Diabetes research
Type 1 and type 2 diabetes, prediabetes and related metabolic research.
451 indexed studies · 208 currently recruiting
Top conditions in this hub
- Type 2 Diabetes71
- Diabetes Mellitus, Type 239
- Diabetes Mellitus35
- Obesity31
- Diabetes31
- Type 1 Diabetes26
- Type 2 Diabetes Mellitus25
- Diabetes Mellitus, Type 122
- Type 1 Diabetes Mellitus14
- Hypertension13
- Cardiovascular Diseases13
- PreDiabetes11
- Heart Failure10
- Diabetic Foot Ulcer10
- Insulin Resistance9
- Gestational Diabetes9
Recent studies
- Enrolling by invitationNA
Combined Bariatric Surgery and Pancreas After Kidney Transplantation for Type II Diabetics
This study looks at combining stomach reduction surgery (sleeve gastrectomy) with a new pancreas and kidney for people with Type 2 diabetes. The goal is to help them stop insulin, control blood sugar, and protect their new kidney from diabetes-related damage.
Canada - AuthorisedHuman Pharmacology (Phase I)- Other
A Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants with Type 2 Diabetes Mellitus(T2DM) and Overweight or Obesity
This study is looking at a new medicine called RO7204239. It wants to see how this medicine affects how your body uses insulin and the makeup of your muscles. It's for people with type 2 diabetes who are also overweight or obese.
Germany - Recruiting
AI Screening for Diabetic Retinopathy
This study looks at using a computer program (AI) to check for eye problems in people with diabetes. It aims to see how good the AI is at spotting diabetic retinopathy, a condition that can affect your sight.
Germany - Enrolling by invitationNA
Diabetes Transition Coordinator Study
This study looks at how a special helper, called a transition coordinator, can support young people with Type 1 diabetes as they move from children's doctors to adult doctors. It checks if this support improves their health, how they feel, and if it's a good way to help.
Canada - Recruiting
Disentangling the Effect of Brain Insulin Resistance on Brain Health
This study looks into why people with diabetes might have memory and thinking problems. We're exploring if how the brain uses insulin, or damage to brain blood vessels, plays a role. We'll compare people with type 1 and type 2 diabetes with healthy individuals using scans and tests.
Denmark · Germany - Recruiting
An Observational Study Called FINEROD to Learn More About the Use of the Treatment Finerenone Including How Safe it is and How Well it Works Under Real-world Conditions
This study looks at how a new medicine, finerenone, is used by people in everyday life. It's for people with long-term kidney problems and type 2 diabetes. Researchers will check if it's safe and how well it works using existing health records, not new tests.
United States · Germany · Japan - RecruitingNA
Evaluating a Digital Intervention for Alleviating Diabetes-specific Emotional Distress in Adults Living With T2DM
This study looks at how a digital helper called covivio might ease the emotional stress linked to type 2 diabetes. 250 adults in Germany will take part to see if it helps improve their mood and health.
Germany - Recruiting
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism
This study looks at how weight-loss surgery affects blood sugar control and how the body uses energy in people with obesity and type 2 diabetes. We want to understand how this surgery improves health, especially for the liver.
Germany - Recruiting
A Biological Atlas of Severe Obesity (Biological Tissue Collection)
This study aims to understand how our genes and lifestyle choices contribute to severe obesity and type 2 diabetes. Researchers will collect tiny tissue samples during planned surgery to learn more about how these complex health conditions develop in different people.
France - RecruitingNA
The Feasibility Of Expectant Management Versus Induction At 38 Weeks Among Individuals With Gestational Diabetes Mellitus: A Randomized Controlled Pilot Trial (EAGER Pilot Trial)
This study looks at the best time to deliver for pregnant people with gestational diabetes. It compares inducing labour at 38 weeks with waiting for labour to start naturally, to see which approach is safer for both parent and baby. This is a small first step to plan a larger study.
Canada - RecruitingNA
Study of the Factors Favoring the Transition From Prediabetes to Diabetes on Reunion Island.
This study looks at why some people with pre-diabetes on Reunion Island go on to develop type 2 diabetes. Researchers want to understand the factors involved to help prevent diabetes in this community, where it is a significant health concern.
France - Active not recruitingPHASE4
Treat & Extend Versus Fixed Dosing With Faricimab for Management of Diabetic Macular Edema: A Pragmatic, Multi-center, Open-label, Randomized, Controlled Trial
This study is looking at new ways to treat diabetic macular edema, an eye condition caused by diabetes. It compares two different schedules for giving a new medicine called faricimab to see which works best for patients in their daily lives.
United States · Australia · Canada - RecruitingNA
CommuniT1D: A Customized Virtual Peer Support Program For People Living With Type 1 Diabetes In Canada
This study, called CommuniT1D, explores a virtual support program for people in Canada with type 1 diabetes (T1D). It aims to connect individuals with shared experiences through online meetings and webinars, helping them feel less alone and improving their well-being. Researchers who also live with T1D are leading this project.
Canada - Active not recruitingNA
Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers
This study looks into a new treatment called shockwave therapy for difficult-to-heal foot sores caused by diabetes. We want to see if sound waves can help these sores heal faster and better, and if it's good value for money. We're testing different strengths of the treatment.
United Kingdom - Active not recruitingPHASE3
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
This study compares two medicines, retatrutide and semaglutide, for adults with Type 2 Diabetes whose current treatment isn't enough. It will check how well they work and if they are safe, aiming to improve blood sugar control.
United States · Argentina · Canada - Active not recruitingPHASE2
Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD)
This study is looking into a new medicine called aldesleukin for children and young adults with newly diagnosed Type 1 diabetes. We want to see if it can help their bodies keep making their own insulin for longer, which could improve their health and make managing diabetes easier.
United Kingdom - RecruitingPHASE1
Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes
This study looks at a new medicine, NNC0487-0111, for adults with Type 2 diabetes. It aims to understand how this medicine affects how your body uses insulin and how well your pancreas works to control blood sugar.
Germany - RecruitingPHASE1
A Phase 1b Study of QX1206 in T2DM Patients With NAFLD
This study is looking at a new drug, QX1206, for people with type 2 diabetes and fatty liver disease. It aims to find the right dose and see if it helps improve their health.
Canada - Recruiting
Mitochondrial Substrate Utilization in the Diabetic Human Heart
This study looks at how diabetes affects the heart's energy use, especially in people with heart failure. Researchers want to understand why diabetes leads to heart problems, hoping to find better ways to diagnose and treat them early.
Germany - Recruiting
Kidney Check: Diabetes, Blood Pressure & Kidney Health Checks & Care in Indigenous Communities.
This study offers free kidney health checks for Indigenous people aged 10-80 in rural areas of Canada. It aims to find kidney problems early, and those at risk of diabetes and high blood pressure, to improve care and create a lasting health system for these communities.
Canada - Recruiting
National Registry of Rare Kidney Diseases
This registry is collecting information from people with rare kidney diseases across the UK. It aims to improve understanding, create better care guidelines, and help develop new treatments for these conditions. If you have a rare kidney disease, your information could help.
United Kingdom - Active not recruitingPHASE3
Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
This study looks at a new medicine called Retatrutide for people with Type 2 Diabetes and kidney problems. It checks if the medicine improves blood sugar control and is safe, compared to a dummy medicine, for those already on insulin.
United States · Argentina · Brazil - RecruitingPHASE3
KHENERFIN Study: A Trial to Evaluate the Efficacy and Safety of Sonlicromanol in Primary Mitochondrial Diseases
This study, called KHENERFIN, looks at a new medicine called sonlicromanol for people with mitochondrial diseases. It aims to see if the medicine can reduce tiredness and improve physical abilities like balance and strength. Participants will take either the medicine or a dummy pill for a year.
United States · Denmark · France - RecruitingPHASE2
SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes
This study is testing a new drug, SAB-142, for people with recently diagnosed Type 1 Diabetes. It aims to see if SAB-142 can slow down the disease, and if it's safe to use. Participants will receive high dose, low dose, or a dummy drug.
United States · Australia · Austria - Active not recruitingPHASE3
The Fenofibrate And Microvascular Events in Type 1 Diabetes Eye.
This study looks into whether a daily tablet called fenofibrate can help protect the eyes of adults with Type 1 diabetes. It aims to see if this medicine can prevent or slow down eye damage, which is a common problem for people with diabetes.
Australia · Hong Kong · New Zealand - Ongoing, recruitingTherapeutic confirmatory (Phase III)
J2A-MC-GZGV: A Phase 3, Randomized, Open-Label Study to Investigate the Efficacy and Safety of Once Daily Oral Orforglipron Compared with Dapagliflozin in Adult Participants with Type 2 Diabetes and Inadequate Glycemic Control with Metformin (ACHIEVE-2)
This study looks at a new drug, orforglipron, for people with type 2 diabetes whose blood sugar isn't well controlled with metformin. It compares orforglipron with an existing drug, dapagliflozin, to see how well they lower blood sugar and if they're safe.
Poland · Germany - Ongoing, recruitingHuman Pharmacology (Phase I)- First administration to humans
A research study Looking into blood levels of the medicine NNC0519-0130 in the body of participants with normal or reduced kidney function
This study is looking at a new medicine, NNC0519-0130, for people with Type 2 Diabetes. Researchers want to see how much of the medicine stays in the blood and for how long, especially in people with normal or reduced kidney function. It's an early-stage study to understand the medicine better.
Germany - Ongoing, recruitingTherapeutic confirmatory (Phase III)
A Study to Evaluate the Efficacy and Safety of Once-weekly Insulin Icodec when Switching from Daily Basal Insulins Compared to Once-daily Insulin Glargine U100 in Adults with Type 2 Diabetes
This study is looking at a new once-a-week insulin treatment, called insulin icodec, for people with type 2 diabetes. It's comparing it to a daily insulin, Lantus, to see if the weekly option is safe and works just as well to control blood sugar.
Poland · Spain · Bulgaria - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Influence of various fast-acting mealtime insulin preparations in individuals with type 1 diabetes, with slow, moderate, and rapid gastric emptying, on postprandial blood glucose and the formation of reactive oxygen species
This study looks at how different fast-acting insulins affect blood sugar levels after meals in people with Type 1 diabetes. It compares insulins like Lyumjev and Humalog to see which works best depending on how quickly food leaves the stomach.
Germany - Ongoing, recruitingTherapeutic exploratory (Phase II)
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema 2.4 mg/2.4 mg) once weekly versus semaglutide 2.4 mg, cagrilintide 2.4 mg and placebo in people with chronic kidney disease and type 2 diabetes living with overweight or obesity.
This study looks at a new combination medicine, CagriSema, for people with type 2 diabetes, kidney disease, and overweight or obesity. It compares CagriSema to existing treatments and a dummy medicine to see how it affects kidney health, weight, and blood sugar, while checking for side effects.
Spain · Hungary · Poland - Ongoing, recruitingTherapeutic exploratory (Phase II)
Study to evaluate the effect of metformin in the prevention of hyperglycemia in HR[+]/HER2[–] PIK3CA-mutated advanced breast cancer patients treated with alpelisib plus endocrine therapy. The Metallica study.
This study, called "Metallica," looks at how metformin might help prevent high blood sugar in people with a specific type of advanced breast cancer. These patients are taking a medicine called alpelisib along with other hormone therapies. The goal is to see if metformin reduces severe blood sugar issues.
Spain - Ongoing, recruitingTherapeutic use (Phase IV)
Optimization of Albuminuria-Lowering Therapies for Individual Patients with Type 2 Diabetes Using Empagliflozin and Finerenone in a Pilot Remote Clinical Trial
This study looks at how well different diabetes medicines work together to protect kidneys in people with type 2 diabetes. It also checks how easy it is for people to take part in a study from home using digital tools, like giving urine samples and checking blood pressure.
Netherlands - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
Randomised, crossover bioequivalence clinical trial of linagliptin/metformin 2.5 mg/1000 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fed conditions.
This study is testing a new version of a common diabetes medicine, linagliptin/metformin. It wants to see if the new tablet works the same way in healthy adults as the original medicine, after they've eaten. This helps make sure new medicines are just as good.
Spain - Recruiting
Hybrid closed loop insulin pumps and early worsening of diabetic retinopathy in Type 1 diabetes
This study looks at how new insulin pumps, called hybrid closed-loop systems, affect the eyes of people with Type 1 diabetes. We want to see if quick blood sugar improvements might temporarily worsen eye health and compare this with other diabetes treatments.
United Kingdom · England - Ongoing, recruitingTherapeutic exploratory (Phase II)
Safety and efficacy of once-weekly subcutaneous and once-daily oral NNC0487-0111 in participants with type 2 diabetes – a dose finding study
This study is testing a new medicine, NNC0487-0111, for people with type 2 diabetes. It's looking at different ways to take the medicine (once a week shot or once a day pill) to see how safe and effective it is at controlling blood sugar.
Romania · Spain · Poland - Recruiting
Pancreas lipotoxicity in type 2 diabetes: Edinburgh Diabetes Remission Study (EDRS)
This study, the Edinburgh Diabetes Remission Study (EDRS), is looking at how fat in the pancreas affects type 2 diabetes. It wants to see if losing weight can reverse the condition. Participants will follow a special low-calorie diet to help researchers understand these changes.
United Kingdom · Scotland - Ongoing, recruitingHuman Pharmacology (Phase I)- Other
Phase 1 study assessing the pharmacokinetics of NEX-22A in subjects with T2D
This early-stage study is for people with type 2 diabetes. It's looking at how a new medicine, NEX-22A, moves through the body. The main goal is to understand how the body handles this new treatment.
Germany - Active not recruitingPHASE4
Ursodeoxycholic Acid vs Metformin in Gestational Diabetes Mellitus
This study compares two medicines, Ursodeoxycholic Acid and Metformin, for treating diabetes that starts during pregnancy (gestational diabetes). We want to see which one works better at controlling blood sugar in women who are overweight or obese and need medicine for their diabetes.
United Kingdom - Ongoing, recruitingHuman Pharmacology (Phase I)- Bioequivalence Study
A randomized, open-label, single dose, 2-way crossover bioequivalence study comparing apixaban 5 mg hard capsules (PG412 [Celon Pharma]) vs apixaban 5 mg film-coated tablets (Eliquis [Bristol-Myers Squibb]) under fasting conditions in healthy volunteers
This study compares two different versions of a medicine called apixaban (one is PG412, the other is Eliquis). Both help prevent blood clots. We want to see if the new version works in the body in the same way as the established one.
Poland - Recruiting
Cardiometabolic Health in First Time Pregnancy
This study looks at how pregnancy complications like high blood pressure can affect a woman's heart health and risk of diabetes later on. It aims to understand these links better and find ways to prevent future problems.
United Kingdom