. We'll see if a depression tablet called mirtazapine helps, compared to a dummy pill. It's a first step to understand if this treatment could be useful.
Major Depressive DisorderInflammatory Bowel DiseasesUnited Kingdom - Active not recruitingPHASE2, PHASE3
A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Who Have Active Cutaneous Lupus Erythematosus
This study investigates an injection called litifilimab for adults with active lupus that mainly affects the skin, known as cutaneous lupus erythematosus (CLE). Researchers want to see if it helps reduce skin symptoms and is safe, especially for those whose current treatments aren't working well.
Subacute Cutaneous Lupus ErythematosusChronic Cutaneous Lupus ErythematosusUnited Kingdom - Active not recruitingPHASE3
A Study to Evaluate the Safety and Efficacy of Zilganersen (ION373) in Patients With Alexander Disease (AxD)
This study is testing a new medicine, zilganersen, for people with Alexander Disease. It aims to see if the medicine is safe and if it can help improve or steady movement abilities. It's a large study, comparing the medicine to a dummy treatment (placebo).
Alexander DiseaseUnited Kingdom - Recruiting
A study exploring a women-only, trauma -informed residential rehabilitation pathway for drug dependent women leaving prison
This study looks at how best to help women leaving prison who have drug problems. It explores if moving them straight into women-only rehab helps them recover and lead better lives, compared to usual support.
Drug-dependent women leaving prisonUnited Kingdom - RecruitingNot Applicable
Medical utility of artificial intelligence for fracture detection in the emergency department
This study looks at how well a special computer program, called AI, can help doctors find broken bones on X-rays in emergency departments. It aims to see if AI can reduce mistakes and improve care for patients with suspected fractures.
Patients undergoing X-ray for suspected fracture in the emergency department or minor injuries unitUnited Kingdom - Completed
Wait Less; an online brief psychological intervention to reduce waiting list distress
This study looks at whether an online talking therapy, MyMindWorks (MMW), can help young people aged 12-17 with depression while they wait for NHS mental health services. It aims to see if MMW is helpful and acceptable, and if it could reduce waiting list distress.
Depression in young people aged 12 to 17 yearsUnited Kingdom - CompletedPhase I
A study to evaluate the safety and effects on the immune system of a tetanus and diphtheria vaccine which does not need any cold chain distribution or storage
This study is testing a new tetanus and diphtheria jab that doesn't need to be kept cold. It's for healthy adults who've had these jabs before but not in the last 10 years. We want to see if it's safe and works as well as existing jabs.
Prevention of tetanus and diphtheria infection in healthy volunteersUnited Kingdom - Recruiting
Real-world exploration of digital innovation for managing excess weight
This study looks at how well a digital app helps people in South East London manage their weight compared to usual care. It aims to see if app-based programs can help more people, save money for the NHS, and improve patient experiences without risks.
Specialty: General Practice, Primary sub-specialty: General Practice; Health Category: Cancer and neoplasms, Cardiovascular, Metabolic and Endocrine, Oral and Gastrointestinal, Stroke; Disease/Condition: Obesity and other hyperalimentationUnited Kingdom - Recruiting
Comparing an easy-to-use swab test and ultrasound for detection of womb cancer
This study compares a new, easy-to-use swab test called WID®-easy with the usual ultrasound scan for detecting womb cancer in women experiencing unusual bleeding. The goal is to see if the new test works better and could be used more widely in the NHS.
Womb cancerUnited Kingdom - RecruitingPhase III
A study comparing the effect of apalutamide treatment before focal therapy with focal therapy alone in men with prostate cancer that has not spread beyond the prostate
This study looks at treating prostate cancer that is still within the prostate. We're comparing focal therapy alone with focal therapy after a short course of a drug called apalutamide. We want to see if using apalutamide first can make the focal therapy work even better.
Localised prostate cancerUnited Kingdom - RecruitingNA
The Effect of Ketone Monoesters on Skeletal Muscle Protein Synthesis and Whole-body Protein Metabolism.
This study looks at how a special drink called a ketone monoester, taken with protein, affects muscle growth and repair in healthy young adults. We want to see if it can help muscles get stronger and recover better.
Healthy ParticipantsUnited Kingdom - Recruiting
Accessing the Clarity and Acceptability of Recruitment Materials for a Study on Thoracic Aortic Disease Surveillance
This study checks if information for people joining health research is easy to understand. It focuses on materials for a future study about a heart condition called thoracic aortic disease, aiming to make sure they are clear, sensitive, and helpful for everyone.
Thoracic Aortic DiseaseUnited Kingdom - RecruitingNA
Effect of Brief-tele Support on Attendance at Physiotherapy Sessions
This study looks at whether a quick phone call can help more people attend their physiotherapy appointments for pelvic floor problems. We're testing if calling before or after appointment letters makes a difference, or if no call is just as effective.
Pelvic Floor DysfunctionsUnited Kingdom - Active not recruiting
Validation of an Artificial Intelligence Enabled Diagnostic Support Software (ArtiQ.Spiro) in Primary Care Spirometry Datasets - a Retrospective Analysis
This study looks back at existing lung function test results (spirometry) from UK GP surgeries. We're checking if an AI computer program, ArtiQ.Spiro, can accurately help diagnose breathing problems and assess the quality of these tests.
Respiratory DiseaseUnited Kingdom - Recruiting
Development of Novel MR Techniques Using Volunteer Participants
This study is developing new ways to use MRI scanners to get better and faster pictures of the body. We need healthy volunteers to help test these new scanning methods safely. It's about improving the technology, not about your health.
HealthyUnited Kingdom - Recruiting
A study to find out if a new blood test (microRNA) can be used to monitor people after surgery for seminoma or dysgerminoma cancer
This study looks at a new blood test to see if cancer has come back in people treated for specific early-stage cancers like seminoma or dysgerminoma. It aims to reduce the need for scans by seeing if a simple blood test can do the job and help find cancer recurrence earlier.
Seminoma and dysgerminomaUnited Kingdom - RecruitingPHASE2
Brivekimig for the Treatment of Moderate to Severe Hidradenitis Suppurativa
This study is testing a new medicine called brivekimig for moderate to severe hidradenitis suppurativa (HS). It compares brivekimig to a dummy medicine (placebo) to see if it's safe and helps reduce HS symptoms.
Hidradenitis SuppurativaUnited Kingdom - RecruitingPHASE2
Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease
This study is testing a new medicine, ADX-038, for adults with certain kidney diseases caused by a problem with the body's immune system, called the complement system. We want to see if it's safe and helps people with conditions like IgA nephropathy (IgAN) or C3 glomerulopathy (C3G).
IgANC3GComplement-mediated Kidney DiseaseIgA Nephropathy (IgAN)United Kingdom - RecruitingPHASE3
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
This study looks at an inhaled medicine called treprostinil for people with progressive pulmonary fibrosis. It aims to see if it's safe and effective in slowing down this lung condition over 52 weeks. Half get the medicine, half get a dummy treatment.
Progressive Pulmonary FibrosisInterstitial Lung DiseaseUnited Kingdom - Recruiting
Impact of Chronic Cough on Activities of Daily Living and Response to Acute High-intensity Exercise
This study looks at how ongoing cough affects daily life and physical activity. We want to see if it changes how active people are compared to those without a cough, and if exercise makes coughing better or worse in the short term.
Chronic Cough (CC)United Kingdom - RecruitingNA
Zenith® Fenestrated+ Clinical Study
This study is looking at a new way to treat serious swellings (aneurysms) in a main blood vessel called the aorta, near the kidneys or chest. It uses a special device called a Zenith Fenestrated+ Endovascular Graft. We want to see how safe and effective this new approach is for patients.
Aortic Aneurysm, AbdominalJuxtarenal Aortic AneurysmExtent IV ThoracoabdominalPararenal AneurysmUnited Kingdom - RecruitingNA
GMP Powdered Substitutes in PKU and TYR
This study looks at new powdered protein drinks for people with Phenylketonuria (PKU) and Tyrosinemia (TYR). These drinks, made from a natural milk ingredient called GMP, aim to be better-tasting and easier to stick with, while still managing the condition effectively.
PhenylketonuriaTyrosinemiaUnited Kingdom - RecruitingPHASE2, PHASE3
Study to Evaluate Switching to Brelovitug for the Treatment of CHD in Participants Receiving Bulevirtide
This study looks at switching from one existing medicine, Bulevirtide, to a new one, Brelovitug, for people with long-term Hepatitis D. Researchers want to see if the new medicine is safe and works better.
Chronic Hepatitis DUnited Kingdom - RecruitingNA
Study of Lesion-Specific Invasive Haemodynamic Angina Thresholds
This study aims to understand why different narrowings in heart arteries cause angina chest pain. Researchers will measure how much a narrowing needs to block blood flow before pain starts, using special tests during a heart procedure.
Angina (Stable)Coronary Artery Disease(CAD)Ischaemic Heart Disease (IHD)United Kingdom - Active not recruitingPHASE3
Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate
This study looks at a new drug called darolutamide, along with standard treatments like radiotherapy and hormone therapy, for men with prostate cancer that's at a very high risk of coming back. The aim is to see if this combination can better stop the cancer from spreading and improve their long-term health.
Prostate CancerUnited Kingdom - Completed
A study of potential treatment-responsive biomarkers and clinical outcomes in Hunter syndrome
This study looked at how Hunter Syndrome affects people over time, including changes in behaviour, thinking abilities, and levels of certain signs in the body. It aimed to understand the condition better and find ways to measure if future treatments are working, without giving any new medicines.
Mucopolysaccharidosis IIUnited Kingdom - RecruitingPHASE3
Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.
This study is testing a new medicine called iptacopan for people aged 12-60 with a kidney disease called C3 Glomerulopathy (C3G). It aims to see if the medicine is safe and helps improve kidney function compared to a dummy pill.
C3GUnited Kingdom - Active not recruitingPHASE3
A Study of Ramucirumab (LY3009806) in Combination With Erlotinib in Previously Untreated Participants With EGFR Mutation-Positive Metastatic NSCLC (RELAY)
This study looks at new ways to treat advanced non-small cell lung cancer with a specific genetic change. It aims to see if combining a drug called ramucirumab with existing treatments like erlotinib, gefitinib, or osimertinib can work better than current approaches.
Metastatic Non-Small Cell Lung CancerUnited Kingdom - Recruiting
Rare AutoImmune SElf-management Programme Development
This study aims to develop a support program for people with rare autoimmune diseases like lupus and vasculitis. It asks patients and healthcare teams across the UK what kind of support is needed to help people manage their conditions and improve their quality of life.
Systemic Lupus ErthematosusSystemic VasculitisInflammatory MyositisSystemic Sclerosis (SSc)United Kingdom - Active not recruitingPHASE2, PHASE3
DTG/3TC Fixed Dose Formulations for the Maintenance of Virological Suppression in Children With HIV Infection Aged 2 to <15 Years Old
This study looks at a two-drug treatment (Dolutegravir and Lamivudine) for children and young people with HIV, aged 2 to 15. It aims to see if it's as safe and effective as their current three-drug therapy.
HIV InfectionsUnited Kingdom - Recruiting
Who Fares Best With Mindfulness Meditation
This study looks at how mindfulness meditation affects different people. It aims to find out who benefits most and who might experience problems. Researchers want to understand why mindfulness works for some and not for others, especially those with past trauma or negative thinking.
HealthyDepressionMental Health IssueUnited Kingdom - Recruiting
A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment
This study looks at how a drug called elafibranor works for people with a rare liver disease called Primary Biliary Cholangitis (PBC) in everyday life. Researchers will check its effects, how safe it is, and how well people tolerate it over about five years.
Primary Biliary CholangitisUnited Kingdom - Active not recruitingNA
INcreasing Adolescent Social and Community SupporT - Full Trial
This study looks at whether a programme called 'Social Prescribing' can help young people aged 9-14 in schools who often feel lonely. It compares this programme to simply giving them information about local support.
LonelinessUnited Kingdom - Recruiting
Pancreas lipotoxicity in type 2 diabetes: Edinburgh Diabetes Remission Study (EDRS)
This study, the Edinburgh Diabetes Remission Study (EDRS), is looking at how fat in the pancreas affects type 2 diabetes. It wants to see if losing weight can reverse the condition. Participants will follow a special low-calorie diet to help researchers understand these changes.
Type 2 diabetesUnited Kingdom - CompletedNot Applicable
Usability and accuracy of the Hormona at-home perimenopause test kit and mobile app
This study looks at how well women aged 40-55 can use the Hormona app and at-home test kit to understand their changing hormones during perimenopause. It aims to make the system easy to use and accurate.
Perimenopause and menopauseUnited Kingdom - Recruiting
EVOKE ECAP-Controlled Lead Placement and Programming in Chronic Pain Patients
This study looks at a new way to place and program spinal cord stimulators for long-term back pain. It aims to make sure the device is placed correctly and works better by measuring nerve signals during the procedure.
Back Pain Lower Back ChronicSpinal Cord StimulationUnited Kingdom - RecruitingNot Applicable
Prospective clinical evaluation of artificial intelligence in radiology
This study looks at how well artificial intelligence (AI) helps NHS doctors read medical scans like X-rays. We're testing AI tools in real hospitals to see if they improve diagnosis and patient care. It aims to make healthcare more accurate and efficient.
Patients undergoing medical imaging as part of routine clinical careUnited Kingdom - Recruiting
Evaluating a new rapid test for urinary tract infections in women
This study is testing a new, quick urine test for women with suspected UTIs. It aims to see if this test can help doctors decide when antibiotics are truly needed, reducing unnecessary antibiotic use and ensuring women get the right treatment.
Specialty: General Practice, Primary sub-specialty: General Practice; Health Category: Infection; Disease/Condition: Other diseases of urinary systemUnited Kingdom - Recruiting
Maximising the impact of speech and language therapy for children with speech sound disorder - Phase 2 England
This study aims to improve speech therapy for children in the UK with speech sound disorder. We're testing a new way to collect information on how well therapy works, so we can find out which treatments are most effective for different children.
Speech sound disorderUnited Kingdom - RecruitingPHASE3
A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy
This study looks at a new drug called Leriglitazone for adult men with a brain condition called cerebral adrenoleukodystrophy (cALD). Researchers want to see if it's safe and helps improve or slow down the disease.
Cerebral Adrenoleukodystrophy (cALD)United Kingdom - Completed
Pilot randomised controlled trial of a shared reading programme to support relationships between children in care and their carers
This study looks at Story Explorers, a fun reading programme for foster families. It aims to see if it helps carers and children aged 2-4 build stronger bonds, improve children's emotional wellbeing, and make them feel more secure. Participants will do online questionnaires and interviews.
attachment difficulties and emotional wellbeing challenges in children in careUnited Kingdom - Active not recruitingNA
EasiVits Acceptability & Tolerance Study
This study looks at new vitamin and mineral supplements called EasiVits for children aged 1-16 with inherited metabolism problems. We want to see how well children like them and how easy they are to take. These new supplements have very little sugar and no flavour, offering more flexibility than current options.
Inborn Errors of MetabolismUnited Kingdom - Recruiting
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
This study looks at how well Medtronic heart devices, like pacemakers and defibrillators, perform over a long time. It helps ensure these devices are reliable and safe for people with heart conditions such as irregular heartbeats or heart failure.
ArrhythmiaBradycardiaHeart FailureSinus TachycardiaUnited Kingdom