Latest studies
- Recruiting
A study exploring a women-only, trauma -informed residential rehabilitation pathway for drug dependent women leaving prison
This study looks at how best to help women leaving prison who have drug problems. It explores if moving them straight into women-only rehab helps them recover and lead better lives, compared to usual support.
Drug-dependent women leaving prisonEngland - RecruitingNot Applicable
Medical utility of artificial intelligence for fracture detection in the emergency department
This study looks at how well a special computer program, called AI, can help doctors find broken bones on X-rays in emergency departments. It aims to see if AI can reduce mistakes and improve care for patients with suspected fractures.
Patients undergoing X-ray for suspected fracture in the emergency department or minor injuries unitEngland - Completed
Wait Less; an online brief psychological intervention to reduce waiting list distress
This study looks at whether an online talking therapy, MyMindWorks (MMW), can help young people aged 12-17 with depression while they wait for NHS mental health services. It aims to see if MMW is helpful and acceptable, and if it could reduce waiting list distress.
Depression in young people aged 12 to 17 yearsEngland - CompletedPhase I
A study to evaluate the safety and effects on the immune system of a tetanus and diphtheria vaccine which does not need any cold chain distribution or storage
This study is testing a new tetanus and diphtheria jab that doesn't need to be kept cold. It's for healthy adults who've had these jabs before but not in the last 10 years. We want to see if it's safe and works as well as existing jabs.
Prevention of tetanus and diphtheria infection in healthy volunteersEngland - Recruiting
Real-world exploration of digital innovation for managing excess weight
This study looks at how well a digital app helps people in South East London manage their weight compared to usual care. It aims to see if app-based programs can help more people, save money for the NHS, and improve patient experiences without risks.
Specialty: General Practice, Primary sub-specialty: General Practice; Health Category: Cancer and neoplasms, Cardiovascular, Metabolic and Endocrine, Oral and Gastrointestinal, Stroke; Disease/Condition: Obesity and other hyperalimentationEngland - Recruiting
Comparing an easy-to-use swab test and ultrasound for detection of womb cancer
This study compares a new, easy-to-use swab test called WID®-easy with the usual ultrasound scan for detecting womb cancer in women experiencing unusual bleeding. The goal is to see if the new test works better and could be used more widely in the NHS.
Womb cancerEngland - RecruitingPhase III
A study comparing the effect of apalutamide treatment before focal therapy with focal therapy alone in men with prostate cancer that has not spread beyond the prostate
This study looks at treating prostate cancer that is still within the prostate. We're comparing focal therapy alone with focal therapy after a short course of a drug called apalutamide. We want to see if using apalutamide first can make the focal therapy work even better.
Localised prostate cancerEngland - Recruiting
A study to find out if a new blood test (microRNA) can be used to monitor people after surgery for seminoma or dysgerminoma cancer
This study looks at a new blood test to see if cancer has come back in people treated for specific early-stage cancers like seminoma or dysgerminoma. It aims to reduce the need for scans by seeing if a simple blood test can do the job and help find cancer recurrence earlier.
Seminoma and dysgerminomaEngland - Completed
A study of potential treatment-responsive biomarkers and clinical outcomes in Hunter syndrome
This study looked at how Hunter Syndrome affects people over time, including changes in behaviour, thinking abilities, and levels of certain signs in the body. It aimed to understand the condition better and find ways to measure if future treatments are working, without giving any new medicines.
Mucopolysaccharidosis IIEngland - CompletedNot Applicable
Usability and accuracy of the Hormona at-home perimenopause test kit and mobile app
This study looks at how well women aged 40-55 can use the Hormona app and at-home test kit to understand their changing hormones during perimenopause. It aims to make the system easy to use and accurate.
Perimenopause and menopauseEngland - RecruitingNot Applicable
Prospective clinical evaluation of artificial intelligence in radiology
This study looks at how well artificial intelligence (AI) helps NHS doctors read medical scans like X-rays. We're testing AI tools in real hospitals to see if they improve diagnosis and patient care. It aims to make healthcare more accurate and efficient.
Patients undergoing medical imaging as part of routine clinical careEngland - Recruiting
Maximising the impact of speech and language therapy for children with speech sound disorder - Phase 2 England
This study aims to improve speech therapy for children in the UK with speech sound disorder. We're testing a new way to collect information on how well therapy works, so we can find out which treatments are most effective for different children.
Speech sound disorderEngland - Completed
Pilot randomised controlled trial of a shared reading programme to support relationships between children in care and their carers
This study looks at Story Explorers, a fun reading programme for foster families. It aims to see if it helps carers and children aged 2-4 build stronger bonds, improve children's emotional wellbeing, and make them feel more secure. Participants will do online questionnaires and interviews.
attachment difficulties and emotional wellbeing challenges in children in careEngland - Recruiting
The DISC Pilot study: testing if taking extra tissue during breast surgery helps make treatment more successful
This study looks at whether removing a small amount of extra tissue during breast cancer surgery for a specific type called DCIS can reduce the need for a second operation. It also checks cosmetic results and patient experiences.
Breast cancerEngland - Recruiting
Timing of nutrition in emergency laparotomy
This study looks at the best time to give special liquid food directly into a vein to adults having urgent belly surgery. It aims to see if starting this feeding early helps reduce problems and speeds up recovery after the operation.
Hospital complications in adults undergoing emergency laparotomyEngland - Recruiting
Supporting honest and reflective engagement after Mental Health Act assessments
This study wants to improve how people are supported after a Mental Health Act assessment. It aims to create a new way for patients and staff to talk about the experience, helping patients feel heard and prevent future compulsory hospital stays.
Mental healthEngland - Completed
Does use of the MindEar app reduce tinnitus-related distress in patients awaiting tinnitus therapy?
This study looks at whether a phone app called MindEar can help people with tinnitus feel better while they wait for specialist NHS care. Participants will either use the app or not, and share how they are feeling.
TinnitusEngland - Recruiting
Discontinuation of hormone replacement therapy: TAPER study
This study looks at why women stop Hormone Replacement Therapy (HRT) and why some choose to restart it. It also explores how healthcare professionals support these decisions. The goal is to better understand experiences and improve care for women going through menopause.
Use of Hormone Replacement TherapyEngland - Completed
Exploring cannabidiol’s impact on behaviour in adults with intellectual disabilities and epilepsy (CANABID-LD)
This study looks at how a medicine called Epidyolex, used for seizures, might also help adults with intellectual disabilities who have certain types of epilepsy (Dravet, Lennox-Gastaut, Tuberous Sclerosis Complex) with challenging behaviours. It follows people already prescribed the medicine.
Adults with Intellectual Disability with Lennox-Gastaut syndrome, Dravet syndrome and tuberous sclerosis complexEngland - Recruiting
Supporting people with long-term health conditions and disabilities at work: a feasibility study of the Co-Manage self-management support programme
This study tests an online toolkit called Co-Manage to help people with long-term health conditions and disabilities manage their health better at work. It aims to support employees, managers, and employers to create healthier workplaces.
Any long-term condition or disability requiring ongoing management for ≥12 months.England - Completed
An international cohort study of wound closure and surgical site infection prevention strategies in abdominal surgery
This study looks at how different ways of closing wounds and preventing infections after tummy surgery affect how well people recover. It aims to improve future surgical care worldwide by gathering information from adults undergoing these operations.
Adult patients (age 18 years and above) undergoing general or colorectal surgical procedures using any type of abdominal incision measuring at least 5 cm (including extraction sites)England - Recruiting
A study of home-use brain stimulation to treat bipolar depression
This study looks at whether a home-use device using mild electrical current can help people with bipolar depression. It aims to see if it's effective, safe, and easy to use at home, compared to a dummy treatment.
Bipolar Disorder; Mental healthEngland - Completed
Effects of short-term consumption of retail-available fermented foods on cognition, mood, and the gut microbiome: an exploratory pilot study.
This study looks at how everyday fermented foods might improve mood, thinking, and gut health in healthy adults. Researchers want to see if these foods change the good bacteria in our gut and how that affects us.
No health conditions, healthy cohort only, not obese.England - Recruiting
Understanding what Social Care organisations do to bring more young people into care roles and keep them in the job
This study looks at how social care organisations attract and keep young people in vital care roles. Researchers will identify successful organisations, interview their senior staff, and share good ideas across the country to help strengthen the social care workforce for the future.
Adult social care workforceEngland - Recruiting
The effectiveness of a cardiovascular ‘health check’ in a workplace setting
This study checks how well a workplace health check works. You'll repeat a home 'Healthy Heart' test you did a year ago, measuring cholesterol. It helps see if these remote checks are a good way to monitor heart health, potentially replacing some traditional NHS checks.
Cardiovascular diseasesEngland - Recruiting
A global study of pleural infection causes, management, and outcomes
This global study, INTERMITTENT, aims to understand why and how lung infections (pleural infections) happen, how they're treated around the world, and what helps patients recover best. Researchers hope to improve care for this serious condition.
Pleural infectionEngland - RecruitingPhase II
A study to explore the effect of immunotherapy drug, tebentafusp, on patients with clear cell sarcoma (ultra-rare, aggressive type of soft tissue sarcoma that primarily affects young adults)
This study looks at a medicine called tebentafusp for a rare cancer called clear cell sarcoma. Researchers want to see if the drug works and how long its effects last. It's for adults with advanced clear cell sarcoma.
Clear cell sarcomaEngland - RecruitingPhase I
First in woman safety and ease of use assessment of 400 mg progesterone Callavid in women with luteal phase progesterone insufficiency
This study looks at a new progesterone treatment for women who have had miscarriages and have low progesterone. We want to see if it’s safe and easy to use, comparing it to an existing treatment. It aims to help improve our understanding of fertility.
Women who have had at least one miscarriage and have luteal phase progesterone insufficiencyEngland - RecruitingPhase III
A flexible initiative to test therapies for Alzheimer’s disease
This study, AD-SMART, is testing if two existing medicines, atomoxetine and metformin, can help people with Alzheimer's disease. Researchers want to see if these drugs improve daily life and memory for about four years, hoping to find better treatments.
Medical condition: Symptomatic Alzheimer’s Disease (Mild Cognitive Impairment, Mild Dementia, Moderate Dementia) Medical condition in lay language: Alzheimer’s disease (AD) Therapeutic areas: Diseases [C] - Nervous System Diseases [C10]England - RecruitingPhase III
Quetiapine effectiveness study in borderline personality disorder (QUEST)
This study looks at whether the drug quetiapine helps people with Borderline Personality Disorder (BPD). Participants will receive either quetiapine or a dummy pill for 12 months, alongside their usual care, to see if it improves symptoms and offers good value for money.
Borderline personality disorderEngland - Recruiting
Comparing large chest drains with small chest drains to explore the best treatments for chest injury
This study compares two types of tubes, small and large, used to drain air or blood from the chest after an injury. It aims to find out which one works best and is safer for patients, and if it could save the NHS money.
Specialty: Trauma and Emergency Care, Primary sub-specialty: Emergency Medicine; Health Category: Injuries and accidents, Respiratory; Disease/Condition: Injuries to the thoraxEngland - Recruiting
Investigating the relationship between physical activity and side effects associated with systemic anti-cancer therapies
This study looks into how exercise might help people with breast, lung, bowel, or prostate cancer manage treatment side effects. It's investigating if it's practical to measure activity and deliver exercise programmes during cancer treatment. It will help plan bigger studies in the future.
Cancer-related functional decline and reduced physical activity in adults receiving systemic anti-cancer therapyEngland - Recruiting
Using high flow moist oxygen early to treat acute severe asthma in children
This study looks at whether giving children high-flow, warm, moist oxygen early can help them recover faster from severe asthma attacks. It aims to see if this treatment reduces the need for stronger medicines given into a vein. Children aged 2 to 18 with acute severe asthma are being invited to take part.
Acute severe asthma in childrenEngland - Recruiting
Arts for the Blues for children and young people aged 9-13 years
This study looks at a creative therapy called 'Arts for the Blues' for 9-13 year olds with depression and anxiety. It uses activities like drawing and movement to help children explore their feelings and improve their mental wellbeing when receiving NHS mental health support.
Children and young people's mental health, specifically, symptoms of depression and anxietyEngland - Recruiting
Evaluating The Skill Mill programme to lower violence and offending in young people
This study looks at 'The Skill Mill' programme, which gives young people aged 16-18 with a past offending history a 6-month paid job. The aim is to see if this helps reduce re-offending and improves their life skills and job prospects. It's funded by the Youth Endowment Fund.
Prevention of re-offending by young people with an offending history with one or multiple convictions of any type of offenceEngland - Completed
Impact of Symprove in Ehlers-Danlos Syndrome
This study looks at how a food supplement called Symprove might help people with Ehlers-Danlos syndromes (EDS) manage their gut symptoms. Participants will take Symprove for 12 weeks and answer surveys online from home. It aims to see if Symprove can improve overall EDS symptoms.
Ehlers-Danlos syndromesEngland - Completed
Piloting and testing the impact of a digital healthy eating intervention on young adults in Jamaica and the UK
This study looks at how digital tools, like WhatsApp and supermarket vouchers, can help young adults in the UK and Jamaica eat healthier. It's for 18-25 year olds who use social media for food content and aims to improve their diet quality.
Improvement of diet quality and dietary behaviours in young adultsEngland - Completed
Liver health screening for Mongolian people in London
This study looks at liver health in Mongolian adults in London. It checks for common liver conditions like hepatitis and fatty liver disease. The aim is to understand these conditions better and help people get the right care. You can take part if you are an adult from the Mongolian community in London.
Viral hepatitis and metabolic dysfunction-associated steatotic liver disease in Mongolian people in LondonEngland - Recruiting
Pharmacogenetics to avoid loss of hearing UK
This study uses a quick genetic test to protect newborn babies from hearing loss. Some babies given a common antibiotic, gentamicin, can become deaf if they have a certain gene. This test identifies those babies quickly so they can receive a safer treatment. It's being tested across the UK.
Use of a genetic test to detect the m.1555A>G variant associated with aminoglycoside-induced hearing loss in neonatal care unitsEngland - Completed
Using a blood test alongside body fat measurements for obesity risk prediction to improve pregnancy outcomes
This study uses existing blood and body fat data from a past study (SHAPES) to better predict pregnancy complications. Researchers are looking for better ways than BMI to identify those at risk, hoping to improve care for pregnant people.
Pregnancy outcomesEngland - Recruiting
LYME-UK – A study of early Lyme disease within GPs in the UK
The LYME-UK study is looking into Lyme disease in the UK. Researchers want to learn more about how many people get it, how it's diagnosed, and what happens to people after treatment. This will help doctors better understand and treat the condition.
Lyme diseaseEngland - Recruiting
Exploring the current use of remote assessment questionnaires in outpatient services to assess the feasibility of standardisation
This study looks at how questionnaires sent home to patients are used in hospital clinics. We want to find out how to make these questionnaires better and more consistent, so they can help doctors provide the best care.
Generic health relevanceEngland - CompletedPhase I
Phase I Trial: Quotient Code QSC301789
This early-stage study, called Quotient Code QSC301789, is looking into a new treatment. We don't have all the details yet, as they will be shared later. It involves adults aged 18 to 55, both men and women. We'll know more about the specific treatment and its purpose after the study is completed.
The sponsor has confirmed that the trial meets the criteria for deferral of publication of the full details of the trial. The full details will be added to the study record within 30 months after the trial has ended.England - Recruiting
PASSPORT trial and evaluation of a flexible physical activity intervention in UK Primary schools
This study looks at how primary schools can help children get more active. It tests a flexible programme where each school chooses activities that suit them. We're checking if this helps Year 4 and 5 pupils in Bristol get more physical activity.
Physical activityEngland - Recruiting
EarMetrics®-Oximeter - a targeted oxygenation observation study
This study tests a new ear device, the EarMetrics®-Oximeter, to measure blood oxygen levels. It aims to be more accurate for people with darker skin. Healthy adults will have their oxygen levels monitored during a temporary, controlled reduction of oxygen.
Healthy volunteersEngland - Recruiting
Clinical trial of digitally enabled cognitive therapy for PTSD in NHS Talking Therapies for anxiety and depression services
This study looks at an online therapy for PTSD, called iCT-PTSD, compared to usual NHS treatment. Researchers want to see if this online approach, supported by a therapist, helps people with PTSD and how it compares to traditional face-to-face care.
Posttraumatic stress disorderEngland - Recruiting
A study to understand the early stages of muscle weakness in people with Dysferlinopathy (a type of limb girdle muscular dystrophy)
This study looks at the early stages of a rare muscle condition called Dysferlinopathy (LGMDR2). Researchers want to understand how it develops to improve future diagnosis and treatments. It involves yearly visits for up to five years, including check-ups, scans, and questionnaires.
Limb Girdle Muscular Dystrophy R2 (LGMDR2, Dysferlinopathy)England - RecruitingNot Specified
Study of whether radiotherapy after surgery to treat a weakened or broken bone caused by cancer helps to reduce pain and improve quality of life
This study looks at whether radiation treatment after surgery for cancer-related broken bones helps with pain and quality of life. Some people will get radiation, others won't immediately, to see if it makes a difference and if it's truly needed after surgery.
Bone metastasesEngland - Recruiting
Clinical trial of digitally enabled cognitive therapy for social anxiety disorder in NHS Talking Therapies for anxiety and depression services
This study looks at a new online therapy for social anxiety disorder in NHS Talking Therapies. It compares this internet-based treatment, where you learn at home with therapist support, to the usual face-to-face NHS treatments, to see which works best and if it helps more people.
Social anxiety disorderEngland - RecruitingPhase IV
Digital multi-component intervention to improve the care of older people living with diabetes and chronic kidney disease
This study looks at whether computer reminders can help GPs give better care to older people with kidney problems caused by diabetes. The aim is to slow down kidney damage and improve health for people in the UK. Researchers will test a digital tool in GP practices.
Diabetic kidney disease (DKD)England